Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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31578528
TITLE
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
ABSTRACT
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implicated the kidney and liver as the main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF4A. Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major urate transporter, in kidney cells, and that HNF4A p.Thr139Ile is a functional variant. Transcriptional coregulation within and across organs may be a general mechanism underlying the observed pleiotropy between urate and cardiometabolic traits.
DATE PUBLISHED
2019 Oct 02
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2019/01/17
accepted 2019/08/27
entrez 2019/10/04 06:00
pubmed 2019/10/04 06:00
medline 2019/10/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Tin A Tin Adrienne A Welch Centre for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA. atin1@jhu.edu.
Marten J Marten Jonathan J Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Halperin Kuhns VL Halperin Kuhns Victoria L VL Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Li Y Li Yong Y Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Wuttke M Wuttke Matthias M Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Kirsten H Kirsten Holger H LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Sieber KB Sieber Karsten B KB Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Qiu C Qiu Chengxiang C Department of Medicine and Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Gorski M Gorski Mathias M Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Yu Z Yu Zhi Z Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Giri A Giri Ayush A Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
Sveinbjornsson G Sveinbjornsson Gardar G deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
Li M Li Man M Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA.
Chu AY Chu Audrey Y AY Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Hoppmann A Hoppmann Anselm A Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
O'Connor LJ O'Connor Luke J LJ Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Prins B Prins Bram B Strangeways Research Laboratory, University of Cambridge, Cambridge, UK.
Nutile T Nutile Teresa T Institute of Genetics and Biophysics Adriano Buzzati-Traverso-CNR, Naples, Italy.
Noce D Noce Damia D Eurac Research, Institute for Biomedicine, Bolzano, Italy.
Akiyama M Akiyama Masato M Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Cocca M Cocca Massimiliano M Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.
Ghasemi S Ghasemi Sahar S DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
van der Most PJ van der Most Peter J PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Horn K Horn Katrin K LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Xu Y Xu Yizhe Y Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA.
Fuchsberger C Fuchsberger Christian C Eurac Research, Institute for Biomedicine, Bolzano, Italy.
Sedaghat S Sedaghat Sanaz S Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Afaq S Afaq Saima S Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar, Pakistan.
Amin N Amin Najaf N Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Ärnlöv J Ärnlöv Johan J School of Health and Social Studies, Dalarna University, Falun, Sweden.
Bakker SJL Bakker Stephan J L SJL Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Bansal N Bansal Nisha N Kidney Research Institute, University of Washington, Seattle, WA, USA.
Baptista D Baptista Daniela D Cardiology, Geneva University Hospitals, Geneva, Switzerland.
Bergmann S Bergmann Sven S Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa.
Biggs ML Biggs Mary L ML Department of Biostatistics, University of Washington, Seattle, WA, USA.
Biino G Biino Ginevra G Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
Boerwinkle E Boerwinkle Eric E Human Genetics Centre, University of Texas Health Science Centre, Houston, TX, USA.
Bottinger EP Bottinger Erwin P EP Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Boutin TS Boutin Thibaud S TS Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Brumat M Brumat Marco M University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy.
Burkhardt R Burkhardt Ralph R Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
Campana E Campana Eric E University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy.
Campbell A Campbell Archie A Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Campbell H Campbell Harry H Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Carroll RJ Carroll Robert J RJ Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Catamo E Catamo Eulalia E Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.
Chambers JC Chambers John C JC MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Ciullo M Ciullo Marina M IRCCS Neuromed, Pozzilli, Italy.
Concas MP Concas Maria Pina MP Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.
Coresh J Coresh Josef J Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Corre T Corre Tanguy T Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Cusi D Cusi Daniele D Bio4Dreams, Milano, Italy.
Felicita SC Felicita Sala Cinzia SC San Raffaele Research Institute, Milano, Italy.
de Borst MH de Borst Martin H MH Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
De Grandi A De Grandi Alessandro A Eurac Research, Institute for Biomedicine, Bolzano, Italy.
de Mutsert R de Mutsert Renée R Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands.
de Vries APJ de Vries Aiko P J APJ Section of Nephrology, Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands.
Delgado G Delgado Graciela G Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Demirkan A Demirkan Ayşe A Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands.
Devuyst O Devuyst Olivier O Institute of Physiology, University of Zurich, Zurich, Switzerland.
Dittrich K Dittrich Katalin K Centre for Pediatric Research, University of Leipzig, Leipzig, Germany.
Eckardt KU Eckardt Kai-Uwe KU Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Ehret G Ehret Georg G Cardiology, Geneva University Hospitals, Geneva, Switzerland.
Endlich K Endlich Karlhans K Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
Evans MK Evans Michele K MK Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Gansevoort RT Gansevoort Ron T RT Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Gasparini P Gasparini Paolo P University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy.
Giedraitis V Giedraitis Vilmantas V Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden.
Gieger C Gieger Christian C German Center for Diabetes Research, Neuherberg, Germany.
Girotto G Girotto Giorgia G University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy.
Gögele M Gögele Martin M Eurac Research, Institute for Biomedicine, Bolzano, Italy.
Gordon SD Gordon Scott D SD QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Gudbjartsson DF Gudbjartsson Daniel F DF deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
Gudnason V Gudnason Vilmundur V Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
German Chronic Kidney Disease Study
Haller T Haller Toomas T Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Hamet P Hamet Pavel P Medpharmgene, Montreal, Quebec, Canada.
Harris TB Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Hayward C Hayward Caroline C Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Hicks AA Hicks Andrew A AA Eurac Research, Institute for Biomedicine, Bolzano, Italy.
Hofer E Hofer Edith E Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
Holm H Holm Hilma H deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
Huang W Huang Wei W Shanghai Industrial Technology Institute, Shanghai, China.
Hutri-Kähönen N Hutri-Kähönen Nina N Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Hwang SJ Hwang Shih-Jen SJ The Centre for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA, USA.
Ikram MA Ikram M Arfan MA Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Lewis RM Lewis Raychel M RM Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Ingelsson E Ingelsson Erik E Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
Jakobsdottir J Jakobsdottir Johanna J The Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland.
Jonsdottir I Jonsdottir Ingileif I deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
Jonsson H Jonsson Helgi H University of Iceland, Reykjavík, Iceland.
Joshi PK Joshi Peter K PK Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Josyula NS Josyula Navya Shilpa NS Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA.
Jung B Jung Bettina B Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Kähönen M Kähönen Mika M Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Kamatani Y Kamatani Yoichiro Y Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kanai M Kanai Masahiro M Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Kerr SM Kerr Shona M SM Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Kiess W Kiess Wieland W Centre for Pediatric Research, University of Leipzig, Leipzig, Germany.
Kleber ME Kleber Marcus E ME Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Koenig W Koenig Wolfgang W Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany.
Kooner JS Kooner Jaspal S JS National Heart and Lung Institute, Imperial College London, London, UK.
Körner A Körner Antje A Centre for Pediatric Research, University of Leipzig, Leipzig, Germany.
Kovacs P Kovacs Peter P Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Krämer BK Krämer Bernhard K BK Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Kronenberg F Kronenberg Florian F Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Kubo M Kubo Michiaki M RIKEN Centre for Integrative Medical Sciences, Yokohama (Kanagawa), Japan.
Kühnel B Kühnel Brigitte B Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany.
La Bianca M La Bianca Martina M Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.
Lange LA Lange Leslie A LA Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA.
Lehne B Lehne Benjamin B Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Lifelines Cohort Study
Liu J Liu Jun J Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Loeffler M Loeffler Markus M LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Loos RJF Loos Ruth J F RJF The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lyytikäinen LP Lyytikäinen Leo-Pekka LP Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Magi R Magi Reedik R Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mahajan A Mahajan Anubha A Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
März W März Winfried W Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Mascalzoni D Mascalzoni Deborah D Eurac Research, Institute for Biomedicine, Bolzano, Italy.
Matsuda K Matsuda Koichi K Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Meisinger C Meisinger Christa C Ludwig-Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany.
Meitinger T Meitinger Thomas T Institute of Human Genetics, Technische Universität München, Munich, Germany.
Metspalu A Metspalu Andres A Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Milaneschi Y Milaneschi Yuri Y Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
V. A. Million Veteran Program
O'Donnell CJ O'Donnell Christopher J CJ Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Wilson OD Wilson Otis D OD Vanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA.
Gaziano JM Gaziano J Michael JM Massachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.
Mishra PP Mishra Pashupati P PP Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Mohlke KL Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Mononen N Mononen Nina N Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Montgomery GW Montgomery Grant W GW University of Queensland, St Lucia, Queensland, Australia.
Mook-Kanamori DO Mook-Kanamori Dennis O DO Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, the Netherlands.
Müller-Nurasyid M Müller-Nurasyid Martina M Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Nadkarni GN Nadkarni Girish N GN Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nalls MA Nalls Mike A MA Data Tecnica International, Glen Echo, MD, USA.
Nauck M Nauck Matthias M Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Nikus K Nikus Kjell K Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Ning B Ning Boting B Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Noordam R Noordam Raymond R Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands.
O'Connell JR O'Connell Jeffrey R JR University of Maryland School of Medicine, Baltimore, MD, USA.
Olafsson I Olafsson Isleifur I Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland.
Padmanabhan S Padmanabhan Sandosh S Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Perls T Perls Thomas T Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
Peters A Peters Annette A German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.
Pirastu M Pirastu Mario M Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy.
Pirastu N Pirastu Nicola N Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Pistis G Pistis Giorgio G Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
Polasek O Polasek Ozren O Gen-info Ltd, Zagreb, Croatia.
Ponte B Ponte Belen B Nephrology Service, Department of Specialties in Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland.
Porteous DJ Porteous David J DJ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Poulain T Poulain Tanja T LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Preuss MH Preuss Michael H MH The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rabelink TJ Rabelink Ton J TJ Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Centre, Leiden, the Netherlands.
Raffield LM Raffield Laura M LM Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Raitakari OT Raitakari Olli T OT Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Rettig R Rettig Rainer R Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany.
Rheinberger M Rheinberger Myriam M Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Rice KM Rice Kenneth M KM Department of Biostatistics, University of Washington, Seattle, WA, USA.
Rizzi F Rizzi Federica F ePhood Scientific Unit, ePhood SRL, Milano, Italy.
Robino A Robino Antonietta A Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.
Rudan I Rudan Igor I Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Krajcoviechova A Krajcoviechova Alena A Thomayer Hospital, Prague, Czech Republic.
Cifkova R Cifkova Renata R Department of Medicine II, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Rueedi R Rueedi Rico R Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Ruggiero D Ruggiero Daniela D IRCCS Neuromed, Pozzilli, Italy.
Ryan KA Ryan Kathleen A KA Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Saba Y Saba Yasaman Y Molecular Biology and Biochemistry, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Salvi E Salvi Erika E Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Schmidt H Schmidt Helena H Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria.
Schmidt R Schmidt Reinhold R Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Shaffer CM Shaffer Christian M CM Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Smith AV Smith Albert V AV Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Smith BH Smith Blair H BH Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Spracklen CN Spracklen Cassandra N CN Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Strauch K Strauch Konstantin K Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
Stumvoll M Stumvoll Michael M Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig, Leipzig, Germany.
Sulem P Sulem Patrick P deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
Tajuddin SM Tajuddin Salman M SM Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Teren A Teren Andrej A Heart Centre Leipzig, Leipzig, Germany.
Thiery J Thiery Joachim J Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
Thio CHL Thio Chris H L CHL Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Thorsteinsdottir U Thorsteinsdottir Unnur U deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
Toniolo D Toniolo Daniela D San Raffaele Research Institute, Milano, Italy.
Tönjes A Tönjes Anke A Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
Tremblay J Tremblay Johanne J Centre de Recherche du CHUM, Montreal, Quebec, Canada.
Uitterlinden AG Uitterlinden André G AG Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Vaccargiu S Vaccargiu Simona S Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy.
van der Harst P van der Harst Pim P Durrer Centre for Cardiovascular Research, the Netherlands Heart Institute, Utrecht, the Netherlands.
van Duijn CM van Duijn Cornelia M CM Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
Verweij N Verweij Niek N Genomics plc, Oxford, UK.
Völker U Völker Uwe U Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Vollenweider P Vollenweider Peter P Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Waeber G Waeber Gerard G Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Waldenberger M Waldenberger Melanie M German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.
Whitfield JB Whitfield John B JB QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Wild SH Wild Sarah H SH Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Wilson JF Wilson James F JF Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Yang Q Yang Qiong Q Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Zhang W Zhang Weihua W Department of Cardiology, Ealing Hospital, London, UK.
Zonderman AB Zonderman Alan B AB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Bochud M Bochud Murielle M Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Wilson JG Wilson James G JG Department of Physiology and Biophysics, University of Mississippi Medical Centre, Jackson, MS, USA.
Pendergrass SA Pendergrass Sarah A SA Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA.
Ho K Ho Kevin K Department of Nephrology, Geisinger, Danville, PA, USA.
Parsa A Parsa Afshin A Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Pramstaller PP Pramstaller Peter P PP Eurac Research, Institute for Biomedicine, Bolzano, Italy.
Psaty BM Psaty Bruce M BM Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Böger CA Böger Carsten A CA Department of Nephrology and Rheumatology, Kliniken Südostbayern AG, Traunstein, Germany.
Snieder H Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Butterworth AS Butterworth Adam S AS Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Okada Y Okada Yukinori Y Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
Edwards TL Edwards Todd L TL Department of Veterans Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
Stefansson K Stefansson Kari K deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
Susztak K Susztak Katalin K Department of Medicine and Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Scholz M Scholz Markus M LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Heid IM Heid Iris M IM Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Hung AM Hung Adriana M AM Department of Veterans Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
Teumer A Teumer Alexander A DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
Pattaro C Pattaro Cristian C Eurac Research, Institute for Biomedicine, Bolzano, Italy.
Woodward OM Woodward Owen M OM Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Vitart V Vitart Veronique V Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Köttgen A Köttgen Anna A Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2019
MONTH: Oct
DAY: 02
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01AR073178-01A1 U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Postdoctoral Fellowship (17POST3650016) American Heart Association (American Heart Association, Inc.)
P30 DK090868 NIDDK NIH HHS United States
R01 DK114091 NIDDK NIH HHS United States
KO 3598/4-1 Deutsche Forschungsgemeinschaft (German Research Foundation)
U54GM115428 U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
016.186.125 Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research)
CRC 1140, project number 246781735 Deutsche Forschungsgemeinschaft (German Research Foundation)
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's