Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
32681593
TITLE
Genetic comorbidity between major depression and cardio-metabolic traits, stratified by age at onset of major depression.
ABSTRACT
It is imperative to understand the specific and shared etiologies of major depression and cardio-metabolic disease, as both traits are frequently comorbid and each represents a major burden to society. This study examined whether there is a genetic association between major depression and cardio-metabolic traits and if this association is stratified by age at onset for major depression. Polygenic risk scores analysis and linkage disequilibrium score regression was performed to examine whether differences in shared genetic etiology exist between depression case control status (N cases = 40,940, N controls = 67,532), earlier (N = 15,844), and later onset depression (N = 15,800) with body mass index, coronary artery disease, stroke, and type 2 diabetes in 11 data sets from the Psychiatric Genomics Consortium, Generation Scotland, and UK Biobank. All cardio-metabolic polygenic risk scores were associated with depression status. Significant genetic correlations were found between depression and body mass index, coronary artery disease, and type 2 diabetes. Higher polygenic risk for body mass index, coronary artery disease, and type 2 diabetes was associated with both early and later onset depression, while higher polygenic risk for stroke was associated with later onset depression only. Significant genetic correlations were found between body mass index and later onset depression, and between coronary artery disease and both early and late onset depression. The phenotypic associations between major depression and cardio-metabolic traits may partly reflect their overlapping genetic etiology irrespective of the age depression first presents.
© 2020 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.
DATE PUBLISHED
2020 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2019/08/08
revised 2020/01/02
accepted 2020/03/09
pubmed 2020/07/19 06:00
medline 2020/07/19 06:00
entrez 2020/07/19 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hagenaars SP Hagenaars Saskia P SP NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
Coleman JRI Coleman Jonathan R I JRI NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
Choi SW Choi Shing Wan SW Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Gaspar H Gaspar Héléna H NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
Adams MJ Adams Mark J MJ Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Howard DM Howard David M DM Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Hodgson K Hodgson Karen K NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
Traylor M Traylor Matthew M Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Air TM Air Tracy M TM Discipline of Medicine, University of Adelaide, Adelaide, Australia.
Andlauer TFM Andlauer Till F M TFM Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Arolt V Arolt Volker V Department of Psychiatry, University of Münster, Münster, Germany.
Baune BT Baune Bernhard T BT Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
Binder EB Binder Elisabeth B EB Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Blackwood DHR Blackwood Douglas H R DHR Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Boomsma DI Boomsma Dorret I DI Netherlands Twin Register, Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
Campbell A Campbell Archie A Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Cearns M Cearns Micah M Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, Australia.
Czamara D Czamara Darina D Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Dannlowski U Dannlowski Udo U Department of Psychiatry, University of Münster, Münster, Germany.
Domschke K Domschke Katharina K Center for NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
de Geus EJC de Geus Eco J C EJC Netherlands Twin Register, Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
Hamilton SP Hamilton Steven P SP Department of Psychiatry, Kaiser Permanente Northern California, San Francisco, California, USA.
Hayward C Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Hickie IB Hickie Ian B IB Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Hottenga JJ Hottenga Jouke Jan JJ Netherlands Twin Register, Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
Ising M Ising Marcus M Max Planck Institute of Psychiatry, Munich, Germany.
Jones I Jones Ian I MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Jones L Jones Lisa L Department of Psychological Medicine, University of Worcester, Worcester, UK.
Kutalik Z Kutalik Zoltan Z Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Lucae S Lucae Susanne S Max Planck Institute of Psychiatry, Munich, Germany.
Martin NG Martin Nicholas G NG Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Milaneschi Y Milaneschi Yuri Y Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience Research Institutes, Amsterdam UMC/Vrije Universiteit, Amsterdam, The Netherlands.
Mueller-Myhsok B Mueller-Myhsok Bertram B Department of Health Data Science, Institute of Population Health, University of Liverpool, Liverpool, UK.
Owen MJ Owen Michael J MJ MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Padmanabhan S Padmanabhan Sandosh S Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience Research Institutes, Amsterdam UMC/Vrije Universiteit, Amsterdam, The Netherlands.
Pistis G Pistis Giorgio G Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Porteous DJ Porteous David J DJ Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Preisig M Preisig Martin M Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Ripke S Ripke Stephan S Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Shyn SI Shyn Stanley I SI Behavioral Health Services, Kaiser Permanente Washington, Seattle, Washington, USA.
Sullivan PF Sullivan Patrick F PF Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Whitfield JB Whitfield John B JB Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Wray NR Wray Naomi R NR Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
McIntosh AM McIntosh Andrew M AM Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Deary IJ Deary Ian J IJ Department of Psychology, University of Edinburgh, Edinburgh, UK.
Breen G Breen Gerome G NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
Lewis CM Lewis Cathryn M CM NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
INVESTIGATORS
JOURNAL
VOLUME: 183
ISSUE: 6
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2020
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1552-485X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
Maudsley Biomedical Research Centre National Institute for Health Research
U01 MH109528 NIMH NIH HHS United States
U01 MH1095320 NIMH NIH HHS United States
European Union
U01 MH109528 NIMH NIH HHS United States
U01 MH1095320 NIMH NIH HHS United States
MR/S0151132 Medical Research Council United Kingdom
MR/N015746/1 Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
KEYWORD
age at onset
cardio-metabolic disease
depression
genetics
polygenic risk scores
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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