|
|
| PMID |
|
|
| TITLE |
|
| Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. |
| METHODS |
NlmCategory: METHODS |
| Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472). |
| RESULTS |
NlmCategory: RESULTS |
| Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472). Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95% confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95% CI = 2.15, 2.86; other EDs: OR = 4.66, 95% CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95% CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95% CI = .31, .42) than with AN (.14, 95% CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472). Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95% confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95% CI = 2.15, 2.86; other EDs: OR = 4.66, 95% CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95% CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95% CI = .31, .42) than with AN (.14, 95% CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes. We observed stronger genetic association with ADHD for non-AN EDs than for AN, highlighting specific genetic correlation beyond a general genetic factor across psychiatric disorders. |
| Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
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| DATE PUBLISHED |
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|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2019/01/30 |
| revised |
2019/04/15 |
| accepted |
2019/04/22 |
| entrez |
2019/07/15 06:00 |
| pubmed |
2019/07/16 06:00 |
| medline |
2019/07/16 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Yao S |
|
Yao |
Shuyang |
S |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Electronic address: shuyang.yao@ki.se. |
| Kuja-Halkola R |
|
Kuja-Halkola |
Ralf |
R |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Martin J |
|
Martin |
Joanna |
J |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. |
| Lu Y |
|
Lu |
Yi |
Y |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Lichtenstein P |
|
Lichtenstein |
Paul |
P |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Norring C |
|
Norring |
Claes |
C |
|
Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden. |
| Birgegård A |
|
Birgegård |
Andreas |
A |
|
Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden. |
| Yilmaz Z |
|
Yilmaz |
Zeynep |
Z |
|
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. |
| Hübel C |
|
Hübel |
Christopher |
C |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. |
| Watson H |
|
Watson |
Hunna |
H |
|
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. |
| Baker J |
|
Baker |
Jessica |
J |
|
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. |
| Almqvist C |
|
Almqvist |
Catarina |
C |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. |
|
Eating Disorders Working Group of the Psychiatric Genomics Consortium |
|
|
|
|
|
| Thornton LM |
|
Thornton |
Laura M |
LM |
|
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. |
| Magnusson PK |
|
Magnusson |
Patrik K |
PK |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Bulik CM |
|
Bulik |
Cynthia M |
CM |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. |
| Larsson H |
|
Larsson |
Henrik |
H |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; School of Medical Sciences, Örebro University, Örebro, Sweden. |
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Adan |
Roger |
R |
|
| Ando |
Tetsuya |
T |
|
| Baker |
Jessica |
J |
|
| Bergen |
Andrew |
A |
|
| Berrettini |
Wade |
W |
|
| Birgegård |
Andreas |
A |
|
| Boni |
Claudette |
C |
|
| Boraska Perica |
Vesna |
V |
|
| Brandt |
Harry |
H |
|
| Burghardt |
Roland |
R |
|
| Cassina |
Matteo |
M |
|
| Cesta |
Carolyn |
C |
|
| Clementi |
Maurizio |
M |
|
| Coleman |
Joni |
J |
|
| Cone |
Roger |
R |
|
| Courtet |
Philippe |
P |
|
| Crawford |
Steven |
S |
|
| Crow |
Scott |
S |
|
| Crowley |
James |
J |
|
| Danner |
Unna |
U |
|
| Davis |
Oliver |
O |
|
| de Zwaan |
Martina |
M |
|
| Dedoussis |
George |
G |
|
| Degortes |
Daniela |
D |
|
| DeSocio |
Janiece |
J |
|
| Dick |
Danielle |
D |
|
| Dikeos |
Dimitris |
D |
|
| Dmitrzak-Weglarz |
Monika |
M |
|
| Docampo |
Elisa |
E |
|
| Egberts |
Karin |
K |
|
| Ehrlich |
Stefan |
S |
|
| Escaramís |
Geòrgia |
G |
|
| Esko |
Tõnu |
T |
|
| Estivill |
Xavier |
X |
|
| Favaro |
Angela |
A |
|
| Fernández-Aranda |
Fernando |
F |
|
| Fichter |
Manfred |
M |
|
| Finan |
Chris |
C |
|
| Fischer |
Krista |
K |
|
| Föcker |
Manuel |
M |
|
| Foretova |
Lenka |
L |
|
| Forzan |
Monica |
M |
|
| Franklin |
Christopher |
C |
|
| Gaspar |
Héléna |
H |
|
| Gonidakis |
Fragiskos |
F |
|
| Gorwood |
Philip |
P |
|
| Gratacos |
Monica |
M |
|
| Guillaume |
Sébastien |
S |
|
| Guo |
Yiran |
Y |
|
| Hakonarson |
Hakon |
H |
|
| Halmi |
Katherine |
K |
|
| Hatzikotoulas |
Konstantinos |
K |
|
| Hauser |
Joanna |
J |
|
| Hebebrand |
Johannes |
J |
|
| Helder |
Sietske |
S |
|
| Hendriks |
Judith |
J |
|
| Herpertz-Dahlmann |
Beate |
B |
|
| Herzog |
Wolfgang |
W |
|
| Hilliard |
Christopher |
C |
|
| Hinney |
Anke |
A |
|
| Huckins |
Laura |
L |
|
| Hudson |
James |
J |
|
| Huemer |
Julia |
J |
|
| Imgart |
Hartmut |
H |
|
| Inoko |
Hidetoshi |
H |
|
| Jiménez-Murcia |
Susana |
S |
|
| Johnson |
Craig |
C |
|
| Jordan |
Jenny |
J |
|
| Juréus |
Anders |
A |
|
| Kalsi |
Gursharan |
G |
|
| Kaminska |
Debora |
D |
|
| Kaplan |
Allan |
A |
|
| Kaprio |
Jaakko |
J |
|
| Karhunen |
Leila |
L |
|
| Karwautz |
Andreas |
A |
|
| Kas |
Martien |
M |
|
| Kaye |
Walter |
W |
|
| Kennedy |
James |
J |
|
| Kennedy |
Martin |
M |
|
| Keski-Rahkonen |
Anna |
A |
|
| Kiezebrink |
Kirsty |
K |
|
| Kim |
Youl-Ri |
YR |
|
| Klump |
Kelly |
K |
|
| Knudsen |
Gun Peggy |
GP |
|
| Koeleman |
Bobby |
B |
|
| Koubek |
Doris |
D |
|
| La Via |
Maria |
M |
|
| Landén |
Mikael |
M |
|
| Levitan |
Robert |
R |
|
| Li |
Dong |
D |
|
| Lichtenstein |
Paul |
P |
|
| Lilenfeld |
Lisa |
L |
|
| Lissowska |
Jolanta |
J |
|
| Magistretti |
Pierre |
P |
|
| Maj |
Mario |
M |
|
| Mannik |
Katrin |
K |
|
| Martin |
Nicholas |
N |
|
| McDevitt |
Sara |
S |
|
| McGuffin |
Peter |
P |
|
| Merl |
Elisabeth |
E |
|
| Metspalu |
Andres |
A |
|
| Meulenbelt |
Ingrid |
I |
|
| Micali |
Nadia |
N |
|
| Mitchell |
James |
J |
|
| Mitchell |
Karen |
K |
|
| Monteleone |
Palmiero |
P |
|
| Monteleone |
Alessio Maria |
AM |
|
| Mortensen |
Preben |
P |
|
| Munn-Chernoff |
Melissa |
M |
|
| Nacmias |
Benedetta |
B |
|
| Nilsson |
Ida |
I |
|
| Norring |
Claes |
C |
|
| Ntalla |
Ioanna |
I |
|
| O'Toole |
Julie |
J |
|
| Pantel |
Jacques |
J |
|
| Papezova |
Hana |
H |
|
| Parker |
Richard |
R |
|
| Rabionet |
Raquel |
R |
|
| Raevuori |
Anu |
A |
|
| Rajewski |
Andrzej |
A |
|
| Ramoz |
Nicolas |
N |
|
| Rayner |
N William |
NW |
|
| Reichborn-Kjennerud |
Ted |
T |
|
| Ricca |
Valdo |
V |
|
| Ripke |
Stephan |
S |
|
| Ritschel |
Franziska |
F |
|
| Roberts |
Marion |
M |
|
| Rotondo |
Alessandro |
A |
|
| Rybakowski |
Filip |
F |
|
| Santonastaso |
Paolo |
P |
|
| Scherag |
André |
A |
|
| Schmidt |
Ulrike |
U |
|
| Schork |
Nicholas |
N |
|
| Schosser |
Alexandra |
A |
|
| Seitz |
Jochen |
J |
|
| Slachtova |
Lenka |
L |
|
| Slagboom |
P Eline |
PE |
|
| Slof-Op't Landt |
Margarita |
M |
|
| Slopien |
Agnieszka |
A |
|
| Smith |
Tosha |
T |
|
| Sorbi |
Sandro |
S |
|
| Strengman |
Eric |
E |
|
| Strober |
Michael |
M |
|
| Sullivan |
Patrick |
P |
|
| Szatkiewicz |
Jin |
J |
|
| Szeszenia-Dabrowska |
Neonila |
N |
|
| Tachmazidou |
Ioanna |
I |
|
| Tenconi |
Elena |
E |
|
| Thornton |
Laura |
L |
|
| Tortorella |
Alfonso |
A |
|
| Tozzi |
Federica |
F |
|
| Treasure |
Janet |
J |
|
| Tsitsika |
Artemis |
A |
|
| Tziouvas |
Konstantinos |
K |
|
| van Elburg |
Annemarie |
A |
|
| van Furth |
Eric |
E |
|
| Wade |
Tracey |
T |
|
| Wagner |
Gudrun |
G |
|
| Walton |
Esther |
E |
|
| Watson |
Hunna |
H |
|
| Woodside |
D Blake |
DB |
|
| Yao |
Shuyang |
S |
|
| Yilmaz |
Zeynep |
Z |
|
| Zeggini |
Eleftheria |
E |
|
| Zerwas |
Stephanie |
S |
|
| Zipfel |
Stephan |
S |
|
| Alfredsson |
Lars |
L |
|
| Andreassen |
Ole |
O |
|
| Aschauer |
Harald |
H |
|
| Barrett |
Jeffrey |
J |
|
| Bencko |
Vladimir |
V |
|
| Carlberg |
Laura |
L |
|
| Cichon |
Sven |
S |
|
| Cohen-Woods |
Sarah |
S |
|
| Dina |
Christian |
C |
|
| Ding |
Bo |
B |
|
| Espeseth |
Thomas |
T |
|
| Floyd |
James |
J |
|
| Gallinger |
Steven |
S |
|
| Gambaro |
Giovanni |
G |
|
| Giegling |
Ina |
I |
|
| Herms |
Stefan |
S |
|
| Janout |
Vladimir |
V |
|
| Julià |
Antonio |
A |
|
| Klareskog |
Lars |
L |
|
| Le Hellard |
Stephanie |
S |
|
| Leboyer |
Marion |
M |
|
| Lundervold |
Astri |
A |
|
| Marsal |
Sara |
S |
|
| Mattingsdal |
Morten |
M |
|
| Navratilova |
Marie |
M |
|
| Ophoff |
Roel |
R |
|
| Palotie |
Aarno |
A |
|
| Pinto |
Dalila |
D |
|
| Ripatti |
Samuli |
S |
|
| Rujescu |
Dan |
D |
|
| Scherer |
Stephen |
S |
|
| Scott |
Laura |
L |
|
| Sladek |
Robert |
R |
|
| Soranzo |
Nicole |
N |
|
| Southam |
Lorraine |
L |
|
| Steen |
Vidar |
V |
|
| Wichmann |
H-Erich |
HE |
|
| Widen |
Elisabeth |
E |
|
| Breen |
Gerome |
G |
|
| Bulik |
Cynthia |
C |
|
|
| JOURNAL |
|
| VOLUME: |
| ISSUE: |
| TITLE: Biological psychiatry |
| ISOABBREVIATION: Biol. Psychiatry |
| YEAR: 2019 |
| MONTH: May |
| DAY: 15 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1873-2402 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Biol Psychiatry |
| COUNTRY: United States |
| ISSNLINKING: 0006-3223 |
| NLMUNIQUEID: 0213264 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| ADHD |
| Anorexia nervosa |
| Bulimia nervosa |
| Eating disorders |
| Genetic epidemiology |
| Polygenic risk score |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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