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| PMID |
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| TITLE |
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| Genetic aetiology of self-harm ideation and behaviour. |
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| ABSTRACT |
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| Family studies have identified a heritable component to self-harm that is partially independent from comorbid psychiatric disorders. However, the genetic aetiology of broad sense (non-suicidal and suicidal) self-harm has not been characterised on the molecular level. In addition, controversy exists about the degree to which suicidal and non-suicidal self-harm share a common genetic aetiology. In the present study, we conduct genome-wide association studies (GWAS) on lifetime self-harm ideation and self-harm behaviour (i.e. any lifetime self-harm act regardless of suicidal intent) using data from the UK Biobank (n > 156,000). We also perform genome wide gene-based tests and characterize the SNP heritability and genetic correlations between these traits. Finally, we test whether polygenic risk scores (PRS) for self-harm ideation and self-harm behaviour predict suicide attempt, suicide thoughts and non-suicidal self-harm (NSSH) in an independent target sample of 8,703 Australian adults. Our GWAS results identified one genome-wide significant locus associated with each of the two phenotypes. SNP heritability (h ) estimates were ~10%, and both traits were highly genetically correlated (LDSC r > 0.8). Gene-based tests identified seven genes associated with self-harm ideation and four with self-harm behaviour. Furthermore, in the target sample, PRS for self-harm ideation were significantly associated with suicide thoughts and NSSH, and PRS for self-harm behaviour predicted suicide thoughts and suicide attempt. Follow up regressions identified a shared genetic aetiology between NSSH and suicide thoughts, and between suicide thoughts and suicide attempt. Evidence for shared genetic aetiology between NSSH and suicide attempt was not statistically significant. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2020/01/14 |
| accepted |
2020/05/11 |
| entrez |
2020/06/18 06:00 |
| pubmed |
2020/06/18 06:00 |
| medline |
2020/06/18 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Campos AI |
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Campos |
Adrian I |
AI |
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Faculty of Medicine, The University of Queensland, Herston, QLD, Australia. adrian.campos@qimrberghofer.edu.au. |
| Verweij KJH |
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Verweij |
Karin J H |
KJH |
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Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands. |
| Statham DJ |
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Statham |
Dixie J |
DJ |
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Discipline of Psychology, School of Health and Life Sciences, Federation University, Ballarat, VIC, 3550, Australia. |
| Madden PAF |
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Madden |
Pamela A F |
PAF |
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Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA. |
| Maciejewski DF |
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Maciejewski |
Dominique F |
DF |
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Department of Developmental Psychopathology, Behavioural Science Institute, Nijmegen, the Netherlands. |
| Davis KAS |
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Davis |
Katrina A S |
KAS |
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South London and Maudsley NHS Foundation Trust, London, UK. |
| John A |
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John |
Ann |
A |
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HDRUK, Swansea University Medical School, Swansea, UK. |
| Hotopf M |
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Hotopf |
Matthew |
M |
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South London and Maudsley NHS Foundation Trust, London, UK. |
| Heath AC |
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Heath |
Andrew C |
AC |
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Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA. |
| Martin NG |
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Martin |
Nicholas G |
NG |
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Department of Genetics & Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia. |
| Rentería ME |
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Rentería |
Miguel E |
ME |
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Faculty of Medicine, The University of Queensland, Herston, QLD, Australia. miguel.renteria@qimrberghofer.edu.au. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 10 |
| ISSUE: 1 |
| TITLE: Scientific reports |
| ISOABBREVIATION: Sci Rep |
| YEAR: 2020 |
| MONTH: Jun |
| DAY: 16 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2045-2322 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Sci Rep |
| COUNTRY: England |
| ISSNLINKING: 2045-2322 |
| NLMUNIQUEID: 101563288 |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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