Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
31636452
TITLE
Genetic architecture of subcortical brain structures in 38,851 individuals.
ABSTRACT
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
DATE PUBLISHED
2019 11
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/09/26
accepted 2019/09/05
pubmed 2019/10/23 06:00
medline 2020/01/23 06:00
entrez 2019/10/23 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Satizabal CL Satizabal Claudia L CL Department of Neurology, Boston University School of Medicine, Boston, MA, USA. satizabal@uthscsa.edu.
Adams HHH Adams Hieab H H HHH Department of Clinical Genetics, Erasmus MC, Rotterdam, the Netherlands.
Hibar DP Hibar Derrek P DP Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
White CC White Charles C CC Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Knol MJ Knol Maria J MJ Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Stein JL Stein Jason L JL UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, USA.
Scholz M Scholz Markus M LIFE: The Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Sargurupremraj M Sargurupremraj Muralidharan M University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, Bordeaux, France.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Roshchupkin GV Roshchupkin Gennady V GV Department of Medical Informatics, Erasmus MC, Rotterdam, the Netherlands.
Smith AV Smith Albert V AV Icelandic Heart Association, Kopavogur, Iceland.
Bis JC Bis Joshua C JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Jian X Jian Xueqiu X The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Luciano M Luciano Michelle M Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Hofer E Hofer Edith E Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
Teumer A Teumer Alexander A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
van der Lee SJ van der Lee Sven J SJ Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Yang J Yang Jingyun J Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Yanek LR Yanek Lisa R LR GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lee TV Lee Tom V TV Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
Li S Li Shuo S Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Hu Y Hu Yanhui Y Department of Genetics, Harvard Medical School, Boston, MA, USA.
Koh JY Koh Jia Yu JY Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Eicher JD Eicher John D JD Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Framingham, MA, USA.
Desrivières S Desrivières Sylvane S MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Arias-Vasquez A Arias-Vasquez Alejandro A Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Chauhan G Chauhan Ganesh G Centre for Brain Research, Indian Institute of Science, Bangalore, India.
Athanasiu L Athanasiu Lavinia L CoE NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Rentería ME Rentería Miguel E ME Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Kim S Kim Sungeun S Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Hoehn D Hoehn David D Max Planck Institute of Psychiatry, Munich, Germany.
Armstrong NJ Armstrong Nicola J NJ Mathematics and Statistics, Murdoch University, Perth, Western Australia, Australia.
Chen Q Chen Qiang Q Lieber Institute for Brain Development, Baltimore, MD, USA.
Holmes AJ Holmes Avram J AJ Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
den Braber A den Braber Anouk A Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, VU Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Kloszewska I Kloszewska Iwona I Medical University of Lodz, Lodz, Poland.
Andersson M Andersson Micael M Umeå Centre for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden.
Espeseth T Espeseth Thomas T Department of Psychology, University of Oslo, Oslo, Norway.
Grimm O Grimm Oliver O Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.
Abramovic L Abramovic Lucija L Department of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Alhusaini S Alhusaini Saud S Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
Milaneschi Y Milaneschi Yuri Y Department of Psychiatry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands.
Papmeyer M Papmeyer Martina M Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.
Axelsson T Axelsson Tomas T Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Ehrlich S Ehrlich Stefan S Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Roiz-Santiañez R Roiz-Santiañez Roberto R Centro Investigación Biomédica en Red Salud Mental, Santander, Spain.
Kraemer B Kraemer Bernd B Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Håberg AK Håberg Asta K AK Department of Radiology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
Jones HJ Jones Hannah J HJ NIHR Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK.
Pike GB Pike G Bruce GB Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Stein DJ Stein Dan J DJ South African Medical Research Council Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa.
Stevens A Stevens Allison A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Bralten J Bralten Janita J Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Vernooij MW Vernooij Meike W MW Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
Harris TB Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Filippi I Filippi Irina I INSERM, Research Unit 1000 'Neuroimaging and Psychiatry', Paris Saclay University and Paris Descartes University-DIGITEO Labs, Gif sur Yvette, France.
Witte AV Witte A Veronica AV Faculty of Medicine, CRC 1052 'Obesity Mechanisms', University of Leipzig, Leipzig, Germany.
Guadalupe T Guadalupe Tulio T Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
Wittfeld K Wittfeld Katharina K German Center for Neurodegenerative Diseases, Greifswald, Germany.
Mosley TH Mosley Thomas H TH Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Becker JT Becker James T JT Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Doan NT Doan Nhat Trung NT CoE NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Hagenaars SP Hagenaars Saskia P SP Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Saba Y Saba Yasaman Y Research Unit-Genetic Epidemiology, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Cuellar-Partida G Cuellar-Partida Gabriel G QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Amin N Amin Najaf N Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Hilal S Hilal Saima S Memory Aging and Cognition Center, National University Health System, Singapore, Singapore.
Nho K Nho Kwangsik K Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Mirza-Schreiber N Mirza-Schreiber Nazanin N Institute of Neurogenomics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.
Arfanakis K Arfanakis Konstantinos K Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL, USA.
Becker DM Becker Diane M DM GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ames D Ames David D National Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Goldman AL Goldman Aaron L AL Lieber Institute for Brain Development, Baltimore, MD, USA.
Lee PH Lee Phil H PH Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, MA, USA.
Boomsma DI Boomsma Dorret I DI Amsterdam Public Health Research Institute, VU Medical Center, Amsterdam, the Netherlands.
Lovestone S Lovestone Simon S NIHR Dementia Biomedical Research Unit, King's College London, London, UK.
Giddaluru S Giddaluru Sudheer S Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Le Hellard S Le Hellard Stephanie S Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Mattheisen M Mattheisen Manuel M Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Bohlken MM Bohlken Marc M MM Department of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Kasperaviciute D Kasperaviciute Dalia D Chalfont Centre for Epilepsy, Bucks, UK.
Schmaal L Schmaal Lianne L Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia.
Lawrie SM Lawrie Stephen M SM Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.
Agartz I Agartz Ingrid I Department of Research and Development, Diakonhjemmet Hospital, Oslo, Norway.
Walton E Walton Esther E Department of Psychology, University of Bath, Bath, UK.
Tordesillas-Gutierrez D Tordesillas-Gutierrez Diana D Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain.
Davies GE Davies Gareth E GE Avera Institute for Human Genetics, Sioux Falls, SD, USA.
Shin J Shin Jean J Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Ipser JC Ipser Jonathan C JC Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Vinke LN Vinke Louis N LN Center for Systems Neuroscience, Boston University, Boston, MA, USA.
Hoogman M Hoogman Martine M Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Jia T Jia Tianye T MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Burkhardt R Burkhardt Ralph R Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
Klein M Klein Marieke M Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Crivello F Crivello Fabrice F Neurodegeneratives Diseases Institute, CNRS UMR 5293, Université de Bordeaux, Bordeaux, France.
Janowitz D Janowitz Deborah D Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany.
Carmichael O Carmichael Owen O Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Haukvik UK Haukvik Unn K UK Department of Adult Psychiatry, Institute for Clinical Medicine, University of Oslo, Oslo, Norway.
Aribisala BS Aribisala Benjamin S BS Department of Computer Science, Lagos State University, Ojo, Nigeria.
Schmidt H Schmidt Helena H Research Unit-Genetic Epidemiology, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Strike LT Strike Lachlan T LT Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Cheng CY Cheng Ching-Yu CY Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
Risacher SL Risacher Shannon L SL Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Pütz B Pütz Benno B Max Planck Institute of Psychiatry, Munich, Germany.
Fleischman DA Fleischman Debra A DA Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.
Assareh AA Assareh Amelia A AA Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Mattay VS Mattay Venkata S VS Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Buckner RL Buckner Randy L RL Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA, USA.
Mecocci P Mecocci Patrizia P Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Dale AM Dale Anders M AM Department of Radiology, University of California, San Diego, San Diego, CA, USA.
Cichon S Cichon Sven S Institute for Neuroscience and Medicine: Structural and Functional Organisation of the Brain (INM-1), Research Centre Jülich, Jülich, Germany.
Boks MP Boks Marco P MP Department of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Matarin M Matarin Mar M Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands.
Calhoun VD Calhoun Vince D VD Tri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Atlanta, GA, USA.
Chakravarty MM Chakravarty M Mallar MM Departments of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, Québec, Canada.
Marquand AF Marquand Andre F AF Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, the Netherlands.
Macare C Macare Christine C MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Kharabian Masouleh S Kharabian Masouleh Shahrzad S Institute for Neuroscience and Medicine: Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
Oosterlaan J Oosterlaan Jaap J Emma Neuroscience Group, Department of Pediatrics, Emma Children's Hospital, Amsterdam Reproduction & Development, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Amouyel P Amouyel Philippe P Institut Pasteur de Lille, Lille, France.
Hegenscheid K Hegenscheid Katrin K Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Rotter JI Rotter Jerome I JI Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, CA, USA.
Schork AJ Schork Andrew J AJ Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Liewald DCM Liewald David C M DCM Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
de Zubicaray GI de Zubicaray Greig I GI Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Wong TY Wong Tien Yin TY Academic Medicine Research Institute, Duke-NUS Medical School, Singapore, Singapore.
Shen L Shen Li L Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA.
Sämann PG Sämann Philipp G PG Max Planck Institute of Psychiatry, Munich, Germany.
Brodaty H Brodaty Henry H Dementia Centre for Research Collaboration, UNSW, Sydney, New South Wales, Australia.
Roffman JL Roffman Joshua L JL Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
de Geus EJC de Geus Eco J C EJC Amsterdam Public Health Research Institute, VU Medical Center, Amsterdam, the Netherlands.
Tsolaki M Tsolaki Magda M 1st Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Erk S Erk Susanne S Division of Mind and Brain Research, D, Corporate member of Freie Universität Berliepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
van Eijk KR van Eijk Kristel R KR Brain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht, Utrecht, the Netherlands.
Cavalleri GL Cavalleri Gianpiero L GL Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
van der Wee NJA van der Wee Nic J A NJA Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, the Netherlands.
McIntosh AM McIntosh Andrew M AM Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.
Gollub RL Gollub Randy L RL Harvard Medical School, Boston, MA, USA.
Bulayeva KB Bulayeva Kazima B KB Department of Evolution and Genetics, Dagestan State University, Makhachkala, Russia.
Bernard M Bernard Manon M Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Richards JS Richards Jennifer S JS University Medical Center Groningen, Department of Psychiatry, University of Groningen, Groningen, the Netherlands.
Himali JJ Himali Jayandra J JJ Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Loeffler M Loeffler Markus M LIFE: The Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Rommelse N Rommelse Nanda N Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands.
Hoffmann W Hoffmann Wolfgang W Section Epidemiology of Health Care and Community Health, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Westlye LT Westlye Lars T LT CoE NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Valdés Hernández MC Valdés Hernández Maria C MC Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Hansell NK Hansell Narelle K NK Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
van Erp TGM van Erp Theo G M TGM Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA, USA.
Wolf C Wolf Christiane C Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany.
Kwok JBJ Kwok John B J JBJ University of New South Wales, Sydney, New South Wales, Australia.
Vellas B Vellas Bruno B Department of Geriatric Medicine, INSERM U 1027, University of Toulouse, Toulouse, France.
Heinz A Heinz Andreas A Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Olde Loohuis LM Olde Loohuis Loes M LM Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Delanty N Delanty Norman N Neurology Division, Beaumont Hospital, Dublin, Ireland.
Ho BC Ho Beng-Choon BC Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Ching CRK Ching Christopher R K CRK Interdepartmental Neuroscience Graduate Program, UCLA School of Medicine, Los Angeles, CA, USA.
Shumskaya E Shumskaya Elena E Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, the Netherlands.
Singh B Singh Baljeet B Imaging of Dementia and Aging Laboratory, Department of Neurology, University of California, Davis, Davis, CA, USA.
Hofman A Hofman Albert A Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
van der Meer D van der Meer Dennis D School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
Homuth G Homuth Georg G Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Psaty BM Psaty Bruce M BM Department of Health Services, University of Washington, Seattle, WA, USA.
Bastin ME Bastin Mark E ME Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Foroud TM Foroud Tatiana M TM Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Reppermund S Reppermund Simone S Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine, Sydney, New South Wales, Australia.
Hottenga JJ Hottenga Jouke-Jan JJ Amsterdam Public Health Research Institute, VU Medical Center, Amsterdam, the Netherlands.
Simmons A Simmons Andrew A Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
Meyer-Lindenberg A Meyer-Lindenberg Andreas A Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.
Cahn W Cahn Wiepke W Department of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Whelan CD Whelan Christopher D CD The Royal College of Surgeons in Ireland, Dublin, Ireland.
van Donkelaar MMJ van Donkelaar Marjolein M J MMJ Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Yang Q Yang Qiong Q Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Hosten N Hosten Norbert N Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Green RC Green Robert C RC Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Thalamuthu A Thalamuthu Anbupalam A Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Mohnke S Mohnke Sebastian S Division of Mind and Brain Research, D, Corporate member of Freie Universität Berliepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Hulshoff Pol HE Hulshoff Pol Hilleke E HE Department of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Lin H Lin Honghuang H Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Jack CR Jr Jack Clifford R CR Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Schofield PR Schofield Peter R PR School of Medical Sciences, UNSW, Sydney, New South Wales, Australia.
Mühleisen TW Mühleisen Thomas W TW Cécile and Oskar Vogt Institute for Brain Research, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Maillard P Maillard Pauline P Imaging of Dementia and Aging Laboratory, Department of Neurology, University of California, Davis, Davis, CA, USA.
Potkin SG Potkin Steven G SG Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.
Wen W Wen Wei W Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Fletcher E Fletcher Evan E Imaging of Dementia and Aging Laboratory, Department of Neurology, University of California, Davis, Davis, CA, USA.
Toga AW Toga Arthur W AW Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Gruber O Gruber Oliver O Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Huentelman M Huentelman Matthew M Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Davey Smith G Davey Smith George G MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.
Launer LJ Launer Lenore J LJ Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Nyberg L Nyberg Lars L Radiation Sciences, Umeå University, Umeå, Sweden.
Jönsson EG Jönsson Erik G EG Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
Crespo-Facorro B Crespo-Facorro Benedicto B Centro Investigación Biomédica en Red Salud Mental, Santander, Spain.
Koen N Koen Nastassja N South African Medical Research Council Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa.
Greve DN Greve Douglas N DN Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Uitterlinden AG Uitterlinden André G AG Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Weinberger DR Weinberger Daniel R DR Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Steen VM Steen Vidar M VM Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Fedko IO Fedko Iryna O IO Amsterdam Public Health Research Institute, VU Medical Center, Amsterdam, the Netherlands.
Groenewold NA Groenewold Nynke A NA Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Niessen WJ Niessen Wiro J WJ Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands.
Toro R Toro Roberto R Institut Pasteur, Paris, France.
Tzourio C Tzourio Christophe C Department of Neurology, CHU de Bordeaux, Bordeaux, France.
Longstreth WT Jr Longstreth William T WT Department of Neurology, University of Washington, Seattle, WA, USA.
Ikram MK Ikram M Kamran MK Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
Smoller JW Smoller Jordan W JW Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, MA, USA.
van Tol MJ van Tol Marie-Jose MJ Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Sussmann JE Sussmann Jessika E JE Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.
Paus T Paus Tomas T Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Lemaître H Lemaître Hervé H INSERM, Research Unit 1000 'Neuroimaging and Psychiatry', Paris Saclay University and Paris Descartes University-DIGITEO Labs, Gif sur Yvette, France.
Schroeter ML Schroeter Matthias L ML Clinic for Cognitive Neurology, University Clinic Leipzig, Leipzig, Germany.
Mazoyer B Mazoyer Bernard B Neurodegeneratives Diseases Institute, CNRS UMR 5293, Université de Bordeaux, Bordeaux, France.
Andreassen OA Andreassen Ole A OA CoE NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Holsboer F Holsboer Florian F HMNC Brain Health, Munich, Germany.
Depondt C Depondt Chantal C Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium.
Veltman DJ Veltman Dick J DJ Department of Psychiatry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands.
Turner JA Turner Jessica A JA Department of Psychology, Georgia State University, Atlanta, GA, USA.
Pausova Z Pausova Zdenka Z Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Schumann G Schumann Gunter G MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
van Rooij D van Rooij Daan D University Medical Center Groningen, Department of Psychiatry, University of Groningen, Groningen, the Netherlands.
Djurovic S Djurovic Srdjan S Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Deary IJ Deary Ian J IJ Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
McMahon KL McMahon Katie L KL Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Müller-Myhsok B Müller-Myhsok Bertram B Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Brouwer RM Brouwer Rachel M RM Department of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Soininen H Soininen Hilkka H Neurocentre Neurology, Kuopio University Hospital, Kuopio, Finland.
Pandolfo M Pandolfo Massimo M Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium.
Wassink TH Wassink Thomas H TH Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Cheung JW Cheung Joshua W JW Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Wolfers T Wolfers Thomas T Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Martinot JL Martinot Jean-Luc JL INSERM, Research Unit 1000 'Neuroimaging and Psychiatry', Paris Saclay University and Paris Descartes University-DIGITEO Labs, Gif sur Yvette, France.
Zwiers MP Zwiers Marcel P MP Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, the Netherlands.
Nauck M Nauck Matthias M German Center for Cardiovascular Research (partner site Greifswald), Greifswald, Germany.
Melle I Melle Ingrid I CoE NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Kanai R Kanai Ryota R School of Psychology, University of Sussex, Brighton, UK.
Westman E Westman Eric E Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Kahn RS Kahn René S RS Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sisodiya SM Sisodiya Sanjay M SM Chalfont Centre for Epilepsy, Bucks, UK.
White T White Tonya T Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.
Saremi A Saremi Arvin A Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
van Bokhoven H van Bokhoven Hans H Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Brunner HG Brunner Han G HG GROW School for Oncology and Developmental Biology, Maastricht, the Netherlands.
Völzke H Völzke Henry H German Center for Cardiovascular Research (partner site Greifswald), Greifswald, Germany.
Wright MJ Wright Margaret J MJ Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
van 't Ent D van 't Ent Dennis D Amsterdam Public Health Research Institute, VU Medical Center, Amsterdam, the Netherlands.
Nöthen MM Nöthen Markus M MM Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
Ophoff RA Ophoff Roel A RA Department of Psychiatry, Erasmus Medical Center, Rotterdam, the Netherlands.
Buitelaar JK Buitelaar Jan K JK Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands.
Fernández G Fernández Guillén G Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Sachdev PS Sachdev Perminder S PS Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Rietschel M Rietschel Marcella M Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.
van Haren NEM van Haren Neeltje E M NEM Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.
Fisher SE Fisher Simon E SE Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
Beiser AS Beiser Alexa S AS Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Francks C Francks Clyde C Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
Saykin AJ Saykin Andrew J AJ Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Mather KA Mather Karen A KA Neuroscience Research Australia, Sydney, New South Wales, Australia.
Romanczuk-Seiferth N Romanczuk-Seiferth Nina N Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Hartman CA Hartman Catharina A CA University Medical Center Groningen, Department of Psychiatry, University of Groningen, Groningen, the Netherlands.
DeStefano AL DeStefano Anita L AL Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Heslenfeld DJ Heslenfeld Dirk J DJ Department of Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
Weiner MW Weiner Michael W MW Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Walter H Walter Henrik H Division of Mind and Brain Research, D, Corporate member of Freie Universität Berliepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Hoekstra PJ Hoekstra Pieter J PJ University Medical Center Groningen, Department of Psychiatry, University of Groningen, Groningen, the Netherlands.
Nyquist PA Nyquist Paul A PA GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Franke B Franke Barbara B Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Bennett DA Bennett David A DA Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Grabe HJ Grabe Hans J HJ German Center for Neurodegenerative Diseases, Greifswald, Germany.
Johnson AD Johnson Andrew D AD Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Framingham, MA, USA.
Chen C Chen Christopher C Memory Aging and Cognition Center, National University Health System, Singapore, Singapore.
van Duijn CM van Duijn Cornelia M CM Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
Lopez OL Lopez Oscar L OL Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Fornage M Fornage Myriam M Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Wardlaw JM Wardlaw Joanna M JM UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Schmidt R Schmidt Reinhold R Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
DeCarli C DeCarli Charles C Department of Neurology, Center for Neuroscience, University of California, Davis, Sacramento, CA, USA.
De Jager PL De Jager Philip L PL Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Villringer A Villringer Arno A Faculty of Medicine, CRC 1052 'Obesity Mechanisms', University of Leipzig, Leipzig, Germany.
Debette S Debette Stéphanie S Department of Neurology, CHU de Bordeaux, Bordeaux, France.
Gudnason V Gudnason Vilmundur V Icelandic Heart Association, Kopavogur, Iceland.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Shulman JM Shulman Joshua M JM Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
Thompson PM Thompson Paul M PM Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Seshadri S Seshadri Sudha S Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Ikram MA Ikram M Arfan MA Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands. m.a.ikram@erasmusmc.nl.
INVESTIGATORS
JOURNAL
VOLUME: 51
ISSUE: 11
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2019
MONTH: 11
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
UH3 NS100605 NINDS NIH HHS United States
R01 NS087541 NINDS NIH HHS United States
U01 HL120393 NHLBI NIH HHS United States
UL1 TR000153 NCATS NIH HHS United States
MR/S015132/1 Medical Research Council United Kingdom
P30 AG010161 NIA NIH HHS United States
R01AG059874 U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) International
R00 MH101367 NIMH NIH HHS United States
U01 AG052409 NIA NIH HHS United States
U01 AG049505 NIA NIH HHS United States
R01 AG054076 NIA NIH HHS United States
R01 HL120393 NHLBI NIH HHS United States
MC_QA137853 Medical Research Council United Kingdom
U01 HL130114 NHLBI NIH HHS United States
MR/M013111/1 Medical Research Council United Kingdom
G1001245 Medical Research Council United Kingdom
MC_UU_00011/1 Medical Research Council United Kingdom
R01 AG017917 NIA NIH HHS United States
R01 HL105756 NHLBI NIH HHS United States
R01MH111671 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) International
MR/N027558/1 Medical Research Council United Kingdom
T32 AG058507 NIA NIH HHS United States
MC_UU_00011/1 RCUK | MRC | Medical Research Foundation International
R01MH117601 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) International
C06RR029965 U.S. Department of Health & Human Services | NIH | National Center for Research Resources (NCRR) International
K99MH116115 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) International
P30 AG010129 NIA NIH HHS United States
MC_PC_17228 Medical Research Council United Kingdom
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
K99MH102357 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) International
R03 AG054936 NIA NIH HHS United States
R01 MH119243 NIMH NIH HHS United States
R01 AG015819 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Animals
Brain metabolism
Cohort Studies metabolism
Drosophila melanogaster metabolism
Genetic Variation metabolism
Genome-Wide Association Study metabolism
Humans metabolism
Magnetic Resonance Imaging metabolism
Middle Aged metabolism
Neurodevelopmental Disorders pathology
Organ Size pathology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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