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| PMID |
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| TITLE |
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| Mapping brain asymmetry in health and disease through the ENIGMA consortium. |
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| ABSTRACT |
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| Left-right asymmetry of the human brain is one of its cardinal features, and also a complex, multivariate trait. Decades of research have suggested that brain asymmetry may be altered in psychiatric disorders. However, findings have been inconsistent and often based on small sample sizes. There are also open questions surrounding which structures are asymmetrical on average in the healthy population, and how variability in brain asymmetry relates to basic biological variables such as age and sex. Over the last 4 years, the ENIGMA-Laterality Working Group has published six studies of gray matter morphological asymmetry based on total sample sizes from roughly 3,500 to 17,000 individuals, which were between one and two orders of magnitude larger than those published in previous decades. A population-level mapping of average asymmetry was achieved, including an intriguing fronto-occipital gradient of cortical thickness asymmetry in healthy brains. ENIGMA's multi-dataset approach also supported an empirical illustration of reproducibility of hemispheric differences across datasets. Effect sizes were estimated for gray matter asymmetry based on large, international, samples in relation to age, sex, handedness, and brain volume, as well as for three psychiatric disorders: autism spectrum disorder was associated with subtly reduced asymmetry of cortical thickness at regions spread widely over the cortex; pediatric obsessive-compulsive disorder was associated with altered subcortical asymmetry; major depressive disorder was not significantly associated with changes of asymmetry. Ongoing studies are examining brain asymmetry in other disorders. Moreover, a groundwork has been laid for possibly identifying shared genetic contributions to brain asymmetry and disorders. |
| © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2019/12/13 |
| revised |
2020/03/18 |
| accepted |
2020/04/29 |
| entrez |
2020/05/19 06:00 |
| pubmed |
2020/05/19 06:00 |
| medline |
2020/05/19 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Kong XZ |
|
Kong |
Xiang-Zhen |
XZ |
|
Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. |
| Postema MC |
|
Postema |
Merel C |
MC |
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Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. |
| Guadalupe T |
|
Guadalupe |
Tulio |
T |
|
Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. |
| de Kovel C |
|
de Kovel |
Carolien |
C |
|
Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. |
| Boedhoe PSW |
|
Boedhoe |
Premika S W |
PSW |
|
Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
| Hoogman M |
|
Hoogman |
Martine |
M |
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Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands. |
| Mathias SR |
|
Mathias |
Samuel R |
SR |
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Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA. |
| van Rooij D |
|
van Rooij |
Daan |
D |
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Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands. |
| Schijven D |
|
Schijven |
Dick |
D |
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Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. |
| Glahn DC |
|
Glahn |
David C |
DC |
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Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut, USA. |
| Medland SE |
|
Medland |
Sarah E |
SE |
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Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Jahanshad N |
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Jahanshad |
Neda |
N |
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Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA. |
| Thomopoulos SI |
|
Thomopoulos |
Sophia I |
SI |
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Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA. |
| Turner JA |
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Turner |
Jessica A |
JA |
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Department of Psychology and Neuroscience, Georgia State University, Atlanta, Georgia, USA. |
| Buitelaar J |
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Buitelaar |
Jan |
J |
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Karakter Child and Adolescent Psychiatry, Nijmegen, The Netherlands. |
| van Erp TGM |
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van Erp |
Theo G M |
TGM |
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Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, California, USA. |
| Franke B |
|
Franke |
Barbara |
B |
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Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. |
| Fisher SE |
|
Fisher |
Simon E |
SE |
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Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands. |
| van den Heuvel OA |
|
van den Heuvel |
Odile A |
OA |
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Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
| Schmaal L |
|
Schmaal |
Lianne |
L |
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Centre for Youth Mental Health, The University of Melbourne, Melbourne, Victoria, Australia. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
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Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, Georgia, USA. |
| Francks C |
|
Francks |
Clyde |
C |
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Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Human brain mapping |
| ISOABBREVIATION: Hum Brain Mapp |
| YEAR: 2020 |
| MONTH: May |
| DAY: 18 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1097-0193 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Hum Brain Mapp |
| COUNTRY: United States |
| ISSNLINKING: 1065-9471 |
| NLMUNIQUEID: 9419065 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Review |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| 115300 |
European Commission |
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| 777394 |
European Commission |
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Max-Planck-Gesellschaft |
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| 1140764 |
National Health and Medical Research Council |
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| P41 EB015922 |
NIH HHS |
United States |
| R01MH116147 |
NIH HHS |
United States |
| U01AG024904U54 |
NIH HHS |
United States |
| EB020403 |
NIH HHS |
United States |
| 016130669 |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
|
| 40017602 |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
|
| 91619115 |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
|
| 91717306 |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| autism spectrum disorder |
| brain asymmetry |
| brain laterality |
| major depressive disorder |
| mega-analysis |
| meta-analysis |
| obsessive-compulsive disorder |
| structural imaging |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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