Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
32816500
TITLE
Sex differences in the relative influence of marital status and parenthood on alcohol use disorder symptoms: A multilevel discordant twin design.
ABSTRACT
Marriage and parenthood are associated with alcohol use and use disorder (AUD), although they are confounded such that many studies struggle to identify their unique and/or causal effects. The present study utilized a genetically informed discordant twin design that strengthens the putative causal role of marital and parental status in the presentation of AUD symptoms by using each individual's cotwin as their own control while simultaneously modeling both predictors among men and women. Participants were 980 complete same-sex twin pairs from the Australian Twin Registry ( = 31.70 [ = 2.48]; 71% women). Marital status, parental status, and past year AUD symptoms were assessed via semistructured interview. Three random-intercept generalized linear mixed models were fit in men and women including (a) marital status only, (b) parental status only, and (c) both marital and parental status; demographics, past year pregnancy, age of first drink, age of regular drinking, personality traits, and antisociality were included as covariates. Models tested for quasi-causal and familial effects. The sole-predictor marital status model (Model 1) provided the best fit among men, while the simultaneous-predictor marital and parental status model (Model 3) provided the best fit among women. Sole-predictor models showed familial effects of both predictors among men and quasi-causal and familial effects of both predictors among women; the simultaneous-predictor model revealed familial effects of marital status only among men and quasi-causal effects of parental status only among women. The present study elucidates important sex differences in the presentation of AUD among midlife adults in the context of notable developmental milestones. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
DATE PUBLISHED
2020 Aug 20
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2020/08/21 06:00
pubmed 2020/08/21 06:00
medline 2020/08/21 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Dash GF Dash Genevieve F GF Department of Psychological Sciences.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research-Berghofer.
Lynskey MT Lynskey Michael T MT Institute of Psychiatry, Psychology and Neuroscience.
Slutske WS Slutske Wendy S WS Department of Psychological Sciences.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Journal of abnormal psychology
ISOABBREVIATION: J Abnorm Psychol
YEAR: 2020
MONTH: Aug
DAY: 20
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1939-1846
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Abnorm Psychol
COUNTRY: United States
ISSNLINKING: 0021-843X
NLMUNIQUEID: 0034461
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
NIDA NIH HHS United States
NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's