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| PMID |
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| TITLE |
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| Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration. |
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| ABSTRACT |
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| Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this study. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2019/11/27 |
| accepted |
2020/03/03 |
| entrez |
2020/04/04 06:00 |
| pubmed |
2020/04/04 06:00 |
| medline |
2020/04/04 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Revez JA |
|
Revez |
Joana A |
JA |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Lin T |
|
Lin |
Tian |
T |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Qiao Z |
|
Qiao |
Zhen |
Z |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Xue A |
|
Xue |
Angli |
A |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Holtz Y |
|
Holtz |
Yan |
Y |
|
Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. |
| Zhu Z |
|
Zhu |
Zhihong |
Z |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Zeng J |
|
Zeng |
Jian |
J |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Wang H |
|
Wang |
Huanwei |
H |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Sidorenko J |
|
Sidorenko |
Julia |
J |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Kemper KE |
|
Kemper |
Kathryn E |
KE |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Vinkhuyzen AAE |
|
Vinkhuyzen |
Anna A E |
AAE |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Frater J |
|
Frater |
Julanne |
J |
|
Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. |
| Eyles D |
|
Eyles |
Darryl |
D |
|
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia. |
| Burne THJ |
|
Burne |
Thomas H J |
THJ |
|
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia. |
| Mitchell B |
|
Mitchell |
Brittany |
B |
|
School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Zhu G |
|
Zhu |
Gu |
G |
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QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Visscher PM |
|
Visscher |
Peter M |
PM |
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Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Yang J |
|
Yang |
Jian |
J |
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Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. |
| Wray NR |
|
Wray |
Naomi R |
NR |
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Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. naomi.wray@uq.edu.au. |
| McGrath JJ |
|
McGrath |
John J |
JJ |
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National Centre for Register-based Research, Aarhus University, Aarhus, Denmark. j.mcgrath@uq.edu.au. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 11 |
| ISSUE: 1 |
| TITLE: Nature communications |
| ISOABBREVIATION: Nat Commun |
| YEAR: 2020 |
| MONTH: Apr |
| DAY: 02 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2041-1723 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Nat Commun |
| COUNTRY: England |
| ISSNLINKING: 2041-1723 |
| NLMUNIQUEID: 101528555 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| CHEMICALS |
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