|
|
| PMID |
|
|
| TITLE |
|
| Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. |
|
| ABSTRACT |
|
|
|
| Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094-92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) was greater than MDD without reported trauma exposure (12%). Simulations showed that this is not confounded by the strong, positive genetic correlation observed between MDD and reported trauma exposure. We also observed that the genetic correlation between MDD and waist circumference was only significant in individuals reporting trauma exposure (rg = 0.24, p = 1.8 × 10 versus rg = -0.05, p = 0.39 in individuals not reporting trauma exposure, difference p = 2.3 × 10 ). Our results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2018/11/01 |
| accepted |
2019/08/19 |
| revised |
2019/07/20 |
| pubmed |
2020/01/24 06:00 |
| medline |
2021/03/18 06:00 |
| entrez |
2020/01/24 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Coleman JRI |
|
Coleman |
Jonathan R I |
JRI |
|
NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK. |
| Peyrot WJ |
|
Peyrot |
Wouter J |
WJ |
|
Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Medical Center, Amsterdam, the Netherlands. |
| Purves KL |
|
Purves |
Kirstin L |
KL |
|
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
| Davis KAS |
|
Davis |
Katrina A S |
KAS |
|
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
| Rayner C |
|
Rayner |
Christopher |
C |
|
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
| Choi SW |
|
Choi |
Shing Wan |
SW |
|
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
| Hübel C |
|
Hübel |
Christopher |
C |
|
NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK. |
| Gaspar HA |
|
Gaspar |
Héléna A |
HA |
|
NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK. |
| Kan C |
|
Kan |
Carol |
C |
|
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
| Van der Auwera S |
|
Van der Auwera |
Sandra |
S |
|
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. |
| Adams MJ |
|
Adams |
Mark James |
MJ |
|
Division of Psychiatry, University of Edinburgh, Edinburgh, UK. |
| Lyall DM |
|
Lyall |
Donald M |
DM |
|
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK. |
| Choi KW |
|
Choi |
Karmel W |
KW |
|
Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. |
|
on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium |
|
|
|
|
|
| Dunn EC |
|
Dunn |
Erin C |
EC |
|
Department of Psychiatry, Harvard Medical School, Boston, MA, USA. |
| Vassos E |
|
Vassos |
Evangelos |
E |
|
NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK. |
| Danese A |
|
Danese |
Andrea |
A |
|
National and Specialist CAMHS Trauma and Anxiety Clinic, South London and Maudsley NHS Foundation Trust, London, UK. |
| Maughan B |
|
Maughan |
Barbara |
B |
|
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
| Grabe HJ |
|
Grabe |
Hans J |
HJ |
|
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. |
| Lewis CM |
|
Lewis |
Cathryn M |
CM |
|
NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK. |
| O'Reilly PF |
|
O'Reilly |
Paul F |
PF |
|
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
| McIntosh AM |
|
McIntosh |
Andrew M |
AM |
|
Division of Psychiatry, University of Edinburgh, Edinburgh, UK. |
| Smith DJ |
|
Smith |
Daniel J |
DJ |
|
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK. |
| Wray NR |
|
Wray |
Naomi R |
NR |
|
Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. |
| Hotopf M |
|
Hotopf |
Matthew |
M |
|
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
| Eley TC |
|
Eley |
Thalia C |
TC |
|
NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK. thalia.eley@kcl.ac.uk. |
| Breen G |
|
Breen |
Gerome |
G |
|
NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK. gerome.breen@kcl.ac.uk. |
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Wray |
Naomi R |
NR |
|
| Ripke |
Stephan |
S |
|
| Mattheisen |
Manuel |
M |
|
| Trzaskowski |
Maciej |
M |
|
| Byrne |
Enda M |
EM |
|
| Abdellaoui |
Abdel |
A |
|
| Adams |
Mark J |
MJ |
|
| Agerbo |
Esben |
E |
|
| Air |
Tracy M |
TM |
|
| Andlauer |
Till F M |
TFM |
|
| Bacanu |
Silviu-Alin |
SA |
|
| Bækvad-Hansen |
Marie |
M |
|
| Beekman |
Aartjan T F |
ATF |
|
| Bigdeli |
Tim B |
TB |
|
| Binder |
Elisabeth B |
EB |
|
| Bryois |
Julien |
J |
|
| Buttenschøn |
Henriette N |
HN |
|
| Bybjerg-Grauholm |
Jonas |
J |
|
| Cai |
Na |
N |
|
| Castelao |
Enrique |
E |
|
| Christensen |
Jane Hvarregaard |
JH |
|
| Clarke |
Toni-Kim |
TK |
|
| Coleman |
Jonathan R I |
JRI |
|
| Colodro-Conde |
Lucía |
L |
|
| Couvy-Duchesne |
Baptiste |
B |
|
| Craddock |
Nick |
N |
|
| Crawford |
Gregory E |
GE |
|
| Davies |
Gail |
G |
|
| Deary |
Ian J |
IJ |
|
| Degenhardt |
Franziska |
F |
|
| Derks |
Eske M |
EM |
|
| Direk |
Nese |
N |
|
| Dolan |
Conor V |
CV |
|
| Dunn |
Erin C |
EC |
|
| Eley |
Thalia C |
TC |
|
| Escott-Price |
Valentina |
V |
|
| Kiadeh |
Farnush Farhadi Hassan |
FFH |
|
| Finucane |
Hilary K |
HK |
|
| Foo |
Jerome C |
JC |
|
| Forstner |
Andreas J |
AJ |
|
| Frank |
Josef |
J |
|
| Gaspar |
Héléna A |
HA |
|
| Gill |
Michael |
M |
|
| Goes |
Fernando S |
FS |
|
| Gordon |
Scott D |
SD |
|
| Grove |
Jakob |
J |
|
| Hall |
Lynsey S |
LS |
|
| Hansen |
Christine Søholm |
CS |
|
| Hansen |
Thomas F |
TF |
|
| Herms |
Stefan |
S |
|
| Hickie |
Ian B |
IB |
|
| Hoffmann |
Per |
P |
|
| Homuth |
Georg |
G |
|
| Horn |
Carsten |
C |
|
| Hottenga |
Jouke-Jan |
JJ |
|
| Hougaard |
David M |
DM |
|
| Howard |
David M |
DM |
|
| Ising |
Marcus |
M |
|
| Jansen |
Rick |
R |
|
| Jones |
Ian |
I |
|
| Jones |
Lisa A |
LA |
|
| Jorgenson |
Eric |
E |
|
| Knowles |
James A |
JA |
|
| Kohane |
Isaac S |
IS |
|
| Kraft |
Julia |
J |
|
| Kretzschmar |
Warren W |
WW |
|
| Kutalik |
Zoltán |
Z |
|
| Li |
Yihan |
Y |
|
| Lind |
Penelope A |
PA |
|
| MacIntyre |
Donald J |
DJ |
|
| MacKinnon |
Dean F |
DF |
|
| Maier |
Robert M |
RM |
|
| Maier |
Wolfgang |
W |
|
| Marchini |
Jonathan |
J |
|
| Mbarek |
Hamdi |
H |
|
| McGrath |
Patrick |
P |
|
| McGuffin |
Peter |
P |
|
| Medland |
Sarah E |
SE |
|
| Mehta |
Divya |
D |
|
| Middeldorp |
Christel M |
CM |
|
| Mihailov |
Evelin |
E |
|
| Milaneschi |
Yuri |
Y |
|
| Milani |
Lili |
L |
|
| Mondimore |
Francis M |
FM |
|
| Montgomery |
Grant W |
GW |
|
| Mostafavi |
Sara |
S |
|
| Mullins |
Niamh |
N |
|
| Nauck |
Matthias |
M |
|
| Ng |
Bernard |
B |
|
| Nivard |
Michel G |
MG |
|
| Nyholt |
Dale R |
DR |
|
| O'Reilly |
Paul F |
PF |
|
| Oskarsson |
Hogni |
H |
|
| Owen |
Michael J |
MJ |
|
| Painter |
Jodie N |
JN |
|
| Pedersen |
Carsten Bøcker |
CB |
|
| Pedersen |
Marianne Giørtz |
MG |
|
| Peterson |
Roseann E |
RE |
|
| Pettersson |
Erik |
E |
|
| Peyrot |
Wouter J |
WJ |
|
| Pistis |
Giorgio |
G |
|
| Posthuma |
Danielle |
D |
|
| Quiroz |
Jorge A |
JA |
|
| Qvist |
Per |
P |
|
| Rice |
John P |
JP |
|
| Riley |
Brien P |
BP |
|
| Rivera |
Margarita |
M |
|
| Mirza |
Saira Saeed |
SS |
|
| Schoevers |
Robert |
R |
|
| Schulte |
Eva C |
EC |
|
| Shen |
Ling |
L |
|
| Shi |
Jianxin |
J |
|
| Shyn |
Stanley I |
SI |
|
| Sigurdsson |
Engilbert |
E |
|
| Sinnamon |
Grant C B |
GCB |
|
| Smit |
Johannes H |
JH |
|
| Smith |
Daniel J |
DJ |
|
| Stefansson |
Hreinn |
H |
|
| Steinberg |
Stacy |
S |
|
| Streit |
Fabian |
F |
|
| Strohmaier |
Jana |
J |
|
| Tansey |
Katherine E |
KE |
|
| Teismann |
Henning |
H |
|
| Teumer |
Alexander |
A |
|
| Thompson |
Wesley |
W |
|
| Thomson |
Pippa A |
PA |
|
| Thorgeirsson |
Thorgeir E |
TE |
|
| Traylor |
Matthew |
M |
|
| Treutlein |
Jens |
J |
|
| Trubetskoy |
Vassily |
V |
|
| Uitterlinden |
Andrés G |
AG |
|
| Umbricht |
Daniel |
D |
|
| Van der Auwera |
Sandra |
S |
|
| van Hemert |
Albert M |
AM |
|
| Viktorin |
Alexander |
A |
|
| Visscher |
Peter M |
PM |
|
| Wang |
Yunpeng |
Y |
|
| Webb |
Bradley T |
BT |
|
| Weinsheimer |
Shantel Marie |
SM |
|
| Wellmann |
Jürgen |
J |
|
| Willemsen |
Gonneke |
G |
|
| Witt |
Stephanie H |
SH |
|
| Wu |
Yang |
Y |
|
| Xi |
Hualin S |
HS |
|
| Yang |
Jian |
J |
|
| Zhang |
Futao |
F |
|
| Arolt |
Volker |
V |
|
| Baune |
Bernhard T |
BT |
|
| Berger |
Klaus |
K |
|
| Boomsma |
Dorret I |
DI |
|
| Cichon |
Sven |
S |
|
| Dannlowski |
Udo |
U |
|
| de Geus |
E J C |
EJC |
|
| DePaulo |
J Raymond |
JR |
|
| Domenici |
Enrico |
E |
|
| Domschke |
Katharina |
K |
|
| Esko |
Tõnu |
T |
|
| Grabe |
Hans J |
HJ |
|
| Hamilton |
Steven P |
SP |
|
| Hayward |
Caroline |
C |
|
| Heath |
Andrew C |
AC |
|
| Kendler |
Kenneth S |
KS |
|
| Kloiber |
Stefan |
S |
|
| Lewis |
Glyn |
G |
|
| Li |
Qingqin S |
QS |
|
| Lucae |
Susanne |
S |
|
| Madden |
Pamela A F |
PAF |
|
| Magnusson |
Patrik K |
PK |
|
| Martin |
Nicholas G |
NG |
|
| McIntosh |
Andrew M |
AM |
|
| Metspalu |
Andres |
A |
|
| Mors |
Ole |
O |
|
| Mortensen |
Preben Bo |
PB |
|
| Müller-Myhsok |
Bertram |
B |
|
| Nordentoft |
Merete |
M |
|
| Nöthen |
Markus M |
MM |
|
| O'Donovan |
Michael C |
MC |
|
| Paciga |
Sara A |
SA |
|
| Pedersen |
Nancy L |
NL |
|
| Penninx |
Brenda W J H |
BWJH |
|
| Perlis |
Roy H |
RH |
|
| Porteous |
David J |
DJ |
|
| Potash |
James B |
JB |
|
| Preisig |
Martin |
M |
|
| Rietschel |
Marcella |
M |
|
| Schaefer |
Catherine |
C |
|
| Schulze |
Thomas G |
TG |
|
| Smoller |
Jordan W |
JW |
|
| Stefansson |
Kari |
K |
|
| Tiemeier |
Henning |
H |
|
| Uher |
Rudolf |
R |
|
| Völzke |
Henry |
H |
|
| Weissman |
Myrna M |
MM |
|
| Werge |
Thomas |
T |
|
| Lewis |
Cathryn M |
CM |
|
| Levinson |
Douglas F |
DF |
|
| Breen |
Gerome |
G |
|
| Børglum |
Anders D |
AD |
|
| Sullivan |
Patrick F |
PF |
|
|
| JOURNAL |
|
| VOLUME: 25 |
| ISSUE: 7 |
| TITLE: Molecular psychiatry |
| ISOABBREVIATION: Mol Psychiatry |
| YEAR: 2020 |
| MONTH: 07 |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1476-5578 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Mol Psychiatry |
| COUNTRY: England |
| ISSNLINKING: 1359-4184 |
| NLMUNIQUEID: 9607835 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| ErratumIn |
Mol Psychiatry. 2020 May 18;: |
32424234 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| MR/N015746/1 |
Medical Research Council |
United Kingdom |
| MC_QA137853 |
Medical Research Council |
United Kingdom |
|
Department of Health |
United Kingdom |
| G0200243 |
Medical Research Council |
United Kingdom |
| U01 MH109514 |
NIMH NIH HHS |
United States |
| MC_PC_12028 |
Medical Research Council |
United Kingdom |
| MC_PC_17228 |
Medical Research Council |
United Kingdom |
| U01 MH109528 |
NIMH NIH HHS |
United States |
| U01 MH109532 |
NIMH NIH HHS |
United States |
| T32 MH017119 |
NIMH NIH HHS |
United States |
| MR/L023784/2 |
Medical Research Council |
United Kingdom |
| MC_PC_17209 |
Medical Research Council |
United Kingdom |
| MR/L010305/1 |
Medical Research Council |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Aged |
|
| Databases, Factual |
|
| Depressive Disorder, Major |
genetics |
| Female |
genetics |
| Gene-Environment Interaction |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Genome-Wide Association Study |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Psychological Trauma |
epidemiology |
| Self Report |
epidemiology |
| United Kingdom |
epidemiology |
| Waist Circumference |
epidemiology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
