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PMID |
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TITLE |
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White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group. |
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ABSTRACT |
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Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12-88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Working Group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium. Processing of diffusion tensor imaging (DTI) data and statistical analyses were harmonized across sites and effects were meta-analyzed across studies. We observed subtle, but widespread, lower fractional anisotropy (FA) in adult MDD patients compared with controls in 16 out of 25 WM tracts of interest (Cohen's d between 0.12 and 0.26). The largest differences were observed in the corpus callosum and corona radiata. Widespread higher radial diffusivity (RD) was also observed (all Cohen's d between 0.12 and 0.18). Findings appeared to be driven by patients with recurrent MDD and an adult age of onset of depression. White matter microstructural differences in a smaller sample of adolescent MDD patients and controls did not survive correction for multiple testing. In this coordinated and harmonized multisite DTI study, we showed subtle, but widespread differences in WM microstructure in adult MDD, which may suggest structural disconnectivity in MDD. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2018/08/23 |
accepted |
2019/05/10 |
revised |
2019/04/15 |
entrez |
2019/09/01 06:00 |
pubmed |
2019/09/01 06:00 |
medline |
2019/09/01 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
van Velzen LS |
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van Velzen |
Laura S |
LS |
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Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia. laurasvanvelzen@gmail.com. |
Kelly S |
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Kelly |
Sinead |
S |
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Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. |
Isaev D |
|
Isaev |
Dmitry |
D |
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Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. |
Aleman A |
|
Aleman |
Andre |
A |
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Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. |
Aftanas LI |
|
Aftanas |
Lyubomir I |
LI |
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Department of Neuroscience, Novosibirsk State University, Novosibirsk, Russia. |
Bauer J |
|
Bauer |
Jochen |
J |
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University of Münster, Institute of Clinical Radiology, Münster, Germany. |
Baune BT |
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Baune |
Bernhard T |
BT |
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The Florey Institute of Neuroscience and Mental Heatlh, The University of Melbourne, Melbourne, VIC, Australia. |
Brak IV |
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Brak |
Ivan V |
IV |
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Lab. of Experimental & Translational Neuroscience, Novosibirsk State University, Novosibirsk, Russia. |
Carballedo A |
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Carballedo |
Angela |
A |
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North Dublin Mental Health Services, Dublin, Ireland. |
Connolly CG |
|
Connolly |
Colm G |
CG |
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Department of Biomedical Sciences, Florida State University, Tallahassee, FL, USA. |
Couvy-Duchesne B |
|
Couvy-Duchesne |
Baptiste |
B |
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Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
Cullen KR |
|
Cullen |
Kathryn R |
KR |
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Department of Psychiatry and Behavioral Sciences, The University of Minnesota, Minneapolis, MN, USA. |
Danilenko KV |
|
Danilenko |
Konstantin V |
KV |
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FSSBI "Scientific Research Institute of Physiology & Basic Medicine", Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia. |
Dannlowski U |
|
Dannlowski |
Udo |
U |
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Department of Psychiatry, University of Münster, Münster, Germany. |
Enneking V |
|
Enneking |
Verena |
V |
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Department of Psychiatry, University of Münster, Münster, Germany. |
Filimonova E |
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Filimonova |
Elena |
E |
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FSSBI "Scientific Research Institute of Physiology & Basic Medicine", Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia. |
Förster K |
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Förster |
Katharina |
K |
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Department of Psychiatry, University of Münster, Münster, Germany. |
Frodl T |
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Frodl |
Thomas |
T |
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German Center for Neurodegenerative Disease, Magdeburg, Germany. |
Gotlib IH |
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Gotlib |
Ian H |
IH |
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Department of Psychology, Stanford University, Stanford, CA, USA. |
Groenewold NA |
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Groenewold |
Nynke A |
NA |
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Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. |
Grotegerd D |
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Grotegerd |
Dominik |
D |
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Department of Psychiatry, University of Münster, Münster, Germany. |
Harris MA |
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Harris |
Mathew A |
MA |
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Division of Psychiatry, University of Edinburgh, Edinburgh, UK. |
Hatton SN |
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Hatton |
Sean N |
SN |
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Youth Mental Health Team, Brain and Mind Centre, University of Sydney, Camperdown, Australia. |
Hawkins EL |
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Hawkins |
Emma L |
EL |
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Division of Psychiatry, University of Edinburgh, Edinburgh, UK. |
Hickie IB |
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Hickie |
Ian B |
IB |
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Youth Mental Health Team, Brain and Mind Centre, University of Sydney, Camperdown, Australia. |
Ho TC |
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Ho |
Tiffany C |
TC |
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Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA. |
Jansen A |
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Jansen |
Andreas |
A |
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Department of Psychiatry, University of Marburg, Marburg, Germany. |
Kircher T |
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Kircher |
Tilo |
T |
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Department of Psychiatry, University of Marburg, Marburg, Germany. |
Klimes-Dougan B |
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Klimes-Dougan |
Bonnie |
B |
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Department of Psychology, The University of Minnesota, Minneapolis, MN, USA. |
Kochunov P |
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Kochunov |
Peter |
P |
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Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. |
Krug A |
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Krug |
Axel |
A |
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Department of Psychiatry, University of Marburg, Marburg, Germany. |
Lagopoulos J |
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Lagopoulos |
Jim |
J |
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Sunshine Coast Mind and Neuroscience-Thompson Institute, Birtinya, QLD, Australia. |
Lee R |
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Lee |
Renick |
R |
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Research Division, Institute of Mental Health, Singapore, Singapore. |
Lett TA |
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Lett |
Tristram A |
TA |
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Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. |
Li M |
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Li |
Meng |
M |
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Department of Neurology, University of Magdeburg, Magdeburg, Germany. |
MacMaster FP |
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MacMaster |
Frank P |
FP |
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Strategic Clinical Network for Addictions and Mental Health, Calgary, Canada. |
Martin NG |
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Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
McIntosh AM |
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McIntosh |
Andrew M |
AM |
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Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. |
McLellan Q |
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McLellan |
Quinn |
Q |
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Alberta Children's Hospital Research Institute, Calgary, Canada. |
Meinert S |
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Meinert |
Susanne |
S |
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Department of Psychiatry, University of Münster, Münster, Germany. |
Nenadić I |
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Nenadić |
Igor |
I |
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Department of Psychiatry, University of Marburg, Marburg, Germany. |
Osipov E |
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Osipov |
Evgeny |
E |
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Lab. of Experimental & Translational Neuroscience, Novosibirsk State University, Novosibirsk, Russia. |
Penninx BWJH |
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Penninx |
Brenda W J H |
BWJH |
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Department of Psychiatry, Amsterdam UMC, The Netherlands. |
Portella MJ |
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Portella |
Maria J |
MJ |
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Universitat Autònoma de Barcelona, Barcelona, Spain. |
Repple J |
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Repple |
Jonathan |
J |
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Department of Psychiatry, University of Münster, Münster, Germany. |
Roos A |
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Roos |
Annerine |
A |
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SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa. |
Sacchet MD |
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Sacchet |
Matthew D |
MD |
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Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA. |
Sämann PG |
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Sämann |
Philipp G |
PG |
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Max Planck Institute of Psychiatry, Munich, Germany. |
Schnell K |
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Schnell |
Knut |
K |
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Department of Psychiatry, University of Heidelberg, Heidelberg, Germany. |
Shen X |
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Shen |
Xueyi |
X |
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Division of Psychiatry, University of Edinburgh, Edinburgh, UK. |
Sim K |
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Sim |
Kang |
K |
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Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. |
Stein DJ |
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Stein |
Dan J |
DJ |
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SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, South Africa. |
van Tol MJ |
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van Tol |
Marie-Jose |
MJ |
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Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. |
Tomyshev AS |
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Tomyshev |
Alexander S |
AS |
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Mental Health Research Center, Moscow, Russia. |
Tozzi L |
|
Tozzi |
Leonardo |
L |
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Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA. |
Veer IM |
|
Veer |
Ilya M |
IM |
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Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. |
Vermeiren R |
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Vermeiren |
Robert |
R |
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Institute of Psychology, Leiden University, Leiden, The Netherlands. |
Vives-Gilabert Y |
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Vives-Gilabert |
Yolanda |
Y |
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Instituto ITACA, Universitat Politècnica de València, València, Spain. |
Walter H |
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Walter |
Henrik |
H |
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Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. |
Walter M |
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Walter |
Martin |
M |
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Department of Psychiatry and Psychotherapy, University of Tübingen, Tubingen, Germany. |
van der Wee NJA |
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van der Wee |
Nic J A |
NJA |
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Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands. |
van der Werff SJA |
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van der Werff |
Steven J A |
SJA |
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Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands. |
Schreiner MW |
|
Schreiner |
Melinda Westlund |
MW |
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Department of Psychology, The University of Minnesota, Minneapolis, MN, USA. |
Whalley HC |
|
Whalley |
Heather C |
HC |
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Division of Psychiatry, University of Edinburgh, Edinburgh, UK. |
Wright MJ |
|
Wright |
Margaret J |
MJ |
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Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia. |
Yang TT |
|
Yang |
Tony T |
TT |
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Department of Psychiatry, University of California, San Francisco, CA, USA. |
Zhu A |
|
Zhu |
Alyssa |
A |
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Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. |
Veltman DJ |
|
Veltman |
Dick J |
DJ |
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Amsterdam Neuroscience, Amsterdam, The Netherlands. |
Thompson PM |
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Thompson |
Paul M |
PM |
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Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. |
Jahanshad N |
|
Jahanshad |
Neda |
N |
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Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. |
Schmaal L |
|
Schmaal |
Lianne |
L |
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Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: |
ISSUE: |
TITLE: Molecular psychiatry |
ISOABBREVIATION: Mol. Psychiatry |
YEAR: 2019 |
MONTH: Aug |
DAY: 30 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1476-5578 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Mol Psychiatry |
COUNTRY: England |
ISSNLINKING: 1359-4184 |
NLMUNIQUEID: 9607835 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
R01MH085734 |
Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) |
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P41 RR008079 |
NCRR NIH HHS |
United States |
R01MH59259 |
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) |
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R37101495 |
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) |
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0801700 |
National Science Foundation (NSF) |
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DGE-1147470 |
National Science Foundation (NSF) |
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GENERAL NOTE |
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