|
PMID |
|
|
TITLE |
|
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. |
|
ABSTRACT |
|
|
|
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d ) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia. |
|
DATE PUBLISHED |
|
|
HISTORY |
|
PUBSTATUS |
PUBSTATUSDATE |
received |
2018/11/01 |
accepted |
2019/06/11 |
entrez |
2019/07/31 06:00 |
pubmed |
2019/07/31 06:00 |
medline |
2019/07/31 06:00 |
|
AUTHORS |
|
NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Evangelou E |
|
Evangelou |
Evangelos |
E |
|
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. |
Gao H |
|
Gao |
He |
H |
|
MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. |
Chu C |
|
Chu |
Congying |
C |
|
Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
Ntritsos G |
|
Ntritsos |
Georgios |
G |
|
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. |
Blakeley P |
|
Blakeley |
Paul |
P |
|
NIHR Imperial Biomedical Research Centre, ITMAT Data Science Group, Imperial College London, London, UK. |
Butts AR |
|
Butts |
Andrew R |
AR |
|
Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA. |
Pazoki R |
|
Pazoki |
Raha |
R |
|
Department of Epidemiology and Biostatistics, Imperial College London, London, UK. |
Suzuki H |
|
Suzuki |
Hideaki |
H |
|
Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. |
Koskeridis F |
|
Koskeridis |
Fotios |
F |
|
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. |
Yiorkas AM |
|
Yiorkas |
Andrianos M |
AM |
|
Section of Investigative Medicine, Imperial College London, London, UK. |
Karaman I |
|
Karaman |
Ibrahim |
I |
|
UK Dementia Research Institute, Imperial College London, London, UK. |
Elliott J |
|
Elliott |
Joshua |
J |
|
Department of Epidemiology and Biostatistics, Imperial College London, London, UK. |
Luo Q |
|
Luo |
Qiang |
Q |
|
Department of Psychology and the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. |
Aeschbacher S |
|
Aeschbacher |
Stefanie |
S |
|
Cardiology Division, University Hospital Basel, Basel, Switzerland. |
Bartz TM |
|
Bartz |
Traci M |
TM |
|
Department of Biostatistics, University of Washington, Seattle, WA, USA. |
Baumeister SE |
|
Baumeister |
Sebastian E |
SE |
|
Chair of Epidemiology, Ludwig-Maximilians-Universitat Munchen, UNIKA-T Augsburg, Augsburg, Germany. |
Braund PS |
|
Braund |
Peter S |
PS |
|
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK. |
Brown MR |
|
Brown |
Michael R |
MR |
|
Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. |
Brody JA |
|
Brody |
Jennifer A |
JA |
|
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. |
Clarke TK |
|
Clarke |
Toni-Kim |
TK |
|
Department of Psychiatry, University of Edinburgh, Edinburgh, UK. |
Dimou N |
|
Dimou |
Niki |
N |
|
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. |
Faul JD |
|
Faul |
Jessica D |
JD |
|
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. |
Homuth G |
|
Homuth |
Georg |
G |
|
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. |
Jackson AU |
|
Jackson |
Anne U |
AU |
|
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. |
Kentistou KA |
|
Kentistou |
Katherine A |
KA |
|
Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK. |
Joshi PK |
|
Joshi |
Peter K |
PK |
|
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Lemaitre RN |
|
Lemaitre |
Rozenn N |
RN |
|
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. |
Lind PA |
|
Lind |
Penelope A |
PA |
|
Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Lyytikäinen LP |
|
Lyytikäinen |
Leo-Pekka |
LP |
|
Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland. |
Mangino M |
|
Mangino |
Massimo |
M |
|
NIHR Biomedical Research Centre, Guy's and St Thomas Foundation Trust, London, UK. |
Milaneschi Y |
|
Milaneschi |
Yuri |
Y |
|
Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands. |
Nelson CP |
|
Nelson |
Christopher P |
CP |
|
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK. |
Nolte IM |
|
Nolte |
Ilja M |
IM |
|
Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. |
Perälä MM |
|
Perälä |
Mia-Maria |
MM |
|
Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland. |
Polasek O |
|
Polasek |
Ozren |
O |
|
Faculty of Medicine, University of Split, Split, Croatia. |
Porteous D |
|
Porteous |
David |
D |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK. |
Ratliff SM |
|
Ratliff |
Scott M |
SM |
|
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA. |
Smith JA |
|
Smith |
Jennifer A |
JA |
|
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA. |
Stančáková A |
|
Stančáková |
Alena |
A |
|
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. |
Teumer A |
|
Teumer |
Alexander |
A |
|
German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany. |
Tuominen S |
|
Tuominen |
Samuli |
S |
|
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland. |
Thériault S |
|
Thériault |
Sébastien |
S |
|
Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec City, Quebec, Canada. |
Vangipurapu J |
|
Vangipurapu |
Jagadish |
J |
|
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. |
Whitfield JB |
|
Whitfield |
John B |
JB |
|
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Wood A |
|
Wood |
Alexis |
A |
|
Department of Pediatrics/Nutrition, Baylor College of Medicine, Houston, TX, USA. |
Yao J |
|
Yao |
Jie |
J |
|
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. |
Yu B |
|
Yu |
Bing |
B |
|
Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. |
Zhao W |
|
Zhao |
Wei |
W |
|
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA. |
Arking DE |
|
Arking |
Dan E |
DE |
|
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. |
Auvinen J |
|
Auvinen |
Juha |
J |
|
Oulunkaari Health Center, Ii, Finland. |
Liu C |
|
Liu |
Chunyu |
C |
|
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. |
Männikkö M |
|
Männikkö |
Minna |
M |
|
Northern Finland Birth Cohorts, Faculty of Medicine, University of Oulu, Oulu, Finland. |
Risch L |
|
Risch |
Lorenz |
L |
|
Private University of the Principality of Liechtenstein, Triesen, Liechtenstein. |
Rotter JI |
|
Rotter |
Jerome I |
JI |
|
The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. |
Snieder H |
|
Snieder |
Harold |
H |
|
Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. |
Veijola J |
|
Veijola |
Juha |
J |
|
Medical research Center Oulu, University and University Hospital of Oulu, Oulu, Finland. |
Blakemore AI |
|
Blakemore |
Alexandra I |
AI |
|
Section of Investigative Medicine, Imperial College London, London, UK. |
Boehnke M |
|
Boehnke |
Michael |
M |
|
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. |
Campbell H |
|
Campbell |
Harry |
H |
|
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Conen D |
|
Conen |
David |
D |
|
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada. |
Eriksson JG |
|
Eriksson |
Johan G |
JG |
|
Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland. |
Grabe HJ |
|
Grabe |
Hans J |
HJ |
|
German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany. |
Guo X |
|
Guo |
Xiuqing |
X |
|
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. |
van der Harst P |
|
van der Harst |
Pim |
P |
|
Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands. |
Hartman CA |
|
Hartman |
Catharina A |
CA |
|
Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. |
Hayward C |
|
Hayward |
Caroline |
C |
|
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK. |
Heath AC |
|
Heath |
Andrew C |
AC |
|
Department of Psychiatry, School of Medicine, Washington University in St Louis, St Louis, MO, USA. |
Jarvelin MR |
|
Jarvelin |
Marjo-Riitta |
MR |
|
Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK. |
Kähönen M |
|
Kähönen |
Mika |
M |
|
Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. |
Kardia SLR |
|
Kardia |
Sharon L R |
SLR |
|
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA. |
Kühne M |
|
Kühne |
Michael |
M |
|
Cardiology Division, University Hospital Basel, Basel, Switzerland. |
Kuusisto J |
|
Kuusisto |
Johanna |
J |
|
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. |
Laakso M |
|
Laakso |
Markku |
M |
|
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. |
Lahti J |
|
Lahti |
Jari |
J |
|
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland. |
Lehtimäki T |
|
Lehtimäki |
Terho |
T |
|
Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and LHealth Technology, Tampere University, Tampere, Finland. |
McIntosh AM |
|
McIntosh |
Andrew M |
AM |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK. |
Mohlke KL |
|
Mohlke |
Karen L |
KL |
|
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. |
Morrison AC |
|
Morrison |
Alanna C |
AC |
|
Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. |
Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Oldehinkel AJ |
|
Oldehinkel |
Albertine J |
AJ |
|
Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. |
Penninx BWJH |
|
Penninx |
Brenda W J H |
BWJH |
|
Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands. |
Psaty BM |
|
Psaty |
Bruce M |
BM |
|
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. |
Raitakari OT |
|
Raitakari |
Olli T |
OT |
|
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. |
Rudan I |
|
Rudan |
Igor |
I |
|
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Samani NJ |
|
Samani |
Nilesh J |
NJ |
|
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK. |
Scott LJ |
|
Scott |
Laura J |
LJ |
|
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. |
Spector TD |
|
Spector |
Tim D |
TD |
|
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. |
Verweij N |
|
Verweij |
Niek |
N |
|
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. |
Weir DR |
|
Weir |
David R |
DR |
|
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. |
Wilson JF |
|
Wilson |
James F |
JF |
|
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK. |
Levy D |
|
Levy |
Daniel |
D |
|
Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. |
Tzoulaki I |
|
Tzoulaki |
Ioanna |
I |
|
MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. |
Bell JD |
|
Bell |
Jimmy D |
JD |
|
Research Centre for Optimal Health, Department of Life Sciences, University of Westminster, London, UK. |
Matthews PM |
|
Matthews |
Paul M |
PM |
|
UK Dementia Research Institute, Imperial College London, London, UK. |
Rothenfluh A |
|
Rothenfluh |
Adrian |
A |
|
Departments of Psychiatry, Neurobiology & Anatomy, Human Genetics, School of Medicine, University of Utah, Salt Lake City, UT, USA. |
Desrivières S |
|
Desrivières |
Sylvane |
S |
|
Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
Schumann G |
|
Schumann |
Gunter |
G |
|
PONS Research Group, Dept of Psychiatry and Psychotherapy, Campus Charite Mitte, Humboldt University, Berlin, Germany and Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, P.R. China. gunter.schumann@kcl.ac.uk. |
Elliott P |
|
Elliott |
Paul |
P |
|
Health Data Research UK London Substantive Site, London, UK. p.elliott@imperial.ac.uk. |
|
INVESTIGATORS |
|
|
JOURNAL |
|
VOLUME: |
ISSUE: |
TITLE: Nature human behaviour |
ISOABBREVIATION: Nat Hum Behav |
YEAR: 2019 |
MONTH: Jul |
DAY: 29 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 2397-3374 |
ISSNTYPE: Electronic |
|
MEDLINE JOURNAL |
|
MEDLINETA: Nat Hum Behav |
COUNTRY: England |
ISSNLINKING: 2397-3374 |
NLMUNIQUEID: 101697750 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
|
COMMENTS AND CORRECTIONS |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
MR/L01341X/1 |
Medical Research Council |
United Kingdom |
|
GENERAL NOTE |
|
|
KEYWORDS |
|
|
MESH HEADINGS |
|
|
SUPPLEMENTARY MESH |
|
|
GENE SYMBOLS |
|
|
CHEMICALS |
|
|
OTHER ID's |
|
|
|