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| PMID |
|
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| TITLE |
|
| A twin study of the psychiatric side effects of oral contraceptives. |
|
| ABSTRACT |
|
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|
| Oral contraceptive (ORC)-related depression and irritability are among the most commonly reported drug-induced psychiatric symptoms. To investigate the etiological role of genetic factors in ORC-related symptoms, we studied questionnaire responses in 715 monozygotic and 416 dizygotic volunteer twin pairs concordant for ORC usage. Biometrical genetic analysis indicated that the liability to ORC-related depression was clearly influenced by genetic but not familial-environmental factors. Similar, but less definitive, results were found for ORC-related irritability. Multivariate genetic analysis indicated that both the genetic and the individual-specific environmental factors that influenced the liability to ORC-related depression and irritability were largely distinct from those that influence baseline levels of psychiatric symptoms. Genes play an important etiological role in ORC-related psychiatric side effects. The genes that influence liability to these side effects appear to differ from those that are etiologically important in baseline psychiatric symptomatology. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1988/03/01 |
| medline |
1988/03/01 00:01 |
| entrez |
1988/03/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Kendler KS |
|
Kendler |
K S |
KS |
|
Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298. |
| Martin NG |
|
Martin |
N G |
NG |
|
|
| Heath AC |
|
Heath |
A C |
AC |
|
|
| Handelsman D |
|
Handelsman |
D |
D |
|
|
| Eaves LJ |
|
Eaves |
L J |
LJ |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
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| VOLUME: 176 |
| ISSUE: 3 |
| TITLE: The Journal of nervous and mental disease |
| ISOABBREVIATION: J. Nerv. Ment. Dis. |
| YEAR: 1988 |
| MONTH: Mar |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0022-3018 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: J Nerv Ment Dis |
| COUNTRY: United States |
| ISSNLINKING: 0022-3018 |
| NLMUNIQUEID: 0375402 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA06781 |
NIAAA NIH HHS |
United States |
| AG04954 |
NIA NIH HHS |
United States |
| GM30250 |
NIGMS NIH HHS |
United States |
|
| GENERAL NOTE |
|
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| KEYWORDS |
|
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Affect |
|
| Affective Symptoms |
psychology |
| Body Weight |
psychology |
| Contraceptives, Oral |
adverse effects |
| Depression |
psychology |
| Diseases in Twins |
psychology |
| Edema |
chemically induced |
| Family |
chemically induced |
| Female |
chemically induced |
| Genes |
chemically induced |
| Humans |
chemically induced |
| Irritable Mood |
chemically induced |
| Models, Genetic |
chemically induced |
| Personality Inventory |
chemically induced |
| Phenotype |
chemically induced |
| Twins, Dizygotic |
chemically induced |
| Twins, Monozygotic |
chemically induced |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
|
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| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Contraceptives, Oral |
|
| OTHER ID's |
|
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|
