Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
32885774
TITLE
Genetic and Environmental Causes of Individual Differences in Borderline Personality Disorder Features and Loneliness are Partially Shared.
ABSTRACT
Loneliness is related to mental and somatic health outcomes, including borderline personality disorder. Here, we analyze the sources of variation that are responsible for the relationship between borderline personality features (including four dimensions, affective instability, identity disturbance, negative relationships, self-harm and a total score) and loneliness. Using genetically informative data from two large nonclinical samples of adult twin pairs from Australia and the Netherlands (N = 11,329), we estimate the phenotypic, genetic and environmental correlations between self-reported borderline personality features and loneliness. Individual differences in borderline personality and loneliness were best explained by additive genetic factors with heritability estimates h2 = 41% for the borderline personality total score and h2 = 36% for loneliness, with the remaining variation explained by environmental influences that were not shared by twins from the same pair. Genetic and environmental factors influencing borderline personality (total score and four subscales separately) were also partial causes of loneliness. The correlation between loneliness and the borderline personality total score was rph = .51. The genetic correlation was estimated at rg = .64 and the environmental correlation at re = .40. Our study suggests common etiological factors in loneliness and borderline personality features.
DATE PUBLISHED
2020 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2020/09/05 06:00
pubmed 2020/09/05 06:00
medline 2020/09/05 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Schermer JA Schermer Julie Aitken JA Management and Organizational Studies, Faculty of Social Science, The University of Western Ontario, London, ON, Canada.
Colodro-Conde L Colodro-Conde Lucía L QIMR Berghofer Medical Research, Brisbane, QLD, Australia.
Grasby KL Grasby Katrina L KL QIMR Berghofer Medical Research, Brisbane, QLD, Australia.
Hickie IB Hickie Ian B IB Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
Burns J Burns Jane J Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
Ligthart L Ligthart Lannie L Netherlands Twin Register, Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Willemsen G Willemsen Gonneke G Netherlands Twin Register, Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Trull TJ Trull Timothy J TJ Department of Psychological Sciences, University of Missouri,Columbia, MI, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research, Brisbane, QLD, Australia.
Boomsma DI Boomsma Dorret I DI Netherlands Twin Register, Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
INVESTIGATORS
JOURNAL
VOLUME: 23
ISSUE: 4
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2020
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Borderline personality disorder
genetic correlation
loneliness
multivariate genetic models
twins
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's