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| PMID |
|
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| TITLE |
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| Changes in thyroid function across adolescence: a longitudinal study. |
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| ABSTRACT |
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| OBJECTIVE |
NlmCategory: OBJECTIVE |
| There are no large, longitudinal studies of thyroid function across adolescence. The aims of this study were to examine longitudinal trends in TSH, fT3 and fT4 and determine age-specific reference ranges. |
| METHODS |
NlmCategory: METHODS |
| There are no large, longitudinal studies of thyroid function across adolescence. The aims of this study were to examine longitudinal trends in TSH, fT3 and fT4 and determine age-specific reference ranges. Thyroid function was assessed in 3415 participants in the Brisbane Longitudinal Twin Study at age 12, 14 and 16, using the Abbott ARCHITECT immunoassay. Longitudinal analyses were adjusted for body mass index and puberty. |
| RESULTS |
NlmCategory: RESULTS |
| There are no large, longitudinal studies of thyroid function across adolescence. The aims of this study were to examine longitudinal trends in TSH, fT3 and fT4 and determine age-specific reference ranges. Thyroid function was assessed in 3415 participants in the Brisbane Longitudinal Twin Study at age 12, 14 and 16, using the Abbott ARCHITECT immunoassay. Longitudinal analyses were adjusted for body mass index and puberty. In girls, mean fT4 (± SE) increased between age 12 and 14 (by 0.30 ± 0.08 pmol/L, P <0.001), while remaining unchanged in boys; from age 14 to 16, fT4 increased in both girls (by 0.42 ± 0.07 pmol/L, P <0.001) and boys (0.64 ± 0.07 pmol/L, P <0.001). Free T3 increased slightly from 12 to 14 years in girls (by 0.07 ± 0.03 pmol/L; P = 0.042) with a more marked increase in boys (0.29 ± 0.03 pmol/L, P < 0.001) then decreased from age 14 to 16 in both sexes (girls, by 0.53 ± 0.02 pmol/L, P <0.001; boys, by 0.62 ± 0.03 pmol/L, P <0.001). From age 12 to 14, TSH showed no significant change in girls or boys, then increased from age 14 to 16 in both sexes (girls, by 4.9%, 95% CI 2.4 to 10.3%, P = 0.020; boys, by 7.2%, 95% CI 3.0 to 11.6%, P=0.001). Reference ranges differed substantially from adults, particularly for fT4 and fT3. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| There are no large, longitudinal studies of thyroid function across adolescence. The aims of this study were to examine longitudinal trends in TSH, fT3 and fT4 and determine age-specific reference ranges. Thyroid function was assessed in 3415 participants in the Brisbane Longitudinal Twin Study at age 12, 14 and 16, using the Abbott ARCHITECT immunoassay. Longitudinal analyses were adjusted for body mass index and puberty. In girls, mean fT4 (± SE) increased between age 12 and 14 (by 0.30 ± 0.08 pmol/L, P <0.001), while remaining unchanged in boys; from age 14 to 16, fT4 increased in both girls (by 0.42 ± 0.07 pmol/L, P <0.001) and boys (0.64 ± 0.07 pmol/L, P <0.001). Free T3 increased slightly from 12 to 14 years in girls (by 0.07 ± 0.03 pmol/L; P = 0.042) with a more marked increase in boys (0.29 ± 0.03 pmol/L, P < 0.001) then decreased from age 14 to 16 in both sexes (girls, by 0.53 ± 0.02 pmol/L, P <0.001; boys, by 0.62 ± 0.03 pmol/L, P <0.001). From age 12 to 14, TSH showed no significant change in girls or boys, then increased from age 14 to 16 in both sexes (girls, by 4.9%, 95% CI 2.4 to 10.3%, P = 0.020; boys, by 7.2%, 95% CI 3.0 to 11.6%, P=0.001). Reference ranges differed substantially from adults, particularly for fT4 and fT3. Thyroid function tests in adolescents display complex, sexually dimorphic patterns. Implementation of adolescence-specific reference ranges may be appropriate. |
| © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2019/10/16 |
| entrez |
2020/01/11 06:00 |
| pubmed |
2020/01/11 06:00 |
| medline |
2020/01/11 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Campbell PJ |
|
Campbell |
Purdey J |
PJ |
|
Department of Endocrinology & Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia. |
| Brown SJ |
|
Brown |
Suzanne J |
SJ |
|
Department of Endocrinology & Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia. |
| Kendrew P |
|
Kendrew |
Phillip |
P |
|
Pathwest Laboratory Medicine, Nedlands, WA, Australia. |
| Lewer M |
|
Lewer |
Michelle |
M |
|
Pathwest Laboratory Medicine, Nedlands, WA, Australia. |
| Lim EM |
|
Lim |
Ee Mun |
EM |
|
Pathwest Laboratory Medicine, Nedlands, WA, Australia. |
| Joseph J |
|
Joseph |
John |
J |
|
Pathwest Laboratory Medicine, Nedlands, WA, Australia. |
| Cross SM |
|
Cross |
Simone M |
SM |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Wilson SG |
|
Wilson |
Scott G |
SG |
|
Department of Twin Research & Genetic Epidemiology, King's College London, London, UK. |
| Walsh JP |
|
Walsh |
John P |
JP |
|
Medical School, University of Western Australia, Crawley, WA, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: The Journal of clinical endocrinology and metabolism |
| ISOABBREVIATION: J. Clin. Endocrinol. Metab. |
| YEAR: 2020 |
| MONTH: Jan |
| DAY: 10 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1945-7197 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: J Clin Endocrinol Metab |
| COUNTRY: United States |
| ISSNLINKING: 0021-972X |
| NLMUNIQUEID: 0375362 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Adolescents |
| Reference ranges |
| TSH |
| Thyroid hormones |
| fT3 |
| fT4 |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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