Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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31308545
TITLE
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.
ABSTRACT
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness , affecting 0.9-4% of women and 0.3% of men , with twin-based heritability estimates of 50-60% . Mortality rates are higher than those in other psychiatric disorders , and outcomes are unacceptably poor . Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI) and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
DATE PUBLISHED
2019 08
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/06/09
accepted 2019/05/14
pubmed 2019/07/17 06:00
medline 2020/01/29 06:00
entrez 2019/07/17 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Watson HJ Watson Hunna J HJ School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia.
Yilmaz Z Yilmaz Zeynep Z Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Thornton LM Thornton Laura M LM Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Hübel C Hübel Christopher C Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Coleman JRI Coleman Jonathan R I JRI National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK.
Gaspar HA Gaspar Héléna A HA National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK.
Bryois J Bryois Julien J Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hinney A Hinney Anke A Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Leppä VM Leppä Virpi M VM Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mattheisen M Mattheisen Manuel M Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Ripke S Ripke Stephan S Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.
Yao S Yao Shuyang S Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Giusti-Rodríguez P Giusti-Rodríguez Paola P Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Anorexia Nervosa Genetics Initiative
Hanscombe KB Hanscombe Ken B KB Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London, UK.
Purves KL Purves Kirstin L KL Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
Eating Disorders Working Group of the Psychiatric Genomics Consortium
Adan RAH Adan Roger A H RAH Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Alfredsson L Alfredsson Lars L Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Ando T Ando Tetsuya T Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Andreassen OA Andreassen Ole A OA NORMENT KG Jebsen Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway.
Baker JH Baker Jessica H JH Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Berrettini WH Berrettini Wade H WH Department of Psychiatry, Center for Neurobiology and Behavior, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Boehm I Boehm Ilka I Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Boni C Boni Claudette C INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
Perica VB Perica Vesna Boraska VB Department of Medical Biology, School of Medicine, University of Split, Split, Croatia.
Buehren K Buehren Katharina K Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Burghardt R Burghardt Roland R Department of Child and Adolescent Psychiatry, Klinikum Frankfurt/Oder, Frankfurt, Germany.
Cassina M Cassina Matteo M Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
Cichon S Cichon Sven S Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Clementi M Clementi Maurizio M Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
Cone RD Cone Roger D RD Life Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Courtet P Courtet Philippe P Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France.
Crow S Crow Scott S Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
Crowley JJ Crowley James J JJ Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Danner UN Danner Unna N UN Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands.
Davis OSP Davis Oliver S P OSP School of Social and Community Medicine, University of Bristol, Bristol, UK.
de Zwaan M de Zwaan Martina M Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany.
Dedoussis G Dedoussis George G Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Degortes D Degortes Daniela D Department of Neurosciences, University of Padova, Padova, Italy.
DeSocio JE DeSocio Janiece E JE College of Nursing, Seattle University, Seattle, WA, USA.
Dick DM Dick Danielle M DM Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Dikeos D Dikeos Dimitris D Department of Psychiatry, Athens University Medical School, Athens University, Athens, Greece.
Dina C Dina Christian C L'institut du thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.
Dmitrzak-Weglarz M Dmitrzak-Weglarz Monika M Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Docampo E Docampo Elisa E Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Duncan LE Duncan Laramie E LE Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Egberts K Egberts Karin K Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Centre for Mental Health, Würzburg, Germany.
Ehrlich S Ehrlich Stefan S Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Escaramís G Escaramís Geòrgia G Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Esko T Esko Tõnu T Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Estivill X Estivill Xavier X Genomics and Disease, Bioinformatics and Genomics Programme, Centre for Genomic Regulation, Barcelona, Spain.
Farmer A Farmer Anne A Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
Favaro A Favaro Angela A Department of Neurosciences, University of Padova, Padova, Italy.
Fernández-Aranda F Fernández-Aranda Fernando F Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.
Fichter MM Fichter Manfred M MM Schön Klinik Roseneck affiliated with the Medical Faculty of the University of Munich (LMU), Munich, Germany.
Fischer K Fischer Krista K Estonian Genome Center, University of Tartu, Tartu, Estonia.
Föcker M Föcker Manuel M Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Foretova L Foretova Lenka L Department of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Forstner AJ Forstner Andreas J AJ Department of Biomedicine, University of Basel, Basel, Switzerland.
Forzan M Forzan Monica M Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
Franklin CS Franklin Christopher S CS Wellcome Sanger Institute, Hinxton, UK.
Gallinger S Gallinger Steven S Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Giegling I Giegling Ina I Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, Germany.
Giuranna J Giuranna Johanna J Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Gonidakis F Gonidakis Fragiskos F First Psychiatric Department, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece.
Gorwood P Gorwood Philip P CMME, Hôpital Sainte-Anne (GHU Paris Psychiatrie et Neurosciences), Paris Descartes University, Paris, France.
Mayora MG Mayora Monica Gratacos MG Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Guillaume S Guillaume Sébastien S Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France.
Guo Y Guo Yiran Y Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Hakonarson H Hakonarson Hakon H Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hatzikotoulas K Hatzikotoulas Konstantinos K Institute of Translational Genomics, Helmholtz Zentrum München, Neuherberg, Germany.
Hauser J Hauser Joanna J Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Hebebrand J Hebebrand Johannes J Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Helder SG Helder Sietske G SG Zorg op Orde, Leidschendam, the Netherlands.
Herms S Herms Stefan S Department of Biomedicine, University of Basel, Basel, Switzerland.
Herpertz-Dahlmann B Herpertz-Dahlmann Beate B Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Herzog W Herzog Wolfgang W Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.
Huckins LM Huckins Laura M LM Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hudson JI Hudson James I JI Biological Psychiatry Laboratory, McLean Hospital/Harvard Medical School, Boston, MA, USA.
Imgart H Imgart Hartmut H Eating Disorders Unit, Parklandklinik, Bad Wildungen, Germany.
Inoko H Inoko Hidetoshi H Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, Isehara, Japan.
Janout V Janout Vladimir V Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic.
Jiménez-Murcia S Jiménez-Murcia Susana S Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.
Julià A Julià Antonio A Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.
Kalsi G Kalsi Gursharan G Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
Kaminská D Kaminská Deborah D Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Kaprio J Kaprio Jaakko J Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Karhunen L Karhunen Leila L Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Karwautz A Karwautz Andreas A Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
Kas MJH Kas Martien J H MJH Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.
Kennedy JL Kennedy James L JL Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Keski-Rahkonen A Keski-Rahkonen Anna A Department of Public Health, University of Helsinki, Helsinki, Finland.
Kiezebrink K Kiezebrink Kirsty K Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
Kim YR Kim Youl-Ri YR Department of Psychiatry, Seoul Paik Hospital, Inje University, Seoul, Korea.
Klareskog L Klareskog Lars L Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Klump KL Klump Kelly L KL Department of Psychology, Michigan State University, East Lansing, MI, USA.
Knudsen GPS Knudsen Gun Peggy S GPS Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
La Via MC La Via Maria C MC Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Le Hellard S Le Hellard Stephanie S Department of Clinical Medicine, Laboratory Building, Haukeland University Hospital, Bergen, Norway.
Levitan RD Levitan Robert D RD Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Li D Li Dong D Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Lilenfeld L Lilenfeld Lisa L American School of Professional Psychology, Argosy University, Northern Virginia, Arlington, VA, USA.
Lin BD Lin Bochao Danae BD Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
Lissowska J Lissowska Jolanta J Department of Cancer Epidemiology and Prevention, M Skłodowska-Curie Cancer Center - Oncology Center, Warsaw, Poland.
Luykx J Luykx Jurjen J Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
Magistretti PJ Magistretti Pierre J PJ Department of Psychiatry, University of Lausanne-University Hospital of Lausanne (UNIL-CHUV), Lausanne, Switzerland.
Maj M Maj Mario M Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Mannik K Mannik Katrin K Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Marsal S Marsal Sara S Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.
Marshall CR Marshall Christian R CR Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Mattingsdal M Mattingsdal Morten M NORMENT KG Jebsen Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway.
McDevitt S McDevitt Sara S HSE National Clinical Programme for Eating Disorders, Cork, Ireland.
McGuffin P McGuffin Peter P Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
Metspalu A Metspalu Andres A Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Meulenbelt I Meulenbelt Ingrid I Department of Biomedical Data Science, Leiden University Medical Centre, Leiden, the Netherlands.
Micali N Micali Nadia N Great Ormond Street Institute of Child Health, University College London, London, UK.
Mitchell K Mitchell Karen K National Center for PTSD, VA Boston Healthcare System, Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Monteleone AM Monteleone Alessio Maria AM Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Monteleone P Monteleone Palmiero P Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.
Munn-Chernoff MA Munn-Chernoff Melissa A MA Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nacmias B Nacmias Benedetta B Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
Navratilova M Navratilova Marie M Department of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Ntalla I Ntalla Ioanna I Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
O'Toole JK O'Toole Julie K JK Kartini Clinic, Portland, OR, USA.
Ophoff RA Ophoff Roel A RA Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.
Padyukov L Padyukov Leonid L Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Palotie A Palotie Aarno A Center for Human Genome Research at the Massachusetts General Hospital, Boston, MA, USA.
Pantel J Pantel Jacques J INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
Papezova H Papezova Hana H Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Pinto D Pinto Dalila D Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rabionet R Rabionet Raquel R Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain.
Raevuori A Raevuori Anu A Department of Public Health, University of Helsinki, Helsinki, Finland.
Ramoz N Ramoz Nicolas N INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
Reichborn-Kjennerud T Reichborn-Kjennerud Ted T Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ricca V Ricca Valdo V Department of Health Science, University of Florence, Florence, Italy.
Ripatti S Ripatti Samuli S Institute for Molecular Medicine Finland (FIMM), HiLIFE Unit, University of Helsinki, Helsinki, Finland.
Ritschel F Ritschel Franziska F Eating Disorders Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Roberts M Roberts Marion M Faculty of Medicine & Health Sciences, University of Aukland, Aukland, New Zealand.
Rotondo A Rotondo Alessandro A Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnologies, University of Pisa, Pisa, Italy.
Rujescu D Rujescu Dan D Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, Germany.
Rybakowski F Rybakowski Filip F Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Santonastaso P Santonastaso Paolo P Department of Neurosciences, Padua Neuroscience Center, University of Padova, Padova, Italy.
Scherag A Scherag André A Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany.
Scherer SW Scherer Stephen W SW Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Schmidt U Schmidt Ulrike U Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, London, UK.
Schork NJ Schork Nicholas J NJ J. Craig Venter Institute (JCVI), La Jolla, CA, USA.
Schosser A Schosser Alexandra A Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Seitz J Seitz Jochen J Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Slachtova L Slachtova Lenka L Department of Pediatrics and Center of Applied Genomics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Slagboom PE Slagboom P Eline PE Department of Biomedical Data Science, Leiden University Medical Centre, Leiden, the Netherlands.
Slof-Op 't Landt MCT Slof-Op 't Landt Margarita C T MCT Department of Psychiatry, Leiden University Medical Centre, Leiden, the Netherlands.
Slopien A Slopien Agnieszka A Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Sorbi S Sorbi Sandro S IRCSS Fondazione Don Carlo Gnocchi, Florence, Italy.
Świątkowska B Świątkowska Beata B Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Szatkiewicz JP Szatkiewicz Jin P JP Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tachmazidou I Tachmazidou Ioanna I Wellcome Sanger Institute, Hinxton, UK.
Tenconi E Tenconi Elena E Department of Neurosciences, University of Padova, Padova, Italy.
Tortorella A Tortorella Alfonso A Department of Psychiatry, University of Perugia, Perugia, Italy.
Tozzi F Tozzi Federica F Brain Sciences Department, Stremble Ventures, Limassol, Cyprus.
Treasure J Treasure Janet J Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, London, UK.
Tsitsika A Tsitsika Artemis A Adolescent Health Unit, Second Department of Pediatrics, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece.
Tyszkiewicz-Nwafor M Tyszkiewicz-Nwafor Marta M Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Tziouvas K Tziouvas Konstantinos K Pediatric Intensive Care Unit, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece.
van Elburg AA van Elburg Annemarie A AA Faculty of Social and Behavioral Sciences, Utrecht University, Utrecht, the Netherlands.
van Furth EF van Furth Eric F EF Department of Psychiatry, Leiden University Medical Centre, Leiden, the Netherlands.
Wagner G Wagner Gudrun G Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
Walton E Walton Esther E Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Widen E Widen Elisabeth E Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Zeggini E Zeggini Eleftheria E Institute of Translational Genomics, Helmholtz Zentrum München, Neuherberg, Germany.
Zerwas S Zerwas Stephanie S Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Zipfel S Zipfel Stephan S Department of Internal Medicine VI, Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tuebingen, Tuebingen, Germany.
Bergen AW Bergen Andrew W AW Oregon Research Institute, Eugene, OR, USA.
Boden JM Boden Joseph M JM Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand.
Brandt H Brandt Harry H The Center for Eating Disorders at Sheppard Pratt, Baltimore, MD, USA.
Crawford S Crawford Steven S The Center for Eating Disorders at Sheppard Pratt, Baltimore, MD, USA.
Halmi KA Halmi Katherine A KA Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA.
Horwood LJ Horwood L John LJ Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand.
Johnson C Johnson Craig C Eating Recovery Center, Denver, CO, USA.
Kaplan AS Kaplan Allan S AS Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Kaye WH Kaye Walter H WH Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Mitchell JE Mitchell James E JE Department of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA.
Olsen CM Olsen Catherine M CM QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Pearson JF Pearson John F JF Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Strober M Strober Michael M David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Werge T Werge Thomas T Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Whiteman DC Whiteman David C DC QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Woodside DB Woodside D Blake DB Program for Eating Disorders, University Health Network, Toronto, Ontario, Canada.
Stuber GD Stuber Garret D GD Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Gordon S Gordon Scott S QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Grove J Grove Jakob J Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
Henders AK Henders Anjali K AK Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Juréus A Juréus Anders A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kirk KM Kirk Katherine M KM QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Larsen JT Larsen Janne T JT Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark.
Parker R Parker Richard R QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Petersen L Petersen Liselotte L Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark.
Jordan J Jordan Jennifer J Canterbury District Health Board, Christchurch, New Zealand.
Kennedy M Kennedy Martin M Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Montgomery GW Montgomery Grant W GW Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Wade TD Wade Tracey D TD School of Psychology, Flinders University, Adelaide, South Australia, Australia.
Birgegård A Birgegård Andreas A Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden.
Lichtenstein P Lichtenstein Paul P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Norring C Norring Claes C Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden.
Landén M Landén Mikael M Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Mortensen PB Mortensen Preben Bo PB Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark.
Sullivan PF Sullivan Patrick F PF Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Breen G Breen Gerome G National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK.
Bulik CM Bulik Cynthia M CM Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. cynthia_bulik@med.unc.edu.
INVESTIGATORS
JOURNAL
VOLUME: 51
ISSUE: 8
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2019
MONTH: 08
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R21 MH104831 NIMH NIH HHS United States
K01 AA025113 NIAAA NIH HHS United States
U01 MH109536 NIMH NIH HHS United States
K01 MH109772 NIMH NIH HHS United States
U01 HG006830 NHGRI NIH HHS United States
K01 MH109782 NIMH NIH HHS United States
K01 MH106675 NIMH NIH HHS United States
R01 MH106611 NIMH NIH HHS United States
R01 MH092793 NIMH NIH HHS United States
U01 MH109528 NIMH NIH HHS United States
R21 MH115397 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Anorexia Nervosa pathology
Body Mass Index pathology
Case-Control Studies pathology
Female pathology
Genetic Predisposition to Disease pathology
Genome-Wide Association Study pathology
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