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| PMID |
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| TITLE |
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| Ten years of enhancing neuro-imaging genetics through meta-analysis: An overview from the ENIGMA Genetics Working Group. |
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| ABSTRACT |
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| Here we review the motivation for creating the enhancing neuroimaging genetics through meta-analysis (ENIGMA) Consortium and the genetic analyses undertaken by the consortium so far. We discuss the methodological challenges, findings, and future directions of the genetics working group. A major goal of the working group is tackling the reproducibility crisis affecting "candidate gene" and genome-wide association analyses in neuroimaging. To address this, we developed harmonized analytic methods, and support their use in coordinated analyses across sites worldwide, which also makes it possible to understand heterogeneity in results across sites. These efforts have resulted in the identification of hundreds of common genomic loci robustly associated with brain structure. We have found both pleiotropic and specific genetic effects associated with brain structures, as well as genetic correlations with psychiatric and neurological diseases. |
| © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2020/09/04 |
| revised |
2020/11/16 |
| accepted |
2020/11/17 |
| entrez |
2020/12/10 08:39 |
| pubmed |
2020/12/11 06:00 |
| medline |
2020/12/11 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Faculty of Medicine, University of Queensland, Brisbane, Australia. |
| Grasby KL |
|
Grasby |
Katrina L |
KL |
|
Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Jahanshad N |
|
Jahanshad |
Neda |
N |
|
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA. |
| Painter JN |
|
Painter |
Jodie N |
JN |
|
Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Colodro-Conde L |
|
Colodro-Conde |
Lucía |
L |
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Faculty of Psychology, University of Murcia, Murcia, Spain. |
| Bralten J |
|
Bralten |
Janita |
J |
|
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands. |
| Hibar DP |
|
Hibar |
Derrek P |
DP |
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Personalized Healthcare, Genentech, Inc., South San Francisco, California, USA. |
| Lind PA |
|
Lind |
Penelope A |
PA |
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School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia. |
| Pizzagalli F |
|
Pizzagalli |
Fabrizio |
F |
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Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA. |
| Thomopoulos SI |
|
Thomopoulos |
Sophia I |
SI |
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Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA. |
| Stein JL |
|
Stein |
Jason L |
JL |
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Department of Genetics & UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. |
| Franke B |
|
Franke |
Barbara |
B |
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Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
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Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA. |
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ENIGMA Genetics Working Group |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Human brain mapping |
| ISOABBREVIATION: Hum Brain Mapp |
| YEAR: 2020 |
| MONTH: Dec |
| DAY: 10 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1097-0193 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Hum Brain Mapp |
| COUNTRY: United States |
| ISSNLINKING: 1065-9471 |
| NLMUNIQUEID: 9419065 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Review |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| EB020403 |
Foundation for the National Institutes of Health |
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| APP1103623 |
National Health and Medical Research Council |
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| APP1158127 |
National Health and Medical Research Council |
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| APP1172917 |
National Health and Medical Research Council |
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| Fellowship |
QIMR Berghofer Medical Research Institute |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| GWAS |
| MRI |
| neuro-imaging genetics |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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