Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
32728164
TITLE
Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts.
ABSTRACT
We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural-geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 countries and including 193,518 twins with information on educational attainment at 25 years of age or older. Genetic factors explained the major part of individual differences in educational attainment (heritability: a  = 0.43; 0.41-0.44), but also environmental variation shared by co-twins was substantial (c  = 0.31; 0.30-0.33). The proportions of educational variation explained by genetic and shared environmental factors did not differ between Europe, North America and Australia, and East Asia. When restricted to twins 30 years or older to confirm finalized education, the heritability was higher in the older cohorts born in 1900-1949 (a  = 0.44; 0.41-0.46) than in the later cohorts born in 1950-1989 (a  = 0.38; 0.36-0.40), with a corresponding lower influence of common environmental factors (c  = 0.31; 0.29-0.33 and c  = 0.34; 0.32-0.36, respectively). In conclusion, both genetic and environmental factors shared by co-twins have an important influence on individual differences in educational attainment. The effect of genetic factors on educational attainment has decreased from the cohorts born before to those born after the 1950s.
DATE PUBLISHED
2020 07 29
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2020/05/13
accepted 2020/07/10
entrez 2020/07/31 06:00
pubmed 2020/07/31 06:00
medline 2020/12/17 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Silventoinen K Silventoinen Karri K Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan. karri.silventoinen@helsinki.fi.
Jelenkovic A Jelenkovic Aline A Department of Public Health, University of Helsinki, Helsinki, Finland.
Sund R Sund Reijo R Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Latvala A Latvala Antti A Department of Social Research, Faculty of Social Sciences, University of Helsinki, P.O. Box 18, 00014, Helsinki, Finland.
Honda C Honda Chika C Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Inui F Inui Fujio F Faculty of Health Science, Kio University, Nara, Japan.
Tomizawa R Tomizawa Rie R Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Watanabe M Watanabe Mikio M Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Sakai N Sakai Norio N Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Rebato E Rebato Esther E Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Busjahn A Busjahn Andreas A HealthTwiSt GmbH, Berlin, Germany.
Tyler J Tyler Jessica J Twins Research Australia, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia.
Hopper JL Hopper John L JL Department of Epidemiology, School of Public Health, Seoul National University, Seoul, Korea.
Ordoñana JR Ordoñana Juan R JR IMIB-Arrixaca, Murcia, Spain.
Sánchez-Romera JF Sánchez-Romera Juan F JF IMIB-Arrixaca, Murcia, Spain.
Colodro-Conde L Colodro-Conde Lucia L Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Calais-Ferreira L Calais-Ferreira Lucas L Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Oliveira VC Oliveira Vinicius C VC Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil.
Ferreira PH Ferreira Paulo H PH Musculoskeletal Health Research Group, Faculty of Health Sciences, The University of Sydney, Sydney, Australia.
Medda E Medda Emanuela E Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health, Rome, Italy.
Nisticò L Nisticò Lorenza L Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health, Rome, Italy.
Toccaceli V Toccaceli Virgilia V Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health, Rome, Italy.
Derom CA Derom Catherine A CA Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium.
Vlietinck RF Vlietinck Robert F RF Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Loos RJF Loos Ruth J F RJF The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine At Mount Sinai, New York, NY, USA.
Siribaddana SH Siribaddana Sisira H SH Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka Saliyapura, Anuradhapura, Sri Lanka.
Hotopf M Hotopf Matthew M South London and Maudsley NHS Foundation Trust, London, UK.
Sumathipala A Sumathipala Athula A Research Institute for Primary Care and Health Sciences, School for Primary Care Research (SPCR), Faculty of Health, Keele University, Staffordshire, UK.
Rijsdijk F Rijsdijk Fruhling F Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Duncan GE Duncan Glen E GE Washington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA.
Buchwald D Buchwald Dedra D Washington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA.
Tynelius P Tynelius Per P Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Rasmussen F Rasmussen Finn F Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Tan Q Tan Qihua Q Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Zhang D Zhang Dongfeng D Department of Public Health, Qingdao University Medical College, Qingdao, China.
Pang Z Pang Zengchang Z Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Dahl Aslan AK Dahl Aslan Anna K AK Institute of Gerontology and Aging Research Network - Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden.
Hwang AE Hwang Amie E AE USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Mack TM Mack Thomas M TM USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Krueger RF Krueger Robert F RF Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
McGue M McGue Matt M Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Pahlen S Pahlen Shandell S Department of Psychology, University of California, Riverside, Riverside, CA, 92521, USA.
Brandt I Brandt Ingunn I Division of Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.
Nilsen TS Nilsen Thomas S TS Division of Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.
Harris JR Harris Jennifer R JR Division of Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.
Martin NG Martin Nicholas G NG Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Medland SE Medland Sarah E SE Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, Amsterdam, The Netherlands.
Bartels M Bartels Meike M Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, Amsterdam, The Netherlands.
van Beijsterveldt CEM van Beijsterveldt Catharina E M CEM Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, Amsterdam, The Netherlands.
Franz CE Franz Carol E CE Department of Psychiatry, University of California, San Diego, CA, USA.
Kremen WS Kremen William S WS VA San Diego Center of Excellence for Stress and Mental Health, La Jolla, CA, USA.
Lyons MJ Lyons Michael J MJ Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Silberg JL Silberg Judy L JL Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Maes HH Maes Hermine H HH Department of Human and Molecular Genetics, Psychiatry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Kandler C Kandler Christian C Department of Psychology, University of Bremen, Bremen, Germany.
Nelson TL Nelson Tracy L TL Department of Health and Exercise Sciences and Colorado School of Public Health, Colorado State University, Fort Collins, USA.
Whitfield KE Whitfield Keith E KE Psychology Department, Wayne State University, Detroit, MI, USA.
Corley RP Corley Robin P RP Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.
Huibregtse BM Huibregtse Brooke M BM Institute of Behavioral Science, University of Colorado, Boulder, CO, USA.
Gatz M Gatz Margaret M Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
Butler DA Butler David A DA Health and Medicine Division, The National Academies of Sciences, Engineering, and Medicine, Washington, DC, USA.
Tarnoki AD Tarnoki Adam D AD Hungarian Twin Registry, Budapest, Hungary.
Tarnoki DL Tarnoki David L DL Hungarian Twin Registry, Budapest, Hungary.
Park HA Park Hang A HA Department of Emergency Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
Lee J Lee Jooyeon J Department of Epidemiology, School of Public Health, Seoul National University, Seoul, Korea.
Lee SJ Lee Soo Ji SJ Institute of Health and Environment, Seoul National University, Seoul, South Korea.
Sung J Sung Joohon J Institute of Health and Environment, Seoul National University, Seoul, South Korea.
Yokoyama Y Yokoyama Yoshie Y Department of Public Health Nursing, Osaka City University, Osaka, Japan.
Sørensen TIA Sørensen Thorkild I A TIA Department of Public Health (Section of Epidemiology), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, Amsterdam, The Netherlands.
Kaprio J Kaprio Jaakko J Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
INVESTIGATORS
JOURNAL
VOLUME: 10
ISSUE: 1
TITLE: Scientific reports
ISOABBREVIATION: Sci Rep
YEAR: 2020
MONTH: 07
DAY: 29
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2045-2322
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Sci Rep
COUNTRY: England
ISSNLINKING: 2045-2322
NLMUNIQUEID: 101563288
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01 AG022982 NIA NIH HHS United States
RC2 HL103416 NHLBI NIH HHS United States
R01 AG018386 NIA NIH HHS United States
R01 AG018384 NIA NIH HHS United States
T32 AG052371 NIA NIH HHS United States
R21 AG039572 NIA NIH HHS United States
R01 ES015150 NIEHS NIH HHS United States
T32 DA017637 NIDA NIH HHS United States
R01 AG022381 NIA NIH HHS United States
R01 AG050595 NIA NIH HHS United States
R01 AG013662 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Academic Success
Adult
Australia
Cohort Studies
Educational Status
Europe
Far East
Female
Gene-Environment Interaction
Humans
Male
North America
Quantitative Trait, Heritable
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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