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| PMID |
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| TITLE |
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| Twenty-Five and Up (25Up) Study: A New Wave of the Brisbane Longitudinal Twin Study. |
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| ABSTRACT |
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| The aim of the 25 and Up (25Up) study was to assess a wide range of psychological and behavioral risk factors behind mental illness in a large cohort of Australian twins and their non-twin siblings. Participants had already been studied longitudinally from the age of 12 and most recently in the 19Up study (mean age = 26.1 years, SD = 4.1, range = 20-39). This subsequent wave follows up these twins several years later in life (mean age = 29.7 years, SD = 2.2, range = 22-44). The resulting data set enables additional detailed investigations of genetic pathways underlying psychiatric illnesses in the Brisbane Longitudinal Twin Study (BLTS). Data were collected between 2016 and 2018 from 2540 twins and their non-twin siblings (59% female, including 341 monozygotic complete twin-pairs, 415 dizygotic complete pairs and 1028 non-twin siblings and singletons). Participants were from South-East Queensland, Australia, and the sample was of predominantly European ancestry. The 25Up study collected information on 20 different mental disorders, including depression, anxiety, substance use, psychosis, bipolar and attention-deficit hyper-activity disorder, as well as general demographic information such as occupation, education level, number of children, self-perceived IQ and household environment. In this article, we describe the prevalence, comorbidities and age of onset for all 20 examined disorders. The 25Up study also assessed general and physical health, including physical activity, sleep patterns, eating behaviors, baldness, acne, migraines and allergies, as well as psychosocial items such as suicidality, perceived stress, loneliness, aggression, sleep-wake cycle, sexual identity and preferences, technology and internet use, traumatic life events, gambling and cyberbullying. In addition, 25Up assessed female health traits such as morning sickness, breastfeeding and endometriosis. Furthermore, given that the 25Up study is an extension of previous BLTS studies, 86% of participants have already been genotyped. This rich resource will enable the assessment of epidemiological risk factors, as well as the heritability and genetic correlations of mental conditions. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2019/06/15 06:00 |
| medline |
2020/01/10 06:00 |
| entrez |
2019/06/15 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
|
Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia. |
| Campos AI |
|
Campos |
Adrian I |
AI |
|
Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia. |
| Rentería ME |
|
Rentería |
Miguel E |
ME |
|
Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia. |
| Parker R |
|
Parker |
Richard |
R |
|
Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia. |
| Sullivan L |
|
Sullivan |
Lenore |
L |
|
Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia. |
| McAloney K |
|
McAloney |
Kerrie |
K |
|
Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia. |
| Couvy-Duchesne B |
|
Couvy-Duchesne |
Baptiste |
B |
|
Institute for Molecular Bioscience,The University of Queensland,Brisbane QLD,Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia. |
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA. |
| Scott J |
|
Scott |
Jan |
J |
|
Brain and Mind Centre,University of Sydney,Sydney, NSW,Australia. |
| Zietsch BP |
|
Zietsch |
Brendan P |
BP |
|
School of Psychology,The University of Queensland,Brisbane QLD,Australia. |
| Lind PA |
|
Lind |
Penelope A |
PA |
|
Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Brain and Mind Centre,University of Sydney,Sydney, NSW,Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 22 |
| ISSUE: 3 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2019 |
| MONTH: 06 |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Mental health |
| cohort study |
| genetics |
| longitudinal |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Anorexia |
epidemiology |
| Bipolar Disorder |
epidemiology |
| Child |
epidemiology |
| Comorbidity |
epidemiology |
| Depression |
epidemiology |
| Female |
epidemiology |
| Humans |
epidemiology |
| Longitudinal Studies |
epidemiology |
| Male |
epidemiology |
| Phenotype |
epidemiology |
| Prevalence |
epidemiology |
| Queensland |
epidemiology |
| Registries |
statistics & numerical data |
| Risk Factors |
statistics & numerical data |
| Twins, Dizygotic |
psychology |
| Twins, Monozygotic |
psychology |
| Young Adult |
psychology |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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