Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
33721783
TITLE
The association between genetically determined ABO blood types and major depressive disorder.
ABSTRACT
ABO blood types and their corresponding antigens have long been assumed to be related to different human diseases. So far, smaller studies on the relationship between mental disorders and blood types yielded contradicting results. In this study we analyzed the association between ABO blood types and lifetime major depressive disorder (MDD). We performed a pooled analysis with data from 26 cohorts that are part of the MDD working group of the Psychiatric Genomics Consortium (PGC). The dataset included 37,208 individuals of largely European ancestry of which 41.6% were diagnosed with lifetime MDD. ABO blood types were identified using three single nucleotide polymorphisms in the ABO gene: rs505922, rs8176746 and rs8176747. Regression analyses were performed to assess associations between the individual ABO blood types and MDD diagnosis as well as putative interaction effects with sex. The models were adjusted for sex, cohort and the first ten genetic principal components. The percentage of blood type A was slightly lower in cases than controls while blood type O was more prominent in cases. However, these differences were not statistically significant. Our analyses found no evidence of an association between ABO blood types and major depressive disorder.
Copyright 2021. Published by Elsevier B.V.
DATE PUBLISHED
2021 Feb 24
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2020/10/21
accepted 2021/02/21
entrez 2021/03/15 20:21
pubmed 2021/03/16 06:00
medline 2021/03/16 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Garvert L Garvert Linda L Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. Electronic address: linda.garvert@med.uni-greifswald.de.
Baune BT Baune Bernhard T BT Department of Psychiatry, University of Münster, Münster, Germany; Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, Australia; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
Berger K Berger Klaus K Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychiatry, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Breen G Breen Gerome G NIHR Maudsley Biomedical Research Centre, King's College London, London, UK; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Greinacher A Greinacher Andreas A Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Hamilton SP Hamilton Steven P SP Department of Psychiatry, Kaiser Permanente Northern California, San Francisco, CA, USA.
Levinson DF Levinson Douglas F DF Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Lewis CM Lewis Cathryn M CM Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK; Department of Medical and Molecular Genetics, King's College London, London, UK.
Lucae S Lucae Susanne S Max Planck Institute of Psychiatry, Munich, Germany.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Martin NG Martin Nicholas G NG Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
McIntosh AM McIntosh Andrew M AM Division of Psychiatry, University of Edinburgh, Edinburgh, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Mors O Mors Ole O Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Müller-Myhsok B Müller-Myhsok Bertram B Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Institute for Translational Medicine, University of Liverpool, Liverpool, UK; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
Perlis RH Perlis Roy H RH Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Pistis G Pistis Giorgio G Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Potash JB Potash James B JB Department of Psychiatry, University of Iowa, Iowa City, IA, USA.
Preisig M Preisig Martin M Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Rietschel M Rietschel Marcella M Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Mannheim, Germany.
Shi J Shi Jianxin J Division of Cancer, Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Smoller JW Smoller Jordan W JW Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Tiemeier H Tiemeier Henning H Department of Psychiatry, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, Rotterdam, The Netherlands.
Uher R Uher Rudolf R Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Völker U Völker Uwe U German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany; Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Völzke H Völzke Henry H Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Weissman MM Weissman Myrna M MM Division of Translational Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Grabe HJ Grabe Hans J HJ Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany; German Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
Van der Auwera S Van der Auwera Sandra S Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany; German Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
INVESTIGATORS
JOURNAL
VOLUME: 299
ISSUE:
TITLE: Psychiatry research
ISOABBREVIATION: Psychiatry Res
YEAR: 2021
MONTH: Feb
DAY: 24
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1872-7123
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Psychiatry Res
COUNTRY: Ireland
ISSNLINKING: 0165-1781
NLMUNIQUEID: 7911385
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Association study
Blood group
Blood type
Depression
MDD
PGC
Psychiatric disorders
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's