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PMID |
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TITLE |
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Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. |
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ABSTRACT |
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Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implicated the kidney and liver as the main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF4A. Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major urate transporter, in kidney cells, and that HNF4A p.Thr139Ile is a functional variant. Transcriptional coregulation within and across organs may be a general mechanism underlying the observed pleiotropy between urate and cardiometabolic traits. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2019/01/17 |
accepted |
2019/08/27 |
entrez |
2019/10/04 06:00 |
pubmed |
2019/10/04 06:00 |
medline |
2019/10/04 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Tin A |
|
Tin |
Adrienne |
A |
|
Welch Centre for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA. atin1@jhu.edu. |
Marten J |
|
Marten |
Jonathan |
J |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Halperin Kuhns VL |
|
Halperin Kuhns |
Victoria L |
VL |
|
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA. |
Li Y |
|
Li |
Yong |
Y |
|
Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. |
Wuttke M |
|
Wuttke |
Matthias |
M |
|
Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. |
Kirsten H |
|
Kirsten |
Holger |
H |
|
LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. |
Sieber KB |
|
Sieber |
Karsten B |
KB |
|
Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA. |
Qiu C |
|
Qiu |
Chengxiang |
C |
|
Department of Medicine and Genetics, University of Pennsylvania, Philadelphia, PA, USA. |
Gorski M |
|
Gorski |
Mathias |
M |
|
Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. |
Yu Z |
|
Yu |
Zhi |
Z |
|
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. |
Giri A |
|
Giri |
Ayush |
A |
|
Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. |
Sveinbjornsson G |
|
Sveinbjornsson |
Gardar |
G |
|
deCODE Genetics, Amgen Inc., Reykjavik, Iceland. |
Li M |
|
Li |
Man |
M |
|
Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA. |
Chu AY |
|
Chu |
Audrey Y |
AY |
|
Genetics, Merck & Co., Inc, Kenilworth, NJ, USA. |
Hoppmann A |
|
Hoppmann |
Anselm |
A |
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Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. |
O'Connor LJ |
|
O'Connor |
Luke J |
LJ |
|
Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. |
Prins B |
|
Prins |
Bram |
B |
|
Strangeways Research Laboratory, University of Cambridge, Cambridge, UK. |
Nutile T |
|
Nutile |
Teresa |
T |
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Institute of Genetics and Biophysics Adriano Buzzati-Traverso-CNR, Naples, Italy. |
Noce D |
|
Noce |
Damia |
D |
|
Eurac Research, Institute for Biomedicine, Bolzano, Italy. |
Akiyama M |
|
Akiyama |
Masato |
M |
|
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. |
Cocca M |
|
Cocca |
Massimiliano |
M |
|
Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy. |
Ghasemi S |
|
Ghasemi |
Sahar |
S |
|
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. |
van der Most PJ |
|
van der Most |
Peter J |
PJ |
|
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Horn K |
|
Horn |
Katrin |
K |
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LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. |
Xu Y |
|
Xu |
Yizhe |
Y |
|
Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA. |
Fuchsberger C |
|
Fuchsberger |
Christian |
C |
|
Eurac Research, Institute for Biomedicine, Bolzano, Italy. |
Sedaghat S |
|
Sedaghat |
Sanaz |
S |
|
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. |
Afaq S |
|
Afaq |
Saima |
S |
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Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar, Pakistan. |
Amin N |
|
Amin |
Najaf |
N |
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Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. |
Ärnlöv J |
|
Ärnlöv |
Johan |
J |
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School of Health and Social Studies, Dalarna University, Falun, Sweden. |
Bakker SJL |
|
Bakker |
Stephan J L |
SJL |
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Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Bansal N |
|
Bansal |
Nisha |
N |
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Kidney Research Institute, University of Washington, Seattle, WA, USA. |
Baptista D |
|
Baptista |
Daniela |
D |
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Cardiology, Geneva University Hospitals, Geneva, Switzerland. |
Bergmann S |
|
Bergmann |
Sven |
S |
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Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa. |
Biggs ML |
|
Biggs |
Mary L |
ML |
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Department of Biostatistics, University of Washington, Seattle, WA, USA. |
Biino G |
|
Biino |
Ginevra |
G |
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Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy. |
Boerwinkle E |
|
Boerwinkle |
Eric |
E |
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Human Genetics Centre, University of Texas Health Science Centre, Houston, TX, USA. |
Bottinger EP |
|
Bottinger |
Erwin P |
EP |
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Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
Boutin TS |
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Boutin |
Thibaud S |
TS |
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Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Brumat M |
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Brumat |
Marco |
M |
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University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy. |
Burkhardt R |
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Burkhardt |
Ralph |
R |
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Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany. |
Campana E |
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Campana |
Eric |
E |
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University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy. |
Campbell A |
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Campbell |
Archie |
A |
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Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Campbell H |
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Campbell |
Harry |
H |
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Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Carroll RJ |
|
Carroll |
Robert J |
RJ |
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Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. |
Catamo E |
|
Catamo |
Eulalia |
E |
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Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy. |
Chambers JC |
|
Chambers |
John C |
JC |
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MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. |
Ciullo M |
|
Ciullo |
Marina |
M |
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IRCCS Neuromed, Pozzilli, Italy. |
Concas MP |
|
Concas |
Maria Pina |
MP |
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Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy. |
Coresh J |
|
Coresh |
Josef |
J |
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Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. |
Corre T |
|
Corre |
Tanguy |
T |
|
Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland. |
Cusi D |
|
Cusi |
Daniele |
D |
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Bio4Dreams, Milano, Italy. |
Felicita SC |
|
Felicita |
Sala Cinzia |
SC |
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San Raffaele Research Institute, Milano, Italy. |
de Borst MH |
|
de Borst |
Martin H |
MH |
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Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
De Grandi A |
|
De Grandi |
Alessandro |
A |
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Eurac Research, Institute for Biomedicine, Bolzano, Italy. |
de Mutsert R |
|
de Mutsert |
Renée |
R |
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Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands. |
de Vries APJ |
|
de Vries |
Aiko P J |
APJ |
|
Section of Nephrology, Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands. |
Delgado G |
|
Delgado |
Graciela |
G |
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Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. |
Demirkan A |
|
Demirkan |
Ayşe |
A |
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Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands. |
Devuyst O |
|
Devuyst |
Olivier |
O |
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Institute of Physiology, University of Zurich, Zurich, Switzerland. |
Dittrich K |
|
Dittrich |
Katalin |
K |
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Centre for Pediatric Research, University of Leipzig, Leipzig, Germany. |
Eckardt KU |
|
Eckardt |
Kai-Uwe |
KU |
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Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany. |
Ehret G |
|
Ehret |
Georg |
G |
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Cardiology, Geneva University Hospitals, Geneva, Switzerland. |
Endlich K |
|
Endlich |
Karlhans |
K |
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Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany. |
Evans MK |
|
Evans |
Michele K |
MK |
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Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA. |
Gansevoort RT |
|
Gansevoort |
Ron T |
RT |
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Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Gasparini P |
|
Gasparini |
Paolo |
P |
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University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy. |
Giedraitis V |
|
Giedraitis |
Vilmantas |
V |
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Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden. |
Gieger C |
|
Gieger |
Christian |
C |
|
German Center for Diabetes Research, Neuherberg, Germany. |
Girotto G |
|
Girotto |
Giorgia |
G |
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University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy. |
Gögele M |
|
Gögele |
Martin |
M |
|
Eurac Research, Institute for Biomedicine, Bolzano, Italy. |
Gordon SD |
|
Gordon |
Scott D |
SD |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Gudbjartsson DF |
|
Gudbjartsson |
Daniel F |
DF |
|
deCODE Genetics, Amgen Inc., Reykjavik, Iceland. |
Gudnason V |
|
Gudnason |
Vilmundur |
V |
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Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. |
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German Chronic Kidney Disease Study |
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|
|
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Haller T |
|
Haller |
Toomas |
T |
|
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. |
Hamet P |
|
Hamet |
Pavel |
P |
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Medpharmgene, Montreal, Quebec, Canada. |
Harris TB |
|
Harris |
Tamara B |
TB |
|
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA. |
Hayward C |
|
Hayward |
Caroline |
C |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Hicks AA |
|
Hicks |
Andrew A |
AA |
|
Eurac Research, Institute for Biomedicine, Bolzano, Italy. |
Hofer E |
|
Hofer |
Edith |
E |
|
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria. |
Holm H |
|
Holm |
Hilma |
H |
|
deCODE Genetics, Amgen Inc., Reykjavik, Iceland. |
Huang W |
|
Huang |
Wei |
W |
|
Shanghai Industrial Technology Institute, Shanghai, China. |
Hutri-Kähönen N |
|
Hutri-Kähönen |
Nina |
N |
|
Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. |
Hwang SJ |
|
Hwang |
Shih-Jen |
SJ |
|
The Centre for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA, USA. |
Ikram MA |
|
Ikram |
M Arfan |
MA |
|
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. |
Lewis RM |
|
Lewis |
Raychel M |
RM |
|
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA. |
Ingelsson E |
|
Ingelsson |
Erik |
E |
|
Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. |
Jakobsdottir J |
|
Jakobsdottir |
Johanna |
J |
|
The Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland. |
Jonsdottir I |
|
Jonsdottir |
Ingileif |
I |
|
deCODE Genetics, Amgen Inc., Reykjavik, Iceland. |
Jonsson H |
|
Jonsson |
Helgi |
H |
|
University of Iceland, Reykjavík, Iceland. |
Joshi PK |
|
Joshi |
Peter K |
PK |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Josyula NS |
|
Josyula |
Navya Shilpa |
NS |
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Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA. |
Jung B |
|
Jung |
Bettina |
B |
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Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. |
Kähönen M |
|
Kähönen |
Mika |
M |
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Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. |
Kamatani Y |
|
Kamatani |
Yoichiro |
Y |
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Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. |
Kanai M |
|
Kanai |
Masahiro |
M |
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Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. |
Kerr SM |
|
Kerr |
Shona M |
SM |
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Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Kiess W |
|
Kiess |
Wieland |
W |
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Centre for Pediatric Research, University of Leipzig, Leipzig, Germany. |
Kleber ME |
|
Kleber |
Marcus E |
ME |
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Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. |
Koenig W |
|
Koenig |
Wolfgang |
W |
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Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany. |
Kooner JS |
|
Kooner |
Jaspal S |
JS |
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National Heart and Lung Institute, Imperial College London, London, UK. |
Körner A |
|
Körner |
Antje |
A |
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Centre for Pediatric Research, University of Leipzig, Leipzig, Germany. |
Kovacs P |
|
Kovacs |
Peter |
P |
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Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany. |
Krämer BK |
|
Krämer |
Bernhard K |
BK |
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Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. |
Kronenberg F |
|
Kronenberg |
Florian |
F |
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Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria. |
Kubo M |
|
Kubo |
Michiaki |
M |
|
RIKEN Centre for Integrative Medical Sciences, Yokohama (Kanagawa), Japan. |
Kühnel B |
|
Kühnel |
Brigitte |
B |
|
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany. |
La Bianca M |
|
La Bianca |
Martina |
M |
|
Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy. |
Lange LA |
|
Lange |
Leslie A |
LA |
|
Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA. |
Lehne B |
|
Lehne |
Benjamin |
B |
|
Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK. |
Lehtimäki T |
|
Lehtimäki |
Terho |
T |
|
Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. |
|
Lifelines Cohort Study |
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|
|
|
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Liu J |
|
Liu |
Jun |
J |
|
Nuffield Department of Population Health, University of Oxford, Oxford, UK. |
Loeffler M |
|
Loeffler |
Markus |
M |
|
LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. |
Loos RJF |
|
Loos |
Ruth J F |
RJF |
|
The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
Lyytikäinen LP |
|
Lyytikäinen |
Leo-Pekka |
LP |
|
Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. |
Magi R |
|
Magi |
Reedik |
R |
|
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. |
Mahajan A |
|
Mahajan |
Anubha |
A |
|
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. |
Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
März W |
|
März |
Winfried |
W |
|
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. |
Mascalzoni D |
|
Mascalzoni |
Deborah |
D |
|
Eurac Research, Institute for Biomedicine, Bolzano, Italy. |
Matsuda K |
|
Matsuda |
Koichi |
K |
|
Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. |
Meisinger C |
|
Meisinger |
Christa |
C |
|
Ludwig-Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany. |
Meitinger T |
|
Meitinger |
Thomas |
T |
|
Institute of Human Genetics, Technische Universität München, Munich, Germany. |
Metspalu A |
|
Metspalu |
Andres |
A |
|
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. |
Milaneschi Y |
|
Milaneschi |
Yuri |
Y |
|
Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands. |
|
V. A. Million Veteran Program |
|
|
|
|
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O'Donnell CJ |
|
O'Donnell |
Christopher J |
CJ |
|
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. |
Wilson OD |
|
Wilson |
Otis D |
OD |
|
Vanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA. |
Gaziano JM |
|
Gaziano |
J Michael |
JM |
|
Massachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA. |
Mishra PP |
|
Mishra |
Pashupati P |
PP |
|
Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. |
Mohlke KL |
|
Mohlke |
Karen L |
KL |
|
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. |
Mononen N |
|
Mononen |
Nina |
N |
|
Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. |
Montgomery GW |
|
Montgomery |
Grant W |
GW |
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University of Queensland, St Lucia, Queensland, Australia. |
Mook-Kanamori DO |
|
Mook-Kanamori |
Dennis O |
DO |
|
Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, the Netherlands. |
Müller-Nurasyid M |
|
Müller-Nurasyid |
Martina |
M |
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Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany. |
Nadkarni GN |
|
Nadkarni |
Girish N |
GN |
|
Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
Nalls MA |
|
Nalls |
Mike A |
MA |
|
Data Tecnica International, Glen Echo, MD, USA. |
Nauck M |
|
Nauck |
Matthias |
M |
|
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. |
Nikus K |
|
Nikus |
Kjell |
K |
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Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. |
Ning B |
|
Ning |
Boting |
B |
|
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. |
Nolte IM |
|
Nolte |
Ilja M |
IM |
|
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Noordam R |
|
Noordam |
Raymond |
R |
|
Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands. |
O'Connell JR |
|
O'Connell |
Jeffrey R |
JR |
|
University of Maryland School of Medicine, Baltimore, MD, USA. |
Olafsson I |
|
Olafsson |
Isleifur |
I |
|
Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland. |
Padmanabhan S |
|
Padmanabhan |
Sandosh |
S |
|
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. |
Penninx BWJH |
|
Penninx |
Brenda W J H |
BWJH |
|
Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands. |
Perls T |
|
Perls |
Thomas |
T |
|
Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA. |
Peters A |
|
Peters |
Annette |
A |
|
German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany. |
Pirastu M |
|
Pirastu |
Mario |
M |
|
Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy. |
Pirastu N |
|
Pirastu |
Nicola |
N |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Pistis G |
|
Pistis |
Giorgio |
G |
|
Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland. |
Polasek O |
|
Polasek |
Ozren |
O |
|
Gen-info Ltd, Zagreb, Croatia. |
Ponte B |
|
Ponte |
Belen |
B |
|
Nephrology Service, Department of Specialties in Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland. |
Porteous DJ |
|
Porteous |
David J |
DJ |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. |
Poulain T |
|
Poulain |
Tanja |
T |
|
LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. |
Preuss MH |
|
Preuss |
Michael H |
MH |
|
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
Rabelink TJ |
|
Rabelink |
Ton J |
TJ |
|
Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Centre, Leiden, the Netherlands. |
Raffield LM |
|
Raffield |
Laura M |
LM |
|
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. |
Raitakari OT |
|
Raitakari |
Olli T |
OT |
|
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. |
Rettig R |
|
Rettig |
Rainer |
R |
|
Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany. |
Rheinberger M |
|
Rheinberger |
Myriam |
M |
|
Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. |
Rice KM |
|
Rice |
Kenneth M |
KM |
|
Department of Biostatistics, University of Washington, Seattle, WA, USA. |
Rizzi F |
|
Rizzi |
Federica |
F |
|
ePhood Scientific Unit, ePhood SRL, Milano, Italy. |
Robino A |
|
Robino |
Antonietta |
A |
|
Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy. |
Rudan I |
|
Rudan |
Igor |
I |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Krajcoviechova A |
|
Krajcoviechova |
Alena |
A |
|
Thomayer Hospital, Prague, Czech Republic. |
Cifkova R |
|
Cifkova |
Renata |
R |
|
Department of Medicine II, First Faculty of Medicine, Charles University, Prague, Czech Republic. |
Rueedi R |
|
Rueedi |
Rico |
R |
|
Swiss Institute of Bioinformatics, Lausanne, Switzerland. |
Ruggiero D |
|
Ruggiero |
Daniela |
D |
|
IRCCS Neuromed, Pozzilli, Italy. |
Ryan KA |
|
Ryan |
Kathleen A |
KA |
|
Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA. |
Saba Y |
|
Saba |
Yasaman |
Y |
|
Molecular Biology and Biochemistry, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria. |
Salvi E |
|
Salvi |
Erika |
E |
|
Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. |
Schmidt H |
|
Schmidt |
Helena |
H |
|
Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria. |
Schmidt R |
|
Schmidt |
Reinhold |
R |
|
Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria. |
Shaffer CM |
|
Shaffer |
Christian M |
CM |
|
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. |
Smith AV |
|
Smith |
Albert V |
AV |
|
Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. |
Smith BH |
|
Smith |
Blair H |
BH |
|
Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. |
Spracklen CN |
|
Spracklen |
Cassandra N |
CN |
|
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. |
Strauch K |
|
Strauch |
Konstantin |
K |
|
Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany. |
Stumvoll M |
|
Stumvoll |
Michael |
M |
|
Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig, Leipzig, Germany. |
Sulem P |
|
Sulem |
Patrick |
P |
|
deCODE Genetics, Amgen Inc., Reykjavik, Iceland. |
Tajuddin SM |
|
Tajuddin |
Salman M |
SM |
|
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA. |
Teren A |
|
Teren |
Andrej |
A |
|
Heart Centre Leipzig, Leipzig, Germany. |
Thiery J |
|
Thiery |
Joachim |
J |
|
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany. |
Thio CHL |
|
Thio |
Chris H L |
CHL |
|
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Thorsteinsdottir U |
|
Thorsteinsdottir |
Unnur |
U |
|
deCODE Genetics, Amgen Inc., Reykjavik, Iceland. |
Toniolo D |
|
Toniolo |
Daniela |
D |
|
San Raffaele Research Institute, Milano, Italy. |
Tönjes A |
|
Tönjes |
Anke |
A |
|
Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany. |
Tremblay J |
|
Tremblay |
Johanne |
J |
|
Centre de Recherche du CHUM, Montreal, Quebec, Canada. |
Uitterlinden AG |
|
Uitterlinden |
André G |
AG |
|
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. |
Vaccargiu S |
|
Vaccargiu |
Simona |
S |
|
Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy. |
van der Harst P |
|
van der Harst |
Pim |
P |
|
Durrer Centre for Cardiovascular Research, the Netherlands Heart Institute, Utrecht, the Netherlands. |
van Duijn CM |
|
van Duijn |
Cornelia M |
CM |
|
Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. |
Verweij N |
|
Verweij |
Niek |
N |
|
Genomics plc, Oxford, UK. |
Völker U |
|
Völker |
Uwe |
U |
|
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. |
Vollenweider P |
|
Vollenweider |
Peter |
P |
|
Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland. |
Waeber G |
|
Waeber |
Gerard |
G |
|
Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland. |
Waldenberger M |
|
Waldenberger |
Melanie |
M |
|
German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany. |
Whitfield JB |
|
Whitfield |
John B |
JB |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Wild SH |
|
Wild |
Sarah H |
SH |
|
Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Wilson JF |
|
Wilson |
James F |
JF |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Yang Q |
|
Yang |
Qiong |
Q |
|
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. |
Zhang W |
|
Zhang |
Weihua |
W |
|
Department of Cardiology, Ealing Hospital, London, UK. |
Zonderman AB |
|
Zonderman |
Alan B |
AB |
|
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA. |
Bochud M |
|
Bochud |
Murielle |
M |
|
Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland. |
Wilson JG |
|
Wilson |
James G |
JG |
|
Department of Physiology and Biophysics, University of Mississippi Medical Centre, Jackson, MS, USA. |
Pendergrass SA |
|
Pendergrass |
Sarah A |
SA |
|
Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA. |
Ho K |
|
Ho |
Kevin |
K |
|
Department of Nephrology, Geisinger, Danville, PA, USA. |
Parsa A |
|
Parsa |
Afshin |
A |
|
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. |
Pramstaller PP |
|
Pramstaller |
Peter P |
PP |
|
Eurac Research, Institute for Biomedicine, Bolzano, Italy. |
Psaty BM |
|
Psaty |
Bruce M |
BM |
|
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. |
Böger CA |
|
Böger |
Carsten A |
CA |
|
Department of Nephrology and Rheumatology, Kliniken Südostbayern AG, Traunstein, Germany. |
Snieder H |
|
Snieder |
Harold |
H |
|
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Butterworth AS |
|
Butterworth |
Adam S |
AS |
|
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. |
Okada Y |
|
Okada |
Yukinori |
Y |
|
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan. |
Edwards TL |
|
Edwards |
Todd L |
TL |
|
Department of Veterans Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. |
Stefansson K |
|
Stefansson |
Kari |
K |
|
deCODE Genetics, Amgen Inc., Reykjavik, Iceland. |
Susztak K |
|
Susztak |
Katalin |
K |
|
Department of Medicine and Genetics, University of Pennsylvania, Philadelphia, PA, USA. |
Scholz M |
|
Scholz |
Markus |
M |
|
LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. |
Heid IM |
|
Heid |
Iris M |
IM |
|
Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. |
Hung AM |
|
Hung |
Adriana M |
AM |
|
Department of Veterans Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. |
Teumer A |
|
Teumer |
Alexander |
A |
|
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. |
Pattaro C |
|
Pattaro |
Cristian |
C |
|
Eurac Research, Institute for Biomedicine, Bolzano, Italy. |
Woodward OM |
|
Woodward |
Owen M |
OM |
|
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA. |
Vitart V |
|
Vitart |
Veronique |
V |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Köttgen A |
|
Köttgen |
Anna |
A |
|
Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de. |
|
INVESTIGATORS |
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JOURNAL |
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VOLUME: |
ISSUE: |
TITLE: Nature genetics |
ISOABBREVIATION: Nat. Genet. |
YEAR: 2019 |
MONTH: Oct |
DAY: 02 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1546-1718 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Nat Genet |
COUNTRY: United States |
ISSNLINKING: 1061-4036 |
NLMUNIQUEID: 9216904 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
R01AR073178-01A1 |
U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
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Postdoctoral Fellowship (17POST3650016) |
American Heart Association (American Heart Association, Inc.) |
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P30 DK090868 |
NIDDK NIH HHS |
United States |
R01 DK114091 |
NIDDK NIH HHS |
United States |
KO 3598/4-1 |
Deutsche Forschungsgemeinschaft (German Research Foundation) |
|
U54GM115428 |
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) |
|
016.186.125 |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) |
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CRC 1140, project number 246781735 |
Deutsche Forschungsgemeinschaft (German Research Foundation) |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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