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| PMID |
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| TITLE |
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| A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA). |
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| ABSTRACT |
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| This prospective cohort study, "Prospective Imaging Study of Ageing: Genes, Brain and Behaviour" (PISA) seeks to characterise the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). In particular, we are recruiting midlife and older Australians with high and low genetic risk of dementia to discover biological markers of early neuropathology, identify modifiable risk factors, and establish the very earliest phenotypic and neuronal signs of disease onset. PISA utilises genetic prediction to recruit and enrich a prospective cohort and follow them longitudinally. Online surveys and cognitive testing are used to characterise an Australia-wide sample currently totalling over 3800 participants. Participants from a defined at-risk cohort and positive controls (clinical cohort of patients with mild cognitive impairment or early AD) are invited for onsite visits for detailed functional, structural and molecular neuroimaging, lifestyle monitoring, detailed neurocognitive testing, plus blood sample donation. This paper describes recruitment of the PISA cohort, study methodology and baseline demographics. |
| Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2020/06/24 |
| revised |
2020/11/11 |
| accepted |
2020/12/04 |
| pubmed |
2020/12/21 06:00 |
| medline |
2020/12/21 06:00 |
| entrez |
2020/12/20 20:30 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Lupton MK |
|
Lupton |
Michelle K |
MK |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. Electronic address: Michelle.Lupton@qimrberghofer.edu.au. |
| Robinson GA |
|
Robinson |
Gail A |
GA |
|
School of Psychology, The University of Queensland, St. Lucia, Brisbane, Australia; Queensland Brain Institute, The University of Queensland, St. Lucia, Brisbane, Australia. |
| Adam RJ |
|
Adam |
Robert J |
RJ |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia; Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Australia; Royal Brisbane and Women's Hospital Mental Health Services, University of Queensland, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia. |
| Rose S |
|
Rose |
Stephen |
S |
|
CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia. |
| Byrne GJ |
|
Byrne |
Gerard J |
GJ |
|
Royal Brisbane and Women's Hospital Mental Health Services, University of Queensland, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia. |
| Salvado O |
|
Salvado |
Olivier |
O |
|
CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia. |
| Pachana NA |
|
Pachana |
Nancy A |
NA |
|
School of Psychology, The University of Queensland, St. Lucia, Brisbane, Australia. |
| Almeida OP |
|
Almeida |
Osvaldo P |
OP |
|
Medical School, University of Western Australia, Perth, Australia; WA Centre for Health and Ageing of the University of Western Australia, Australia. |
| McAloney K |
|
McAloney |
Kerrie |
K |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Gordon SD |
|
Gordon |
Scott D |
SD |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Raniga P |
|
Raniga |
Parnesh |
P |
|
CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia. |
| Fazlollahi A |
|
Fazlollahi |
Amir |
A |
|
CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia. |
| Xia Y |
|
Xia |
Ying |
Y |
|
CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia. |
| Ceslis A |
|
Ceslis |
Amelia |
A |
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School of Psychology, The University of Queensland, St. Lucia, Brisbane, Australia. |
| Sonkusare S |
|
Sonkusare |
Saurabh |
S |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Zhang Q |
|
Zhang |
Qing |
Q |
|
CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia. |
| Kholghi M |
|
Kholghi |
Mahnoosh |
M |
|
CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia. |
| Karunanithi M |
|
Karunanithi |
Mohan |
M |
|
CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia. |
| Mosley PE |
|
Mosley |
Philip E |
PE |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia; Queensland Brain Institute, The University of Queensland, St. Lucia, Brisbane, Australia; Neurosciences Queensland, Brisbane, Queensland, Australia. |
| Lv J |
|
Lv |
Jinglei |
J |
|
Sydney Imaging & School of Biomedical Engineering, The University of Sydney, Sydney, Australia. |
| Borne L |
|
Borne |
Léonie |
L |
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The University of Newcastle, Newcastle, Australia. |
| Adsett J |
|
Adsett |
Jessica |
J |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Garden N |
|
Garden |
Natalie |
N |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Fripp J |
|
Fripp |
Jurgen |
J |
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CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Guo CC |
|
Guo |
Christine C |
CC |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Breakspear M |
|
Breakspear |
Michael |
M |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia; The University of Newcastle, Newcastle, Australia. |
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 29 |
| ISSUE: |
| TITLE: NeuroImage. Clinical |
| ISOABBREVIATION: Neuroimage Clin |
| YEAR: 2020 |
| MONTH: Dec |
| DAY: 08 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2213-1582 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Neuroimage Clin |
| COUNTRY: Netherlands |
| ISSNLINKING: 2213-1582 |
| NLMUNIQUEID: 101597070 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| U24 AG021886 |
NIA NIH HHS |
United States |
| U01 AG032984 |
NIA NIH HHS |
United States |
| U01 AG016976 |
NIA NIH HHS |
United States |
| R01 HL105756 |
NHLBI NIH HHS |
United States |
| R01 AG033193 |
NIA NIH HHS |
United States |
|
Wellcome Trust |
United Kingdom |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Alzheimer’s disease |
| At risk cohort |
| Genetic risk prediction |
| Neuroimaging |
| Neuropsychology |
| Protocol |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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