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| PMID |
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| TITLE |
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| The association between genetically determined ABO blood types and major depressive disorder. |
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| ABSTRACT |
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| ABO blood types and their corresponding antigens have long been assumed to be related to different human diseases. So far, smaller studies on the relationship between mental disorders and blood types yielded contradicting results. In this study we analyzed the association between ABO blood types and lifetime major depressive disorder (MDD). We performed a pooled analysis with data from 26 cohorts that are part of the MDD working group of the Psychiatric Genomics Consortium (PGC). The dataset included 37,208 individuals of largely European ancestry of which 41.6% were diagnosed with lifetime MDD. ABO blood types were identified using three single nucleotide polymorphisms in the ABO gene: rs505922, rs8176746 and rs8176747. Regression analyses were performed to assess associations between the individual ABO blood types and MDD diagnosis as well as putative interaction effects with sex. The models were adjusted for sex, cohort and the first ten genetic principal components. The percentage of blood type A was slightly lower in cases than controls while blood type O was more prominent in cases. However, these differences were not statistically significant. Our analyses found no evidence of an association between ABO blood types and major depressive disorder. |
| Copyright © 2021. Published by Elsevier B.V. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2020/10/21 |
| accepted |
2021/02/21 |
| entrez |
2021/03/15 20:21 |
| pubmed |
2021/03/16 06:00 |
| medline |
2021/03/16 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Garvert L |
|
Garvert |
Linda |
L |
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Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. Electronic address: linda.garvert@med.uni-greifswald.de. |
| Baune BT |
|
Baune |
Bernhard T |
BT |
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Department of Psychiatry, University of Münster, Münster, Germany; Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, Australia; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia. |
| Berger K |
|
Berger |
Klaus |
K |
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Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany. |
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
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Department of Biological Psychiatry, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
| Breen G |
|
Breen |
Gerome |
G |
|
NIHR Maudsley Biomedical Research Centre, King's College London, London, UK; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK. |
| Greinacher A |
|
Greinacher |
Andreas |
A |
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Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany. |
| Hamilton SP |
|
Hamilton |
Steven P |
SP |
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Department of Psychiatry, Kaiser Permanente Northern California, San Francisco, CA, USA. |
| Levinson DF |
|
Levinson |
Douglas F |
DF |
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Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. |
| Lewis CM |
|
Lewis |
Cathryn M |
CM |
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Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK; Department of Medical and Molecular Genetics, King's College London, London, UK. |
| Lucae S |
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Lucae |
Susanne |
S |
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Max Planck Institute of Psychiatry, Munich, Germany. |
| Magnusson PKE |
|
Magnusson |
Patrik K E |
PKE |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| McIntosh AM |
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McIntosh |
Andrew M |
AM |
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Division of Psychiatry, University of Edinburgh, Edinburgh, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. |
| Mors O |
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Mors |
Ole |
O |
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Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark. |
| Müller-Myhsok B |
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Müller-Myhsok |
Bertram |
B |
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Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Institute for Translational Medicine, University of Liverpool, Liverpool, UK; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. |
| Penninx BWJH |
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Penninx |
Brenda W J H |
BWJH |
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Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands. |
| Perlis RH |
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Perlis |
Roy H |
RH |
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Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. |
| Pistis G |
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Pistis |
Giorgio |
G |
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Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. |
| Potash JB |
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Potash |
James B |
JB |
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Department of Psychiatry, University of Iowa, Iowa City, IA, USA. |
| Preisig M |
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Preisig |
Martin |
M |
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Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. |
| Rietschel M |
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Rietschel |
Marcella |
M |
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Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Mannheim, Germany. |
| Shi J |
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Shi |
Jianxin |
J |
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Division of Cancer, Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. |
| Smoller JW |
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Smoller |
Jordan W |
JW |
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Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA. |
| Tiemeier H |
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Tiemeier |
Henning |
H |
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Department of Psychiatry, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, Rotterdam, The Netherlands. |
| Uher R |
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Uher |
Rudolf |
R |
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Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. |
| Völker U |
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Völker |
Uwe |
U |
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German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany; Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany. |
| Völzke H |
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Völzke |
Henry |
H |
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Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. |
| Weissman MM |
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Weissman |
Myrna M |
MM |
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Division of Translational Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. |
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Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium |
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| Grabe HJ |
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Grabe |
Hans J |
HJ |
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Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany; German Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany. |
| Van der Auwera S |
|
Van der Auwera |
Sandra |
S |
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Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany; German Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 299 |
| ISSUE: |
| TITLE: Psychiatry research |
| ISOABBREVIATION: Psychiatry Res |
| YEAR: 2021 |
| MONTH: Feb |
| DAY: 24 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1872-7123 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Psychiatry Res |
| COUNTRY: Ireland |
| ISSNLINKING: 0165-1781 |
| NLMUNIQUEID: 7911385 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Association study |
| Blood group |
| Blood type |
| Depression |
| MDD |
| PGC |
| Psychiatric disorders |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| CHEMICALS |
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