Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
32060260
TITLE
Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank.
ABSTRACT
Although snoring is common in the general population, its aetiology has been largely understudied. Here we report a genetic study on snoring (n ~ 408,000; snorers ~ 152,000) using data from the UK Biobank. We identify 42 genome-wide significant loci, with an SNP-based heritability estimate of ~10% on the liability scale. Genetic correlations with body mass index, alcohol intake, smoking, schizophrenia, anorexia nervosa and neuroticism are observed. Gene-based associations identify 173 genes, including DLEU7, MSRB3 and POC5, highlighting genes expressed in the brain, cerebellum, lungs, blood and oesophagus. We use polygenic scores (PGS) to predict recent snoring and probable obstructive sleep apnoea (OSA) in an independent Australian sample (n ~ 8000). Mendelian randomization analyses suggest a potential causal relationship between high BMI and snoring. Altogether, our results uncover insights into the aetiology of snoring as a complex sleep-related trait and its role in health and disease beyond it being a cardinal symptom of OSA.
DATE PUBLISHED
2020 Feb 14
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2019/10/22
accepted 2020/01/22
entrez 2020/02/16 06:00
pubmed 2020/02/16 06:00
medline 2020/02/16 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Campos AI Campos Adrián I AI Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
García-Marín LM García-Marín Luis M LM Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Zapopan, Jalisco, México.
Byrne EM Byrne Enda M EM Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology Lab, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Cuéllar-Partida G Cuéllar-Partida Gabriel G University of Queensland Diamantina Institute, Brisbane, QLD, Australia. g.cuellarpartida@uq.edu.au.
Rentería ME Rentería Miguel E ME Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. miguel.renteria@qimrberghofer.edu.au.
INVESTIGATORS
JOURNAL
VOLUME: 11
ISSUE: 1
TITLE: Nature communications
ISOABBREVIATION: Nat Commun
YEAR: 2020
MONTH: Feb
DAY: 14
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2041-1723
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Commun
COUNTRY: England
ISSNLINKING: 2041-1723
NLMUNIQUEID: 101528555
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's