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PMID |
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TITLE |
|
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. |
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ABSTRACT |
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The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5-20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson's disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2019/07/25 |
accepted |
2019/09/18 |
entrez |
2019/10/10 06:00 |
pubmed |
2019/10/09 06:00 |
medline |
2020/02/20 06:00 |
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AUTHORS |
|
NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Nievergelt CM |
|
Nievergelt |
Caroline M |
CM |
|
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA. cnievergelt@ucsd.edu. |
Maihofer AX |
|
Maihofer |
Adam X |
AX |
|
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA. |
Klengel T |
|
Klengel |
Torsten |
T |
|
University Medical Center Goettingen, Department of Psychiatry, Göttingen, DE, Germany. |
Atkinson EG |
|
Atkinson |
Elizabeth G |
EG |
|
Massachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA. |
Chen CY |
|
Chen |
Chia-Yen |
CY |
|
Massachusetts General Hospital, Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Boston, MA, USA. |
Choi KW |
|
Choi |
Karmel W |
KW |
|
Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA. |
Coleman JRI |
|
Coleman |
Jonathan R I |
JRI |
|
King's College London, NIHR BRC at the Maudsley, London, GB, USA. |
Dalvie S |
|
Dalvie |
Shareefa |
S |
|
University of Cape Town, SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Cape Town, Western Cape, ZA, USA. |
Duncan LE |
|
Duncan |
Laramie E |
LE |
|
Stanford University, Department of Psychiatry and Behavioral Sciences, Stanford, CA, USA. |
Gelernter J |
|
Gelernter |
Joel |
J |
|
VA Connecticut Healthcare Center, West Haven, CT, USA. |
Levey DF |
|
Levey |
Daniel F |
DF |
|
Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA. |
Logue MW |
|
Logue |
Mark W |
MW |
|
VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA. |
Polimanti R |
|
Polimanti |
Renato |
R |
|
Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA. |
Provost AC |
|
Provost |
Allison C |
AC |
|
Cohen Veterans Bioscience, Cambridge, MA, USA. |
Ratanatharathorn A |
|
Ratanatharathorn |
Andrew |
A |
|
Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA. |
Stein MB |
|
Stein |
Murray B |
MB |
|
Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA. |
Torres K |
|
Torres |
Katy |
K |
|
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA. |
Aiello AE |
|
Aiello |
Allison E |
AE |
|
Gillings School of Global Public Health, Department of Epidemiology, Chapel Hill, NC, USA. |
Almli LM |
|
Almli |
Lynn M |
LM |
|
Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA. |
Amstadter AB |
|
Amstadter |
Ananda B |
AB |
|
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA. |
Andersen SB |
|
Andersen |
Søren B |
SB |
|
The Danish Veteran Centre, Research and Knowledge Centre, Ringsted, Sjaelland, Denmark. |
Andreassen OA |
|
Andreassen |
Ole A |
OA |
|
University of Oslo, Institute of Clinical Medicine, Oslo, NO, Norway. |
Arbisi PA |
|
Arbisi |
Paul A |
PA |
|
Minneapolis VA Health Care System, Mental Health Service Line, Minneapolis, MN, USA. |
Ashley-Koch AE |
|
Ashley-Koch |
Allison E |
AE |
|
Duke University, Duke Molecular Physiology Institute, Durham, NC, USA. |
Austin SB |
|
Austin |
S Bryn |
SB |
|
Harvard School of Public Health, Department of Social and Behavioral Sciences, Boston, MA, USA. |
Avdibegovic E |
|
Avdibegovic |
Esmina |
E |
|
University Clinical Center of Tuzla, Department of Psychiatry, Tuzla, BA, Bosnia and Herzegovina. |
Babić D |
|
Babić |
Dragan |
D |
|
University Clinical Center of Mostar, Department of Psychiatry, Mostar, BA, Bosnia and Herzegovina. |
Bækvad-Hansen M |
|
Bækvad-Hansen |
Marie |
M |
|
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK, Denmark. |
Baker DG |
|
Baker |
Dewleen G |
DG |
|
Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA. |
Beckham JC |
|
Beckham |
Jean C |
JC |
|
VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), Genetics Research Laboratory, Durham, NC, USA. |
Bierut LJ |
|
Bierut |
Laura J |
LJ |
|
Washington University in Saint Louis School of Medicine, Department of Psychiatry, Saint Louis, MO, USA. |
Bisson JI |
|
Bisson |
Jonathan I |
JI |
|
Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, UK. |
Boks MP |
|
Boks |
Marco P |
MP |
|
UMC Utrecht Brain Center Rudolf Magnus, Department of Translational Neuroscience, Utrecht, Utrecht, NL, Netherlands. |
Bolger EA |
|
Bolger |
Elizabeth A |
EA |
|
McLean Hospital, Belmont, MA, USA. |
Børglum AD |
|
Børglum |
Anders D |
AD |
|
Aarhus University, Department of Biomedicine - Human Genetics, Aarhus, DK, Denmark. |
Bradley B |
|
Bradley |
Bekh |
B |
|
Atlanta VA Health Care System, Mental Health Service Line, Decatur, GA, USA. |
Brashear M |
|
Brashear |
Megan |
M |
|
Louisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology, New Orleans, LA, USA. |
Breen G |
|
Breen |
Gerome |
G |
|
King's College London, NIHR BRC at the Maudsley, London, GB, USA. |
Bryant RA |
|
Bryant |
Richard A |
RA |
|
University of New South Wales, Department of Psychology, Sydney, NSW, Australia. |
Bustamante AC |
|
Bustamante |
Angela C |
AC |
|
University of Michigan Medical School, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ann Arbor, MI, USA. |
Bybjerg-Grauholm J |
|
Bybjerg-Grauholm |
Jonas |
J |
|
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK, Denmark. |
Calabrese JR |
|
Calabrese |
Joseph R |
JR |
|
University Hospitals, Department of Psychiatry, Cleveland, OH, USA. |
Caldas-de-Almeida JM |
|
Caldas-de-Almeida |
José M |
JM |
|
CEDOC -Chronic Diseases Research Centre, Lisbon Institute of Global Mental Health, Lisbon, PT, Portugal. |
Dale AM |
|
Dale |
Anders M |
AM |
|
University of California San Diego, Department of Radiology, Department of Neurosciences, La Jolla, CA, USA. |
Daly MJ |
|
Daly |
Mark J |
MJ |
|
Massachusetts General Hospital, Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Boston, MA, USA. |
Daskalakis NP |
|
Daskalakis |
Nikolaos P |
NP |
|
Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, USA. |
Deckert J |
|
Deckert |
Jürgen |
J |
|
University Hospital of Würzburg, Center of Mental Health, Psychiatry, Psychosomatics and Psychotherapy, Würzburg, DE, Germany. |
Delahanty DL |
|
Delahanty |
Douglas L |
DL |
|
Kent State University, Research and Sponsored Programs, Kent, OH, USA. |
Dennis MF |
|
Dennis |
Michelle F |
MF |
|
VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), Genetics Research Laboratory, Durham, NC, USA. |
Disner SG |
|
Disner |
Seth G |
SG |
|
Minneapolis VA Health Care System, Research Service Line, Minneapolis, MN, USA. |
Domschke K |
|
Domschke |
Katharina |
K |
|
University of Freiburg, Faculty of Medicine, Centre for Basics in Neuromodulation, Freiburg, DE, Germany. |
Dzubur-Kulenovic A |
|
Dzubur-Kulenovic |
Alma |
A |
|
University Clinical Center of Sarajevo, Department of Psychiatry, Sarajevo, BA, Bosnia and Herzegovina. |
Erbes CR |
|
Erbes |
Christopher R |
CR |
|
Minneapolis VA Health Care System, Center for Care Delivery and Outcomes Research (CCDOR), Minneapolis, MN, USA. |
Evans A |
|
Evans |
Alexandra |
A |
|
Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, South Glamorgan, GB, USA. |
Farrer LA |
|
Farrer |
Lindsay A |
LA |
|
Boston University School of Medicine, Department of Medicine, Boston, MA, USA. |
Feeny NC |
|
Feeny |
Norah C |
NC |
|
Case Western Reserve University, Department of Psychological Sciences, Cleveland, OH, USA. |
Flory JD |
|
Flory |
Janine D |
JD |
|
Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, USA. |
Forbes D |
|
Forbes |
David |
D |
|
University of Melbourne, Department of Psychiatry, Melbourne, VIC, AU, USA. |
Franz CE |
|
Franz |
Carol E |
CE |
|
University of California San Diego, Department of Psychiatry, La Jolla, CA, USA. |
Galea S |
|
Galea |
Sandro |
S |
|
Boston University, Department of Psychological and Brain Sciences, Boston, MA, USA. |
Garrett ME |
|
Garrett |
Melanie E |
ME |
|
Duke University, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA. |
Gelaye B |
|
Gelaye |
Bizu |
B |
|
Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA. |
Geuze E |
|
Geuze |
Elbert |
E |
|
UMC Utrecht Brain Center Rudolf Magnus, Department of Psychiatry, Utrecht, Utrecht, NL, Netherlands. |
Gillespie C |
|
Gillespie |
Charles |
C |
|
Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA. |
Uka AG |
|
Uka |
Aferdita Goci |
AG |
|
University Clinical Centre of Kosovo, Department of Psychiatry, Prishtina, Kosovo, XK, USA. |
Gordon SD |
|
Gordon |
Scott D |
SD |
|
QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, Queensland, Australia. |
Guffanti G |
|
Guffanti |
Guia |
G |
|
McLean Hospital, Belmont, MA, USA. |
Hammamieh R |
|
Hammamieh |
Rasha |
R |
|
US Army Medical Research and Materiel Command, USACEHR, Fort Detrick, MD, USA. |
Harnal S |
|
Harnal |
Supriya |
S |
|
Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA. |
Hauser MA |
|
Hauser |
Michael A |
MA |
|
Duke University, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA. |
Heath AC |
|
Heath |
Andrew C |
AC |
|
Washington University in Saint Louis School of Medicine, Department of Genetics, Saint Louis, MO, USA. |
Hemmings SMJ |
|
Hemmings |
Sian M J |
SMJ |
|
Stellenbosch University Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA, South Africa. |
Hougaard DM |
|
Hougaard |
David Michael |
DM |
|
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK, Denmark. |
Jakovljevic M |
|
Jakovljevic |
Miro |
M |
|
University Hospital Center of Zagreb, Department of Psychiatry, Zagreb, HR, USA. |
Jett M |
|
Jett |
Marti |
M |
|
US Army Medical Research and Materiel Command, USACEHR, Fort Detrick, MD, USA. |
Johnson EO |
|
Johnson |
Eric Otto |
EO |
|
RTI International, Behavioral Health and Criminal Justice Division, Research Triangle Park, NC, USA. |
Jones I |
|
Jones |
Ian |
I |
|
Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, South Glamorgan, GB, USA. |
Jovanovic T |
|
Jovanovic |
Tanja |
T |
|
Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA. |
Qin XJ |
|
Qin |
Xue-Jun |
XJ |
|
Duke University, Duke Molecular Physiology Institute, Durham, NC, USA. |
Junglen AG |
|
Junglen |
Angela G |
AG |
|
Kent State University, Department of Psychological Sciences, Kent, OH, USA. |
Karstoft KI |
|
Karstoft |
Karen-Inge |
KI |
|
University of Copenhagen, Department of Psychology, Copenhagen, DK, Denmark. |
Kaufman ML |
|
Kaufman |
Milissa L |
ML |
|
McLean Hospital, Belmont, MA, USA. |
Kessler RC |
|
Kessler |
Ronald C |
RC |
|
Harvard Medical School, Department of Psychiatry, Boston, MA, USA. |
Khan A |
|
Khan |
Alaptagin |
A |
|
Harvard Medical School, Department of Health Care Policy, Boston, MA, USA. |
Kimbrel NA |
|
Kimbrel |
Nathan A |
NA |
|
VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), Genetics Research Laboratory, Durham, NC, USA. |
King AP |
|
King |
Anthony P |
AP |
|
University of Michigan Medical School, Department of Psychiatry, Ann Arbor, MI, USA. |
Koen N |
|
Koen |
Nastassja |
N |
|
University of Cape Town, SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Cape Town, Western Cape, ZA, USA. |
Kranzler HR |
|
Kranzler |
Henry R |
HR |
|
Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA. |
Kremen WS |
|
Kremen |
William S |
WS |
|
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA. |
Lawford BR |
|
Lawford |
Bruce R |
BR |
|
Queensland University of Technology, School of Biomedical Sciences, Kelvin Grove, QLD, AU, Australia. |
Lebois LAM |
|
Lebois |
Lauren A M |
LAM |
|
McLean Hospital, Belmont, MA, USA. |
Lewis CE |
|
Lewis |
Catrin E |
CE |
|
Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, South Glamorgan, GB, USA. |
Linnstaedt SD |
|
Linnstaedt |
Sarah D |
SD |
|
UNC Institute for Trauma Recovery, Department of Anesthesiology, Chapel Hill, NC, USA. |
Lori A |
|
Lori |
Adriana |
A |
|
Emory University, Department of Gynecology and Obstetrics, Atlanta, GA, USA. |
Lugonja B |
|
Lugonja |
Bozo |
B |
|
Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, South Glamorgan, GB, USA. |
Luykx JJ |
|
Luykx |
Jurjen J |
JJ |
|
UMC Utrecht Brain Center Rudolf Magnus, Department of Psychiatry, Utrecht, Utrecht, NL, Netherlands. |
Lyons MJ |
|
Lyons |
Michael J |
MJ |
|
Boston University, Dean's Office, Boston, MA, USA. |
Maples-Keller J |
|
Maples-Keller |
Jessica |
J |
|
Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA. |
Marmar C |
|
Marmar |
Charles |
C |
|
New York University School of Medicine, Department of Psychiatry, New York, NY, USA. |
Martin AR |
|
Martin |
Alicia R |
AR |
|
Massachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA. |
Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, Queensland, Australia. |
Maurer D |
|
Maurer |
Douglas |
D |
|
United States Army, Command, Fort Sill, OK, USA. |
Mavissakalian MR |
|
Mavissakalian |
Matig R |
MR |
|
University Hospitals, Department of Psychiatry, Cleveland, OH, USA. |
McFarlane A |
|
McFarlane |
Alexander |
A |
|
University of Adelaide, Department of Psychiatry, Adelaide, South Australia, AU, Australia. |
McGlinchey RE |
|
McGlinchey |
Regina E |
RE |
|
VA Boston Health Care System, GRECC/TRACTS, Boston, MA, USA. |
McLaughlin KA |
|
McLaughlin |
Katie A |
KA |
|
Harvard University, Department of Psychology, Boston, MA, USA. |
McLean SA |
|
McLean |
Samuel A |
SA |
|
UNC Institute for Trauma Recovery, Department of Emergency Medicine, Chapel Hill, NC, USA. |
McLeay S |
|
McLeay |
Sarah |
S |
|
Gallipoli Medical Research Institute, PTSD Initiative, Greenslopes, Queensland, AU, Australia. |
Mehta D |
|
Mehta |
Divya |
D |
|
Queensland University of Technology, School of Psychology and Counseling, Faculty of Health, Kelvin Grove, QLD, AU, Australia. |
Milberg WP |
|
Milberg |
William P |
WP |
|
VA Boston Health Care System, GRECC/TRACTS, Boston, MA, USA. |
Miller MW |
|
Miller |
Mark W |
MW |
|
VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA. |
Morey RA |
|
Morey |
Rajendra A |
RA |
|
Duke University, Duke Molecular Physiology Institute, Durham, NC, USA. |
Morris CP |
|
Morris |
Charles Phillip |
CP |
|
Queensland University of Technology, School of Biomedical Sciences, Kelvin Grove, QLD, AU, Australia. |
Mors O |
|
Mors |
Ole |
O |
|
Aarhus University Hospital, Psychosis Research Unit, Risskov, DK, Denmark. |
Mortensen PB |
|
Mortensen |
Preben B |
PB |
|
Aarhus University, National Centre for Register-Based Research, Aarhus, DK, Denmark. |
Neale BM |
|
Neale |
Benjamin M |
BM |
|
Massachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA. |
Nelson EC |
|
Nelson |
Elliot C |
EC |
|
Washington University in Saint Louis School of Medicine, Department of Psychiatry, Saint Louis, MO, USA. |
Nordentoft M |
|
Nordentoft |
Merete |
M |
|
University of Copenhagen, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, Copenhagen, DK, Denmark. |
Norman SB |
|
Norman |
Sonya B |
SB |
|
National Center for Post Traumatic Stress Disorder, Executive Division, White River Junction, San Diego, VT, USA. |
O'Donnell M |
|
O'Donnell |
Meaghan |
M |
|
University of Melbourne, Department of Psychiatry, Melbourne, VIC, AU, USA. |
Orcutt HK |
|
Orcutt |
Holly K |
HK |
|
Northern Illinois University, Department of Psychology, DeKalb, IL, USA. |
Panizzon MS |
|
Panizzon |
Matthew S |
MS |
|
University of California San Diego, Department of Psychiatry, La Jolla, CA, USA. |
Peters ES |
|
Peters |
Edward S |
ES |
|
Louisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology, New Orleans, LA, USA. |
Peterson AL |
|
Peterson |
Alan L |
AL |
|
University of Texas Health Science Center at San Antonio, Department of Psychiatry, San Antonio, TX, USA. |
Peverill M |
|
Peverill |
Matthew |
M |
|
University of Washington, Department of Psychology, Seattle, WA, USA. |
Pietrzak RH |
|
Pietrzak |
Robert H |
RH |
|
U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, West Haven, CT, USA. |
Polusny MA |
|
Polusny |
Melissa A |
MA |
|
Minneapolis VA Health Care System, Department of Psychology, Minneapolis, MN, USA. |
Rice JP |
|
Rice |
John P |
JP |
|
Washington University in Saint Louis School of Medicine, Department of Psychiatry, Saint Louis, MO, USA. |
Ripke S |
|
Ripke |
Stephan |
S |
|
Charité - Universitätsmedizin, Department of Psychiatry and Psychotherapy, Berlin, GE, Germany. |
Risbrough VB |
|
Risbrough |
Victoria B |
VB |
|
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA. |
Roberts AL |
|
Roberts |
Andrea L |
AL |
|
Harvard T.H. Chan School of Public Health, Department of Environmental Health, Boston, MA, USA. |
Rothbaum AO |
|
Rothbaum |
Alex O |
AO |
|
Case Western Reserve University, Department of Psychological Sciences, Cleveland, OH, USA. |
Rothbaum BO |
|
Rothbaum |
Barbara O |
BO |
|
Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA. |
Roy-Byrne P |
|
Roy-Byrne |
Peter |
P |
|
University of Washington, Department of Psychology, Seattle, WA, USA. |
Ruggiero K |
|
Ruggiero |
Ken |
K |
|
Medical University of South Carolina, Department of Nursing and Department of Psychiatry, Charleston, SC, USA. |
Rung A |
|
Rung |
Ariane |
A |
|
Louisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology, New Orleans, LA, USA. |
Rutten BPF |
|
Rutten |
Bart P F |
BPF |
|
Maastricht Universitair Medisch Centrum, School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht, Limburg, NL, Netherlands. |
Saccone NL |
|
Saccone |
Nancy L |
NL |
|
Washington University in Saint Louis School of Medicine, Department of Psychiatry, Saint Louis, MO, USA. |
Sanchez SE |
|
Sanchez |
Sixto E |
SE |
|
Universidad Peruana de Ciencias Aplicadas Facultad de Ciencias de la Salud, Department of Medicine, Lima, Lima, PE, USA. |
Schijven D |
|
Schijven |
Dick |
D |
|
UMC Utrecht Brain Center Rudolf Magnus, Department of Psychiatry, Utrecht, Utrecht, NL, Netherlands. |
Seedat S |
|
Seedat |
Soraya |
S |
|
Stellenbosch University Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA, South Africa. |
Seligowski AV |
|
Seligowski |
Antonia V |
AV |
|
McLean Hospital, Belmont, MA, USA. |
Seng JS |
|
Seng |
Julia S |
JS |
|
University of Michigan, School of Nursing, Ann Arbor, MI, USA. |
Sheerin CM |
|
Sheerin |
Christina M |
CM |
|
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA. |
Silove D |
|
Silove |
Derrick |
D |
|
University of New South Wales, Department of Psychiatry, Sydney, NSW, AU, USA. |
Smith AK |
|
Smith |
Alicia K |
AK |
|
Emory University, Department of Gynecology and Obstetrics, Atlanta, GA, USA. |
Smoller JW |
|
Smoller |
Jordan W |
JW |
|
Massachusetts General Hospital, Department of Psychiatry, Boston, MA, USA. |
Sponheim SR |
|
Sponheim |
Scott R |
SR |
|
University of Minnesota, Department of Psychiatry, Minneapolis, MN, USA. |
Stein DJ |
|
Stein |
Dan J |
DJ |
|
University of Cape Town, SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Cape Town, Western Cape, ZA, USA. |
Stevens JS |
|
Stevens |
Jennifer S |
JS |
|
Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA. |
Sumner JA |
|
Sumner |
Jennifer A |
JA |
|
Columbia University Medical Center, Department of Medicine, New York, NY, USA. |
Teicher MH |
|
Teicher |
Martin H |
MH |
|
McLean Hospital, Belmont, MA, USA. |
Thompson WK |
|
Thompson |
Wesley K |
WK |
|
Oslo University Hospital, KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo, NO, USA. |
Trapido E |
|
Trapido |
Edward |
E |
|
Louisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology, New Orleans, LA, USA. |
Uddin M |
|
Uddin |
Monica |
M |
|
University of South Florida College of Public Health, Genomics Program, Tampa, FL, USA. |
Ursano RJ |
|
Ursano |
Robert J |
RJ |
|
Uniformed Services University, Department of Psychiatry, Bethesda, Maryland, USA. |
van den Heuvel LL |
|
van den Heuvel |
Leigh Luella |
LL |
|
Stellenbosch University Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA, South Africa. |
Van Hooff M |
|
Van Hooff |
Miranda |
M |
|
University of Adelaide, Department of Psychiatry, Adelaide, South Australia, AU, Australia. |
Vermetten E |
|
Vermetten |
Eric |
E |
|
Netherlands Defense Department, Research Center, Utrecht, UT, Netherlands. |
Vinkers CH |
|
Vinkers |
Christiaan H |
CH |
|
Amsterdam UMC (location VUmc), Department of Psychiatry, Amsterdam, Holland, NL, Netherlands. |
Voisey J |
|
Voisey |
Joanne |
J |
|
Queensland University of Technology, School of Biomedical Sciences, Kelvin Grove, QLD, AU, Australia. |
Wang Y |
|
Wang |
Yunpeng |
Y |
|
Oslo University Hospital, KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo, NO, USA. |
Wang Z |
|
Wang |
Zhewu |
Z |
|
Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston, SC, USA. |
Werge T |
|
Werge |
Thomas |
T |
|
University of Copenhagen, Department of Clinical Medicine, Copenhagen, Denmark. |
Williams MA |
|
Williams |
Michelle A |
MA |
|
Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA. |
Williamson DE |
|
Williamson |
Douglas E |
DE |
|
Duke University, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA. |
Winternitz S |
|
Winternitz |
Sherry |
S |
|
McLean Hospital, Belmont, MA, USA. |
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Wolf |
Christiane |
C |
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University Hospital of Würzburg, Center of Mental Health, Psychiatry, Psychosomatics and Psychotherapy, Würzburg, DE, Germany. |
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Wolf |
Erika J |
EJ |
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VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA. |
Wolff JD |
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Wolff |
Jonathan D |
JD |
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McLean Hospital, Belmont, MA, USA. |
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Yehuda |
Rachel |
R |
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James J Peters VA Medical Center, Department of Mental Health, Bronx, NY, USA. |
Young RM |
|
Young |
Ross McD |
RM |
|
Queensland University of Technology, School of Psychology and Counseling, Faculty of Health, Kelvin Grove, QLD, AU, Australia. |
Young KA |
|
Young |
Keith A |
KA |
|
CTVHCS, COE for Research on Returning War Veterans, Waco, TX, USA. |
Zhao H |
|
Zhao |
Hongyu |
H |
|
Yale University, Department of Biostatistics, New Haven, CT, USA. |
Zoellner LA |
|
Zoellner |
Lori A |
LA |
|
University of Washington, Department of Psychiatry and Behavioral Sciences, Seattle, WA, USA. |
Liberzon I |
|
Liberzon |
Israel |
I |
|
University of Michigan Medical School, Department of Psychiatry, Ann Arbor, MI, USA. |
Ressler KJ |
|
Ressler |
Kerry J |
KJ |
|
Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA. |
Haas M |
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Haas |
Magali |
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Cohen Veterans Bioscience, Cambridge, MA, USA. |
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Koenen |
Karestan C |
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Harvard School of Public Health, Department of Epidemiology, Boston, MA, USA. |
|
INVESTIGATORS |
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JOURNAL |
|
VOLUME: 10 |
ISSUE: 1 |
TITLE: Nature communications |
ISOABBREVIATION: Nat Commun |
YEAR: 2019 |
MONTH: 10 |
DAY: 08 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 2041-1723 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Nat Commun |
COUNTRY: England |
ISSNLINKING: 2041-1723 |
NLMUNIQUEID: 101528555 |
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PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
Meta-Analysis |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
|
COMMENTS AND CORRECTIONS |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
R01 MD011728 |
NIMHD NIH HHS |
United States |
F32 MH109274 |
NIMH NIH HHS |
United States |
IK2 RX002922 |
RRD VA |
United States |
R21 MH112956 |
NIMH NIH HHS |
United States |
IK1 RX002325 |
RRD VA |
United States |
U01 MH109536 |
NIMH NIH HHS |
United States |
R01 MH106595 |
NIMH NIH HHS |
United States |
K01 MH118467 |
NIMH NIH HHS |
United States |
MR/L010305/1 |
Medical Research Council |
United Kingdom |
|
GENERAL NOTE |
|
|
KEYWORDS |
|
|
MESH HEADINGS |
|
DESCRIPTORNAME |
QUALIFIERNAME |
African Continental Ancestry Group |
genetics |
Datasets as Topic |
genetics |
European Continental Ancestry Group |
genetics |
Female |
genetics |
Genetic Loci |
genetics |
Genetic Predisposition to Disease |
genetics |
Genome-Wide Association Study |
genetics |
Humans |
genetics |
Male |
genetics |
Sex Factors |
genetics |
Stress Disorders, Post-Traumatic |
genetics |
Ubiquitin-Protein Ligases |
genetics |
Veterans |
statistics & numerical data |
|
SUPPLEMENTARY MESH |
|
|
GENE SYMBOLS |
|
|
CHEMICALS |
|
REGISTRYNUMBER |
NAMEOFSUBSTANCE |
EC 2.3.2.27 |
Ubiquitin-Protein Ligases |
EC 2.3.2.27 |
parkin protein |
|
OTHER ID's |
|
|
|