Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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31926635
TITLE
The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Multiple approaches have shown considerable sharing of risk factors across mood disorders despite their diagnostic distinction.
METHODS NlmCategory: METHODS
Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Multiple approaches have shown considerable sharing of risk factors across mood disorders despite their diagnostic distinction. To clarify the shared molecular genetic basis of major depressive disorder and bipolar disorder and to highlight disorder-specific associations, we meta-analyzed data from the latest Psychiatric Genomics Consortium genome-wide association studies of major depression (including data from 23andMe) and bipolar disorder, and an additional major depressive disorder cohort from UK Biobank (total: 185,285 cases, 439,741 controls; nonoverlapping N = 609,424).
RESULTS NlmCategory: RESULTS
Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Multiple approaches have shown considerable sharing of risk factors across mood disorders despite their diagnostic distinction. To clarify the shared molecular genetic basis of major depressive disorder and bipolar disorder and to highlight disorder-specific associations, we meta-analyzed data from the latest Psychiatric Genomics Consortium genome-wide association studies of major depression (including data from 23andMe) and bipolar disorder, and an additional major depressive disorder cohort from UK Biobank (total: 185,285 cases, 439,741 controls; nonoverlapping N = 609,424). Seventy-three loci reached genome-wide significance in the meta-analysis, including 15 that are novel for mood disorders. More loci from the Psychiatric Genomics Consortium analysis of major depression than from that for bipolar disorder reached genome-wide significance. Genetic correlations revealed that type 2 bipolar disorder correlates strongly with recurrent and single-episode major depressive disorder. Systems biology analyses highlight both similarities and differences between the mood disorders, particularly in the mouse brain cell types implicated by the expression patterns of associated genes. The mood disorders also differ in their genetic correlation with educational attainment-the relationship is positive in bipolar disorder but negative in major depressive disorder.
CONCLUSIONS NlmCategory: CONCLUSIONS
Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Multiple approaches have shown considerable sharing of risk factors across mood disorders despite their diagnostic distinction. To clarify the shared molecular genetic basis of major depressive disorder and bipolar disorder and to highlight disorder-specific associations, we meta-analyzed data from the latest Psychiatric Genomics Consortium genome-wide association studies of major depression (including data from 23andMe) and bipolar disorder, and an additional major depressive disorder cohort from UK Biobank (total: 185,285 cases, 439,741 controls; nonoverlapping N = 609,424). Seventy-three loci reached genome-wide significance in the meta-analysis, including 15 that are novel for mood disorders. More loci from the Psychiatric Genomics Consortium analysis of major depression than from that for bipolar disorder reached genome-wide significance. Genetic correlations revealed that type 2 bipolar disorder correlates strongly with recurrent and single-episode major depressive disorder. Systems biology analyses highlight both similarities and differences between the mood disorders, particularly in the mouse brain cell types implicated by the expression patterns of associated genes. The mood disorders also differ in their genetic correlation with educational attainment-the relationship is positive in bipolar disorder but negative in major depressive disorder. The mood disorders share several genetic associations, and genetic studies of major depressive disorder and bipolar disorder can be combined effectively to enable the discovery of variants not identified by studying either disorder alone. However, we demonstrate several differences between these disorders. Analyzing subtypes of major depressive disorder and bipolar disorder provides evidence for a genetic mood disorders spectrum.
Copyright 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
DATE PUBLISHED
2019 Nov 01
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2019/05/02
revised 2019/09/27
accepted 2019/10/15
entrez 2020/01/14 06:00
pubmed 2020/01/14 06:00
medline 2020/01/14 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Coleman JRI Coleman Jonathan R I JRI Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Biomedical Research Centre, King's College London, London, United Kingdom.
Gaspar HA Gaspar Héléna A HA Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Biomedical Research Centre, King's College London, London, United Kingdom.
Bryois J Bryois Julien J Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Bipolar Disorder Working Group of the Psychiatric Genomics Consortium
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Breen G Breen Gerome G Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Biomedical Research Centre, King's College London, London, United Kingdom. Electronic address: gerome.breen@kcl.ac.uk.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Byrne Enda M EM
Forstner Andreas J AJ
Holmans Peter A PA
de Leeuw Christiaan A CA
Mattheisen Manuel M
McQuillin Andrew A
Whitehead Pavlides Jennifer M JM
Pers Tune H TH
Ripke Stephan S
Stahl Eli A EA
Steinberg Stacy S
Trubetskoy Vassily V
Trzaskowski Maciej M
Wang Yunpeng Y
Abbott Liam L
Abdellaoui Abdel A
Adams Mark J MJ
Adolfsson Annelie Nordin AN
Agerbo Esben E
Akil Huda H
Albani Diego D
Alliey-Rodriguez Ney N
Als Thomas D TD
Andlauer Till F M TFM
Anjorin Adebayo A
Antilla Verneri V
Van der Auwera Sandra S
Awasthi Swapnil S
Bacanu Silviu-Alin SA
Badner Judith A JA
Bækvad-Hansen Marie M
Barchas Jack D JD
Bass Nicholas N
Bauer Michael M
Beekman Aartjan T F ATF
Belliveau Richard R
Bergen Sarah E SE
Bigdeli Tim B TB
Binder Elisabeth B EB
Bøen Erlend E
Boks Marco M
Boocock James J
Budde Monika M
Bunney William W
Burmeister Margit M
Buttenschøn Henriette N HN
Bybjerg-Grauholm Jonas J
Byerley William W
Cai Na N
Casas Miquel M
Castelao Enrique E
Cerrato Felecia F
Cervantes Pablo P
Chambert Kimberly K
Charney Alexander W AW
Chen Danfeng D
Christensen Jane Hvarregaard JH
Churchhouse Claire C
St Clair David D
Clarke Toni-Kim TK
Colodro-Conde Lucía L
Coryell William W
Couvy-Duchesne Baptiste B
Craig David W DW
Crawford Gregory E GE
Cruceanu Cristiana C
Czerski Piotr M PM
Dale Anders M AM
Davies Gail G
Deary Ian J IJ
Degenhardt Franziska F
Del-Favero Jurgen J
DePaulo J Raymond JR
Derks Eske M EM
Direk Nese N
Djurovic Srdjan S
Dobbyn Amanda L AL
Dolan Conor V CV
Dumont Ashley A
Dunn Erin C EC
Eley Thalia C TC
Elvsåshagen Torbjørn T
Escott-Price Valentina V
Fan Chun Chieh CC
Finucane Hilary K HK
Fischer Sascha B SB
Flickinger Matthew M
Foo Jerome C JC
Foroud Tatiana M TM
Forty Liz L
Frank Josef J
Fraser Christine C
Freimer Nelson B NB
Frisén Louise L
Gade Katrin K
Gage Diane D
Garnham Julie J
Giambartolomei Claudia C
Goes Fernando S FS
Goldstein Jaqueline J
Gordon Scott D SD
Gordon-Smith Katherine K
Green Elaine K EK
Green Melissa J MJ
Greenwood Tiffany A TA
Grove Jakob J
Guan Weihua W
Hall Lynsey S LS
Hamshere Marian L ML
Hansen Christine Søholm CS
Hansen Thomas F TF
Hautzinger Martin M
Heilbronner Urs U
van Hemert Albert M AM
Herms Stefan S
Hickie Ian B IB
Hipolito Maria M
Hoffmann Per P
Holland Dominic D
Homuth Georg G
Horn Carsten C
Hottenga Jouke-Jan JJ
Huckins Laura L
Ising Marcus M
Jamain Stéphane S
Jansen Rick R
Johnson Jessica S JS
de Jong Simone S
Jorgenson Eric E
Juréus Anders A
Kandaswamy Radhika R
Karlsson Robert R
Kennedy James L JL
Hassan Kiadeh Farnush Farhadi FF
Kittel-Schneider Sarah S
Knowles James A JA
Kogevinas Manolis M
Kohane Isaac S IS
Koller Anna C AC
Kraft Julia J
Kretzschmar Warren W WW
Krogh Jesper J
Kupka Ralph R
Kutalik Zoltán Z
Lavebratt Catharina C
Lawrence Jacob J
Lawson William B WB
Leber Markus M
Lee Phil H PH
Levy Shawn E SE
Li Jun Z JZ
Li Yihan Y
Lind Penelope A PA
Liu Chunyu C
Olde Loohuis Loes M LM
Maaser Anna A
MacIntyre Donald J DJ
MacKinnon Dean F DF
Mahon Pamela B PB
Maier Wolfgang W
Maier Robert M RM
Marchini Jonathan J
Martinsson Lina L
Mbarek Hamdi H
McCarroll Steve S
McGrath Patrick P
McGuffin Peter P
McInnis Melvin G MG
McKay James D JD
Medeiros Helena H
Medland Sarah E SE
Mehta Divya D
Meng Fan F
Middeldorp Christel M CM
Mihailov Evelin E
Milaneschi Yuri Y
Milani Lili L
Mirza Saira Saeed SS
Mondimore Francis M FM
Montgomery Grant W GW
Morris Derek W DW
Mostafavi Sara S
Mühleisen Thomas W TW
Mullins Niamh N
Nauck Matthias M
Ng Bernard B
Nguyen Hoang H
Nievergelt Caroline M CM
Nivard Michel G MG
Nwulia Evaristus A EA
Nyholt Dale R DR
O'Donovan Claire C
O'Reilly Paul F PF
Ori Anil P S APS
Oruc Lilijana L
Ösby Urban U
Oskarsson Hogni H
Painter Jodie N JN
Parra José Guzman JG
Pedersen Carsten Bøcker CB
Pedersen Marianne Giørtz MG
Perry Amy A
Peterson Roseann E RE
Pettersson Erik E
Peyrot Wouter J WJ
Pfennig Andrea A
Pistis Giorgio G
Purcell Shaun M SM
Quiroz Jorge A JA
Qvist Per P
Regeer Eline J EJ
Reif Andreas A
Reinbold Céline S CS
Rice John P JP
Riley Brien P BP
Rivas Fabio F
Rivera Margarita M
Roussos Panos P
Ruderfer Douglas M DM
Ryu Euijung E
Sánchez-Mora Cristina C
Schatzberg Alan F AF
Scheftner William A WA
Schoevers Robert R
Schork Nicholas J NJ
Schulte Eva C EC
Shehktman Tatyana T
Shen Ling L
Shi Jianxin J
Shilling Paul D PD
Shyn Stanley I SI
Sigurdsson Engilbert E
Slaney Claire C
Smeland Olav B OB
Smit Johannes H JH
Smith Daniel J DJ
Sobell Janet L JL
Spijker Anne T AT
Steffens Michael M
Strauss John S JS
Streit Fabian F
Strohmaier Jana J
Szelinger Szabolcs S
Tansey Katherine E KE
Teismann Henning H
Teumer Alexander A
Thompson Robert C RC
Thompson Wesley W
Thomson Pippa A PA
Thorgeirsson Thorgeir E TE
Traylor Matthew M
Treutlein Jens J
Uitterlinden André G AG
Umbricht Daniel D
Vedder Helmut H
Viktorin Alexander A
Visscher Peter M PM
Wang Weiqing W
Watson Stanley J SJ
Webb Bradley T BT
Weickert Cynthia Shannon CS
Weickert Thomas W TW
Weinsheimer Shantel Marie SM
Wellmann Jürgen J
Willemsen Gonneke G
Witt Stephanie H SH
Wu Yang Y
Xi Hualin S HS
Xu Wei W
Yang Jian J
Young Allan H AH
Zandi Peter P
Zhang Peng P
Zhang Futao F
Zollner Sebastian S
Adolfsson Rolf R
Agartz Ingrid I
Alda Martin M
Arolt Volker V
Backlund Lena L
Baune Bernhard T BT
Bellivier Frank F
Berger Klaus K
Berrettini Wade H WH
Biernacka Joanna M JM
Blackwood Douglas H R DHR
Boehnke Michael M
Boomsma Dorret I DI
Corvin Aiden A
Craddock Nicholas N
Daly Mark J MJ
Dannlowski Udo U
Domenici Enrico E
Domschke Katharina K
Esko Tõnu T
Etain Bruno B
Frye Mark M
Fullerton Janice M JM
Gershon Elliot S ES
de Geus E J C EJC
Gill Michael M
Goes Fernando F
Grabe Hans J HJ
Grigoroiu-Serbanescu Maria M
Hamilton Steven P SP
Hauser Joanna J
Hayward Caroline C
Heath Andrew C AC
Hougaard David M DM
Hultman Christina M CM
Jones Ian I
Jones Lisa A LA
Kahn René S RS
Kendler Kenneth S KS
Kirov George G
Kloiber Stefan S
Landén Mikael M
Leboyer Marion M
Lewis Glyn G
Li Qingqin S QS
Lissowska Jolanta J
Lucae Susanne S
Madden Pamela A F PAF
Magnusson Patrik K PK
Martin Nicholas G NG
Mayoral Fermin F
McElroy Susan L SL
McIntosh Andrew M AM
McMahon Francis J FJ
Melle Ingrid I
Metspalu Andres A
Mitchell Philip B PB
Morken Gunnar G
Mors Ole O
Mortensen Preben Bo PB
Müller-Myhsok Bertram B
Myers Richard M RM
Neale Benjamin M BM
Nimgaonkar Vishwajit V
Nordentoft Merete M
Nöthen Markus M MM
O'Donovan Michael C MC
Oedegaard Ketil J KJ
Owen Michael J MJ
Paciga Sara A SA
Pato Carlos C
Pato Michele T MT
Pedersen Nancy L NL
Penninx Brenda W J H BWJH
Perlis Roy H RH
Porteous David J DJ
Posthuma Danielle D
Potash James B JB
Preisig Martin M
Ramos-Quiroga Josep Antoni JA
Ribasés Marta M
Rietschel Marcella M
Rouleau Guy A GA
Schaefer Catherine C
Schalling Martin M
Schofield Peter R PR
Schulze Thomas G TG
Serretti Alessandro A
Smoller Jordan W JW
Stefansson Hreinn H
Stefansson Kari K
Stordal Eystein E
Tiemeier Henning H
Turecki Gustavo G
Uher Rudolf R
Vaaler Arne E AE
Vieta Eduard E
Vincent John B JB
Völzke Henry H
Weissman Myrna M MM
Werge Thomas T
Andreassen Ole A OA
Børglum Anders D AD
Cichon Sven S
Edenberg Howard J HJ
Di Florio Arianna A
Kelsoe John J
Levinson Douglas F DF
Lewis Cathryn M CM
Nurnberger John I JI
Ophoff Roel A RA
Scott Laura J LJ
Sklar Pamela P
Sullivan Patrick F PF
Wray Naomi R NR
Byrne Enda M EM
Forstner Andreas J AJ
Holmans Peter A PA
de Leeuw Christiaan A CA
Mattheisen Manuel M
McQuillin Andrew A
Whitehead Pavlides Jennifer M JM
Pers Tune H TH
Ripke Stephan S
Stahl Eli A EA
Steinberg Stacy S
Trubetskoy Vassily V
Trzaskowski Maciej M
Wang Yunpeng Y
Abbott Liam L
Abdellaoui Abdel A
Adams Mark J MJ
Adolfsson Annelie Nordin AN
Agerbo Esben E
Akil Huda H
Albani Diego D
Alliey-Rodriguez Ney N
Als Thomas D TD
Andlauer Till F M TFM
Anjorin Adebayo A
Antilla Verneri V
Van der Auwera Sandra S
Awasthi Swapnil S
Bacanu Silviu-Alin SA
Badner Judith A JA
Bækvad-Hansen Marie M
Barchas Jack D JD
Bass Nicholas N
Bauer Michael M
Beekman Aartjan T F ATF
Belliveau Richard R
Bergen Sarah E SE
Bigdeli Tim B TB
Binder Elisabeth B EB
Bøen Erlend E
Boks Marco M
Boocock James J
Budde Monika M
Bunney William W
Burmeister Margit M
Buttenschøn Henriette N HN
Bybjerg-Grauholm Jonas J
Byerley William W
Cai Na N
Casas Miquel M
Castelao Enrique E
Cerrato Felecia F
Cervantes Pablo P
Chambert Kimberly K
Charney Alexander W AW
Chen Danfeng D
Christensen Jane Hvarregaard JH
Churchhouse Claire C
St Clair David D
Clarke Toni-Kim TK
Colodro-Conde Lucía L
Coryell William W
Couvy-Duchesne Baptiste B
Craig David W DW
Crawford Gregory E GE
Cruceanu Cristiana C
Czerski Piotr M PM
Dale Anders M AM
Davies Gail G
Deary Ian J IJ
Degenhardt Franziska F
Del-Favero Jurgen J
DePaulo J Raymond JR
Derks Eske M EM
Direk Nese N
Djurovic Srdjan S
Dobbyn Amanda L AL
Dolan Conor V CV
Dumont Ashley A
Dunn Erin C EC
Eley Thalia C TC
Elvsåshagen Torbjørn T
Escott-Price Valentina V
Fan Chun Chieh CC
Finucane Hilary K HK
Fischer Sascha B SB
Flickinger Matthew M
Foo Jerome C JC
Foroud Tatiana M TM
Forty Liz L
Frank Josef J
Fraser Christine C
Freimer Nelson B NB
Frisén Louise L
Gade Katrin K
Gage Diane D
Garnham Julie J
Giambartolomei Claudia C
Goes Fernando S FS
Goldstein Jaqueline J
Gordon Scott D SD
Gordon-Smith Katherine K
Green Elaine K EK
Green Melissa J MJ
Greenwood Tiffany A TA
Grove Jakob J
Guan Weihua W
Hall Lynsey S LS
Hamshere Marian L ML
Hansen Christine Søholm CS
Hansen Thomas F TF
Hautzinger Martin M
Heilbronner Urs U
van Hemert Albert M AM
Herms Stefan S
Hickie Ian B IB
Hipolito Maria M
Hoffmann Per P
Holland Dominic D
Homuth Georg G
Horn Carsten C
Hottenga Jouke-Jan JJ
Huckins Laura L
Ising Marcus M
Jamain Stéphane S
Jansen Rick R
Johnson Jessica S JS
de Jong Simone S
Jorgenson Eric E
Juréus Anders A
Kandaswamy Radhika R
Karlsson Robert R
Kennedy James L JL
Hassan Kiadeh Farnush Farhadi FF
Kittel-Schneider Sarah S
Knowles James A JA
Kogevinas Manolis M
Kohane Isaac S IS
Koller Anna C AC
Kraft Julia J
Kretzschmar Warren W WW
Krogh Jesper J
Kupka Ralph R
Kutalik Zoltán Z
Lavebratt Catharina C
Lawrence Jacob J
Lawson William B WB
Leber Markus M
Lee Phil H PH
Levy Shawn E SE
Li Jun Z JZ
Li Yihan Y
Lind Penelope A PA
Liu Chunyu C
Olde Loohuis Loes M LM
Maaser Anna A
MacIntyre Donald J DJ
MacKinnon Dean F DF
Mahon Pamela B PB
Maier Wolfgang W
Maier Robert M RM
Marchini Jonathan J
Martinsson Lina L
Mbarek Hamdi H
McCarroll Steve S
McGrath Patrick P
McGuffin Peter P
McInnis Melvin G MG
McKay James D JD
Medeiros Helena H
Medland Sarah E SE
Mehta Divya D
Meng Fan F
Middeldorp Christel M CM
Mihailov Evelin E
Milaneschi Yuri Y
Milani Lili L
Mirza Saira Saeed SS
Mondimore Francis M FM
Montgomery Grant W GW
Morris Derek W DW
Mostafavi Sara S
Mühleisen Thomas W TW
Mullins Niamh N
Nauck Matthias M
Ng Bernard B
Nguyen Hoang H
Nievergelt Caroline M CM
Nivard Michel G MG
Nwulia Evaristus A EA
Nyholt Dale R DR
O'Donovan Claire C
O'Reilly Paul F PF
Ori Anil P S APS
Oruc Lilijana L
Ösby Urban U
Oskarsson Hogni H
Painter Jodie N JN
Parra José Guzman JG
Pedersen Carsten Bøcker CB
Pedersen Marianne Giørtz MG
Perry Amy A
Peterson Roseann E RE
Pettersson Erik E
Peyrot Wouter J WJ
Pfennig Andrea A
Pistis Giorgio G
Purcell Shaun M SM
Quiroz Jorge A JA
Qvist Per P
Regeer Eline J EJ
Reif Andreas A
Reinbold Céline S CS
Rice John P JP
Riley Brien P BP
Rivas Fabio F
Rivera Margarita M
Roussos Panos P
Ruderfer Douglas M DM
Ryu Euijung E
Sánchez-Mora Cristina C
Schatzberg Alan F AF
Scheftner William A WA
Schoevers Robert R
Schork Nicholas J NJ
Schulte Eva C EC
Shehktman Tatyana T
Shen Ling L
Shi Jianxin J
Shilling Paul D PD
Shyn Stanley I SI
Sigurdsson Engilbert E
Slaney Claire C
Smeland Olav B OB
Smit Johannes H JH
Smith Daniel J DJ
Sobell Janet L JL
Spijker Anne T AT
Steffens Michael M
Strauss John S JS
Streit Fabian F
Strohmaier Jana J
Szelinger Szabolcs S
Tansey Katherine E KE
Teismann Henning H
Teumer Alexander A
Thompson Robert C RC
Thompson Wesley W
Thomson Pippa A PA
Thorgeirsson Thorgeir E TE
Traylor Matthew M
Treutlein Jens J
Uitterlinden André G AG
Umbricht Daniel D
Vedder Helmut H
Viktorin Alexander A
Visscher Peter M PM
Wang Weiqing W
Watson Stanley J SJ
Webb Bradley T BT
Weickert Cynthia Shannon CS
Weickert Thomas W TW
Weinsheimer Shantel Marie SM
Wellmann Jürgen J
Willemsen Gonneke G
Witt Stephanie H SH
Wu Yang Y
Xi Hualin S HS
Xu Wei W
Yang Jian J
Young Allan H AH
Zandi Peter P
Zhang Peng P
Zhang Futao F
Zollner Sebastian S
Adolfsson Rolf R
Agartz Ingrid I
Alda Martin M
Arolt Volker V
Backlund Lena L
Baune Bernhard T BT
Bellivier Frank F
Berger Klaus K
Berrettini Wade H WH
Biernacka Joanna M JM
Blackwood Douglas H R DHR
Boehnke Michael M
Boomsma Dorret I DI
Corvin Aiden A
Craddock Nicholas N
Daly Mark J MJ
Dannlowski Udo U
Domenici Enrico E
Domschke Katharina K
Esko Tõnu T
Etain Bruno B
Frye Mark M
Fullerton Janice M JM
Gershon Elliot S ES
de Geus E J C EJC
Gill Michael M
Goes Fernando F
Grabe Hans J HJ
Grigoroiu-Serbanescu Maria M
Hamilton Steven P SP
Hauser Joanna J
Hayward Caroline C
Heath Andrew C AC
Hougaard David M DM
Hultman Christina M CM
Jones Ian I
Jones Lisa A LA
Kahn René S RS
Kendler Kenneth S KS
Kirov George G
Kloiber Stefan S
Landén Mikael M
Leboyer Marion M
Lewis Glyn G
Li Qingqin S QS
Lissowska Jolanta J
Lucae Susanne S
Madden Pamela A F PAF
Magnusson Patrik K PK
Martin Nicholas G NG
Mayoral Fermin F
McElroy Susan L SL
McIntosh Andrew M AM
McMahon Francis J FJ
Melle Ingrid I
Metspalu Andres A
Mitchell Philip B PB
Morken Gunnar G
Mors Ole O
Mortensen Preben Bo PB
Müller-Myhsok Bertram B
Myers Richard M RM
Neale Benjamin M BM
Nimgaonkar Vishwajit V
Nordentoft Merete M
Nöthen Markus M MM
O'Donovan Michael C MC
Oedegaard Ketil J KJ
Owen Michael J MJ
Paciga Sara A SA
Pato Carlos C
Pato Michele T MT
Pedersen Nancy L NL
Penninx Brenda W J H BWJH
Perlis Roy H RH
Porteous David J DJ
Posthuma Danielle D
Potash James B JB
Preisig Martin M
Ramos-Quiroga Josep Antoni JA
Ribasés Marta M
Rietschel Marcella M
Rouleau Guy A GA
Schaefer Catherine C
Schalling Martin M
Schofield Peter R PR
Schulze Thomas G TG
Serretti Alessandro A
Smoller Jordan W JW
Stefansson Hreinn H
Stefansson Kari K
Stordal Eystein E
Tiemeier Henning H
Turecki Gustavo G
Uher Rudolf R
Vaaler Arne E AE
Vieta Eduard E
Vincent John B JB
Völzke Henry H
Weissman Myrna M MM
Werge Thomas T
Andreassen Ole A OA
Børglum Anders D AD
Cichon Sven S
Edenberg Howard J HJ
Di Florio Arianna A
Kelsoe John J
Levinson Douglas F DF
Lewis Cathryn M CM
Nurnberger John I JI
Ophoff Roel A RA
Scott Laura J LJ
Sklar Pamela P
Sullivan Patrick F PF
Wray Naomi R NR
JOURNAL
VOLUME:
ISSUE:
TITLE: Biological psychiatry
ISOABBREVIATION: Biol. Psychiatry
YEAR: 2019
MONTH: Nov
DAY: 01
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1873-2402
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Biol Psychiatry
COUNTRY: United States
ISSNLINKING: 0006-3223
NLMUNIQUEID: 0213264
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Affective disorders
Bipolar disorder
Genetic correlation
Genome-wide association study
Major depressive disorder
Mood disorders
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's