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| PMID |
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| TITLE |
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| The reliability and heritability of cortical folds and their genetic correlations across hemispheres. |
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| ABSTRACT |
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| Cortical folds help drive the parcellation of the human cortex into functionally specific regions. Variations in the length, depth, width, and surface area of these sulcal landmarks have been associated with disease, and may be genetically mediated. Before estimating the heritability of sulcal variation, the extent to which these metrics can be reliably extracted from in-vivo MRI must be established. Using four independent test-retest datasets, we found high reliability across the brain (intraclass correlation interquartile range: 0.65-0.85). Heritability estimates were derived for three family-based cohorts using variance components analysis and pooled (total N > 3000); the overall sulcal heritability pattern was correlated to that derived for a large population cohort (N > 9000) calculated using genomic complex trait analysis. Overall, sulcal width was the most heritable metric, and earlier forming sulci showed higher heritability. The inter-hemispheric genetic correlations were high, yet select sulci showed incomplete pleiotropy, suggesting hemisphere-specific genetic influences. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2019/10/22 |
| accepted |
2020/07/24 |
| entrez |
2020/09/16 05:35 |
| pubmed |
2020/09/17 06:00 |
| medline |
2020/09/17 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Pizzagalli F |
|
Pizzagalli |
Fabrizio |
F |
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Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. fabrizio.pizzagalli@unito.it. |
| Auzias G |
|
Auzias |
Guillaume |
G |
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Institut de Neurosciences de la Timone, UMR7289, Aix-Marseille Université & CNRS, Marseille, France. |
| Yang Q |
|
Yang |
Qifan |
Q |
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Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. |
| Mathias SR |
|
Mathias |
Samuel R |
SR |
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Yale University School of Medicine, New Haven, CT, USA. |
| Faskowitz J |
|
Faskowitz |
Joshua |
J |
|
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. |
| Boyd JD |
|
Boyd |
Joshua D |
JD |
|
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. |
| Amini A |
|
Amini |
Armand |
A |
|
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. |
| Rivière D |
|
Rivière |
Denis |
D |
|
CATI, Multicenter Neuroimaging Platform, Paris, France. |
| McMahon KL |
|
McMahon |
Katie L |
KL |
|
School of Clinical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia. |
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
Faculty of Health, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Mangin JF |
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Mangin |
Jean-François |
JF |
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CATI, Multicenter Neuroimaging Platform, Paris, France. |
| Glahn DC |
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Glahn |
David C |
DC |
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Yale University School of Medicine, New Haven, CT, USA. |
| Blangero J |
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Blangero |
John |
J |
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South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA. |
| Wright MJ |
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Wright |
Margaret J |
MJ |
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Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, 4072, Australia. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
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Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. |
| Kochunov P |
|
Kochunov |
Peter |
P |
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Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. |
| Jahanshad N |
|
Jahanshad |
Neda |
N |
|
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. neda.jahanshad@usc.edu. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 3 |
| ISSUE: 1 |
| TITLE: Communications biology |
| ISOABBREVIATION: Commun Biol |
| YEAR: 2020 |
| MONTH: Sep |
| DAY: 15 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2399-3642 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Commun Biol |
| COUNTRY: England |
| ISSNLINKING: 2399-3642 |
| NLMUNIQUEID: 101719179 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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