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| PMID |
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| TITLE |
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| Genetic Similarity Assessment of Twin-Family Populations by Custom-Designed Genotyping Array. |
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| ABSTRACT |
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| Twin registries often take part in large collaborative projects and are major contributors to genome-wide association (GWA) meta-analysis studies. In this article, we describe genotyping of twin-family populations from Australia, the Midwestern USA (Avera Twin Register), the Netherlands (Netherlands Twin Register), as well as a sample of mothers of twins from Nigeria to assess the extent, if any, of genetic differences between them. Genotyping in all cohorts was done using a custom-designed Illumina Global Screening Array (GSA), optimized to improve imputation quality for population-specific GWA studies. We investigated the degree of genetic similarity between the populations using several measures of population variation with genotype data generated from the GSA. Visualization of principal component analysis (PCA) revealed that the Australian, Dutch and Midwestern American populations exhibit negligible interpopulation stratification when compared to each other, to a reference European population and to globally distant populations. Estimations of fixation indices (FST values) between the Australian, Midwestern American and Netherlands populations suggest minimal genetic differentiation compared to the estimates between each population and a genetically distinct cohort (i.e., samples from Nigeria genotyped on GSA). Thus, results from this study demonstrate that genotype data from the Australian, Dutch and Midwestern American twin-family populations can be reasonably combined for joint-genetic analysis. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2019/08/06 06:00 |
| pubmed |
2019/08/06 06:00 |
| medline |
2019/08/06 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Beck JJ |
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Beck |
Jeffrey J |
JJ |
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Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center,Sioux Falls, SD,USA. |
| Hottenga JJ |
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Hottenga |
Jouke-Jan |
JJ |
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Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit,Amsterdam,the Netherlands. |
| Mbarek H |
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Mbarek |
Hamdi |
H |
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Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit,Amsterdam,the Netherlands. |
| Finnicum CT |
|
Finnicum |
Casey T |
CT |
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Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center,Sioux Falls, SD,USA. |
| Ehli EA |
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Ehli |
Erik A |
EA |
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Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center,Sioux Falls, SD,USA. |
| Hur YM |
|
Hur |
Yoon-Mi |
YM |
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Department of Education, Education Research Institute, Mokpo National University,Jeonnam,South Korea. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute,Brisbane, Queensland,Australia. |
| de Geus EJC |
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de Geus |
Eco J C |
EJC |
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Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit,Amsterdam,the Netherlands. |
| Boomsma DI |
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Boomsma |
Dorret I |
DI |
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Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center,Sioux Falls, SD,USA. |
| Davies GE |
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Davies |
Gareth E |
GE |
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Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center,Sioux Falls, SD,USA. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2019 |
| MONTH: Aug |
| DAY: 05 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Genetic similarity assessment |
| genotyping microarray |
| population genetics |
| population structure |
| principal component analysis |
| twin |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| CHEMICALS |
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