Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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31673082
TITLE
Associations of autozygosity with a broad range of human phenotypes.
ABSTRACT
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
DATE PUBLISHED
2019 10 31
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/11/01
accepted 2019/08/30
entrez 2019/11/02 06:00
pubmed 2019/11/02 06:00
medline 2020/03/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Clark DW Clark David W DW Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
Okada Y Okada Yukinori Y Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Osaka, 565-0871, Japan.
Moore KHS Moore Kristjan H S KHS deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
Mason D Mason Dan D Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Trust, Bradford, BD96RJ, UK.
Pirastu N Pirastu Nicola N Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
Gandin I Gandin Ilaria I Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Mattsson H Mattsson Hannele H Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Barnes CLK Barnes Catriona L K CLK Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
Lin K Lin Kuang K Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Zhao JH Zhao Jing Hua JH Cardiovascular Epidemiology Unit, Department of Public health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Deelen P Deelen Patrick P Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, 9700 RB, The Netherlands.
Rohde R Rohde Rebecca R Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
Schurmann C Schurmann Claudia C The Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Guo X Guo Xiuqing X Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
Giulianini F Giulianini Franco F Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Zhang W Zhang Weihua W Department of Cardiology, Ealing Hospital, Middlesex, Middlesex, UB1 3HW, UK.
Medina-Gomez C Medina-Gomez Carolina C The Generation R Study Group, Erasmus University Medical Center, Rotterdam, 3015 CN, The Netherlands.
Karlsson R Karlsson Robert R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden.
Bao Y Bao Yanchun Y Institute for Social and Economic Research, University of Essex, Colchester, CO4 3SQ, UK.
Bartz TM Bartz Traci M TM Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, 98101, USA.
Baumbach C Baumbach Clemens C Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Biino G Biino Ginevra G Institute of Molecular Genetics, National Research Council of Italy, Pavia, 27100, Italy.
Bixley MJ Bixley Matthew J MJ Department of Biochemistry, University of Otago, Dunedin, 9054, New Zealand.
Brumat M Brumat Marco M Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Chai JF Chai Jin-Fang JF Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, 117549, Singapore.
Corre T Corre Tanguy T Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.
Cousminer DL Cousminer Diana L DL Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Dekker AM Dekker Annelot M AM Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
Eccles DA Eccles David A DA Malaghan Institute of Medical Research, Wellington, 6242, New Zealand.
van Eijk KR van Eijk Kristel R KR Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
Fuchsberger C Fuchsberger Christian C Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.
Gao H Gao He H MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK.
Germain M Germain Marine M ICAN Institute for Cardiometabolism and Nutrition, Paris, 75013, France.
Gordon SD Gordon Scott D SD QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
de Haan HG de Haan Hugoline G HG Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Harris SE Harris Sarah E SE Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Hofer E Hofer Edith E Institute of Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, 8036, Austria.
Huerta-Chagoya A Huerta-Chagoya Alicia A CONACyT, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, 03940, México.
Igartua C Igartua Catherine C Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.
Jansen IE Jansen Iris E IE Alzheimer Center Department of Neurology, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, 1081HV, The Netherlands.
Jia Y Jia Yucheng Y Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
Kacprowski T Kacprowski Tim T Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising-Weihenstephan, 85354, Germany.
Karlsson T Karlsson Torgny T Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75108, Uppsala, Sweden.
Kleber ME Kleber Marcus E ME Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
Li SA Li Shengchao Alfred SA Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research, Frederick, MD, USA.
Li-Gao R Li-Gao Ruifang R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Mahajan A Mahajan Anubha A Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Matsuda K Matsuda Koichi K Department of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Tokyo, 108-8639, Japan.
Meidtner K Meidtner Karina K German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
Meng W Meng Weihua W Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, UK.
Montasser ME Montasser May E ME Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, 21201, USA.
van der Most PJ van der Most Peter J PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
Munz M Munz Matthias M Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany.
Nutile T Nutile Teresa T Institute of Genetics and Biophysics A. Buzzati-Traverso - CNR, Naples, 80131, Italy.
Palviainen T Palviainen Teemu T Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
Prasad G Prasad Gauri G Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110020, India.
Prasad RB Prasad Rashmi B RB Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Skåne University Hospital, Malmö, 20502, Sweden.
Priyanka TDS Priyanka Tallapragada Divya Sri TDS Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, 500007, India.
Rizzi F Rizzi Federica F Department of Health Sciences, University of Milano, Milano, 20139, Italy.
Salvi E Salvi Erika E Neuroalgology Unit, IRCCS Foundation Carlo Besta Neurological Institute, Milano, 20133, Italy.
Sapkota BR Sapkota Bishwa R BR Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Shriner D Shriner Daniel D Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
Skotte L Skotte Line L Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DK-2300, Denmark.
Smart MC Smart Melissa C MC Institute for Social and Economic Research, University of Essex, Colchester, CO4 3SQ, UK.
Smith AV Smith Albert Vernon AV Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, 101, Iceland.
van der Spek A van der Spek Ashley A Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
Spracklen CN Spracklen Cassandra N CN Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.
Strawbridge RJ Strawbridge Rona J RJ Cardiovascular Medicine Unit, Department of Medicine Solna, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, 171 76, Sweden.
Tajuddin SM Tajuddin Salman M SM Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, Maryland, 21224, USA.
Trompet S Trompet Stella S Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, 2300RC, the Netherlands.
Turman C Turman Constance C Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Verweij N Verweij Niek N University of Groningen, University Medical Center Groningen, Department of Cardiology, Ther Netherlands, Groningen, 9713 GZ, the Netherlands.
Viberti C Viberti Clara C Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences, University of Turin, Italy, Turin, 10126, Italy.
Wang L Wang Lihua L Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, 63110-1093, USA.
Warren HR Warren Helen R HR Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Wootton RE Wootton Robyn E RE School of Psychological Science, University of Bristol, Bristol, BS8 1TU, UK.
Yanek LR Yanek Lisa R LR Department of Medicine, GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Yao J Yao Jie J Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
Yousri NA Yousri Noha A NA Computer and Systems Engineering, Alexandria University, Alexandria, Egypt.
Zhao W Zhao Wei W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Adeyemo AA Adeyemo Adebowale A AA Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
Afaq S Afaq Saima S Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Aguilar-Salinas CA Aguilar-Salinas Carlos Alberto CA Unidad de Investigacion de Enfermades Metabolicas, Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, N.L., 64710, México.
Akiyama M Akiyama Masato M Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, 812-8582, Japan.
Albert ML Albert Matthew L ML Department of Cancer Immunology, Genentech Inc, San Francisco, California, 94080, USA.
Allison MA Allison Matthew A MA Division of Preventive Medicine, Department of Family Medicine and Public Health, UC San Diego School of Medicine, La Jolla, California, 92093, USA.
Alver M Alver Maris M Estonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
Aung T Aung Tin T Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 119228, SG, Singapore.
Azizi F Azizi Fereidoun F Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19839-63113, Iran.
Bentley AR Bentley Amy R AR Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
Boeing H Boeing Heiner H Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Boerwinkle E Boerwinkle Eric E Health Science Center at Houston, UTHealth School of Public Health, University of Texas, Houston, TX, 77030, USA.
Borja JB Borja Judith B JB USC-Office of Population Studies Foundation, Inc., Department of Nutrition and Dietetics, Talamban, University of San Carlos, Cebu City, 6000, Cebu, Philippines.
de Borst GJ de Borst Gert J GJ Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX, Netherlands.
Bottinger EP Bottinger Erwin P EP Digital Health Center, Hasso Plattner Institute, Universität Potsdam, Potsdam, 14482, Germany.
Broer L Broer Linda L Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
Campbell H Campbell Harry H Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
Chanock S Chanock Stephen S Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Chee ML Chee Miao-Li ML Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, 169856, Singapore.
Chen G Chen Guanjie G Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
Chen YI Chen Yii-Der I YI Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
Chen Z Chen Zhengming Z Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Chiu YF Chiu Yen-Feng YF Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan, Taiwan.
Cocca M Cocca Massimiliano M Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, 34137, Italy.
Collins FS Collins Francis S FS National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA.
Concas MP Concas Maria Pina MP Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, 34137, Italy.
Corley J Corley Janie J Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Cugliari G Cugliari Giovanni G Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences, University of Turin, Italy, Turin, 10126, Italy.
van Dam RM van Dam Rob M RM Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, 02115, USA.
Damulina A Damulina Anna A Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
Daneshpour MS Daneshpour Maryam S MS Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19839-63113, Iran.
Day FR Day Felix R FR MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Delgado GE Delgado Graciela E GE Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
Dhana K Dhana Klodian K Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.
Doney ASF Doney Alexander S F ASF MEMO Research, Molecular and Clinical Medicine, University of Dundee, Dundee, DD19SY, UK.
Dörr M Dörr Marcus M DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.
Doumatey AP Doumatey Ayo P AP Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
Dzimiri N Dzimiri Nduna N Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, KSA, 12713, Saudi Arabia.
Ebenesersdóttir SS Ebenesersdóttir S Sunna SS Department of Anthropology, University of Iceland, Reykjavik, 101, Iceland.
Elliott J Elliott Joshua J Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Elliott P Elliott Paul P Health Data Research UK - London, London, England.
Ewert R Ewert Ralf R Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany.
Felix JF Felix Janine F JF Department of Pediatrics, Erasmus University Medical Center, Rotterdam, 3015CN, The Netherlands.
Fischer K Fischer Krista K Estonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
Freedman BI Freedman Barry I BI Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27101, US.
Girotto G Girotto Giorgia G Medical Genetics, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
Goel A Goel Anuj A Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Gögele M Gögele Martin M Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.
Goodarzi MO Goodarzi Mark O MO Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
Graff M Graff Mariaelisa M Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
Granot-Hershkovitz E Granot-Hershkovitz Einat E Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Grodstein F Grodstein Francine F Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Guarrera S Guarrera Simonetta S Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences, University of Turin, Italy, Turin, 10126, Italy.
Gudbjartsson DF Gudbjartsson Daniel F DF School of Engineering and Natural Sciences, University of Iceland, Reykjavik, 101, Iceland.
Guity K Guity Kamran K Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19839-63113, Iran.
Gunnarsson B Gunnarsson Bjarni B deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
Guo Y Guo Yu Y Chinese Academy of Medical Sciences, Beijing, 100730, China.
Hagenaars SP Hagenaars Saskia P SP Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
Haiman CA Haiman Christopher A CA Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, 90089, USA.
Halevy A Halevy Avner A Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Harris TB Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, Maryland, 21224, USA.
Hedayati M Hedayati Mehdi M Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19839-63113, Iran.
van Heel DA van Heel David A DA Blizard Institute, Queen Mary University of London, London, E1 2AT, UK.
Hirata M Hirata Makoto M Laboratory of Genome Technology, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.
Höfer I Höfer Imo I Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX, Netherlands.
Hsiung CA Hsiung Chao Agnes CA Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan, Taiwan.
Huang J Huang Jinyan J Shanghai Institute of Hematology, State Key Laboratory Of Medical Genomics, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 200025, China.
Hung YJ Hung Yi-Jen YJ School of Medicine, National Defense Medical Center, Taipei, Taiwan, Taiwan.
Ikram MA Ikram M Arfan MA Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
Jagadeesan A Jagadeesan Anuradha A Department of Anthropology, University of Iceland, Reykjavik, 101, Iceland.
Jousilahti P Jousilahti Pekka P Unit of Public Health Promotion, National Institute for Health and Welfare, Helsinki, Finland.
Kamatani Y Kamatani Yoichiro Y Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Kanai M Kanai Masahiro M Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA.
Kerrison ND Kerrison Nicola D ND MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Kessler T Kessler Thorsten T Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, 80636, Germany.
Khaw KT Khaw Kay-Tee KT Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 0SR, UK.
Khor CC Khor Chiea Chuen CC Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, 138672, Singapore.
de Kleijn DPV de Kleijn Dominique P V DPV Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX, Netherlands.
Koh WP Koh Woon-Puay WP Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore, 169857.
Kolcic I Kolcic Ivana I Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia.
Kraft P Kraft Peter P Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, 02115, USA.
Krämer BK Krämer Bernhard K BK Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
Kutalik Z Kutalik Zoltán Z Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.
Kuusisto J Kuusisto Johanna J Kuopio University Hospital, Kuopio, Finland.
Langenberg C Langenberg Claudia C MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Launer LJ Launer Lenore J LJ Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, Maryland, 21224, USA.
Lawlor DA Lawlor Deborah A DA Population Health Science, Bristol Medical School, Bristol, BS8 2BY, UK.
Lee IT Lee I-Te IT School of Medicine, Chung Shan Medical University, Taichung, Taiwan, Taichung City, 402, Taiwan.
Lee WJ Lee Wen-Jane WJ Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Taiwan.
Lerch MM Lerch Markus M MM Department of Internal Medicine A, University Medicine Greifswald, Greifswald, 17475, Germany.
Li L Li Liming L Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing, 100191, China.
Liu J Liu Jianjun J Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, 138672, Singapore.
Loh M Loh Marie M Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 117596, Singapore.
London SJ London Stephanie J SJ National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC, 27709, USA.
Loomis S Loomis Stephanie S Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Lu Y Lu Yingchang Y The Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Luan J Luan Jian'an J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Mägi R Mägi Reedik R Estonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
Manichaikul AW Manichaikul Ani W AW Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Manunta P Manunta Paolo P Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Università Vita Salute San Raffaele, Milano, 20132, Italy.
Másson G Másson Gísli G deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
Matoba N Matoba Nana N Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Mei XW Mei Xue W XW Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Meisinger C Meisinger Christa C Helmholtz Zentrum München, Independent Research Group Clinical Epidemiology, Neuherberg, 85764, Germany.
Meitinger T Meitinger Thomas T DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, 80802, Germany.
Mezzavilla M Mezzavilla Massimo M Medical Genetics, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
Milani L Milani Lili L Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.
Millwood IY Millwood Iona Y IY Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Momozawa Y Momozawa Yukihide Y Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Moore A Moore Amy A Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Morange PE Morange Pierre-Emmanuel PE INSERM UMR_S 1263, Center for CardioVascular and Nutrition research (C2VN), Aix-Marseille University, Marseille, France.
Moreno-Macías H Moreno-Macías Hortensia H Departamento de Economía, Universidad Autónoma Metropolitana, Mexico, 09340, México.
Mori TA Mori Trevor A TA Medical School, The University of Western Australia, Perth, Western Australia/Australia, 6009, Australia.
Morrison AC Morrison Alanna C AC The University of Texas Health Science Center at Houston, School of Public Health, Department of Epidemiology, Human Genetics and Environmental Sciences, Houston, Texas, 77030, USA.
Muka T Muka Taulant T Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Murakami Y Murakami Yoshinori Y Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.
Murray AD Murray Alison D AD The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
de Mutsert R de Mutsert Renée R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Mychaleckyj JC Mychaleckyj Josyf C JC Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Nalls MA Nalls Mike A MA Data Tecnica International LLC, Glen Echo, MD, 20812, USA.
Nauck M Nauck Matthias M Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.
Neville MJ Neville Matt J MJ Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
Ong KK Ong Ken K KK Department of Paediatrics, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Orozco L Orozco Lorena L Instituto Nacional de Medicina Genómica, Mexico, 14610, México.
Padmanabhan S Padmanabhan Sandosh S Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Pálsson G Pálsson Gunnar G deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
Pankow JS Pankow James S JS Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA.
Pattaro C Pattaro Cristian C Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.
Pattie A Pattie Alison A Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Polasek O Polasek Ozren O Gen-info Ltd, Zagreb, Croatia, Zagreb, Select a Province, 10000, Croatia.
Poulter N Poulter Neil N Imperial Clinical Trials Unit, Imperial College London, London, London, W12 7TA, UK.
Pramstaller PP Pramstaller Peter P PP Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.
Quintana-Murci L Quintana-Murci Lluis L Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris, 75015, France.
Räikkönen K Räikkönen Katri K Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, University of Helsinki, Helsinki, 00014, Finland.
Ralhan S Ralhan Sarju S Hero Heart Institute and Dyanand Medical College and Hospital, Ludhiana, Punjab, India.
Rao DC Rao Dabeeru C DC Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
van Rheenen W van Rheenen Wouter W Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
Rich SS Rich Stephen S SS Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Ridker PM Ridker Paul M PM Harvard Medical School, Boston, MA, 02115, USA.
Rietveld CA Rietveld Cornelius A CA Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus University Rotterdam, Rotterdam, 3062 PA, The Netherlands.
Robino A Robino Antonietta A Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, 34137, Italy.
van Rooij FJA van Rooij Frank J A FJA Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
Ruggiero D Ruggiero Daniela D IRCCS Neuromed, Pozzilli (IS), 86077, Italy.
Saba Y Saba Yasaman Y Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Molecular Biology and Biochemistry, Medical University of Graz, 8010, Graz, Austria.
Sabanayagam C Sabanayagam Charumathi C Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 119228, SG, Singapore.
Sabater-Lleal M Sabater-Lleal Maria M Unit of Genomics of Complex Diseases, Institut de Recerca Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain.
Sala CF Sala Cinzia Felicita CF San Raffaele Research Institute, Milano, Italy.
Salomaa V Salomaa Veikko V Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Sandow K Sandow Kevin K Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
Schmidt H Schmidt Helena H Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Molecular Biology and Biochemistry, Medical University of Graz, 8010, Graz, Austria.
Scott LJ Scott Laura J LJ Department of Biostatistics, and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Scott WR Scott William R WR Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Sedaghati-Khayat B Sedaghati-Khayat Bahareh B Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19839-63113, Iran.
Sennblad B Sennblad Bengt B Dept of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, SE-752 37, Uppsala, Sweden.
van Setten J van Setten Jessica J Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3485 CX, Netherlands.
Sever PJ Sever Peter J PJ International Centre for Circulatory Health, Imperial College London, London, W2 1PG, UK.
Sheu WH Sheu Wayne H-H WH Institute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan, Taiwan.
Shi Y Shi Yuan Y Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, 169856, Singapore.
Shrestha S Shrestha Smeeta S School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, Karnataka, 560078, India.
Shukla SR Shukla Sharvari Rahul SR Symbiosis Statistical Institute, Symbiosis International University, Pune, Maharashtra, 411007, India.
Sigurdsson JK Sigurdsson Jon K JK deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
Sikka TT Sikka Timo Tonis TT Estonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
Singh JR Singh Jai Rup JR Panjab University, Chandigarh, India.
Smith BH Smith Blair H BH Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
Stančáková A Stančáková Alena A Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Stanton A Stanton Alice A RCSI Molecular & Cellular Therapeutics (MCT), Royal College of Surgeons in Ireland, RCSI Education & Research Centre, Beaumont Hospital, Dublin 9, Ireland.
Starr JM Starr John M JM Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, Scotland.
Stefansdottir L Stefansdottir Lilja L deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
Straker L Straker Leon L School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Perth, Western Australia/Australia, 6102, Australia.
Sulem P Sulem Patrick P deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
Sveinbjornsson G Sveinbjornsson Gardar G deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
Swertz MA Swertz Morris A MA Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, 9700 RB, The Netherlands.
Taylor AM Taylor Adele M AM Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Taylor KD Taylor Kent D KD Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
Terzikhan N Terzikhan Natalie N Department of Respiratory Medicine, Ghent University Hospital, Ghent, 9000, Belgium.
Tham YC Tham Yih-Chung YC Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore, 169857, Singapore.
Thorleifsson G Thorleifsson Gudmar G deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
Thorsteinsdottir U Thorsteinsdottir Unnur U Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, 101, Iceland.
Tillander A Tillander Annika A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden.
Tracy RP Tracy Russell P RP Department of Pathology, University of Vermont, Colchester, VT, 05446, USA.
Tusié-Luna T Tusié-Luna Teresa T Unidad De Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, 14080, México.
Tzoulaki I Tzoulaki Ioanna I Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece.
Vaccargiu S Vaccargiu Simona S Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy, Rome, Italy.
Vangipurapu J Vangipurapu Jagadish J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Veldink JH Veldink Jan H JH Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
Vitart V Vitart Veronique V MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, Scotland.
Völker U Völker Uwe U DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.
Vuoksimaa E Vuoksimaa Eero E Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.
Wakil SM Wakil Salma M SM Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, KSA, 12713, Saudi Arabia.
Waldenberger M Waldenberger Melanie M Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Wander GS Wander Gurpreet S GS Department of Cardiology, Hero DMC Heart Institute, Dayanand Medical College & Hospital, Ludhiana, Punjab, 141001, India.
Wang YX Wang Ya Xing YX Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China, 100005, China.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Wild S Wild Sarah S Centre for Population Health Sciences, Usher Institute of Population Health and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
Yajnik CS Yajnik Chittaranjan S CS Diabetes Unit, K.E.M. Hospital Research Centre, Pune, MAH, 411011, India.
Yuan JM Yuan Jian-Min JM Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Zeng L Zeng Lingyao L Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, 80636, Germany.
Zhang L Zhang Liang L Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, 169856, Singapore.
Zhou J Zhou Jie J Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
Amin N Amin Najaf N Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
Asselbergs FW Asselbergs Folkert W FW Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, UK.
Bakker SJL Bakker Stephan J L SJL Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, 9713GZ, The Netherlands.
Becker DM Becker Diane M DM Department of Medicine, GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Lehne B Lehne Benjamin B Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Bennett DA Bennett David A DA Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, 60612, USA.
van den Berg LH van den Berg Leonard H LH Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
Berndt SI Berndt Sonja I SI Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Bharadwaj D Bharadwaj Dwaipayan D Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.
Bielak LF Bielak Lawrence F LF Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Bochud M Bochud Murielle M Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Boehnke M Boehnke Mike M Department of Biostatistics, and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Bouchard C Bouchard Claude C Pennington Biomedical Research Center, Baton Rouge, Louisiane, 70808, USA.
Bradfield JP Bradfield Jonathan P JP Quantinuum Research LLC, San Diego, CA, 92101, USA.
Brody JA Brody Jennifer A JA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.
Campbell A Campbell Archie A Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Carmi S Carmi Shai S Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Caulfield MJ Caulfield Mark J MJ Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Cesarini D Cesarini David D Research Institute for Industrial Economics (IFN), Stockholm, 102 15, Sweden.
Chambers JC Chambers John C JC Imperial College Healthcare NHS Trust, London, London, W12 0HS, UK.
Chandak GR Chandak Giriraj Ratan GR Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, 500007, India.
Cheng CY Cheng Ching-Yu CY Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 119228, SG, Singapore.
Ciullo M Ciullo Marina M IRCCS Neuromed, Pozzilli (IS), 86077, Italy.
Cornelis M Cornelis Marilyn M Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Cusi D Cusi Daniele D Bio4Dreams Scientific Unit, Bio4Dreams SRL, Bio4Dreams - business nursery for life sciences, Milano, 20121, Italy.
Smith GD Smith George Davey GD Population Health Science, Bristol Medical School, Bristol, BS8 2BY, UK.
Deary IJ Deary Ian J IJ Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Dorajoo R Dorajoo Rajkumar R Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, 138672, Singapore.
van Duijn CM van Duijn Cornelia M CM Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
Ellinghaus D Ellinghaus David D Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, 24105, Kiel, Germany.
Erdmann J Erdmann Jeanette J Institute for Cardiogenetics, University of Lübeck, Lübeck, 23562, Germany.
Eriksson JG Eriksson Johan G JG Vasa Central Hospital, Vaasa, Finland.
Evangelou E Evangelou Evangelos E Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece.
Evans MK Evans Michele K MK Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, Maryland, 21224, USA.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48014, USA.
Feenstra B Feenstra Bjarke B Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DK-2300, Denmark.
Feitosa M Feitosa Mary M Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, 63110-1093, USA.
Foisy S Foisy Sylvain S Montreal Heart Institute, Montreal, QC, Canada.
Franke A Franke Andre A Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, 24105, Kiel, Germany.
Friedlander Y Friedlander Yechiel Y Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Gasparini P Gasparini Paolo P Medical Genetics, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
Gieger C Gieger Christian C German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
Gonzalez C Gonzalez Clicerio C Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, 01120, México.
Goyette P Goyette Philippe P Montreal Heart Institute, Montreal, QC, Canada.
Grant SFA Grant Struan F A SFA Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Griffiths LR Griffiths Lyn R LR Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, 4059, Australia.
Groop L Groop Leif L Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Skåne University Hospital, Malmö, 20502, Sweden.
Gudnason V Gudnason Vilmundur V Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, 101, Iceland.
Gyllensten U Gyllensten Ulf U Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75108, Uppsala, Sweden.
Hakonarson H Hakonarson Hakon H Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Hamsten A Hamsten Anders A Cardiovascular Medicine Unit, Department of Medicine Solna, Centre for Molecular Medicine, Stockholm, 171 76, Sweden.
van der Harst P van der Harst Pim P University of Groningen, University Medical Center Groningen, Department of Cardiology, Ther Netherlands, Groningen, 9713 GZ, the Netherlands.
Heng CK Heng Chew-Kiat CK Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Hicks AA Hicks Andrew A AA Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.
Hochner H Hochner Hagit H Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Huikuri H Huikuri Heikki H Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, 90014, Finland.
Hunt SC Hunt Steven C SC Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, 84108, USA.
Jaddoe VWV Jaddoe Vincent W V VWV Department of Pediatrics, Erasmus University Medical Center, Rotterdam, 3015CN, The Netherlands.
De Jager PL De Jager Philip L PL Cell Circuits Program, Broad Institute, Cambridge, MA, 02142, USA.
Johannesson M Johannesson Magnus M Department of Economics, Stockholm School of Economics, Stockholm, SE-113 83, Sweden.
Johansson Å Johansson Åsa Å Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75108, Uppsala, Sweden.
Jonas JB Jonas Jost B JB Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, 698167, Germany.
Jukema JW Jukema J Wouter JW Department of Cardiology, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands.
Junttila J Junttila Juhani J Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, 90014, Finland.
Kaprio J Kaprio Jaakko J Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland.
Kardia SLR Kardia Sharon L R SLR Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Karpe F Karpe Fredrik F Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Kumari M Kumari Meena M Institute for Social and Economic Research, University of Essex, Colchester, CO4 3SQ, UK.
Laakso M Laakso Markku M Kuopio University Hospital, Kuopio, Finland.
van der Laan SW van der Laan Sander W SW Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, University of Utrecht, Utrecht, 3584 CX, Netherlands.
Lahti J Lahti Jari J Helsinki Collegium for Advanced Studies, University of Helsinki, University of Helsinki, Helsinki, 00014, Finland.
Laudes M Laudes Matthias M University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Kiel, 24105, Germany.
Lea RA Lea Rodney A RA Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, 4059, Australia.
Lieb W Lieb Wolfgang W Institute of Epidemiology and PopGen Biobank, University of Kiel, Kiel, Schleswig Holstein, 24105, Germany.
Lumley T Lumley Thomas T Department of Statistics, University of Auckland, Auckland, New Zealand.
Martin NG Martin Nicholas G NG QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
März W März Winfried W Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.
Matullo G Matullo Giuseppe G Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences, University of Turin, Italy, Turin, 10126, Italy.
McCarthy MI McCarthy Mark I MI Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Medland SE Medland Sarah E SE QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Merriman TR Merriman Tony R TR Department of Biochemistry, University of Otago, Dunedin, 9054, New Zealand.
Metspalu A Metspalu Andres A Estonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
Meyer BF Meyer Brian F BF Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia.
Mohlke KL Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Mook-Kanamori D Mook-Kanamori Dennis D Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Munroe PB Munroe Patricia B PB Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
North KE North Kari E KE Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
Nyholt DR Nyholt Dale R DR School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, 4059, Australia.
O'connell JR O'connell Jeffery R JR Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, 21201, USA.
Ober C Ober Carole C Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.
Oldehinkel AJ Oldehinkel Albertine J AJ Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
Palmas W Palmas Walter W Department of Medicine, Columbia University Medical Center, New York, New York, USA.
Palmer C Palmer Colin C Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, The School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.
Pasterkamp GG Pasterkamp Gerard G GG Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX, Netherlands.
Patin E Patin Etienne E Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris, 75015, France.
Pennell CE Pennell Craig E CE Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia/Australia, 6009, Australia.
Perusse L Perusse Louis L Institute of Nutrition and Functional Foods, Laval University, Quebec, QC, G1V 0A6, Canada.
Peyser PA Peyser Patricia A PA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Pirastu M Pirastu Mario M Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy, Sassari, 07100, Italy.
Polderman TJC Polderman Tinca J C TJC Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, 1081 HV, The Netherlands.
Porteous DJ Porteous David J DJ Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Posthuma D Posthuma Danielle D Department of Clinical Genetics, Amsterdam Neuroscience, VU Medical Centre, Amsterdam, 1081HV, The Netherlands.
Psaty BM Psaty Bruce M BM Kaiser Permanente Washington Health Research Institute, Seattle, WA, 98101, USA.
Rioux JD Rioux John D JD Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Rivadeneira F Rivadeneira Fernando F The Generation R Study Group, Erasmus University Medical Center, Rotterdam, 3015 CN, The Netherlands.
Rotimi C Rotimi Charles C Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
Rotter JI Rotter Jerome I JI Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
Rudan I Rudan Igor I Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
Den Ruijter HM Den Ruijter Hester M HM Laboratory of Experimental Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX, Netherlands.
Sanghera DK Sanghera Dharambir K DK Oklahoma Center for Neuroscience, Oklahoma City, OK, 73104, USA.
Sattar N Sattar Naveed N Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Schmidt R Schmidt Reinhold R Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
Schulze MB Schulze Matthias B MB Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany.
Schunkert H Schunkert Heribert H Deutsches Zentrum für Herz- und Kreislauferkrankungen (DZHK), Munich Heart Alliance, Munich, 80636, Germany.
Scott RA Scott Robert A RA MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Shuldiner AR Shuldiner Alan R AR Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591-6607, USA.
Sim X Sim Xueling X Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, 117549, Singapore.
Small N Small Neil N Faculty of Health Studies, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK.
Smith JA Smith Jennifer A JA Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48014, USA.
Sotoodehnia N Sotoodehnia Nona N Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, 98101, USA.
Tai ES Tai E-Shyong ES Duke-NUS Medical School, National University of Singapore, Singapore, Singapore, 169857, SG, Singapore.
Teumer A Teumer Alexander A Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.
Timpson NJ Timpson Nicholas J NJ Avon Longitudinal Study of Parents and Children (ALSPAC), University of Bristol, Bristol, BS8 2PR, UK.
Toniolo D Toniolo Daniela D San Raffaele Research Institute, Milano, Italy.
Tregouet DA Tregouet David-Alexandre DA INSERM UMR_S 1166, Sorbonne Universités, Paris, 75013, France.
Tuomi T Tuomi Tiinamaija T Research Program of Diabetes and Endocrinology, University of Helsinki, Helsinki, Finland.
Vollenweider P Vollenweider Peter P Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, 1011, Switzerland.
Wang CA Wang Carol A CA Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia/Australia, 6009, Australia.
Weir DR Weir David R DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48014, USA.
Whitfield JB Whitfield John B JB QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Wijmenga C Wijmenga Cisca C Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, 9700 RB, The Netherlands.
Wong TY Wong Tien-Yin TY Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore, 169857, Singapore.
Wright J Wright John J Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Trust, Bradford, BD96RJ, UK.
Yang J Yang Jingyun J Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, 60612, USA.
Yu L Yu Lei L Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, 60612, USA.
Zemel BS Zemel Babette S BS Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, 19146, USA.
Zonderman AB Zonderman Alan B AB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, Maryland, 21224, USA.
Perola M Perola Markus M Unit of Genomics and Biomarkers, National Institute for Health and Welfare, Helsinki, 00271, Finland.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden.
Uitterlinden AG Uitterlinden André G AG The Generation R Study Group, Erasmus University Medical Center, Rotterdam, 3015 CN, The Netherlands.
Kooner JS Kooner Jaspal S JS National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, MA, 02115, USA.
Loos RJF Loos Ruth J F RJF The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Franceschini N Franceschini Nora N Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
Franke L Franke Lude L Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, 9700 RB, The Netherlands.
Haley CS Haley Chris S CS Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, Scotland.
Hayward C Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, Scotland.
Walters RG Walters Robin G RG Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Perry JRB Perry John R B JRB MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Esko T Esko Tōnu T Program in Medical and Population Genetics, Broad Institute, Broad Institute, Cambridge, MASSACHUSETTS, 02142, USA.
Helgason A Helgason Agnar A Department of Anthropology, University of Iceland, Reykjavik, 101, Iceland.
Stefansson K Stefansson Kari K Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, 101, Iceland.
Joshi PK Joshi Peter K PK Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
Kubo M Kubo Michiaki M Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Wilson JF Wilson James F JF MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, Scotland. jim.wilson@ed.ac.uk.
INVESTIGATORS
JOURNAL
VOLUME: 10
ISSUE: 1
TITLE: Nature communications
ISOABBREVIATION: Nat Commun
YEAR: 2019
MONTH: 10
DAY: 31
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2041-1723
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Commun
COUNTRY: England
ISSNLINKING: 2041-1723
NLMUNIQUEID: 101528555
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
212946/Z/18/Z Wellcome Trust United Kingdom
MR/N003284/1 Medical Research Council United Kingdom
MR/M009203/1 Medical Research Council United Kingdom
G0401527 Medical Research Council United Kingdom
MC_UU_00017/1 Medical Research Council United Kingdom
MR/R023484/1 Medical Research Council United Kingdom
T32 DK091317 NIDDK NIH HHS United States
R01 AG015819 NIA NIH HHS United States
R01 DK093757 NIDDK NIH HHS United States
MC_UU_00007/10 Medical Research Council United Kingdom
MC_U137686851 Medical Research Council United Kingdom
G9521010 Medical Research Council United Kingdom
MR/K002414/1 Medical Research Council United Kingdom
R01 HL120393 NHLBI NIH HHS United States
MC_QA137853 Medical Research Council United Kingdom
U01 HL130114 NHLBI NIH HHS United States
U01 HL120393 NHLBI NIH HHS United States
MC_UU_00011/7 Medical Research Council United Kingdom
R01 DK072193 NIDDK NIH HHS United States
MR/N024397/1 Medical Research Council United Kingdom
CS/16/4/32482 British Heart Foundation United Kingdom
MC_UU_12026/2 Medical Research Council United Kingdom
MC_UP_1605/7 Medical Research Council United Kingdom
MC_PC_14089 Medical Research Council United Kingdom
MC_UU_00011/1 Medical Research Council United Kingdom
R01 AG017917 NIA NIH HHS United States
MC_UU_12015/1 Medical Research Council United Kingdom
R01 HL119443 NHLBI NIH HHS United States
R01 DK062370 NIDDK NIH HHS United States
R01 HL105756 NHLBI NIH HHS United States
MC_UU_12015/2 Medical Research Council United Kingdom
MC_PC_14135 Medical Research Council United Kingdom
P30 AG010161 NIA NIH HHS United States
14136 Cancer Research UK United Kingdom
MC_PC_U127592696 Medical Research Council United Kingdom
MC_EX_MR/M009203/1 Medical Research Council United Kingdom
MC_UU_00011/6 Medical Research Council United Kingdom
U01 DK062370 NIDDK NIH HHS United States
K99 HD099330 NICHD NIH HHS United States
MC_PC_17228 Medical Research Council United Kingdom
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
U01 CA182913 NCI NIH HHS United States
FS/12/82/29736 British Heart Foundation United Kingdom
MC_PC_13049 Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Alleles
Body Size genetics
Cognition genetics
Consanguinity genetics
Fertility genetics
Haplotypes genetics
Health Status genetics
Homozygote genetics
Humans genetics
Inbreeding Depression genetics
Risk-Taking genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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