Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
31471575
TITLE
White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group.
ABSTRACT
Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12-88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Working Group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium. Processing of diffusion tensor imaging (DTI) data and statistical analyses were harmonized across sites and effects were meta-analyzed across studies. We observed subtle, but widespread, lower fractional anisotropy (FA) in adult MDD patients compared with controls in 16 out of 25 WM tracts of interest (Cohen's d between 0.12 and 0.26). The largest differences were observed in the corpus callosum and corona radiata. Widespread higher radial diffusivity (RD) was also observed (all Cohen's d between 0.12 and 0.18). Findings appeared to be driven by patients with recurrent MDD and an adult age of onset of depression. White matter microstructural differences in a smaller sample of adolescent MDD patients and controls did not survive correction for multiple testing. In this coordinated and harmonized multisite DTI study, we showed subtle, but widespread differences in WM microstructure in adult MDD, which may suggest structural disconnectivity in MDD.
DATE PUBLISHED
2019 Aug 30
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/08/23
accepted 2019/05/10
revised 2019/04/15
entrez 2019/09/01 06:00
pubmed 2019/09/01 06:00
medline 2019/09/01 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
van Velzen LS van Velzen Laura S LS Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia. laurasvanvelzen@gmail.com.
Kelly S Kelly Sinead S Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Isaev D Isaev Dmitry D Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Aleman A Aleman Andre A Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Aftanas LI Aftanas Lyubomir I LI Department of Neuroscience, Novosibirsk State University, Novosibirsk, Russia.
Bauer J Bauer Jochen J University of Münster, Institute of Clinical Radiology, Münster, Germany.
Baune BT Baune Bernhard T BT The Florey Institute of Neuroscience and Mental Heatlh, The University of Melbourne, Melbourne, VIC, Australia.
Brak IV Brak Ivan V IV Lab. of Experimental & Translational Neuroscience, Novosibirsk State University, Novosibirsk, Russia.
Carballedo A Carballedo Angela A North Dublin Mental Health Services, Dublin, Ireland.
Connolly CG Connolly Colm G CG Department of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.
Couvy-Duchesne B Couvy-Duchesne Baptiste B Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Cullen KR Cullen Kathryn R KR Department of Psychiatry and Behavioral Sciences, The University of Minnesota, Minneapolis, MN, USA.
Danilenko KV Danilenko Konstantin V KV FSSBI "Scientific Research Institute of Physiology & Basic Medicine", Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia.
Dannlowski U Dannlowski Udo U Department of Psychiatry, University of Münster, Münster, Germany.
Enneking V Enneking Verena V Department of Psychiatry, University of Münster, Münster, Germany.
Filimonova E Filimonova Elena E FSSBI "Scientific Research Institute of Physiology & Basic Medicine", Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia.
Förster K Förster Katharina K Department of Psychiatry, University of Münster, Münster, Germany.
Frodl T Frodl Thomas T German Center for Neurodegenerative Disease, Magdeburg, Germany.
Gotlib IH Gotlib Ian H IH Department of Psychology, Stanford University, Stanford, CA, USA.
Groenewold NA Groenewold Nynke A NA Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Grotegerd D Grotegerd Dominik D Department of Psychiatry, University of Münster, Münster, Germany.
Harris MA Harris Mathew A MA Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Hatton SN Hatton Sean N SN Youth Mental Health Team, Brain and Mind Centre, University of Sydney, Camperdown, Australia.
Hawkins EL Hawkins Emma L EL Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Hickie IB Hickie Ian B IB Youth Mental Health Team, Brain and Mind Centre, University of Sydney, Camperdown, Australia.
Ho TC Ho Tiffany C TC Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA.
Jansen A Jansen Andreas A Department of Psychiatry, University of Marburg, Marburg, Germany.
Kircher T Kircher Tilo T Department of Psychiatry, University of Marburg, Marburg, Germany.
Klimes-Dougan B Klimes-Dougan Bonnie B Department of Psychology, The University of Minnesota, Minneapolis, MN, USA.
Kochunov P Kochunov Peter P Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Krug A Krug Axel A Department of Psychiatry, University of Marburg, Marburg, Germany.
Lagopoulos J Lagopoulos Jim J Sunshine Coast Mind and Neuroscience-Thompson Institute, Birtinya, QLD, Australia.
Lee R Lee Renick R Research Division, Institute of Mental Health, Singapore, Singapore.
Lett TA Lett Tristram A TA Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Li M Li Meng M Department of Neurology, University of Magdeburg, Magdeburg, Germany.
MacMaster FP MacMaster Frank P FP Strategic Clinical Network for Addictions and Mental Health, Calgary, Canada.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
McIntosh AM McIntosh Andrew M AM Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
McLellan Q McLellan Quinn Q Alberta Children's Hospital Research Institute, Calgary, Canada.
Meinert S Meinert Susanne S Department of Psychiatry, University of Münster, Münster, Germany.
Nenadić I Nenadić Igor I Department of Psychiatry, University of Marburg, Marburg, Germany.
Osipov E Osipov Evgeny E Lab. of Experimental & Translational Neuroscience, Novosibirsk State University, Novosibirsk, Russia.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, Amsterdam UMC, The Netherlands.
Portella MJ Portella Maria J MJ Universitat Autònoma de Barcelona, Barcelona, Spain.
Repple J Repple Jonathan J Department of Psychiatry, University of Münster, Münster, Germany.
Roos A Roos Annerine A SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Sacchet MD Sacchet Matthew D MD Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Sämann PG Sämann Philipp G PG Max Planck Institute of Psychiatry, Munich, Germany.
Schnell K Schnell Knut K Department of Psychiatry, University of Heidelberg, Heidelberg, Germany.
Shen X Shen Xueyi X Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Sim K Sim Kang K Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Stein DJ Stein Dan J DJ SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, South Africa.
van Tol MJ van Tol Marie-Jose MJ Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Tomyshev AS Tomyshev Alexander S AS Mental Health Research Center, Moscow, Russia.
Tozzi L Tozzi Leonardo L Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA.
Veer IM Veer Ilya M IM Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Vermeiren R Vermeiren Robert R Institute of Psychology, Leiden University, Leiden, The Netherlands.
Vives-Gilabert Y Vives-Gilabert Yolanda Y Instituto ITACA, Universitat Politècnica de València, València, Spain.
Walter H Walter Henrik H Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Walter M Walter Martin M Department of Psychiatry and Psychotherapy, University of Tübingen, Tubingen, Germany.
van der Wee NJA van der Wee Nic J A NJA Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
van der Werff SJA van der Werff Steven J A SJA Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Schreiner MW Schreiner Melinda Westlund MW Department of Psychology, The University of Minnesota, Minneapolis, MN, USA.
Whalley HC Whalley Heather C HC Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Wright MJ Wright Margaret J MJ Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
Yang TT Yang Tony T TT Department of Psychiatry, University of California, San Francisco, CA, USA.
Zhu A Zhu Alyssa A Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Veltman DJ Veltman Dick J DJ Amsterdam Neuroscience, Amsterdam, The Netherlands.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Schmaal L Schmaal Lianne L Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol. Psychiatry
YEAR: 2019
MONTH: Aug
DAY: 30
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01MH085734 Brain and Behavior Research Foundation (Brain & Behavior Research Foundation)
P41 RR008079 NCRR NIH HHS United States
R01MH59259 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
R37101495 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
0801700 National Science Foundation (NSF)
DGE-1147470 National Science Foundation (NSF)
GENERAL NOTE
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