Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
33300665
TITLE
Ten years of enhancing neuro-imaging genetics through meta-analysis: An overview from the ENIGMA Genetics Working Group.
ABSTRACT
Here we review the motivation for creating the enhancing neuroimaging genetics through meta-analysis (ENIGMA) Consortium and the genetic analyses undertaken by the consortium so far. We discuss the methodological challenges, findings, and future directions of the genetics working group. A major goal of the working group is tackling the reproducibility crisis affecting "candidate gene" and genome-wide association analyses in neuroimaging. To address this, we developed harmonized analytic methods, and support their use in coordinated analyses across sites worldwide, which also makes it possible to understand heterogeneity in results across sites. These efforts have resulted in the identification of hundreds of common genomic loci robustly associated with brain structure. We have found both pleiotropic and specific genetic effects associated with brain structures, as well as genetic correlations with psychiatric and neurological diseases.
2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
DATE PUBLISHED
2020 Dec 10
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2020/09/04
revised 2020/11/16
accepted 2020/11/17
entrez 2020/12/10 08:39
pubmed 2020/12/11 06:00
medline 2020/12/11 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Medland SE Medland Sarah E SE Faculty of Medicine, University of Queensland, Brisbane, Australia.
Grasby KL Grasby Katrina L KL Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA.
Painter JN Painter Jodie N JN Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Colodro-Conde L Colodro-Conde Lucía L Faculty of Psychology, University of Murcia, Murcia, Spain.
Bralten J Bralten Janita J Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Hibar DP Hibar Derrek P DP Personalized Healthcare, Genentech, Inc., South San Francisco, California, USA.
Lind PA Lind Penelope A PA School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
Pizzagalli F Pizzagalli Fabrizio F Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA.
Thomopoulos SI Thomopoulos Sophia I SI Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA.
Stein JL Stein Jason L JL Department of Genetics & UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Franke B Franke Barbara B Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Martin NG Martin Nicholas G NG Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA.
ENIGMA Genetics Working Group
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Human brain mapping
ISOABBREVIATION: Hum Brain Mapp
YEAR: 2020
MONTH: Dec
DAY: 10
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1097-0193
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hum Brain Mapp
COUNTRY: United States
ISSNLINKING: 1065-9471
NLMUNIQUEID: 9419065
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Review
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
EB020403 Foundation for the National Institutes of Health
APP1103623 National Health and Medical Research Council
APP1158127 National Health and Medical Research Council
APP1172917 National Health and Medical Research Council
Fellowship QIMR Berghofer Medical Research Institute
GENERAL NOTE
KEYWORDS
KEYWORD
GWAS
MRI
neuro-imaging genetics
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's