Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
32242144
TITLE
Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.
ABSTRACT
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this study.
DATE PUBLISHED
2020 Apr 02
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2019/11/27
accepted 2020/03/03
entrez 2020/04/04 06:00
pubmed 2020/04/04 06:00
medline 2020/04/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Revez JA Revez Joana A JA Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Lin T Lin Tian T Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Qiao Z Qiao Zhen Z Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Xue A Xue Angli A Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Holtz Y Holtz Yan Y Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Zhu Z Zhu Zhihong Z Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Zeng J Zeng Jian J Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Wang H Wang Huanwei H Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Sidorenko J Sidorenko Julia J Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Kemper KE Kemper Kathryn E KE Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Vinkhuyzen AAE Vinkhuyzen Anna A E AAE Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Frater J Frater Julanne J Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Eyles D Eyles Darryl D Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia.
Burne THJ Burne Thomas H J THJ Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia.
Mitchell B Mitchell Brittany B School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Zhu G Zhu Gu G QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Visscher PM Visscher Peter M PM Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Yang J Yang Jian J Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Wray NR Wray Naomi R NR Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. naomi.wray@uq.edu.au.
McGrath JJ McGrath John J JJ National Centre for Register-based Research, Aarhus University, Aarhus, Denmark. j.mcgrath@uq.edu.au.
INVESTIGATORS
JOURNAL
VOLUME: 11
ISSUE: 1
TITLE: Nature communications
ISOABBREVIATION: Nat Commun
YEAR: 2020
MONTH: Apr
DAY: 02
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2041-1723
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Commun
COUNTRY: England
ISSNLINKING: 2041-1723
NLMUNIQUEID: 101528555
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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