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| PMID |
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| TITLE |
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| Educational attainment polygenic scores are associated with cortical total surface area and regions important for language and memory. |
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| ABSTRACT |
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| It is well established that higher cognitive ability is associated with larger brain size. However, individual variation in intelligence exists despite brain size and recent studies have shown that a simple unifactorial view of the neurobiology underpinning cognitive ability is probably unrealistic. Educational attainment (EA) is often used as a proxy for cognitive ability since it is easily measured, resulting in large sample sizes and, consequently, sufficient statistical power to detect small associations. This study investigates the association between three global (total surface area (TSA), intra-cranial volume (ICV) and average cortical thickness) and 34 regional cortical measures with educational attainment using a polygenic scoring (PGS) approach. Analyses were conducted on two independent target samples of young twin adults with neuroimaging data, from Australia (N = 1097) and the USA (N = 723), and found that higher EA-PGS were significantly associated with larger global brain size measures, ICV and TSA (R = 0.006 and 0.016 respectively, p < 0.001) but not average thickness. At the regional level, we identified seven cortical regions-in the frontal and temporal lobes-that showed variation in surface area and average cortical thickness over-and-above the global effect. These regions have been robustly implicated in language, memory, visual recognition and cognitive processing. Additionally, we demonstrate that these identified brain regions partly mediate the association between EA-PGS and cognitive test performance. Altogether, these findings advance our understanding of the neurobiology that underpins educational attainment and cognitive ability, providing focus points for future research. |
| Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2019/07/17 |
| revised |
2020/02/06 |
| accepted |
2020/02/26 |
| pubmed |
2020/03/04 06:00 |
| medline |
2021/02/16 06:00 |
| entrez |
2020/03/04 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
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Department of Genetics & Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia. Electronic address: Brittany.mitchell@qimrberghofer.edu.au. |
| Cuéllar-Partida G |
|
Cuéllar-Partida |
Gabriel |
G |
|
The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia. |
| Grasby KL |
|
Grasby |
Katrina L |
KL |
|
Department of Genetics & Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Campos AI |
|
Campos |
Adrian I |
AI |
|
Department of Genetics & Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. |
| Strike LT |
|
Strike |
Lachlan T |
LT |
|
Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. |
| Hwang LD |
|
Hwang |
Liang-Dar |
LD |
|
The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia. |
| Okbay A |
|
Okbay |
Aysu |
A |
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Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
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Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Department of Genetics & Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Department of Genetics & Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia. |
| Wright MJ |
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Wright |
Margaret J |
MJ |
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Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia; Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia. |
| Rentería ME |
|
Rentería |
Miguel E |
ME |
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Department of Genetics & Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 212 |
| ISSUE: |
| TITLE: NeuroImage |
| ISOABBREVIATION: Neuroimage |
| YEAR: 2020 |
| MONTH: 05 |
| DAY: 15 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1095-9572 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Neuroimage |
| COUNTRY: United States |
| ISSNLINKING: 1053-8119 |
| NLMUNIQUEID: 9215515 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| U54 EB020403 |
NIBIB NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
| U54 MH091657 |
NIMH NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Brain structure |
| Broca’s area |
| Educational attainment |
| Intelligence |
| Polygenic scores |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Academic Success |
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| Adolescent |
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| Adult |
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| Cerebral Cortex |
anatomy & histology |
| Educational Status |
anatomy & histology |
| Female |
anatomy & histology |
| Humans |
anatomy & histology |
| Intelligence |
physiology |
| Language |
physiology |
| Magnetic Resonance Imaging |
physiology |
| Male |
physiology |
| Memory |
physiology |
| Multifactorial Inheritance |
physiology |
| Organ Size |
physiology |
| Young Adult |
physiology |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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