Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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31152163
TITLE
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
ABSTRACT
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
DATE PUBLISHED
2019 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/09/16
accepted 2019/03/29
entrez 2019/06/02 06:00
pubmed 2019/06/04 06:00
medline 2019/06/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wuttke M Wuttke Matthias M Renal Division, Department of Medicine IV, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Li Y Li Yong Y Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Li M Li Man M Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA.
Sieber KB Sieber Karsten B KB Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Feitosa MF Feitosa Mary F MF Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Gorski M Gorski Mathias M Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Tin A Tin Adrienne A Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA.
Wang L Wang Lihua L Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Chu AY Chu Audrey Y AY Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Hoppmann A Hoppmann Anselm A Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Kirsten H Kirsten Holger H LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Giri A Giri Ayush A Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
Chai JF Chai Jin-Fang JF Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Sveinbjornsson G Sveinbjornsson Gardar G deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Tayo BO Tayo Bamidele O BO Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
Nutile T Nutile Teresa T Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.
Fuchsberger C Fuchsberger Christian C Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Marten J Marten Jonathan J Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Cocca M Cocca Massimiliano M Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Ghasemi S Ghasemi Sahar S DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Xu Y Xu Yizhe Y Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA.
Horn K Horn Katrin K LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Noce D Noce Damia D Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
van der Most PJ van der Most Peter J PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Sedaghat S Sedaghat Sanaz S Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Yu Z Yu Zhi Z Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Akiyama M Akiyama Masato M Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Afaq S Afaq Saima S Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar, Pakistan.
Ahluwalia TS Ahluwalia Tarunveer S TS Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Almgren P Almgren Peter P Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
Amin N Amin Najaf N Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Ärnlöv J Ärnlöv Johan J School of Health and Social Studies, Dalarna University, Stockholm, Sweden.
Bakker SJL Bakker Stephan J L SJL Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Bansal N Bansal Nisha N Kidney Research Institute, University of Washington, Seattle, WA, USA.
Baptista D Baptista Daniela D Cardiology, Geneva University Hospitals, Geneva, Switzerland.
Bergmann S Bergmann Sven S Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa.
Biggs ML Biggs Mary L ML Department of Biostatistics, University of Washington, Seattle, WA, USA.
Biino G Biino Ginevra G Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
Boehnke M Boehnke Michael M Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Boerwinkle E Boerwinkle Eric E Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA.
Boissel M Boissel Mathilde M CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
Bottinger EP Bottinger Erwin P EP Digital Health Center, Hasso Plattner Institute and University of Potsdam, Potsdam, Germany.
Boutin TS Boutin Thibaud S TS Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Brenner H Brenner Hermann H Network Aging Research, University of Heidelberg, Heidelberg, Germany.
Brumat M Brumat Marco M Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Burkhardt R Burkhardt Ralph R Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
Butterworth AS Butterworth Adam S AS National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
Campana E Campana Eric E Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Campbell A Campbell Archie A Center for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Campbell H Campbell Harry H Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Canouil M Canouil Mickaël M CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
Carroll RJ Carroll Robert J RJ Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Catamo E Catamo Eulalia E Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Chambers JC Chambers John C JC MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
Chee ML Chee Miao-Ling ML Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Chee ML Chee Miao-Li ML Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Chen X Chen Xu X Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Cheng CY Cheng Ching-Yu CY Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Cheng Y Cheng Yurong Y Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Christensen K Christensen Kaare K Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Southern Denmark University, Odense, Denmark.
Cifkova R Cifkova Renata R Department of Medicine II, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic.
Ciullo M Ciullo Marina M IRCCS Neuromed, Pozzilli, Italy.
Concas MP Concas Maria Pina MP Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Cook JP Cook James P JP Department of Biostatistics, University of Liverpool, Liverpool, UK.
Coresh J Coresh Josef J Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Corre T Corre Tanguy T Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Sala CF Sala Cinzia Felicita CF San Raffaele Research Institute, Milan, Italy.
Cusi D Cusi Daniele D Bio4Dreams-Business Nursery for Life Sciences, Milan, Italy.
Danesh J Danesh John J Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Daw EW Daw E Warwick EW Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
de Borst MH de Borst Martin H MH Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
De Grandi A De Grandi Alessandro A Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
de Mutsert R de Mutsert Renée R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
de Vries APJ de Vries Aiko P J APJ Section of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Degenhardt F Degenhardt Frauke F Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Delgado G Delgado Graciela G Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Demirkan A Demirkan Ayse A Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Di Angelantonio E Di Angelantonio Emanuele E NHS Blood and Transplant, Cambridge, UK.
Dittrich K Dittrich Katalin K Center for Pediatric Research, University of Leipzig, Leipzig, Germany.
Divers J Divers Jasmin J Public Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Dorajoo R Dorajoo Rajkumar R Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
Eckardt KU Eckardt Kai-Uwe KU Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Ehret G Ehret Georg G Cardiology, Geneva University Hospitals, Geneva, Switzerland.
Elliott P Elliott Paul P Health Data Research UK-London, London, UK.
Endlich K Endlich Karlhans K Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
Evans MK Evans Michele K MK Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
Felix JF Felix Janine F JF Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Foo VHX Foo Valencia Hui Xian VHX Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Franco OH Franco Oscar H OH Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Franke A Franke Andre A Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Freedman BI Freedman Barry I BI Section on Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Freitag-Wolf S Freitag-Wolf Sandra S Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
Friedlander Y Friedlander Yechiel Y School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Froguel P Froguel Philippe P Department of Genomics of Common Disease, Imperial College London, London, UK.
Gansevoort RT Gansevoort Ron T RT Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Gao H Gao He H Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
Gasparini P Gasparini Paolo P Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Gaziano JM Gaziano J Michael JM Massachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.
Giedraitis V Giedraitis Vilmantas V Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Gieger C Gieger Christian C German Center for Diabetes Research (DZD), Neuherberg, Germany.
Girotto G Girotto Giorgia G Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Giulianini F Giulianini Franco F Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Gögele M Gögele Martin M Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Gordon SD Gordon Scott D SD QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Gudbjartsson DF Gudbjartsson Daniel F DF deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Gudnason V Gudnason Vilmundur V Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Haller T Haller Toomas T Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Hamet P Hamet Pavel P Medpharmgene, Montreal, Quebec, Canada.
Harris TB Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA.
Hartman CA Hartman Catharina A CA Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Hayward C Hayward Caroline C Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Hellwege JN Hellwege Jacklyn N JN Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
Heng CK Heng Chew-Kiat CK Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Hicks AA Hicks Andrew A AA Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Hofer E Hofer Edith E Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
Huang W Huang Wei W Shanghai Industrial Technology Institute, Shanghai, China.
Hutri-Kähönen N Hutri-Kähönen Nina N Department of Pediatrics, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Hwang SJ Hwang Shih-Jen SJ The Center for Population Studies, NHLBI, Framingham, MA, USA.
Ikram MA Ikram M Arfan MA Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Indridason OS Indridason Olafur S OS Division of Nephrology, Internal Medicine Services, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.
Ingelsson E Ingelsson Erik E Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
Ising M Ising Marcus M Max Planck Institute of Psychiatry, Munich, Germany.
Jaddoe VWV Jaddoe Vincent W V VWV Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Jakobsdottir J Jakobsdottir Johanna J The Center of Public Health Sciences, University of Iceland, Reykjavík, Iceland.
Jonas JB Jonas Jost B JB Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Joshi PK Joshi Peter K PK Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Josyula NS Josyula Navya Shilpa NS Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA.
Jung B Jung Bettina B Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Kähönen M Kähönen Mika M Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Kamatani Y Kamatani Yoichiro Y Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kammerer CM Kammerer Candace M CM Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Kanai M Kanai Masahiro M Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Kastarinen M Kastarinen Mika M Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
Kerr SM Kerr Shona M SM Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Khor CC Khor Chiea-Chuen CC Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
Kiess W Kiess Wieland W Center for Pediatric Research, University of Leipzig, Leipzig, Germany.
Kleber ME Kleber Marcus E ME Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Koenig W Koenig Wolfgang W Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany.
Kooner JS Kooner Jaspal S JS National Heart and Lung Institute, Imperial College London, London, UK.
Körner A Körner Antje A Center for Pediatric Research, University of Leipzig, Leipzig, Germany.
Kovacs P Kovacs Peter P Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Kraja AT Kraja Aldi T AT Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Krajcoviechova A Krajcoviechova Alena A Department of Medicine II, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic.
Kramer H Kramer Holly H Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, IL, USA.
Krämer BK Krämer Bernhard K BK Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Kronenberg F Kronenberg Florian F Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Kubo M Kubo Michiaki M RIKEN Center for Integrative Medical Sciences (IMS), Yokohama (Kanagawa), Japan.
Kühnel B Kühnel Brigitte B Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Kuokkanen M Kuokkanen Mikko M Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland.
Kuusisto J Kuusisto Johanna J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
La Bianca M La Bianca Martina M Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Laakso M Laakso Markku M Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Lange LA Lange Leslie A LA Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA.
Langefeld CD Langefeld Carl D CD Public Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Lee JJ Lee Jeannette Jen-Mai JJ Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Lehne B Lehne Benjamin B Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Lieb W Lieb Wolfgang W Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany.
Lifelines Cohort Study
Lim SC Lim Su-Chi SC Diabetes Center, Khoo Teck Puat Hospital, Singapore, Singapore.
Lind L Lind Lars L Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Lindgren CM Lindgren Cecilia M CM Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Liu J Liu Jun J Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Liu J Liu Jianjun J Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Loeffler M Loeffler Markus M LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Loos RJF Loos Ruth J F RJF The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lucae S Lucae Susanne S Max Planck Institute of Psychiatry, Munich, Germany.
Lukas MA Lukas Mary Ann MA Target Sciences-Genetics, GlaxoSmithKline, Albuquerque, NM, USA.
Lyytikäinen LP Lyytikäinen Leo-Pekka LP Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Mägi R Mägi Reedik R Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mahajan A Mahajan Anubha A Oxford Center for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Martins J Martins Jade J Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
März W März Winfried W Medical Clinic V, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Mascalzoni D Mascalzoni Deborah D Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Matsuda K Matsuda Koichi K Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Meisinger C Meisinger Christa C Chair of Epidemiology, Ludwig- Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany.
Meitinger T Meitinger Thomas T Institute of Human Genetics, Technische Universität München, Munich, Germany.
Melander O Melander Olle O Hypertension and Cardiovascular Disease, Department of Clincial Sciences Malmö, Lund University, Malmö, Sweden.
Metspalu A Metspalu Andres A Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mikaelsdottir EK Mikaelsdottir Evgenia K EK deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Milaneschi Y Milaneschi Yuri Y Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
Miliku K Miliku Kozeta K Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Mishra PP Mishra Pashupati P PP Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
V. A. Million Veteran Program
Mohlke KL Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Mononen N Mononen Nina N Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia.
Mook-Kanamori DO Mook-Kanamori Dennis O DO Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.
Mychaleckyj JC Mychaleckyj Josyf C JC Center for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville, VA, USA.
Nadkarni GN Nadkarni Girish N GN Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nalls MA Nalls Mike A MA Data Tecnica International, Glen Echo, MD, USA.
Nauck M Nauck Matthias M Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Nikus K Nikus Kjell K Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, Tampere University, Tampere, Finland.
Ning B Ning Boting B Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Noordam R Noordam Raymond R Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
O'Connell J O'Connell Jeffrey J University of Maryland School of Medicine, Baltimore, MD, USA.
O'Donoghue ML O'Donoghue Michelle L ML TIMI Study Group, Boston, MA, USA.
Olafsson I Olafsson Isleifur I Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland.
Oldehinkel AJ Oldehinkel Albertine J AJ Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Orho-Melander M Orho-Melander Marju M Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
Ouwehand WH Ouwehand Willem H WH Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Padmanabhan S Padmanabhan Sandosh S Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Palmer ND Palmer Nicholette D ND Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Palsson R Palsson Runolfur R Division of Nephrology, Internal Medicine Services, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
Perls T Perls Thomas T Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
Perola M Perola Markus M National Institute for Health and Welfare, Helsinki, Finland.
Pirastu M Pirastu Mario M Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy.
Pirastu N Pirastu Nicola N Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Pistis G Pistis Giorgio G Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
Podgornaia AI Podgornaia Anna I AI Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Polasek O Polasek Ozren O Gen-info Ltd, Zagreb, Croatia.
Ponte B Ponte Belen B Service de Néphrologie, Geneva University Hospitals, Geneva, Switzerland.
Porteous DJ Porteous David J DJ Center for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Poulain T Poulain Tanja T LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Pramstaller PP Pramstaller Peter P PP Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Preuss MH Preuss Michael H MH Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Prins BP Prins Bram P BP MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Province MA Province Michael A MA Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Rabelink TJ Rabelink Ton J TJ Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Center, Leiden, the Netherlands.
Raffield LM Raffield Laura M LM Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Raitakari OT Raitakari Olli T OT Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Reilly DF Reilly Dermot F DF Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Rettig R Rettig Rainer R Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany.
Rheinberger M Rheinberger Myriam M Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Rice KM Rice Kenneth M KM Department of Biostatistics, University of Washington, Seattle, WA, USA.
Ridker PM Ridker Paul M PM Harvard Medical School, Boston, MA, USA.
Rivadeneira F Rivadeneira Fernando F Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Rizzi F Rizzi Federica F ePhood Scientific Unit, ePhood SRL, Milano, Italy.
Roberts DJ Roberts David J DJ NHS Blood and Transplant, BRC Oxford Haematology Theme; Nuffield Division of Clinical Laboratory Sciences; University of Oxford, Oxford, UK.
Robino A Robino Antonietta A Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Rossing P Rossing Peter P Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Rudan I Rudan Igor I Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Rueedi R Rueedi Rico R Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Ruggiero D Ruggiero Daniela D IRCCS Neuromed, Pozzilli, Italy.
Ryan KA Ryan Kathleen A KA Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Saba Y Saba Yasaman Y Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Sabanayagam C Sabanayagam Charumathi C Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Salomaa V Salomaa Veikko V National Institute for Health and Welfare, Helsinki, Finland.
Salvi E Salvi Erika E Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy.
Saum KU Saum Kai-Uwe KU Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Schmidt H Schmidt Helena H Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Graz, Austria.
Schmidt R Schmidt Reinhold R Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Schöttker B Schöttker Ben B Network Aging Research, University of Heidelberg, Heidelberg, Germany.
Schulz CA Schulz Christina-Alexandra CA Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
Schupf N Schupf Nicole N Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, USA.
Shaffer CM Shaffer Christian M CM Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Shi Y Shi Yuan Y Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Smith AV Smith Albert V AV Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Smith BH Smith Blair H BH Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Soranzo N Soranzo Nicole N Human Genetics, Wellcome Sanger Institute, Hinxton, UK.
Spracklen CN Spracklen Cassandra N CN Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Strauch K Strauch Konstantin K Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Ludwig-Maximilians-Universität München, München, Germany.
Stringham HM Stringham Heather M HM Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Stumvoll M Stumvoll Michael M Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
Svensson PO Svensson Per O PO Department of Cardiology, Södersjukhuset, Stockholm, Sweden.
Szymczak S Szymczak Silke S Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
Tai ES Tai E-Shyong ES Duke-NUS Medical School, Singapore, Singapore.
Tajuddin SM Tajuddin Salman M SM Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
Tan NYQ Tan Nicholas Y Q NYQ Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Taylor KD Taylor Kent D KD The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Teren A Teren Andrej A Heart Center Leipzig, Leipzig, Germany.
Tham YC Tham Yih-Chung YC Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Thiery J Thiery Joachim J Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
Thio CHL Thio Chris H L CHL Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Thomsen H Thomsen Hauke H Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Thorleifsson G Thorleifsson Gudmar G deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Toniolo D Toniolo Daniela D San Raffaele Research Institute, Milan, Italy.
Tönjes A Tönjes Anke A Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
Tremblay J Tremblay Johanne J CRCHUM, Montreal, Canada.
Tzoulaki I Tzoulaki Ioanna I Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Uitterlinden AG Uitterlinden André G AG Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Vaccargiu S Vaccargiu Simona S Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy.
van Dam RM van Dam Rob M RM Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
van der Harst P van der Harst Pim P Durrer Center for Cardiovascular Research, The Netherlands Heart Institute, Utrecht, the Netherlands.
van Duijn CM van Duijn Cornelia M CM Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Velez Edward DR Velez Edward Digna R DR Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA.
Verweij N Verweij Niek N Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Vogelezang S Vogelezang Suzanne S Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Völker U Völker Uwe U Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Vollenweider P Vollenweider Peter P Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Waeber G Waeber Gerard G Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Waldenberger M Waldenberger Melanie M DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Wallentin L Wallentin Lars L Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Wang YX Wang Ya Xing YX Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Wang C Wang Chaolong C School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Waterworth DM Waterworth Dawn M DM Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Bin Wei W Bin Wei Wen W Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
White H White Harvey H Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand.
Whitfield JB Whitfield John B JB QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Wild SH Wild Sarah H SH Center for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Wilson JF Wilson James F JF Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Wojczynski MK Wojczynski Mary K MK Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Wong C Wong Charlene C Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Wong TY Wong Tien-Yin TY Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Xu L Xu Liang L Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Yang Q Yang Qiong Q Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Yasuda M Yasuda Masayuki M Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Yerges-Armstrong LM Yerges-Armstrong Laura M LM Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Zhang W Zhang Weihua W Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
Zonderman AB Zonderman Alan B AB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
Rotter JI Rotter Jerome I JI Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
Bochud M Bochud Murielle M Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Psaty BM Psaty Bruce M BM Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Vitart V Vitart Veronique V Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Wilson JG Wilson James G JG Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Dehghan A Dehghan Abbas A Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
Parsa A Parsa Afshin A Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, MA, USA.
Ho K Ho Kevin K Department of Nephrology, Geisinger, Danville, PA, USA.
Morris AP Morris Andrew P AP Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK.
Devuyst O Devuyst Olivier O Institute of Physiology, University of Zurich, Zurich, Switzerland.
Akilesh S Akilesh Shreeram S Anatomic Pathology, University of Washington Medical Center, Seattle, WA, USA.
Pendergrass SA Pendergrass Sarah A SA Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA.
Sim X Sim Xueling X Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Böger CA Böger Carsten A CA Department of Nephrology and Rheumatology, Kliniken Südostbayern, Regensburg, Germany.
Okada Y Okada Yukinori Y Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
Edwards TL Edwards Todd L TL Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Snieder H Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Stefansson K Stefansson Kari K deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Hung AM Hung Adriana M AM Vanderbilt University Medical Center, Division of Nephrology & Hypertension, Nashville, TN, USA.
Heid IM Heid Iris M IM Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Scholz M Scholz Markus M LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Teumer A Teumer Alexander A DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Köttgen A Köttgen Anna A Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.de.
Pattaro C Pattaro Cristian C Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. cristian.pattaro@eurac.edu.
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JOURNAL
VOLUME: 51
ISSUE: 6
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2019
MONTH: Jun
DAY:
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CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
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