Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
32457298
TITLE
Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program.
ABSTRACT
Chronic opioid usage not only causes addiction behavior through the central nervous system, but also modulates the peripheral immune system. However, how opioid impacts the immune system is still barely characterized systematically. In order to understand the immune modulatory effect of opioids in an unbiased way, here we perform single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells from opioid-dependent individuals and controls to show that chronic opioid usage evokes widespread suppression of antiviral gene program in naive monocytes, as well as in multiple immune cell types upon stimulation with the pathogen component lipopolysaccharide. Furthermore, scRNA-seq reveals the same phenomenon after a short in vitro morphine treatment. These findings indicate that both acute and chronic opioid exposure may be harmful to our immune system by suppressing the antiviral gene program. Our results suggest that further characterization of the immune modulatory effects of opioid is critical to ensure the safety of clinical opioids.
DATE PUBLISHED
2020 May 26
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2019/07/18
accepted 2020/04/19
entrez 2020/05/28 06:00
pubmed 2020/05/28 06:00
medline 2020/05/28 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Karagiannis TT Karagiannis Tanya T TT Department of Biology, Boston University, 5 Cummington Mall, Boston, MA, 02215, USA.
Cleary JP Jr Cleary John P JP Program in Molecular Biology, Cell Biology and Biochemistry, Boston University, 24 Cummington Mall, Boston, MA, 02215, USA.
Gok B Gok Busra B Program in Cell and Molecular Biology, Boston University, 24 Cummington Mall, Boston, MA, 02215, USA.
Henderson AJ Henderson Andrew J AJ Department of Medicine and Microbiology, Boston University School of Medicine, 650 Albany St, Boston, MA, 02215, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Yajima M Yajima Masanao M Department of Mathematics and Statistics, Boston University, 111 Cummington Mall, Boston, MA, 02215, USA.
Nelson EC Nelson Elliot C EC Department of Psychiatry, Washington University School of Medicine, 660S. Euclid Ave, St. Louis, MO, 63110, USA.
Cheng CS Cheng Christine S CS Program in Cell and Molecular Biology, Boston University, 24 Cummington Mall, Boston, MA, 02215, USA. chcheng@bu.edu.
INVESTIGATORS
JOURNAL
VOLUME: 11
ISSUE: 1
TITLE: Nature communications
ISOABBREVIATION: Nat Commun
YEAR: 2020
MONTH: May
DAY: 26
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2041-1723
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Commun
COUNTRY: England
ISSNLINKING: 2041-1723
NLMUNIQUEID: 101528555
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R61DA047032 U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
GENERAL NOTE
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