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| PMID |
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| TITLE |
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| Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. |
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| ABSTRACT |
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| Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2018/08/21 |
| accepted |
2019/07/24 |
| revised |
2019/07/17 |
| pubmed |
2019/11/13 06:00 |
| medline |
2021/05/15 06:00 |
| entrez |
2019/11/13 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Andlauer TFM |
|
Andlauer |
Till F M |
TFM |
|
Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany. |
| Guzman-Parra J |
|
Guzman-Parra |
Jose |
J |
|
Department of Mental Health, University Regional Hospital of Málaga, Institute of Biomedicine of Málaga (IBIMA), Málaga, Spain. |
| Streit F |
|
Streit |
Fabian |
F |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
| Strohmaier J |
|
Strohmaier |
Jana |
J |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
| González MJ |
|
González |
Maria José |
MJ |
|
Department of Mental Health, Hospital of Puerto Real, Cádiz, Spain. |
| Gil Flores S |
|
Gil Flores |
Susana |
S |
|
Department of Mental Health, University Hospital of Reina Sofia, Córdoba, Spain. |
| Cabaleiro Fabeiro FJ |
|
Cabaleiro Fabeiro |
Francisco J |
FJ |
|
Department of Mental Health, Hospital of Jaén, Jaén, Spain. |
| Del Río Noriega F |
|
Del Río Noriega |
Francisco |
F |
|
Department of Mental Health, Hospital of Jerez de la Frontera, Jerez de la Frontera, Spain. |
| Perez FP |
|
Perez |
Fermin Perez |
FP |
|
Department of Mental Health, Hospital of Puerto Real, Cádiz, Spain. |
| Haro González J |
|
Haro González |
Jesus |
J |
|
Department of Mental Health, Hospital Punta de Europa, Algeciras, Spain. |
| Orozco Diaz G |
|
Orozco Diaz |
Guillermo |
G |
|
Unidad de Gestión Clínica del Dispositivo de Cuidados Críticos y Urgencias del Distrito Sanitario Málaga-Coin-Guadalhorce, Málaga, Spain. |
| de Diego-Otero Y |
|
de Diego-Otero |
Yolanda |
Y |
|
Department of Mental Health, University Regional Hospital of Málaga, Institute of Biomedicine of Málaga (IBIMA), Málaga, Spain. |
| Moreno-Küstner B |
|
Moreno-Küstner |
Berta |
B |
|
Department of Personality, Assessment and Psychological Treatment, University of Malaga, Institute of Biomedicine of Málaga (IBIMA), Málaga, Spain. |
| Auburger G |
|
Auburger |
Georg |
G |
|
Department of Neurology, Goethe University Medical School, Frankfurt am Main, Germany. |
| Degenhardt F |
|
Degenhardt |
Franziska |
F |
|
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany. |
| Heilmann-Heimbach S |
|
Heilmann-Heimbach |
Stefanie |
S |
|
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany. |
| Herms S |
|
Herms |
Stefan |
S |
|
Department of Biomedicine, University of Basel, Basel, Switzerland. |
| Hoffmann P |
|
Hoffmann |
Per |
P |
|
Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany. |
| Frank J |
|
Frank |
Josef |
J |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
| Foo JC |
|
Foo |
Jerome C |
JC |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
| Treutlein J |
|
Treutlein |
Jens |
J |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
| Witt SH |
|
Witt |
Stephanie H |
SH |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
| Cichon S |
|
Cichon |
Sven |
S |
|
Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany. |
| Kogevinas M |
|
Kogevinas |
Manolis |
M |
|
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. |
|
Bipolar Disorder Working Group of the Psychiatric Genomics Consortium |
|
|
|
|
|
|
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium |
|
|
|
|
|
| Rivas F |
|
Rivas |
Fabio |
F |
|
Department of Mental Health, University Regional Hospital of Málaga, Institute of Biomedicine of Málaga (IBIMA), Málaga, Spain. |
| Mayoral F |
|
Mayoral |
Fermín |
F |
|
Department of Mental Health, University Regional Hospital of Málaga, Institute of Biomedicine of Málaga (IBIMA), Málaga, Spain. |
| Müller-Myhsok B |
|
Müller-Myhsok |
Bertram |
B |
|
Institute of Translational Medicine, University of Liverpool, Liverpool, UK. |
| Forstner AJ |
|
Forstner |
Andreas J |
AJ |
|
Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. |
| Nöthen MM |
|
Nöthen |
Markus M |
MM |
|
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany. |
| Rietschel M |
|
Rietschel |
Marcella |
M |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Marcella.Rietschel@zi-mannheim.de. |
|
| INVESTIGATORS |
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| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Stahl |
Eli A |
EA |
|
| Breen |
Gerome |
G |
|
| Forstner |
Andreas J |
AJ |
|
| McQuillin |
Andrew |
A |
|
| Ripke |
Stephan |
S |
|
| Trubetskoy |
Vassily |
V |
|
| Mattheisen |
Manuel |
M |
|
| Wang |
Yunpeng |
Y |
|
| Coleman |
Jonathan R I |
JRI |
|
| Gaspar |
Héléna A |
HA |
|
| de Leeuw |
Christiaan A |
CA |
|
| Steinberg |
Stacy |
S |
|
| Pavlides |
Jennifer M Whitehead |
JMW |
|
| Trzaskowski |
Maciej |
M |
|
| Pers |
Tune H |
TH |
|
| Holmans |
Peter A |
PA |
|
| Abbott |
Liam |
L |
|
| Agerbo |
Esben |
E |
|
| Akil |
Huda |
H |
|
| Albani |
Diego |
D |
|
| Alliey-Rodriguez |
Ney |
N |
|
| Als |
Thomas D |
TD |
|
| Anjorin |
Adebayo |
A |
|
| Antilla |
Verneri |
V |
|
| Awasthi |
Swapnil |
S |
|
| Badner |
Judith A |
JA |
|
| Bækvad-Hansen |
Marie |
M |
|
| Barchas |
Jack D |
JD |
|
| Bass |
Nicholas |
N |
|
| Bauer |
Michael |
M |
|
| Belliveau |
Richard |
R |
|
| Bergen |
Sarah E |
SE |
|
| Pedersen |
Carsten Bøcker |
CB |
|
| Bøen |
Erlend |
E |
|
| Boks |
Marco |
M |
|
| Boocock |
James |
J |
|
| Budde |
Monika |
M |
|
| Bunney |
William |
W |
|
| Burmeister |
Margit |
M |
|
| Bybjerg-Grauholm |
Jonas |
J |
|
| Byerley |
William |
W |
|
| Casas |
Miquel |
M |
|
| Cerrato |
Felecia |
F |
|
| Cervantes |
Pablo |
P |
|
| Chambert |
Kimberly |
K |
|
| Charney |
Alexander W |
AW |
|
| Chen |
Danfeng |
D |
|
| Churchhouse |
Claire |
C |
|
| Clarke |
Toni-Kim |
TK |
|
| Coryell |
William |
W |
|
| Craig |
David W |
DW |
|
| Cruceanu |
Cristiana |
C |
|
| Czerski |
Piotr M |
PM |
|
| Dale |
Anders M |
AM |
|
| de Jong |
Simone |
S |
|
| Degenhardt |
Franziska |
F |
|
| Del-Favero |
Jurgen |
J |
|
| DePaulo |
J Raymond |
JR |
|
| Djurovic |
Srdjan |
S |
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| Dobbyn |
Amanda L |
AL |
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| Dumont |
Ashley |
A |
|
| Elvsåshagen |
Torbjørn |
T |
|
| Escott-Price |
Valentina |
V |
|
| Fan |
Chun Chieh |
CC |
|
| Fischer |
Sascha B |
SB |
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| Flickinger |
Matthew |
M |
|
| Foroud |
Tatiana M |
TM |
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| Forty |
Liz |
L |
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| Frank |
Josef |
J |
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| Fraser |
Christine |
C |
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| Freimer |
Nelson B |
NB |
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| Frisén |
Louise |
L |
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| Gade |
Katrin |
K |
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| Gage |
Diane |
D |
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| Garnham |
Julie |
J |
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| Giambartolomei |
Claudia |
C |
|
| Pedersen |
Marianne Giørtz |
MG |
|
| Goldstein |
Jaqueline |
J |
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| Gordon |
Scott D |
SD |
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| Gordon-Smith |
Katherine |
K |
|
| Green |
Elaine K |
EK |
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| Green |
Melissa J |
MJ |
|
| Greenwood |
Tiffany A |
TA |
|
| Grove |
Jakob |
J |
|
| Guan |
Weihua |
W |
|
| Parra |
José Guzman |
JG |
|
| Hamshere |
Marian L |
ML |
|
| Hautzinger |
Martin |
M |
|
| Heilbronner |
Urs |
U |
|
| Herms |
Stefan |
S |
|
| Hipolito |
Maria |
M |
|
| Hoffmann |
Per |
P |
|
| Holland |
Dominic |
D |
|
| Huckins |
Laura |
L |
|
| Jamain |
Stéphane |
S |
|
| Johnson |
Jessica S |
JS |
|
| Juréus |
Anders |
A |
|
| Kandaswamy |
Radhika |
R |
|
| Karlsson |
Robert |
R |
|
| Kennedy |
James L |
JL |
|
| Kittel-Schneider |
Sarah |
S |
|
| Knowles |
James A |
JA |
|
| Kogevinas |
Manolis |
M |
|
| Koller |
Anna C |
AC |
|
| Kupka |
Ralph |
R |
|
| Lavebratt |
Catharina |
C |
|
| Lawrence |
Jacob |
J |
|
| Lawson |
William B |
WB |
|
| Leber |
Markus |
M |
|
| Lee |
Phil H |
PH |
|
| Levy |
Shawn E |
SE |
|
| Li |
Jun Z |
JZ |
|
| Liu |
Chunyu |
C |
|
| Lucae |
Susanne |
S |
|
| Maaser |
Anna |
A |
|
| MacIntyre |
Donald J |
DJ |
|
| Mahon |
Pamela B |
PB |
|
| Maier |
Wolfgang |
W |
|
| Martinsson |
Lina |
L |
|
| McCarroll |
Steve |
S |
|
| McGuffin |
Peter |
P |
|
| McInnis |
Melvin G |
MG |
|
| McKay |
James D |
JD |
|
| Medeiros |
Helena |
H |
|
| Medland |
Sarah E |
SE |
|
| Meng |
Fan |
F |
|
| Milani |
Lili |
L |
|
| Montgomery |
Grant W |
GW |
|
| Morris |
Derek W |
DW |
|
| Mühleisen |
Thomas W |
TW |
|
| Mullins |
Niamh |
N |
|
| Nguyen |
Hoang |
H |
|
| Nievergelt |
Caroline M |
CM |
|
| Adolfsson |
Annelie Nordin |
AN |
|
| Nwulia |
Evaristus A |
EA |
|
| O'Donovan |
Claire |
C |
|
| Loohuis |
Loes M Olde |
LMO |
|
| Ori |
Anil P S |
APS |
|
| Oruc |
Lilijana |
L |
|
| Ösby |
Urban |
U |
|
| Perlis |
Roy H |
RH |
|
| Perry |
Amy |
A |
|
| Pfennig |
Andrea |
A |
|
| Potash |
James B |
JB |
|
| Purcell |
Shaun M |
SM |
|
| Regeer |
Eline J |
EJ |
|
| Reif |
Andreas |
A |
|
| Reinbold |
Céline S |
CS |
|
| Rice |
John P |
JP |
|
| Richards |
Alexander L |
AL |
|
| Rivas |
Fabio |
F |
|
| Rivera |
Margarita |
M |
|
| Roussos |
Panos |
P |
|
| Ruderfer |
Douglas M |
DM |
|
| Ryu |
Euijung |
E |
|
| Sánchez-Mora |
Cristina |
C |
|
| Schatzberg |
Alan F |
AF |
|
| Scheftner |
William A |
WA |
|
| Schork |
Nicholas J |
NJ |
|
| Weickert |
Cynthia Shannon |
CS |
|
| Shehktman |
Tatyana |
T |
|
| Shilling |
Paul D |
PD |
|
| Sigurdsson |
Engilbert |
E |
|
| Slaney |
Claire |
C |
|
| Smeland |
Olav B |
OB |
|
| Sobell |
Janet L |
JL |
|
| Hansen |
Christine Søholm |
CS |
|
| Spijker |
Anne T |
AT |
|
| Clair |
David St |
DS |
|
| Steffens |
Michael |
M |
|
| Strauss |
John S |
JS |
|
| Streit |
Fabian |
F |
|
| Strohmaier |
Jana |
J |
|
| Szelinger |
Szabolcs |
S |
|
| Thompson |
Robert C |
RC |
|
| EThorgeirsson |
Thorgeir |
T |
|
| Treutlein |
Jens |
J |
|
| Vedde |
Helmut |
H |
|
| Wang |
Weiqing |
W |
|
| Watson |
Stanley J |
SJ |
|
| Weickert |
Thomas W |
TW |
|
| Witt |
Stephanie H |
SH |
|
| Xi |
Simon |
S |
|
| Xu |
Wei |
W |
|
| Young |
Allan H |
AH |
|
| Zandi |
Peter |
P |
|
| Zhang |
Peng |
P |
|
| Zollner |
Sebastian |
S |
|
| Adolfsson |
Rolf |
R |
|
| Agartz |
Ingrid |
I |
|
| Alda |
Martin |
M |
|
| Backlund |
Lena |
L |
|
| Baune |
Bernhard T |
BT |
|
| Bellivier |
Frank |
F |
|
| Berrettini |
Wade H |
WH |
|
| Biernacka |
Joanna M |
JM |
|
| Blackwood |
Douglas H R |
DHR |
|
| Boehnke |
Michael |
M |
|
| Børglum |
Anders D |
AD |
|
| Corvin |
Aiden |
A |
|
| Craddock |
Nicholas |
N |
|
| Daly |
Mark J |
MJ |
|
| Dannlowski |
Udo |
U |
|
| Esko |
Tõnu |
T |
|
| Etain |
Bruno |
B |
|
| Frye |
Mark |
M |
|
| Fullerton |
Janice M |
JM |
|
| Gershon |
Elliot S |
ES |
|
| Gill |
Michael |
M |
|
| Goes |
Fernando |
F |
|
| Grigoroiu-Serbanescu |
Maria |
M |
|
| Hauser |
Joanna |
J |
|
| Hougaard |
David M |
DM |
|
| Hultman |
Christina M |
CM |
|
| Jones |
Ian |
I |
|
| Jones |
Lisa A |
LA |
|
| Kahn |
René S |
RS |
|
| Kirov |
George |
G |
|
| Landén |
Mikael |
M |
|
| Leboyer |
Marion |
M |
|
| Lewis |
Cathryn M |
CM |
|
| Li |
Qingqin S |
QS |
|
| Lissowska |
Jolanta |
J |
|
| Martin |
Nicholas G |
NG |
|
| Mayoral |
Fermin |
F |
|
| McElroy |
Susan L |
SL |
|
| McIntosh |
Andrew M |
AM |
|
| McMahon |
Francis J |
FJ |
|
| Melle |
Ingrid |
I |
|
| Metspalu |
Andres |
A |
|
| Mitchell |
Philip B |
PB |
|
| Morken |
Gunnar |
G |
|
| Mors |
Ole |
O |
|
| Mortensen |
Preben Bo |
PB |
|
| Müller-Myhsok |
Bertram |
B |
|
| Myers |
Richard M |
RM |
|
| Neale |
Benjamin M |
BM |
|
| Nimgaonkar |
Vishwajit |
V |
|
| Nordentoft |
Merete |
M |
|
| Nöthen |
Markus M |
MM |
|
| O'Donovan |
Michael C |
MC |
|
| Oedegaard |
Ketil J |
KJ |
|
| Owen |
Michael J |
MJ |
|
| Paciga |
Sara A |
SA |
|
| Pato |
Carlos |
C |
|
| Pato |
Michele T |
MT |
|
| Posthuma |
Danielle |
D |
|
| Ramos-Quiroga |
Josep Antoni |
JA |
|
| Ribasés |
Marta |
M |
|
| Rietschel |
Marcella |
M |
|
| Rouleau |
Guy A |
GA |
|
| Schalling |
Martin |
M |
|
| Schofield |
Peter R |
PR |
|
| Schulze |
Thomas G |
TG |
|
| Serretti |
Alessandro |
A |
|
| Smoller |
Jordan W |
JW |
|
| Stefansson |
Hreinn |
H |
|
| Stefansson |
Kari |
K |
|
| Stordal |
Eystein |
E |
|
| Sullivan |
Patrick F |
PF |
|
| Turecki |
Gustavo |
G |
|
| Vaaler |
Arne E |
AE |
|
| Vieta |
Eduard |
E |
|
| Vincent |
John B |
JB |
|
| Werge |
Thomas |
T |
|
| Nurnberger |
John I |
JI |
|
| Wray |
Naomi R |
NR |
|
| Florio |
Arianna Di |
AD |
|
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Howard J |
HJ |
|
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Sven |
S |
|
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Roel A |
RA |
|
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Laura J |
LJ |
|
| Andreassen |
Ole A |
OA |
|
| Kelsoe |
John |
J |
|
| Sklar |
Pamela |
P |
|
| Wray |
Naomi R |
NR |
|
| Ripke |
Stephan |
S |
|
| Mattheisen |
Manuel |
M |
|
| Trzaskowski |
Maciej |
M |
|
| Byrne |
Enda M |
EM |
|
| Abdellaoui |
Abdel |
A |
|
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Mark J |
MJ |
|
| Agerbo |
Esben |
E |
|
| Air |
Tracy M |
TM |
|
| Andlauer |
Till F M |
TFM |
|
| Bacanu |
Silviu-Alin |
SA |
|
| Bækvad-Hansen |
Marie |
M |
|
| Beekman |
Aartjan T F |
ATF |
|
| Bigdeli |
Tim B |
TB |
|
| Binder |
Elisabeth B |
EB |
|
| Bryois |
Julien |
J |
|
| Buttenschøn |
Henriette N |
HN |
|
| Bybjerg-Grauholm |
Jonas |
J |
|
| Cai |
Na |
N |
|
| Castelao |
Enrique |
E |
|
| Christensen |
Jane Hvarregaard |
JH |
|
| Clarke |
Toni-Kim |
TK |
|
| Coleman |
Jonathan R I |
JRI |
|
| Colodro-Conde |
Lucía |
L |
|
| Couvy-Duchesne |
Baptiste |
B |
|
| Craddock |
Nick |
N |
|
| Crawford |
Gregory E |
GE |
|
| Davies |
Gail |
G |
|
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Ian J |
IJ |
|
| Degenhardt |
Franziska |
F |
|
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Eske M |
EM |
|
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Nese |
N |
|
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Conor V |
CV |
|
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Erin C |
EC |
|
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Thalia C |
TC |
|
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Valentina |
V |
|
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Farnush Farhadi Hassan |
FFH |
|
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Hilary K |
HK |
|
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Jerome C |
JC |
|
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Andreas J |
AJ |
|
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Josef |
J |
|
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Héléna A |
HA |
|
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Michael |
M |
|
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Fernando S |
FS |
|
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Scott D |
SD |
|
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Jakob |
J |
|
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Lynsey S |
LS |
|
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Christine Søholm |
CS |
|
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Thomas F |
TF |
|
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Stefan |
S |
|
| Hickie |
Ian B |
IB |
|
| Hoffmann |
Per |
P |
|
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Georg |
G |
|
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Carsten |
C |
|
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Jouke-Jan |
JJ |
|
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David M |
DM |
|
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David M |
DM |
|
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Marcus |
M |
|
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Rick |
R |
|
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Ian |
I |
|
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Lisa A |
LA |
|
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Eric |
E |
|
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James A |
JA |
|
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Isaac S |
IS |
|
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Julia |
J |
|
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Warren W |
WW |
|
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Zoltán |
Z |
|
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Yihan |
Y |
|
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Penelope A |
PA |
|
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Donald J |
DJ |
|
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Dean F |
DF |
|
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Robert M |
RM |
|
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Wolfgang |
W |
|
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Jonathan |
J |
|
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Hamdi |
H |
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Patrick |
P |
|
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Peter |
P |
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Sarah E |
SE |
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Divya |
D |
|
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Christel M |
CM |
|
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Evelin |
E |
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Yuri |
Y |
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Lili |
L |
|
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Francis M |
FM |
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Grant W |
GW |
|
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Sara |
S |
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Niamh |
N |
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Matthias |
M |
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Bernard |
B |
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Michel G |
MG |
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Dale R |
DR |
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Paul F |
PF |
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Hogni |
H |
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Michael J |
MJ |
|
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Jodie N |
JN |
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Carsten Bøcker |
CB |
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Marianne Giørtz |
MG |
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Roseann E |
RE |
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Erik |
E |
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Wouter J |
WJ |
|
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Giorgio |
G |
|
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Danielle |
D |
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Jorge A |
JA |
|
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Per |
P |
|
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John P |
JP |
|
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Brien P |
BP |
|
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Margarita |
M |
|
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Saira Saeed |
SS |
|
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Robert |
R |
|
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Eva C |
EC |
|
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Ling |
L |
|
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Jianxin |
J |
|
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Stanley I |
SI |
|
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Engilbert |
E |
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Grant C B |
GCB |
|
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Johannes H |
JH |
|
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Daniel J |
DJ |
|
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Hreinn |
H |
|
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Stacy |
S |
|
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Fabian |
F |
|
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Jana |
J |
|
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Katherine E |
KE |
|
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Henning |
H |
|
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Alexander |
A |
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Wesley |
W |
|
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Pippa A |
PA |
|
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Thorgeir E |
TE |
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Matthew |
M |
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Jens |
J |
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Vassily |
V |
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André G |
AG |
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Daniel |
D |
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Sandra |
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AM |
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Alexander |
A |
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Peter M |
PM |
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Yunpeng |
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Bradley T |
BT |
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SM |
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SH |
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HS |
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Jian |
J |
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Futao |
F |
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Volker |
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Bernhard T |
BT |
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Klaus |
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Dorret I |
DI |
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Sven |
S |
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Udo |
U |
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E J C |
EJC |
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J Raymond |
JR |
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Enrico |
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Brenda W J H |
BWJH |
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RH |
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David J |
DJ |
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James B |
JB |
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M |
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Marcella |
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TG |
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Jordan W |
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Kari |
K |
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Henning |
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Rudolf |
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Henry |
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Myrna M |
MM |
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Cathryn M |
CM |
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DF |
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Anders D |
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Patrick F |
PF |
|
|
| JOURNAL |
|
| VOLUME: 26 |
| ISSUE: 4 |
| TITLE: Molecular psychiatry |
| ISOABBREVIATION: Mol Psychiatry |
| YEAR: 2021 |
| MONTH: 04 |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1476-5578 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Mol Psychiatry |
| COUNTRY: England |
| ISSNLINKING: 1359-4184 |
| NLMUNIQUEID: 9607835 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| G1000708 |
Medical Research Council |
United Kingdom |
| G0200243 |
Medical Research Council |
United Kingdom |
| U01 MH109532 |
NIMH NIH HHS |
United States |
| U01 MH109528 |
NIMH NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Bipolar Disorder |
genetics |
| Case-Control Studies |
genetics |
| Depressive Disorder, Major |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Humans |
genetics |
| Schizophrenia |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
