|
|
| PMID |
|
|
| TITLE |
|
| Cohort profile: the Australian genetics of depression study. |
|
| ABSTRACT |
|
| PURPOSE |
|
| Depression is the most common psychiatric disorder and the largest contributor to global disability. The Australian Genetics of Depression study was established to recruit a large cohort of individuals who have been diagnosed with depression at some point in their lifetime. The purpose of establishing this cohort is to investigate genetic and environmental risk factors for depression and response to commonly prescribed antidepressants. |
| PARTICIPANTS |
|
| Depression is the most common psychiatric disorder and the largest contributor to global disability. The Australian Genetics of Depression study was established to recruit a large cohort of individuals who have been diagnosed with depression at some point in their lifetime. The purpose of establishing this cohort is to investigate genetic and environmental risk factors for depression and response to commonly prescribed antidepressants. A total of 20 689 participants were recruited through the Australian Department of Human Services and a media campaign, 75% of whom were female. The average age of participants was 43 years±15 years. Participants completed an online questionnaire that consisted of a compulsory module that assessed self-reported psychiatric history, clinical depression using the Composite Interview Diagnostic Interview Short Form and experiences of using commonly prescribed antidepressants. Further voluntary modules assessed a wide range of traits of relevance to psychopathology. Participants who reported they were willing to provide a DNA sample (75%) were sent a saliva kit in the mail. |
| FINDINGS TO DATE |
|
| Depression is the most common psychiatric disorder and the largest contributor to global disability. The Australian Genetics of Depression study was established to recruit a large cohort of individuals who have been diagnosed with depression at some point in their lifetime. The purpose of establishing this cohort is to investigate genetic and environmental risk factors for depression and response to commonly prescribed antidepressants. A total of 20 689 participants were recruited through the Australian Department of Human Services and a media campaign, 75% of whom were female. The average age of participants was 43 years±15 years. Participants completed an online questionnaire that consisted of a compulsory module that assessed self-reported psychiatric history, clinical depression using the Composite Interview Diagnostic Interview Short Form and experiences of using commonly prescribed antidepressants. Further voluntary modules assessed a wide range of traits of relevance to psychopathology. Participants who reported they were willing to provide a DNA sample (75%) were sent a saliva kit in the mail. 95% of participants reported being given a diagnosis of depression by a medical practitioner and 88% met the criteria for a lifetime depressive episode. 68% of the sample report having been diagnosed with another psychiatric disorder in addition to depression. In line with findings from clinical trials, only 33% of the sample report responding well to the first antidepressant they were prescribed. |
| FUTURE PLANS |
|
| Depression is the most common psychiatric disorder and the largest contributor to global disability. The Australian Genetics of Depression study was established to recruit a large cohort of individuals who have been diagnosed with depression at some point in their lifetime. The purpose of establishing this cohort is to investigate genetic and environmental risk factors for depression and response to commonly prescribed antidepressants. A total of 20 689 participants were recruited through the Australian Department of Human Services and a media campaign, 75% of whom were female. The average age of participants was 43 years±15 years. Participants completed an online questionnaire that consisted of a compulsory module that assessed self-reported psychiatric history, clinical depression using the Composite Interview Diagnostic Interview Short Form and experiences of using commonly prescribed antidepressants. Further voluntary modules assessed a wide range of traits of relevance to psychopathology. Participants who reported they were willing to provide a DNA sample (75%) were sent a saliva kit in the mail. 95% of participants reported being given a diagnosis of depression by a medical practitioner and 88% met the criteria for a lifetime depressive episode. 68% of the sample report having been diagnosed with another psychiatric disorder in addition to depression. In line with findings from clinical trials, only 33% of the sample report responding well to the first antidepressant they were prescribed. A number of analyses to investigate the genetic architecture of depression and common comorbidities will be conducted. The cohort will contribute to the global effort to identify genetic variants that increase risk to depression. Furthermore, a thorough investigation of genetic and psychosocial predictors of antidepressant response and side effects is planned. |
| © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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| DATE PUBLISHED |
|
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2020/05/29 06:00 |
| pubmed |
2020/05/29 06:00 |
| medline |
2021/05/15 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Byrne EM |
|
Byrne |
Enda M |
EM |
|
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia enda.byrne@uq.edu.au. |
| Kirk KM |
|
Kirk |
Katherine M |
KM |
|
QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. |
| McGrath JJ |
|
McGrath |
John J |
JJ |
|
National Center for Register-based Research, University of Aarhus, Aarhus, Denmark. |
| Colodro-Conde L |
|
Colodro-Conde |
Lucia |
L |
|
QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. |
| Parker R |
|
Parker |
Richard |
R |
|
QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. |
| Cross S |
|
Cross |
Simone |
S |
|
QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. |
| Sullivan L |
|
Sullivan |
Lenore |
L |
|
QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. |
| Statham DJ |
|
Statham |
Dixie J |
DJ |
|
School of Health and Life Sciences, Federation University, Ballarat, Victoria, Australia. |
| Levinson DF |
|
Levinson |
Douglas F |
DF |
|
Department of Psychiatry and Behavioural Sciences, Stanford University, Stanford, California, USA. |
| Licinio J |
|
Licinio |
Julio |
J |
|
College of Medicine, State University of New York Upstate Medical University, Syracuse, NY, United States. |
| Wray NR |
|
Wray |
Naomi R |
NR |
|
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 10 |
| ISSUE: 5 |
| TITLE: BMJ open |
| ISOABBREVIATION: BMJ Open |
| YEAR: 2020 |
| MONTH: 05 |
| DAY: 26 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2044-6055 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
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| MEDLINETA: BMJ Open |
| COUNTRY: England |
| ISSNLINKING: 2044-6055 |
| NLMUNIQUEID: 101552874 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
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| GRANTS |
|
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| GENERAL NOTE |
|
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| KEYWORDS |
|
| KEYWORD |
| anxiety disorders |
| depression & mood disorders |
| genetics |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Antidepressive Agents |
therapeutic use |
| Australia |
epidemiology |
| Depression |
genetics |
| Depressive Disorder, Major |
drug therapy |
| Female |
drug therapy |
| Humans |
drug therapy |
| Male |
drug therapy |
| Surveys and Questionnaires |
drug therapy |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Antidepressive Agents |
|
| OTHER ID's |
|
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|
