Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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32203155
TITLE
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder.
ABSTRACT
Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS p value thresholds using genetic data obtained from 2586 bipolar patients who received lithium treatment and took part in the Consortium on Lithium Genetics (ConLi Gen) study. Summary statistics from genome-wide association studies in MD (135,458 cases and 344,901 controls) from the Psychiatric Genomics Consortium (PGC) were used for PGS weighting. Response to lithium treatment was defined by continuous scores and categorical outcome (responders versus non-responders) using measurements on the Alda scale. Associations between PGSs of MD and lithium treatment response were assessed using a linear and binary logistic regression modeling for the continuous and categorical outcomes, respectively. The analysis was performed for the entire cohort, and for European and Asian sub-samples. The PGSs for MD were significantly associated with lithium treatment response in multi-ethnic, European or Asian populations, at various p value thresholds. Bipolar patients with a low polygenic load for MD were more likely to respond well to lithium, compared to those patients with high polygenic load [lowest vs highest PGS quartiles, multi-ethnic sample: OR = 1.54 (95% CI: 1.18-2.01) and European sample: OR = 1.75 (95% CI: 1.30-2.36)]. While our analysis in the Asian sample found equivalent effect size in the same direction: OR = 1.71 (95% CI: 0.61-4.90), this was not statistically significant. Using PGS decile comparison, we found a similar trend of association between a high genetic loading for MD and lower response to lithium. Our findings underscore the genetic contribution to lithium response in BD and support the emerging concept of a lithium-responsive biotype in BD.
DATE PUBLISHED
2020 Mar 16
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/11/22
accepted 2020/02/13
revised 2020/01/28
pubmed 2020/03/24 06:00
medline 2020/03/24 06:00
entrez 2020/03/24 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Amare AT Amare Azmeraw T AT South Australian Academic Health Science and Translation Centre, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
Schubert KO Schubert Klaus Oliver KO Northern Adelaide Local Health Network, Mental Health Services, Adelaide, SA, Australia.
Hou L Hou Liping L Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
Clark SR Clark Scott R SR Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.
Papiol S Papiol Sergi S Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Munich, Germany.
Cearns M Cearns Micah M Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.
Heilbronner U Heilbronner Urs U Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.
Degenhardt F Degenhardt Franziska F Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Tekola-Ayele F Tekola-Ayele Fasil F Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Hsu YH Hsu Yi-Hsiang YH Program for Quantitative Genomics, Harvard School of Public Health, Boston, MA, USA.
Shekhtman T Shekhtman Tatyana T Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Adli M Adli Mazda M Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Akula N Akula Nirmala N Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
Akiyama K Akiyama Kazufumi K Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.
Ardau R Ardau Raffaella R Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Arias B Arias Bárbara B Unitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina (IBUB), University of Barcelona, CIBERSAM, Barcelona, Spain.
Aubry JM Aubry Jean-Michel JM Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.
Backlund L Backlund Lena L Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Bhattacharjee AK Bhattacharjee Abesh Kumar AK Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Bellivier F Bellivier Frank F INSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Benabarre A Benabarre Antonio A Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Bengesser S Bengesser Susanne S Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria.
Biernacka JM Biernacka Joanna M JM Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Birner A Birner Armin A Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria.
Brichant-Petitjean C Brichant-Petitjean Clara C INSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Cervantes P Cervantes Pablo P The Neuromodulation Unit, McGill University Health Centre, Montreal, QC, Canada.
Chen HC Chen Hsi-Chung HC Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.
Chillotti C Chillotti Caterina C Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Cichon S Cichon Sven S Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Cruceanu C Cruceanu Cristiana C Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Czerski PM Czerski Piotr M PM Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
Dalkner N Dalkner Nina N Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria.
Dayer A Dayer Alexandre A Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.
Del Zompo M Del Zompo Maria M Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
DePaulo JR DePaulo J Raymond JR Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Étain B Étain Bruno B INSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Jamain S Jamain Stephane S Inserm U955, Translational Psychiatry laboratory, Fondation FondaMental, Créteil, France.
Falkai P Falkai Peter P Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Munich, Germany.
Forstner AJ Forstner Andreas J AJ Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.
Frisen L Frisen Louise L Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Frye MA Frye Mark A MA Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Fullerton JM Fullerton Janice M JM School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Gard S Gard Sébastien S Service de psychiatrie, Hôpital Charles Perrens, Bordeaux, France.
Garnham JS Garnham Julie S JS Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Goes FS Goes Fernando S FS Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Grigoroiu-Serbanescu M Grigoroiu-Serbanescu Maria M Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Grof P Grof Paul P Mood Disorders Center of Ottawa, Ottawa, ON, Canada.
Hashimoto R Hashimoto Ryota R Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
Hauser J Hauser Joanna J Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
Herms S Herms Stefan S Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Hoffmann P Hoffmann Per P Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Hofmann A Hofmann Andrea A Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Jiménez E Jiménez Esther E Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Kahn JP Kahn Jean-Pierre JP Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy, France.
Kassem L Kassem Layla L Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
Kuo PH Kuo Po-Hsiu PH Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Kato T Kato Tadafumi T Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Saitama, Japan.
Kelsoe JR Kelsoe John R JR Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Kittel-Schneider S Kittel-Schneider Sarah S Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Kliwicki S Kliwicki Sebastian S Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
König B König Barbara B Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.
Kusumi I Kusumi Ichiro I Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Laje G Laje Gonzalo G Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
Landén M Landén Mikael M Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Lavebratt C Lavebratt Catharina C Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Leboyer M Leboyer Marion M Inserm U955, Translational Psychiatry laboratory, Université Paris-Est-Créteil, Department of Psychiatry and Addictology of Mondor University Hospital, AP-HP, Fondation FondaMental, Créteil, France.
Leckband SG Leckband Susan G SG Office of Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
Tortorella A Tortorella Alfonso A Department of Psychiatry, University of Perugia, Perugia, Italy.
Manchia M Manchia Mirko M Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
Martinsson L Martinsson Lina L Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.
McCarthy MJ McCarthy Michael J MJ Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA.
McElroy SL McElroy Susan L SL Department of Psychiatry, Lindner Center of Hope / University of Cincinnati, Mason, OH, USA.
Colom F Colom Francesc F Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Mitjans M Mitjans Marina M Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Mondimore FM Mondimore Francis M FM Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Monteleone P Monteleone Palmiero P Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Nievergelt CM Nievergelt Caroline M CM Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Nöthen MM Nöthen Markus M MM Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Novák T Novák Tomas T National Institute of Mental Health, Klecany, Czech Republic.
O'Donovan C O'Donovan Claire C Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Ozaki N Ozaki Norio N Department of Psychiatry & Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ösby U Ösby Urban U Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Pfennig A Pfennig Andrea A Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Potash JB Potash James B JB Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Reif A Reif Andreas A Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Reininghaus E Reininghaus Eva E Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria.
Rouleau GA Rouleau Guy A GA Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Rybakowski JK Rybakowski Janusz K JK Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Schalling M Schalling Martin M Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Schofield PR Schofield Peter R PR School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Schweizer BW Schweizer Barbara W BW Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Severino G Severino Giovanni G Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Shilling PD Shilling Paul D PD Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Shimoda K Shimoda Katzutaka K Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.
Simhandl C Simhandl Christian C Bipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria.
Slaney CM Slaney Claire M CM Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Squassina A Squassina Alessio A Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Stamm T Stamm Thomas T Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Stopkova P Stopkova Pavla P National Institute of Mental Health, Klecany, Czech Republic.
Maj M Maj Mario M Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Turecki G Turecki Gustavo G Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Vieta E Vieta Eduard E Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Veeh J Veeh Julia J Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Witt SH Witt Stephanie H SH Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Wright A Wright Adam A School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.
Zandi PP Zandi Peter P PP Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Mitchell PB Mitchell Philip B PB School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.
Bauer M Bauer Michael M Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Alda M Alda Martin M National Institute of Mental Health, Klecany, Czech Republic.
Rietschel M Rietschel Marcella M Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
McMahon FJ McMahon Francis J FJ Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
Schulze TG Schulze Thomas G TG Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Baune BT Baune Bernhard T BT The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia. bernhard.baune@ukmuenster.de.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Wray Naomi R NR
Ripke Stephan S
Mattheisen Manuel M
Trzaskowski Maciej M
Byrne Enda M EM
Abdellaoui Abdel A
Adams Mark J MJ
Agerbo Esben E
Air Tracy M TM
Andlauer Till F M TFM
Bacanu Silviu-Alin SA
Bækvad-Hansen Marie M
Beekman Aartjan T F ATF
Bigdeli Tim B TB
Binder Elisabeth B EB
Blackwood Douglas H R DHR
Bryois Julien J
Buttenschøn Henriette N HN
Bybjerg-Grauholm Jonas J
Cai Na N
Castelao Enrique E
Christensen Jane Varregaard JV
Clarke Toni-Kim TK
Coleman Jonathan R I JRI
Colodro-Conde Lucía L
Couvy-Duchesne Baptiste B
Craddock Nick N
Crawford Gregory E GE
Davies Gail G
Deary Ian J IJ
Degenhardt Franziska F
Derks Eske M EM
Direk Nese N
Dolan Conor V CV
Dunn Erin C EC
Eley Thalia C TC
Escott-Price Valentina V
Kiadeh Farnush Farhadi Hassan FFH
Finucane Hilary K HK
Forstner Andreas J AJ
Frank Josef J
Gaspar Héléna A HA
Gill Michael M
Goes Fernando S FS
Gordon Scott D SD
Grove Jakob J
Hall Lynsey S LS
Hansen Christine Søholm CS
Hansen Thomas F TF
Herms Stefan S
Hickie Ian B IB
Hoffmann Per P
Homuth Georg G
Horn Carsten C
Hottenga Jouke-Jan JJ
Hougaard David M DM
Ising Marcus M
Jansen Rick R
Jorgenson Eric E
Knowles James A JA
Kohane Isaac S IS
Kraft Julia J
Kretzschmar Warren W WW
Krogh Jesper J
Kutalik Zoltán Z
Li Yihan Y
Lind Penelope A PA
MacIntyre Donald J DJ
MacKinnon Dean F DF
Maier Robert M RM
Maier Wolfgang W
Marchini Jonathan J
Mbarek Hamdi H
McGrath Patrick P
McGuffin Peter P
Medland Sarah E SE
Mehta Divya D
Middeldorp Christel M CM
Mihailov Evelin E
Milaneschi Yuri Y
Milani Lili L
Mondimore Francis M FM
Montgomery Grant W GW
Mostafavi Sara S
Mullins Niamh N
Nauck Matthias M
Ng Bernard B
Nivard Michel G MG
Nyholt Dale R DR
O'Reilly Paul F PF
Oskarsson Hogni H
Owen Michael J MJ
Painter Jodie N JN
Pedersen Carsten Bøcker CB
Pedersen Marianne Giørtz MG
Peterson Roseann E RE
Pettersson Erik E
Peyrot Wouter J WJ
Pistis Giorgio G
Posthuma Danielle D
Quiroz Jorge A JA
Qvist Per P
Rice John P JP
Riley Brien P BP
Rivera Margarita M
Mirza Saira Saeed SS
Schoevers Robert R
Schulte Eva C EC
Shen Ling L
Shi Jianxin J
Shyn Stanley I SI
Sigurdsson Engilbert E
Sinnamon Grant C B GCB
Smit Johannes H JH
Smith Daniel J DJ
Stefansson Hreinn H
Steinberg Stacy S
Streit Fabian F
Strohmaier Jana J
Tansey Katherine E KE
Teismann Henning H
Teumer Alexander A
Thompson Wesley W
Thomson Pippa A PA
Thorgeirsson Thorgeir E TE
Traylor Matthew M
Treutlein Jens J
Trubetskoy Vassily V
Uitterlinden André G AG
Umbricht Daniel D
Van der Auwera Sandra S
van Hemert Albert M AM
Viktorin Alexander A
Visscher Peter M PM
Wang Yunpeng Y
Webb Bradley T BT
Weinsheimer Shantel Marie SM
Wellmann Jürgen J
Willemsen Gonneke G
Witt Stephanie H SH
Wu Yang Y
Xi Hualin S HS
Yang Jian J
Zhang Futao F
Arolt Volker V
Baune Bernhard T BT
Berger Klaus K
Boomsma Dorret I DI
Cichon Sven S
Dannlowski Udo U
de Geus E J C EJC
DePaulo J Raymond JR
Domenici Enrico E
Domschke Katharina K
Esko Tõnu T
Grabe Hans J HJ
Hamilton Steven P SP
Hayward Caroline C
Heath Andrew C AC
Kendler Kenneth S KS
Kloiber Stefan S
Lewis Glyn G
Li Qingqin S QS
Lucae Susanne S
Madden Pamela A F PAF
Magnusson Patrik K PK
Martin Nicholas G NG
McIntosh Andrew M AM
Metspalu Andres A
Mors Ole O
Mortensen Preben Bo PB
Müller-Myhsok Bertram B
Nordentoft Merete M
Nöthen Markus M MM
O'Donovan Michael C MC
Paciga Sara A SA
Pedersen Nancy L NL
Penninx Brenda W J H BWJH
Perlis Roy H RH
Porteous David J DJ
Potash James B JB
Preisig Martin M
Rietschel Marcella M
Schaefer Catherine C
Schulze Thomas G TG
Smoller Jordan W JW
Stefansson Kari K
Tiemeier Henning H
Uher Rudolf R
Völzke Henry H
Weissman Myrna M MM
Werge Thomas T
Lewis Cathryn M CM
Levinson Douglas F DF
Breen Gerome G
Børglum Anders D AD
Sullivan Patrick F PF
JOURNAL
VOLUME:
ISSUE:
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol Psychiatry
YEAR: 2020
MONTH: Mar
DAY: 16
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
G0200243 Medical Research Council United Kingdom
MR/L010305/1 Medical Research Council United Kingdom
MR/L023784/2 Medical Research Council United Kingdom
GENERAL NOTE
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