Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
31358974
TITLE
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.
ABSTRACT
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d ) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.
DATE PUBLISHED
2019 Jul 29
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/11/01
accepted 2019/06/11
entrez 2019/07/31 06:00
pubmed 2019/07/31 06:00
medline 2019/07/31 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Evangelou E Evangelou Evangelos E Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Gao H Gao He H MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
Chu C Chu Congying C Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Ntritsos G Ntritsos Georgios G Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Blakeley P Blakeley Paul P NIHR Imperial Biomedical Research Centre, ITMAT Data Science Group, Imperial College London, London, UK.
Butts AR Butts Andrew R AR Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Pazoki R Pazoki Raha R Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Suzuki H Suzuki Hideaki H Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Koskeridis F Koskeridis Fotios F Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Yiorkas AM Yiorkas Andrianos M AM Section of Investigative Medicine, Imperial College London, London, UK.
Karaman I Karaman Ibrahim I UK Dementia Research Institute, Imperial College London, London, UK.
Elliott J Elliott Joshua J Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Luo Q Luo Qiang Q Department of Psychology and the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Aeschbacher S Aeschbacher Stefanie S Cardiology Division, University Hospital Basel, Basel, Switzerland.
Bartz TM Bartz Traci M TM Department of Biostatistics, University of Washington, Seattle, WA, USA.
Baumeister SE Baumeister Sebastian E SE Chair of Epidemiology, Ludwig-Maximilians-Universitat Munchen, UNIKA-T Augsburg, Augsburg, Germany.
Braund PS Braund Peter S PS NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Brown MR Brown Michael R MR Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Brody JA Brody Jennifer A JA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Clarke TK Clarke Toni-Kim TK Department of Psychiatry, University of Edinburgh, Edinburgh, UK.
Dimou N Dimou Niki N Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Homuth G Homuth Georg G Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Jackson AU Jackson Anne U AU Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Kentistou KA Kentistou Katherine A KA Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Joshi PK Joshi Peter K PK Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Lemaitre RN Lemaitre Rozenn N RN Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Lind PA Lind Penelope A PA Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Lyytikäinen LP Lyytikäinen Leo-Pekka LP Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.
Mangino M Mangino Massimo M NIHR Biomedical Research Centre, Guy's and St Thomas Foundation Trust, London, UK.
Milaneschi Y Milaneschi Yuri Y Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Nelson CP Nelson Christopher P CP NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Perälä MM Perälä Mia-Maria MM Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
Polasek O Polasek Ozren O Faculty of Medicine, University of Split, Split, Croatia.
Porteous D Porteous David D Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK.
Ratliff SM Ratliff Scott M SM Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Smith JA Smith Jennifer A JA Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Stančáková A Stančáková Alena A Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Teumer A Teumer Alexander A German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.
Tuominen S Tuominen Samuli S Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Thériault S Thériault Sébastien S Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec City, Quebec, Canada.
Vangipurapu J Vangipurapu Jagadish J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Whitfield JB Whitfield John B JB Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Wood A Wood Alexis A Department of Pediatrics/Nutrition, Baylor College of Medicine, Houston, TX, USA.
Yao J Yao Jie J The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Yu B Yu Bing B Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Zhao W Zhao Wei W Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Arking DE Arking Dan E DE McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Auvinen J Auvinen Juha J Oulunkaari Health Center, Ii, Finland.
Liu C Liu Chunyu C Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Männikkö M Männikkö Minna M Northern Finland Birth Cohorts, Faculty of Medicine, University of Oulu, Oulu, Finland.
Risch L Risch Lorenz L Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
Rotter JI Rotter Jerome I JI The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Snieder H Snieder Harold H Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Veijola J Veijola Juha J Medical research Center Oulu, University and University Hospital of Oulu, Oulu, Finland.
Blakemore AI Blakemore Alexandra I AI Section of Investigative Medicine, Imperial College London, London, UK.
Boehnke M Boehnke Michael M Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Campbell H Campbell Harry H Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Conen D Conen David D Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Eriksson JG Eriksson Johan G JG Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland.
Grabe HJ Grabe Hans J HJ German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany.
Guo X Guo Xiuqing X The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
van der Harst P van der Harst Pim P Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands.
Hartman CA Hartman Catharina A CA Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Hayward C Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Heath AC Heath Andrew C AC Department of Psychiatry, School of Medicine, Washington University in St Louis, St Louis, MO, USA.
Jarvelin MR Jarvelin Marjo-Riitta MR Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.
Kähönen M Kähönen Mika M Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Kardia SLR Kardia Sharon L R SLR Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Kühne M Kühne Michael M Cardiology Division, University Hospital Basel, Basel, Switzerland.
Kuusisto J Kuusisto Johanna J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Laakso M Laakso Markku M Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Lahti J Lahti Jari J Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and LHealth Technology, Tampere University, Tampere, Finland.
McIntosh AM McIntosh Andrew M AM Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK.
Mohlke KL Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Morrison AC Morrison Alanna C AC Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Martin NG Martin Nicholas G NG Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Oldehinkel AJ Oldehinkel Albertine J AJ Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Psaty BM Psaty Bruce M BM Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Raitakari OT Raitakari Olli T OT Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Rudan I Rudan Igor I Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Samani NJ Samani Nilesh J NJ NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Scott LJ Scott Laura J LJ Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Verweij N Verweij Niek N Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Weir DR Weir David R DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Wilson JF Wilson James F JF MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Levy D Levy Daniel D Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Tzoulaki I Tzoulaki Ioanna I MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
Bell JD Bell Jimmy D JD Research Centre for Optimal Health, Department of Life Sciences, University of Westminster, London, UK.
Matthews PM Matthews Paul M PM UK Dementia Research Institute, Imperial College London, London, UK.
Rothenfluh A Rothenfluh Adrian A Departments of Psychiatry, Neurobiology & Anatomy, Human Genetics, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Desrivières S Desrivières Sylvane S Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Schumann G Schumann Gunter G PONS Research Group, Dept of Psychiatry and Psychotherapy, Campus Charite Mitte, Humboldt University, Berlin, Germany and Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, P.R. China. gunter.schumann@kcl.ac.uk.
Elliott P Elliott Paul P Health Data Research UK London Substantive Site, London, UK. p.elliott@imperial.ac.uk.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Nature human behaviour
ISOABBREVIATION: Nat Hum Behav
YEAR: 2019
MONTH: Jul
DAY: 29
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2397-3374
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Hum Behav
COUNTRY: England
ISSNLINKING: 2397-3374
NLMUNIQUEID: 101697750
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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GRANTID AGENCY COUNTRY
MR/L01341X/1 Medical Research Council United Kingdom
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