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| PMID |
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| TITLE |
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| Genetic and Environmental Causes of Individual Differences in Borderline Personality Disorder Features and Loneliness are Partially Shared. |
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| ABSTRACT |
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| Loneliness is related to mental and somatic health outcomes, including borderline personality disorder. Here, we analyze the sources of variation that are responsible for the relationship between borderline personality features (including four dimensions, affective instability, identity disturbance, negative relationships, self-harm and a total score) and loneliness. Using genetically informative data from two large nonclinical samples of adult twin pairs from Australia and the Netherlands (N = 11,329), we estimate the phenotypic, genetic and environmental correlations between self-reported borderline personality features and loneliness. Individual differences in borderline personality and loneliness were best explained by additive genetic factors with heritability estimates h2 = 41% for the borderline personality total score and h2 = 36% for loneliness, with the remaining variation explained by environmental influences that were not shared by twins from the same pair. Genetic and environmental factors influencing borderline personality (total score and four subscales separately) were also partial causes of loneliness. The correlation between loneliness and the borderline personality total score was rph = .51. The genetic correlation was estimated at rg = .64 and the environmental correlation at re = .40. Our study suggests common etiological factors in loneliness and borderline personality features. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2020/09/05 06:00 |
| pubmed |
2020/09/05 06:00 |
| medline |
2020/09/05 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Schermer JA |
|
Schermer |
Julie Aitken |
JA |
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Management and Organizational Studies, Faculty of Social Science, The University of Western Ontario, London, ON, Canada. |
| Colodro-Conde L |
|
Colodro-Conde |
Lucía |
L |
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QIMR Berghofer Medical Research, Brisbane, QLD, Australia. |
| Grasby KL |
|
Grasby |
Katrina L |
KL |
|
QIMR Berghofer Medical Research, Brisbane, QLD, Australia. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
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Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia. |
| Burns J |
|
Burns |
Jane |
J |
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Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia. |
| Ligthart L |
|
Ligthart |
Lannie |
L |
|
Netherlands Twin Register, Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. |
| Willemsen G |
|
Willemsen |
Gonneke |
G |
|
Netherlands Twin Register, Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. |
| Trull TJ |
|
Trull |
Timothy J |
TJ |
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Department of Psychological Sciences, University of Missouri,Columbia, MI, USA. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research, Brisbane, QLD, Australia. |
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
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Netherlands Twin Register, Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 23 |
| ISSUE: 4 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2020 |
| MONTH: Aug |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Borderline personality disorder |
| genetic correlation |
| loneliness |
| multivariate genetic models |
| twins |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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