Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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32989287
TITLE
Genome-wide association study identifies 48 common genetic variants associated with handedness.
ABSTRACT
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10 ) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.
DATE PUBLISHED
2021 01
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2020/02/03
accepted 2020/08/18
pubmed 2020/09/30 06:00
medline 2021/03/05 06:00
entrez 2020/09/29 05:35
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Cuellar-Partida G Cuellar-Partida Gabriel G 23andMe, Inc., Sunnyvale, CA, USA.
Tung JY Tung Joyce Y JY 23andMe, Inc., Sunnyvale, CA, USA.
Eriksson N Eriksson Nicholas N 23andMe, Inc., Sunnyvale, CA, USA.
Albrecht E Albrecht Eva E Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Aliev F Aliev Fazil F Karabuk University, Faculty of Business, Karabük, Turkey.
Andreassen OA Andreassen Ole A OA Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Barroso I Barroso Inês I Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Beckmann JS Beckmann Jacques S JS Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Boks MP Boks Marco P MP Department of Psychiatry, UMC Utrecht Brain Center, University Utrecht, Utrecht, The Netherlands.
Boomsma DI Boomsma Dorret I DI Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Boyd HA Boyd Heather A HA Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Breteler MMB Breteler Monique M B MMB Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Campbell H Campbell Harry H Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, MA, USA.
Cherkas LF Cherkas Lynn F LF Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Davies G Davies Gail G Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
de Geus EJC de Geus Eco J C EJC Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Deary IJ Deary Ian J IJ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Deloukas P Deloukas Panos P William Harvey Research Institute, Barts and the London Medical School, and the Centre for Genomic Health, Queen Mary University of London, London, UK.
Dick DM Dick Danielle M DM Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Duffy DL Duffy David L DL Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Eriksson JG Eriksson Johan G JG Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Esko T Esko Tõnu T Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Feenstra B Feenstra Bjarke B Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Geller F Geller Frank F Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Gieger C Gieger Christian C German Center for Diabetes Research (DZD), München-Neuherberg, Neuherberg, Germany.
Giegling I Giegling Ina I University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Gordon SD Gordon Scott D SD Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Han J Han Jiali J Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
Hansen TF Hansen Thomas F TF Danish Headache Center, Copenhagen University Hospital, Glostrup, Denmark.
Hartmann AM Hartmann Annette M AM University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Hayward C Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Heikkilä K Heikkilä Kauko K Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.
Hicks AA Hicks Andrew A AA Institute for Biomedicine, Eurac Research, Bolzano, Italy.
Hirschhorn JN Hirschhorn Joel N JN Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Hottenga JJ Hottenga Jouke-Jan JJ Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Huffman JE Huffman Jennifer E JE MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Hwang LD Hwang Liang-Dar LD The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.
Ikram MA Ikram M Arfan MA Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Kaprio J Kaprio Jaakko J Department of Public Health, University of Helsinki, Helsinki, Finland.
Kemp JP Kemp John P JP Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Khaw KT Khaw Kay-Tee KT Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Klopp N Klopp Norman N Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.
Konte B Konte Bettina B University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Kutalik Z Kutalik Zoltan Z Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Lahti J Lahti Jari J Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Li X Li Xin X Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
Loos RJF Loos Ruth J F RJF The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Luciano M Luciano Michelle M Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Magnusson SH Magnusson Sigurdur H SH deCODE Genetics, Reykjavik, Iceland.
Mangino M Mangino Massimo M Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Marques-Vidal P Marques-Vidal Pedro P Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Martin NG Martin Nicholas G NG Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
McArdle WL McArdle Wendy L WL Bristol Medical School, University of Bristol, Bristol, UK.
McCarthy MI McCarthy Mark I MI Human Genetics, Genentech, South San Francisco, CA, USA.
Medina-Gomez C Medina-Gomez Carolina C Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Melbye M Melbye Mads M Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Melville SA Melville Scott A SA Institute for Biomedicine, Eurac Research, Bolzano, Italy.
Metspalu A Metspalu Andres A Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Milani L Milani Lili L Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mooser V Mooser Vincent V Service of Clinical Chemistry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Nelis M Nelis Mari M Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Nyholt DR Nyholt Dale R DR School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
O'Connell KS O'Connell Kevin S KS NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ophoff RA Ophoff Roel A RA Department of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands.
Palmer C Palmer Cameron C Department of Computer Science, Columbia University, New York, NY, USA.
Palotie A Palotie Aarno A Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.
Palviainen T Palviainen Teemu T Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.
Pare G Pare Guillaume G Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Paternoster L Paternoster Lavinia L MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Peltonen L Peltonen Leena L Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, Amsterdam UMC, VU University, Amsterdam, The Netherlands.
Polasek O Polasek Ozren O Research Unit, Psychiatric Hospital Sveti Ivan, Zagreb, Croatia.
Pramstaller PP Pramstaller Peter P PP Institute for Biomedicine, Eurac Research, Bolzano, Italy.
Prokopenko I Prokopenko Inga I Section of Genomics of Common Disease, Department of Medicine, Imperial College London, London, UK.
Raikkonen K Raikkonen Katri K Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Ripatti S Ripatti Samuli S Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.
Rivadeneira F Rivadeneira Fernando F Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Rudan I Rudan Igor I Centre for Global Health Research, The Usher Institute, University of Edinburgh, Edinburgh, UK.
Rujescu D Rujescu Dan D University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Smit JH Smit Johannes H JH Department of Psychiatry, Amsterdam UMC, VU University, Amsterdam, The Netherlands.
Smith GD Smith George Davey GD MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Smoller JW Smoller Jordan W JW Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Soranzo N Soranzo Nicole N Human Genetics, Wellcome Sanger Institute, Hinxton, UK.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Pourcain BS Pourcain Beate St BS Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Starr JM Starr John M JM Centre for Cognitive Ageing and Cognitive Epidemilogy, University of Edinburgh, Edinburgh, UK.
Stefánsson H Stefánsson Hreinn H deCODE Genetics, Reykjavik, Iceland.
Steinberg S Steinberg Stacy S deCODE Genetics, Reykjavik, Iceland.
Teder-Laving M Teder-Laving Maris M Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Thorleifsson G Thorleifsson Gudmar G deCODE Genetics, Reykjavik, Iceland.
Stefánsson K Stefánsson Kári K deCODE Genetics, Reykjavik, Iceland.
Timpson NJ Timpson Nicholas J NJ MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Uitterlinden AG Uitterlinden André G AG Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
van Duijn CM van Duijn Cornelia M CM Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
van Rooij FJA van Rooij Frank J A FJA Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Vink JM Vink Jaqueline M JM Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
Vollenweider P Vollenweider Peter P Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Vuoksimaa E Vuoksimaa Eero E Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.
Waeber G Waeber Gérard G Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Warrington N Warrington Nicole N The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.
Waterworth D Waterworth Dawn D Human Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Werge T Werge Thomas T The Lundbeck Foundation's IPSYCH Initiative, Copenhagen, Denmark.
Wichmann HE Wichmann H-Erich HE Institute of Epidemiology, Helmholtz Center, Munich, Germany.
Widen E Widen Elisabeth E Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Wright AF Wright Alan F AF MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Wright MJ Wright Margaret J MJ Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia.
Xu M Xu Mousheng M Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard Medical School, Boston, MA, USA.
Zhao JH Zhao Jing Hua JH Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Kraft P Kraft Peter P Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard Medical School, Boston, MA, USA.
Hinds DA Hinds David A DA 23andMe, Inc., Sunnyvale, CA, USA.
Lindgren CM Lindgren Cecilia M CM Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Mägi R Mägi Reedik R Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Neale BM Neale Benjamin M BM Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Evans DM Evans David M DM MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. d.evans1@uq.edu.au.
Medland SE Medland Sarah E SE Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Sarah.Medland@qimrberghofer.edu.au.
INVESTIGATORS
JOURNAL
VOLUME: 5
ISSUE: 1
TITLE: Nature human behaviour
ISOABBREVIATION: Nat Hum Behav
YEAR: 2021
MONTH: 01
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2397-3374
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Hum Behav
COUNTRY: England
ISSNLINKING: 2397-3374
NLMUNIQUEID: 101697750
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
APP1104818 Department of Health | National Health and Medical Research Council (NHMRC)
090532, 106130, 098381, 203141, 212259, 095101, 200837, 099673/Z/12/Z Wellcome Trust (Wellcome)
MC_UU_00011/1 Medical Research Council United Kingdom
APP1103623 Department of Health | National Health and Medical Research Council (NHMRC)
MC_UU_12015/1 Medical Research Council United Kingdom
R01 MH058799 NIMH NIH HHS United States
5P50HD028138-27 DH | NIHR | Health Services Research Programme (NIHR Health Services Research Programme)
MC_UU_12013/4 Medical Research Council United Kingdom
DE180100976 Department of Education and Training | Australian Research Council (ARC)
R01 DK092127 NIDDK NIH HHS United States
RC2 MH089951 NIMH NIH HHS United States
MC_UU_00007/10 Medical Research Council United Kingdom
NF-SI-0617-10090 DH | NIHR | Health Services Research Programme (NIHR Health Services Research Programme)
P50 HD028138 NICHD NIH HHS United States
RC2 MH089995 NIMH NIH HHS United States
086596 Wellcome Trust United Kingdom
MC_UU_00006/1 Medical Research Council United Kingdom
APP1137714 Department of Health | National Health and Medical Research Council (NHMRC)
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Female
Functional Laterality genetics
Gene Frequency genetics
Genetic Loci genetics
Genetic Variation genetics
Genome-Wide Association Study genetics
Humans genetics
Linkage Disequilibrium genetics
Male genetics
Middle Aged genetics
Polymorphism, Single Nucleotide genetics
Quantitative Trait, Heritable genetics
Sex Factors genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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