Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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33096046
TITLE
A large-scale genome-wide association study meta-analysis of cannabis use disorder.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50-70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder.
METHODS NlmCategory: METHODS
Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50-70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder. To conduct this GWAS meta-analysis of cannabis use disorder and identify associations with genetic loci, we used samples from the Psychiatric Genomics Consortium Substance Use Disorders working group, iPSYCH, and deCODE (20 916 case samples, 363 116 control samples in total), contrasting cannabis use disorder cases with controls. To examine the genetic overlap between cannabis use disorder and 22 traits of interest (chosen because of previously published phenotypic correlations [eg, psychiatric disorders] or hypothesised associations [eg, chronotype] with cannabis use disorder), we used linkage disequilibrium score regression to calculate genetic correlations.
FINDINGS NlmCategory: RESULTS
Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50-70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder. To conduct this GWAS meta-analysis of cannabis use disorder and identify associations with genetic loci, we used samples from the Psychiatric Genomics Consortium Substance Use Disorders working group, iPSYCH, and deCODE (20 916 case samples, 363 116 control samples in total), contrasting cannabis use disorder cases with controls. To examine the genetic overlap between cannabis use disorder and 22 traits of interest (chosen because of previously published phenotypic correlations [eg, psychiatric disorders] or hypothesised associations [eg, chronotype] with cannabis use disorder), we used linkage disequilibrium score regression to calculate genetic correlations. We identified two genome-wide significant loci: a novel chromosome 7 locus (FOXP2, lead single-nucleotide polymorphism [SNP] rs7783012; odds ratio [OR] 1·11, 95% CI 1·07-1·15, p=1·84 × 10 ) and the previously identified chromosome 8 locus (near CHRNA2 and EPHX2, lead SNP rs4732724; OR 0·89, 95% CI 0·86-0·93, p=6·46 × 10 ). Cannabis use disorder and cannabis use were genetically correlated (r 0·50, p=1·50 × 10 ), but they showed significantly different genetic correlations with 12 of the 22 traits we tested, suggesting at least partially different genetic underpinnings of cannabis use and cannabis use disorder. Cannabis use disorder was positively genetically correlated with other psychopathology, including ADHD, major depression, and schizophrenia.
INTERPRETATION NlmCategory: CONCLUSIONS
Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50-70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder. To conduct this GWAS meta-analysis of cannabis use disorder and identify associations with genetic loci, we used samples from the Psychiatric Genomics Consortium Substance Use Disorders working group, iPSYCH, and deCODE (20 916 case samples, 363 116 control samples in total), contrasting cannabis use disorder cases with controls. To examine the genetic overlap between cannabis use disorder and 22 traits of interest (chosen because of previously published phenotypic correlations [eg, psychiatric disorders] or hypothesised associations [eg, chronotype] with cannabis use disorder), we used linkage disequilibrium score regression to calculate genetic correlations. We identified two genome-wide significant loci: a novel chromosome 7 locus (FOXP2, lead single-nucleotide polymorphism [SNP] rs7783012; odds ratio [OR] 1·11, 95% CI 1·07-1·15, p=1·84 × 10 ) and the previously identified chromosome 8 locus (near CHRNA2 and EPHX2, lead SNP rs4732724; OR 0·89, 95% CI 0·86-0·93, p=6·46 × 10 ). Cannabis use disorder and cannabis use were genetically correlated (r 0·50, p=1·50 × 10 ), but they showed significantly different genetic correlations with 12 of the 22 traits we tested, suggesting at least partially different genetic underpinnings of cannabis use and cannabis use disorder. Cannabis use disorder was positively genetically correlated with other psychopathology, including ADHD, major depression, and schizophrenia. These findings support the theory that cannabis use disorder has shared genetic liability with other psychopathology, and there is a distinction between genetic liability to cannabis use and cannabis use disorder.
FUNDING NlmCategory: BACKGROUND
Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50-70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder. To conduct this GWAS meta-analysis of cannabis use disorder and identify associations with genetic loci, we used samples from the Psychiatric Genomics Consortium Substance Use Disorders working group, iPSYCH, and deCODE (20 916 case samples, 363 116 control samples in total), contrasting cannabis use disorder cases with controls. To examine the genetic overlap between cannabis use disorder and 22 traits of interest (chosen because of previously published phenotypic correlations [eg, psychiatric disorders] or hypothesised associations [eg, chronotype] with cannabis use disorder), we used linkage disequilibrium score regression to calculate genetic correlations. We identified two genome-wide significant loci: a novel chromosome 7 locus (FOXP2, lead single-nucleotide polymorphism [SNP] rs7783012; odds ratio [OR] 1·11, 95% CI 1·07-1·15, p=1·84 × 10 ) and the previously identified chromosome 8 locus (near CHRNA2 and EPHX2, lead SNP rs4732724; OR 0·89, 95% CI 0·86-0·93, p=6·46 × 10 ). Cannabis use disorder and cannabis use were genetically correlated (r 0·50, p=1·50 × 10 ), but they showed significantly different genetic correlations with 12 of the 22 traits we tested, suggesting at least partially different genetic underpinnings of cannabis use and cannabis use disorder. Cannabis use disorder was positively genetically correlated with other psychopathology, including ADHD, major depression, and schizophrenia. These findings support the theory that cannabis use disorder has shared genetic liability with other psychopathology, and there is a distinction between genetic liability to cannabis use and cannabis use disorder. National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse; Center for Genomics and Personalized Medicine and the Centre for Integrative Sequencing; The European Commission, Horizon 2020; National Institute of Child Health and Human Development; Health Research Council of New Zealand; National Institute on Aging; Wellcome Trust Case Control Consortium; UK Research and Innovation Medical Research Council (UKRI MRC); The Brain & Behavior Research Foundation; National Institute on Deafness and Other Communication Disorders; Substance Abuse and Mental Health Services Administration (SAMHSA); National Institute of Biomedical Imaging and Bioengineering; National Health and Medical Research Council (NHMRC) Australia; Tobacco-Related Disease Research Program of the University of California; Families for Borderline Personality Disorder Research (Beth and Rob Elliott) 2018 NARSAD Young Investigator Grant; The National Child Health Research Foundation (Cure Kids); The Canterbury Medical Research Foundation; The New Zealand Lottery Grants Board; The University of Otago; The Carney Centre for Pharmacogenomics; The James Hume Bequest Fund; National Institutes of Health: Genes, Environment and Health Initiative; National Institutes of Health; National Cancer Institute; The William T Grant Foundation; Australian Research Council; The Virginia Tobacco Settlement Foundation; The VISN 1 and VISN 4 Mental Illness Research, Education, and Clinical Centers of the US Department of Veterans Affairs; The 5th Framework Programme (FP-5) GenomEUtwin Project; The Lundbeck Foundation; NIH-funded Shared Instrumentation Grant S10RR025141; Clinical Translational Sciences Award grants; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences.
Copyright 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.
DATE PUBLISHED
2020 Oct 20
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2020/05/18
revised 2020/07/15
accepted 2020/07/16
entrez 2020/10/23 20:10
pubmed 2020/10/24 06:00
medline 2020/10/24 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Johnson EC Johnson Emma C EC Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. Electronic address: emma.c.johnson@wustl.edu.
Demontis D Demontis Ditte D Department of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark.
Thorgeirsson TE Thorgeirsson Thorgeir E TE CNS Department, Reykjavik, Iceland.
Walters RK Walters Raymond K RK Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Polimanti R Polimanti Renato R Division of Human Genetics, Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Hatoum AS Hatoum Alexander S AS Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Sanchez-Roige S Sanchez-Roige Sandra S Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Paul SE Paul Sarah E SE Department of Psychological and Brain Sciences, Washington University in Saint Louis, St. Louis, MO, USA.
Wendt FR Wendt Frank R FR Division of Human Genetics, Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Clarke TK Clarke Toni-Kim TK Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Lai D Lai Dongbing D Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Reginsson GW Reginsson Gunnar W GW CNS Department, Reykjavik, Iceland.
Zhou H Zhou Hang H Division of Human Genetics, Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
He J He June J Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Baranger DAA Baranger David A A DAA Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Gudbjartsson DF Gudbjartsson Daniel F DF Statistics Department, Reykjavik, Iceland; School of Engineering and Natural Sciences, Iceland University, Reykjavik, Iceland.
Wedow R Wedow Robbee R Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Adkins DE Adkins Daniel E DE Department of Psychiatry, University of Utah, Salt Lake City, UT, USA; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA; College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, VA, USA.
Adkins AE Adkins Amy E AE Department of Psychiatry, University of Utah, Salt Lake City, UT, USA; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA; College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, VA, USA.
Alexander J Alexander Jeffry J Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, VA, USA.
Bacanu SA Bacanu Silviu-Alin SA Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, VA, USA.
Bigdeli TB Bigdeli Tim B TB Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Boden J Boden Joseph J Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Brown SA Brown Sandra A SA Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; Department of Psychology and Office of Research Affairs, University of California San Diego, La Jolla, CA, USA.
Bucholz KK Bucholz Kathleen K KK Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Bybjerg-Grauholm J Bybjerg-Grauholm Jonas J The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Department for Congenital Disorders, Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark.
Corley RP Corley Robin P RP Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Degenhardt L Degenhardt Louisa L National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia.
Dick DM Dick Danielle M DM Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA; Department of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Domingue BW Domingue Benjamin W BW Stanford University Graduate School of Education, Stanford University, Stanford, CA, USA.
Fox L Fox Louis L Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Goate AM Goate Alison M AM Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gordon SD Gordon Scott D SD QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Hack LM Hack Laura M LM Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Hancock DB Hancock Dana B DB GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, Durham, NC, USA.
Hartz SM Hartz Sarah M SM Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Hickie IB Hickie Ian B IB Brain and Mind Centre, University of Sydney, Sydney, Australia.
Hougaard DM Hougaard David M DM The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Department for Congenital Disorders, Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark.
Krauter K Krauter Kenneth K Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA; University of Colorado Boulder, Boulder, CO, USA.
Lind PA Lind Penelope A PA QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
McClintick JN McClintick Jeanette N JN Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
McQueen MB McQueen Matthew B MB Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Meyers JL Meyers Jacquelyn L JL Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA; Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, University of Queensland, QLD, Australia.
Mors O Mors Ole O The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark.
Mortensen PB Mortensen Preben B PB National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark; Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Nordentoft M Nordentoft Merete M The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
Pearson JF Pearson John F JF Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand; Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Peterson RE Peterson Roseann E RE Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Reynolds MD Reynolds Maureen D MD School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Rice JP Rice John P JP Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Runarsdottir V Runarsdottir Valgerdur V SAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland.
Saccone NL Saccone Nancy L NL Department of Genetics, Washington University School of Medicine, St Louis, MO, USA; Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA.
Sherva R Sherva Richard R Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Silberg JL Silberg Judy L JL Department of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Tarter RE Tarter Ralph E RE School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Tyrfingsson T Tyrfingsson Thorarinn T SAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland.
Wall TL Wall Tamara L TL Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Webb BT Webb Bradley T BT Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, VA, USA.
Werge T Werge Thomas T The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine, and Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.
Wetherill L Wetherill Leah L Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Wright MJ Wright Margaret J MJ Queensland Brain Institute, University of Queensland, QLD, Australia.
Zellers S Zellers Stephanie S Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Adams MJ Adams Mark J MJ Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Bierut LJ Bierut Laura J LJ Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Boardman JD Boardman Jason D JD Institute of Behavioral Science and Department of Sociology, University of Colorado Boulder, Boulder, CO, USA.
Copeland WE Copeland William E WE Department of Psychiatry, University of Vermont Medical Center, Burlington, VT, USA.
Farrer LA Farrer Lindsay A LA Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Foroud TM Foroud Tatiana M TM Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Gillespie NA Gillespie Nathan A NA Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Grucza RA Grucza Richard A RA Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Harris KM Harris Kathleen Mullan KM Department of Sociology, and The Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Hesselbrock V Hesselbrock Victor V Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
Hewitt JK Hewitt John K JK Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Hopfer CJ Hopfer Christian J CJ Department of Psychiatry, University of Colorado Denver, Aurora, CO, USA.
Horwood J Horwood John J Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Iacono WG Iacono William G WG Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Johnson EO Johnson Eric O EO GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, Durham, NC, USA.
Kendler KS Kendler Kenneth S KS Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Kennedy MA Kennedy Martin A MA Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Kranzler HR Kranzler Henry R HR Center for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; VISN 4 MIRECC, Crescenz VAMC, Philadelphia, PA, USA.
Madden PAF Madden Pamela A F PAF Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Maes HH Maes Hermine H HH Department of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Maher BS Maher Brion S BS Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
McGue M McGue Matthew M Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
McIntosh AM McIntosh Andrew M AM Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Nelson EC Nelson Elliot C EC Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Porjesz B Porjesz Bernice B Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA; Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Riley BP Riley Brien P BP Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, VA, USA.
Stallings MC Stallings Michael C MC Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Vanyukov MM Vanyukov Michael M MM School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Vrieze S Vrieze Scott S Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Psychiatric Genomics Consortium Substance Use Disorders Workgroup
Davis LK Davis Lea K LK Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Psychiatry and Behavioral Sciences, and Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Bogdan R Bogdan Ryan R Department of Psychological and Brain Sciences, Washington University in Saint Louis, St. Louis, MO, USA.
Gelernter J Gelernter Joel J Division of Human Genetics, Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Genetics, and Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA; Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Edenberg HJ Edenberg Howard J HJ Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Stefansson K Stefansson Kari K deCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Børglum AD Børglum Anders D AD Department of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark.
Agrawal A Agrawal Arpana A Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Walters Raymond R
Polimanti Renato R
Johnson Emma E
McClintick Jeanette J
Hatoum Alexander A
He June J
Wendt Frank F
Zhou Hang H
Adams Mark M
Adkins Amy A
Aliev Fazil F
Bacanu Silviu-Alin SA
Batzler Anthony A
Bertelsen Sarah S
Biernacka Joanna J
Bigdeli Tim T
Chen Li-Shiun LS
Clarke Toni-Kim TK
Chou Yi-Ling YL
Degenhardt Franziska F
Docherty Anna A
Edwards Alexis A
Fontanillas Pierre P
Foo Jerome J
Fox Louis L
Frank Josef J
Giegling Ina I
Gordon Scott S
Hack Laura L
Hartmann Annette A
Hartz Sarah S
Heilmann-Heimbach Stefanie S
Herms Stefan S
Hodgkinson Colin C
Hoffman Per P
Hottenga Jouke J
Kennedy Martin M
Alanne-Kinnunen Mervi M
Konte Bettina B
Lahti Jari J
Lahti-Pulkkinen Marius M
Lai Dongbing D
Ligthart Lannie L
Loukola Anu A
Maher Brion B
Mbarek Hamdi H
McIntosh Andrew A
McQueen Matthew M
Meyers Jacquelyn J
Milaneschi Yuri Y
Palviainen Teemu T
Pearson John J
Peterson Roseann R
Ripatti Samuli S
Ryu Euijung E
Saccone Nancy N
Salvatore Jessica J
Sanchez-Roige Sandra S
Schwandt Melanie M
Sherva Richard R
Streit Fabian F
Strohmaier Jana J
Thomas Nathaniel N
Wang Jen-Chyong JC
Webb Bradley B
Wedow Robbee R
Wetherill Leah L
Wills Amanda A
Boardman Jason J
Chen Danfeng D
Choi Doo-Sup DS
Copeland William W
Culverhouse Robert R
Dahmen Norbert N
Degenhardt Louisa L
Domingue Benjamin B
Elson Sarah S
Frye Mark M
Gäbel Wolfgang W
Hayward Caroline C
Ising Marcus M
Keyes Margaret M
Kiefer Falk F
Kramer John J
Kuperman Samuel S
Lucae Susanne S
Lynskey Michael M
Maier Wolfgang W
Mann Karl K
Männistö Satu S
Müller-Myhsok Bertram B
Murray Alison A
Nurnberger John J
Palotie Aarno A
Preuss Ulrich U
Räikkönen Katri K
Reynolds Maureen M
Ridinger Monika M
Scherbaum Norbert N
Schuckit Marc M
Soyka Michael M
Treutlein Jens J
Witt Stephanie S
Wodarz Norbert N
Zill Peter P
Adkins Daniel D
Boden Joseph J
Boomsma Dorret D
Bierut Laura L
Brown Sandra S
Bucholz Kathleen K
Cichon Sven S
Costello E Jane EJ
de Wit Harriet H
Diazgranados Nancy N
Dick Danielle D
Eriksson Johan J
Farrer Lindsay L
Foroud Tatiana T
Gillespie Nathan N
Goate Alison A
Goldman David D
Grucza Richard R
Hancock Dana D
Harris Kathleen Mullan KM
Heath Andrew A
Hesselbrock Victor V
Hewitt John J
Hopfer Christian C
Horwood John J
Iacono William W
Johnson Eric E
Kaprio Jaakko J
Karpyak Victor V
Kendler Kenneth K
Kranzler Henry H
Krauter Kenneth K
Lichtenstein Paul P
Lind Penelope P
McGue Matt M
MacKillop James J
Madden Pamela P
Maes Hermine H
Magnusson Patrik P
Martin Nicholas N
Medland Sarah S
Montgomery Grant G
Nelson Elliot E
Nöthen Markus M
Palmer Abraham A
Pederson Nancy N
Penninx Brenda B
Porjesz Bernice B
Rice John J
Rietschel Marcella M
Riley Brien B
Rose Richard R
Rujescu Dan D
Shen Pei-Hong PH
Silberg Judy J
Stallings Michael M
Tarter Ralph R
Vanyukov Michael M
Vrieze Scott S
Wall Tamara T
Whitfield John J
Zhao Hongyu H
Neale Benjamin B
Gelernter Joel J
Edenberg Howard H
Agrawal Arpana A
JOURNAL
VOLUME:
ISSUE:
TITLE: The lancet. Psychiatry
ISOABBREVIATION: Lancet Psychiatry
YEAR: 2020
MONTH: Oct
DAY: 20
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2215-0374
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Lancet Psychiatry
COUNTRY: England
ISSNLINKING: 2215-0366
NLMUNIQUEID: 101638123
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
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