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PMID |
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TITLE |
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Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility. |
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ABSTRACT |
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Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly genotyped) and 375,188 controls identified 54 significant (P < 5 × 10 ) loci with 68 independent single nucleotide polymorphisms. Analysis of risk estimates across geographical regions and host factors suggests the acral melanoma subtype is uniquely unrelated to pigmentation. Combining this meta-analysis with GWAS of nevus count and hair color, and transcriptome association approaches, uncovered 31 potential secondary loci for a total of 85 cutaneous melanoma susceptibility loci. These findings provide insights into cutaneous melanoma genetic architecture, reinforcing the importance of nevogenesis, pigmentation and telomere maintenance, together with identifying potential new pathways for cutaneous melanoma pathogenesis. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2019/07/10 |
accepted |
2020/03/09 |
pubmed |
2020/04/29 06:00 |
medline |
2020/08/04 06:00 |
entrez |
2020/04/29 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Landi MT |
|
Landi |
Maria Teresa |
MT |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. landim@mail.nih.gov. |
Bishop DT |
|
Bishop |
D Timothy |
DT |
|
Leeds Institute of Medical Research at St James's, Leeds Institute for Data Analytics, University of Leeds, Leeds, UK. |
MacGregor S |
|
MacGregor |
Stuart |
S |
|
Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Machiela MJ |
|
Machiela |
Mitchell J |
MJ |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
Stratigos AJ |
|
Stratigos |
Alexander J |
AJ |
|
Department of Dermatology, Andreas Syggros Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. |
Ghiorzo P |
|
Ghiorzo |
Paola |
P |
|
Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa, Italy. |
Brossard M |
|
Brossard |
Myriam |
M |
|
Genetic Epidemiology and Functional Genomics of Multifactorial Diseases Team, Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS-1124, Université Paris Descartes, Paris, France. |
Calista D |
|
Calista |
Donato |
D |
|
Department of Dermatology, Maurizio Bufalini Hospital, Cesena, Italy. |
Choi J |
|
Choi |
Jiyeon |
J |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
Fargnoli MC |
|
Fargnoli |
Maria Concetta |
MC |
|
Department of Dermatology & Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. |
Zhang T |
|
Zhang |
Tongwu |
T |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
Rodolfo M |
|
Rodolfo |
Monica |
M |
|
Unit of Immunotherapy of Human Tumors, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. |
Trower AJ |
|
Trower |
Adam J |
AJ |
|
Leeds Institute for Data Analytics, University of Leeds, Leeds, UK. |
Menin C |
|
Menin |
Chiara |
C |
|
Immunology and Molecular Oncology Unit, Venito Institute of Oncology IOV-IRCCS, Padua, Italy. |
Martinez J |
|
Martinez |
Jacobo |
J |
|
Red Valenciana de Biobancos, FISABIO, Valencia, Spain. |
Hadjisavvas A |
|
Hadjisavvas |
Andreas |
A |
|
Department of EM/Molecular Pathology & The Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus. |
Song L |
|
Song |
Lei |
L |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
Stefanaki I |
|
Stefanaki |
Irene |
I |
|
Department of Dermatology, University of Athens School of Medicine, Andreas Sygros Hospital, Athens, Greece. |
Scolyer R |
|
Scolyer |
Richard |
R |
|
New South Wales Health Pathology, Sydney, New South Wales, Australia. |
Yang R |
|
Yang |
Rose |
R |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
Goldstein AM |
|
Goldstein |
Alisa M |
AM |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
Potrony M |
|
Potrony |
Miriam |
M |
|
Dermatology Department, Melanoma Unit, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, CIBERER, Barcelona, Spain. |
Kypreou KP |
|
Kypreou |
Katerina P |
KP |
|
Department of Dermatology, University of Athens School of Medicine, Andreas Sygros Hospital, Athens, Greece. |
Pastorino L |
|
Pastorino |
Lorenza |
L |
|
Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa, Italy. |
Queirolo P |
|
Queirolo |
Paola |
P |
|
Medical Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy. |
Pellegrini C |
|
Pellegrini |
Cristina |
C |
|
Department of Dermatology & Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. |
Cattaneo L |
|
Cattaneo |
Laura |
L |
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Pathology Unit, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy. |
Zawistowski M |
|
Zawistowski |
Matthew |
M |
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Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA. |
Gimenez-Xavier P |
|
Gimenez-Xavier |
Pol |
P |
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Dermatology Department, Melanoma Unit, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, CIBERER, Barcelona, Spain. |
Rodriguez A |
|
Rodriguez |
Arantxa |
A |
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Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain. |
Elefanti L |
|
Elefanti |
Lisa |
L |
|
Immunology and Molecular Oncology Unit, Venito Institute of Oncology IOV-IRCCS, Padua, Italy. |
Manoukian S |
|
Manoukian |
Siranoush |
S |
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Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. |
Rivoltini L |
|
Rivoltini |
Licia |
L |
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Unit of Immunotherapy of Human Tumors, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. |
Smith BH |
|
Smith |
Blair H |
BH |
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Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. |
Loizidou MA |
|
Loizidou |
Maria A |
MA |
|
Department of EM/Molecular Pathology & The Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus. |
Del Regno L |
|
Del Regno |
Laura |
L |
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Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy. |
Massi D |
|
Massi |
Daniela |
D |
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Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy. |
Mandala M |
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Mandala |
Mario |
M |
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Department of Oncology, Giovanni XXIII Hospital, Bergamo, Italy. |
Khosrotehrani K |
|
Khosrotehrani |
Kiarash |
K |
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Department of Dermatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia. |
Akslen LA |
|
Akslen |
Lars A |
LA |
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Department of Pathology, Haukeland University Hospital, Bergen, Norway. |
Amos CI |
|
Amos |
Christopher I |
CI |
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Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA. |
Andresen PA |
|
Andresen |
Per A |
PA |
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Department of Pathology, Molecular Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway. |
Avril MF |
|
Avril |
Marie-Françoise |
MF |
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Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes, Paris, France. |
Azizi E |
|
Azizi |
Esther |
E |
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Oncogenetics Unit, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. |
Soyer HP |
|
Soyer |
H Peter |
HP |
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Dermatology Research Centre, The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia. |
Bataille V |
|
Bataille |
Veronique |
V |
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Department of Dermatology, West Herts NHS Trust, Herts, UK. |
Dalmasso B |
|
Dalmasso |
Bruna |
B |
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Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa, Italy. |
Bowdler LM |
|
Bowdler |
Lisa M |
LM |
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Sample Processing, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Burdon KP |
|
Burdon |
Kathryn P |
KP |
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Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. |
Chen WV |
|
Chen |
Wei V |
WV |
|
Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. |
Codd V |
|
Codd |
Veryan |
V |
|
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK. |
Craig JE |
|
Craig |
Jamie E |
JE |
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Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia. |
Dębniak T |
|
Dębniak |
Tadeusz |
T |
|
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland. |
Falchi M |
|
Falchi |
Mario |
M |
|
Department of Dermatology, West Herts NHS Trust, Herts, UK. |
Fang S |
|
Fang |
Shenying |
S |
|
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. |
Friedman E |
|
Friedman |
Eitan |
E |
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Oncogenetics Unit, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. |
Simi S |
|
Simi |
Sarah |
S |
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Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy. |
Galan P |
|
Galan |
Pilar |
P |
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Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Institut National de la Santé et de la Recherche Médicale (INSERM U1153), Institut National de la Recherche Agronomique (INRA U1125), Conservatoire National des Arts et Métiers, Communauté d'Université Sorbonne Paris Cité, Bobigny, France. |
Garcia-Casado Z |
|
Garcia-Casado |
Zaida |
Z |
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Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain. |
Gillanders EM |
|
Gillanders |
Elizabeth M |
EM |
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Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA. |
Gordon S |
|
Gordon |
Scott |
S |
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Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Green A |
|
Green |
Adele |
A |
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CRUK Manchester Institute, Institute of Inflammation and Repair, University of Manchester, Manchester, UK. |
Gruis NA |
|
Gruis |
Nelleke A |
NA |
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Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands. |
Hansson J |
|
Hansson |
Johan |
J |
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Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. |
Harland M |
|
Harland |
Mark |
M |
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Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. |
Harris J |
|
Harris |
Jessica |
J |
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Translational Research Institute, Institute of Health and Biomedical Innovation, Princess Alexandra Hospital, Queensland University of Technology, Brisbane, Queensland, Australia. |
Helsing P |
|
Helsing |
Per |
P |
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Department of Dermatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway. |
Henders A |
|
Henders |
Anjali |
A |
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Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. |
Hočevar M |
|
Hočevar |
Marko |
M |
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Department of Surgical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia. |
Höiom V |
|
Höiom |
Veronica |
V |
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Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. |
Hunter D |
|
Hunter |
David |
D |
|
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. |
Ingvar C |
|
Ingvar |
Christian |
C |
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Department of Surgery, Clinical Sciences, Lund University, Lund, Sweden. |
Kumar R |
|
Kumar |
Rajiv |
R |
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Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany. |
Lang J |
|
Lang |
Julie |
J |
|
Department of Medical Genetics, University of Glasgow, Glasgow, UK. |
Lathrop GM |
|
Lathrop |
G Mark |
GM |
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McGill University and Genome Quebec Innovation Centre, Montreal, Canada. |
Lee JE |
|
Lee |
Jeffrey E |
JE |
|
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. |
Li X |
|
Li |
Xin |
X |
|
Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA. |
Lubiński J |
|
Lubiński |
Jan |
J |
|
International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland. |
Mackie RM |
|
Mackie |
Rona M |
RM |
|
Department of Public Health, University of Glasgow, Glasgow, UK. |
Malt M |
|
Malt |
Maryrose |
M |
|
Cancer and Population Studies, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Malvehy J |
|
Malvehy |
Josep |
J |
|
Dermatology Department, Melanoma Unit, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, CIBERER, Barcelona, Spain. |
McAloney K |
|
McAloney |
Kerrie |
K |
|
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Mohamdi H |
|
Mohamdi |
Hamida |
H |
|
Genetic Epidemiology and Functional Genomics of Multifactorial Diseases Team, Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS-1124, Université Paris Descartes, Paris, France. |
Molven A |
|
Molven |
Anders |
A |
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Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway. |
Moses EK |
|
Moses |
Eric K |
EK |
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Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, Crawley, Western Australia, Australia. |
Neale RE |
|
Neale |
Rachel E |
RE |
|
Cancer Aetiology & Prevention, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Novaković S |
|
Novaković |
Srdjan |
S |
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Department of Molecular Diagnostics, Institute of Oncology Ljubljana, Ljubljana, Slovenia. |
Nyholt DR |
|
Nyholt |
Dale R |
DR |
|
School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. |
Olsson H |
|
Olsson |
Håkan |
H |
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Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden. |
Orr N |
|
Orr |
Nicholas |
N |
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Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK. |
Fritsche LG |
|
Fritsche |
Lars G |
LG |
|
Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA. |
Puig-Butille JA |
|
Puig-Butille |
Joan Anton |
JA |
|
Biochemistry and Molecular Genetics Department, Melanoma Unit, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona,CIBERER, Barcelona, Spain. |
Qureshi AA |
|
Qureshi |
Abrar A |
AA |
|
Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI, USA. |
Radford-Smith GL |
|
Radford-Smith |
Graham L |
GL |
|
University of Queensland School of Medicine, Herston Campus, Brisbane, Queensland, Australia. |
Randerson-Moor J |
|
Randerson-Moor |
Juliette |
J |
|
Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. |
Requena C |
|
Requena |
Celia |
C |
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Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain. |
Rowe C |
|
Rowe |
Casey |
C |
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UQ Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia. |
Samani NJ |
|
Samani |
Nilesh J |
NJ |
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NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK. |
Sanna M |
|
Sanna |
Marianna |
M |
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Department of Dermatology, West Herts NHS Trust, Herts, UK. |
Schadendorf D |
|
Schadendorf |
Dirk |
D |
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German Consortium Translational Cancer Research (DKTK), Heidelberg, Germany. |
Schulze HJ |
|
Schulze |
Hans-Joachim |
HJ |
|
Department of Dermatology, Fachklinik Hornheide, Institute for Tumors of the Skin, University of Münster, Münster, Germany. |
Simms LA |
|
Simms |
Lisa A |
LA |
|
Inflammatory Bowel Diseases, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Smithers M |
|
Smithers |
Mark |
M |
|
Mater Research Institute, The University of Queensland, St Lucia, Queensland, Australia. |
Song F |
|
Song |
Fengju |
F |
|
Departments of Epidemiology and Biostatistics, Key Laboratory of Cancer Prevention and Therapy, Tianjin, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P. R. China. |
Swerdlow AJ |
|
Swerdlow |
Anthony J |
AJ |
|
Division of Breast Cancer Research, The Institute of Cancer Research, London, UK. |
van der Stoep N |
|
van der Stoep |
Nienke |
N |
|
Department of Clinical Genetics, Center of Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands. |
Kukutsch NA |
|
Kukutsch |
Nicole A |
NA |
|
Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands. |
Visconti A |
|
Visconti |
Alessia |
A |
|
Department of Dermatology, West Herts NHS Trust, Herts, UK. |
Wallace L |
|
Wallace |
Leanne |
L |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. |
Ward SV |
|
Ward |
Sarah V |
SV |
|
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. |
Wheeler L |
|
Wheeler |
Lawrie |
L |
|
Translational Research Institute, Institute of Health and Biomedical Innovation, Princess Alexandra Hospital, Queensland University of Technology, Brisbane, Queensland, Australia. |
Sturm RA |
|
Sturm |
Richard A |
RA |
|
Dermatology Research Centre, The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia. |
Hutchinson A |
|
Hutchinson |
Amy |
A |
|
Cancer Genome Research Laboratory, Leidos Biomedical Research, Bethesda, MD, USA. |
Jones K |
|
Jones |
Kristine |
K |
|
Cancer Genome Research Laboratory, Leidos Biomedical Research, Bethesda, MD, USA. |
Malasky M |
|
Malasky |
Michael |
M |
|
Cancer Genome Research Laboratory, Leidos Biomedical Research, Bethesda, MD, USA. |
Vogt A |
|
Vogt |
Aurelie |
A |
|
Cancer Genome Research Laboratory, Leidos Biomedical Research, Bethesda, MD, USA. |
Zhou W |
|
Zhou |
Weiyin |
W |
|
Cancer Genome Research Laboratory, Leidos Biomedical Research, Bethesda, MD, USA. |
Pooley KA |
|
Pooley |
Karen A |
KA |
|
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK. |
Elder DE |
|
Elder |
David E |
DE |
|
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. |
Han J |
|
Han |
Jiali |
J |
|
Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA. |
Hicks B |
|
Hicks |
Belynda |
B |
|
Cancer Genome Research Laboratory, Leidos Biomedical Research, Bethesda, MD, USA. |
Hayward NK |
|
Hayward |
Nicholas K |
NK |
|
Oncogenomics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Kanetsky PA |
|
Kanetsky |
Peter A |
PA |
|
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. |
Brummett C |
|
Brummett |
Chad |
C |
|
Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA. |
Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. |
Olsen CM |
|
Olsen |
Catherine M |
CM |
|
Cancer Control Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Hayward C |
|
Hayward |
Caroline |
C |
|
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK. |
Dunning AM |
|
Dunning |
Alison M |
AM |
|
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK. |
Martin NG |
|
Martin |
Nicholas G |
NG |
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Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Evangelou E |
|
Evangelou |
Evangelos |
E |
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Department of Epidemiology and Biostatistics, Imperial College London, London, UK. |
Mann GJ |
|
Mann |
Graham J |
GJ |
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John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia. |
Long G |
|
Long |
Georgina |
G |
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Royal North Shore Hospital, Sydney, Australia. |
Pharoah PDP |
|
Pharoah |
Paul D P |
PDP |
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Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK. |
Easton DF |
|
Easton |
Douglas F |
DF |
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Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK. |
Barrett JH |
|
Barrett |
Jennifer H |
JH |
|
Leeds Institute for Data Analytics, University of Leeds, Leeds, UK. |
Cust AE |
|
Cust |
Anne E |
AE |
|
Cancer Epidemiology and Prevention Research, Sydney School of Public Health, Sydney, Australia. |
Abecasis G |
|
Abecasis |
Goncalo |
G |
|
Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. |
Duffy DL |
|
Duffy |
David L |
DL |
|
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Whiteman DC |
|
Whiteman |
David C |
DC |
|
Cancer Control Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Gogas H |
|
Gogas |
Helen |
H |
|
First Department of Internal Medicine, Laikon General Hospital Greece, National and Kapodistrian University of Athens, Athens, Greece. |
De Nicolo A |
|
De Nicolo |
Arcangela |
A |
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Cancer Genomics Program, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. |
Tucker MA |
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Tucker |
Margaret A |
MA |
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Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
Newton-Bishop JA |
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Newton-Bishop |
Julia A |
JA |
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Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. |
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GenoMEL Consortium |
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Q-MEGA and QTWIN Investigators |
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ATHENS Melanoma Study Group |
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23andMe |
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SDH Study Group |
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IBD Investigators |
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Essen-Heidelberg Investigators |
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AMFS Investigators |
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MelaNostrum Consortium |
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Peris K |
|
Peris |
Ketty |
K |
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Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy. |
Chanock SJ |
|
Chanock |
Stephen J |
SJ |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
Demenais F |
|
Demenais |
Florence |
F |
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Genetic Epidemiology and Functional Genomics of Multifactorial Diseases Team, Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS-1124, Université Paris Descartes, Paris, France. |
Brown KM |
|
Brown |
Kevin M |
KM |
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Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
Puig S |
|
Puig |
Susana |
S |
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Dermatology Department, Melanoma Unit, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, CIBERER, Barcelona, Spain. |
Nagore E |
|
Nagore |
Eduardo |
E |
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Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain. |
Shi J |
|
Shi |
Jianxin |
J |
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Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
Iles MM |
|
Iles |
Mark M |
MM |
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Leeds Institute for Data Analytics, University of Leeds, Leeds, UK. M.M.Iles@leeds.ac.uk. |
Law MH |
|
Law |
Matthew H |
MH |
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Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Matthew.Law@qimrberghofer.edu.au. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 52 |
ISSUE: 5 |
TITLE: Nature genetics |
ISOABBREVIATION: Nat Genet |
YEAR: 2020 |
MONTH: 05 |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1546-1718 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Nat Genet |
COUNTRY: United States |
ISSNLINKING: 1061-4036 |
NLMUNIQUEID: 9216904 |
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PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
Meta-Analysis |
Research Support, N.I.H., Extramural |
Research Support, N.I.H., Intramural |
Research Support, Non-U.S. Gov't |
Research Support, U.S. Gov't, Non-P.H.S. |
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COMMENTS AND CORRECTIONS |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
P01 CA087969 |
NCI NIH HHS |
United States |
ZIA CP010200 |
Intramural NIH HHS |
United States |
C490/A16561 |
Cancer Research UK |
United Kingdom |
P30 CA008748 |
NCI NIH HHS |
United States |
R01 CA122838 |
NCI NIH HHS |
United States |
|
Wellcome Trust |
United Kingdom |
R01 CA049449 |
NCI NIH HHS |
United States |
U01 CA049449 |
NCI NIH HHS |
United States |
R01 CA100264 |
NCI NIH HHS |
United States |
R01 CA133996 |
NCI NIH HHS |
United States |
R01 CA083115 |
NCI NIH HHS |
United States |
P01 CA055075 |
NCI NIH HHS |
United States |
WT084766/Z/08/Z |
Wellcome Trust |
United Kingdom |
R01 CA088363 |
NCI NIH HHS |
United States |
U19 CA148112 |
NCI NIH HHS |
United States |
10118 |
Cancer Research UK |
United Kingdom |
10589 |
Cancer Research UK |
United Kingdom |
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GENERAL NOTE |
|
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Female |
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Genetic Loci |
genetics |
Genetic Predisposition to Disease |
genetics |
Genome-Wide Association Study |
methods |
Genotype |
methods |
Humans |
methods |
Male |
methods |
Melanoma |
genetics |
Phenotype |
genetics |
Pigmentation |
genetics |
Polymorphism, Single Nucleotide |
genetics |
Skin Neoplasms |
genetics |
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SUPPLEMENTARY MESH |
|
SUPPLMESHNAME |
SUPPLMESHTYPE |
Melanoma, Cutaneous Malignant |
Disease |
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GENE SYMBOLS |
|
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CHEMICALS |
|
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OTHER ID's |
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|