Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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31043756
TITLE
Genome-wide association study identifies 30 loci associated with bipolar disorder.
ABSTRACT
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10 ) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.
DATE PUBLISHED
2019 05
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/03/11
accepted 2019/03/18
pubmed 2019/05/03 06:00
medline 2019/06/14 06:00
entrez 2019/05/03 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Stahl EA Stahl Eli A EA Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. eli.stahl@mssm.edu.
Breen G Breen Gerome G NIHR BRC for Mental Health, King's College London, London, UK.
Forstner AJ Forstner Andreas J AJ Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
McQuillin A McQuillin Andrew A Division of Psychiatry, University College London, London, UK.
Ripke S Ripke Stephan S Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Trubetskoy V Trubetskoy Vassily V Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
Mattheisen M Mattheisen Manuel M iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Wang Y Wang Yunpeng Y Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Coleman JRI Coleman Jonathan R I JRI NIHR BRC for Mental Health, King's College London, London, UK.
Gaspar HA Gaspar Héléna A HA NIHR BRC for Mental Health, King's College London, London, UK.
de Leeuw CA de Leeuw Christiaan A CA Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Steinberg S Steinberg Stacy S deCODE Genetics/Amgen, Reykjavik, Iceland.
Pavlides JMW Pavlides Jennifer M Whitehead JMW Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Trzaskowski M Trzaskowski Maciej M Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Byrne EM Byrne Enda M EM Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Pers TH Pers Tune H TH Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.
Holmans PA Holmans Peter A PA Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Richards AL Richards Alexander L AL Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Abbott L Abbott Liam L Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Agerbo E Agerbo Esben E National Centre for Register-based Research and Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.
Akil H Akil Huda H Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
Albani D Albani Diego D Department of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Alliey-Rodriguez N Alliey-Rodriguez Ney N Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Als TD Als Thomas D TD iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Anjorin A Anjorin Adebayo A Department of Psychiatry, Berkshire Healthcare NHS Foundation Trust, Bracknell, UK.
Antilla V Antilla Verneri V Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Awasthi S Awasthi Swapnil S Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
Badner JA Badner Judith A JA Department of Psychiatry, Rush University Medical Center, Chicago, IL, USA.
Bækvad-Hansen M Bækvad-Hansen Marie M Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Barchas JD Barchas Jack D JD Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA.
Bass N Bass Nicholas N Division of Psychiatry, University College London, London, UK.
Bauer M Bauer Michael M Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Belliveau R Belliveau Richard R Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Bergen SE Bergen Sarah E SE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Pedersen CB Pedersen Carsten Bøcker CB National Centre for Register-based Research and Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.
Bøen E Bøen Erlend E Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Boks MP Boks Marco P MP Psychiatry, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, the Netherlands.
Boocock J Boocock James J Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Budde M Budde Monika M Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany.
Bunney W Bunney William W Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.
Burmeister M Burmeister Margit M Molecular & Behavioral Neuroscience Institute and Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Bybjerg-Grauholm J Bybjerg-Grauholm Jonas J Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Byerley W Byerley William W Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Casas M Casas Miquel M Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut, Universitat Autònoma de Barcelona, Barcelona, Spain.
Cerrato F Cerrato Felecia F Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Cervantes P Cervantes Pablo P Department of Psychiatry, Mood Disorders Program, McGill University Health Center, Montreal, Quebec, Canada.
Chambert K Chambert Kimberly K Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Charney AW Charney Alexander W AW Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chen D Chen Danfeng D Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Churchhouse C Churchhouse Claire C Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Clarke TK Clarke Toni-Kim TK Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland.
Coryell W Coryell William W University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Craig DW Craig David W DW Translational Genomics, USC, Phoenix, AZ, USA.
Cruceanu C Cruceanu Cristiana C Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Curtis D Curtis David D UCL Genetics Institute, University College London, London, UK.
Czerski PM Czerski Piotr M PM Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Dale AM Dale Anders M AM Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA.
de Jong S de Jong Simone S NIHR BRC for Mental Health, King's College London, London, UK.
Degenhardt F Degenhardt Franziska F Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Del-Favero J Del-Favero Jurgen J Applied Molecular Genomics Unit, VIB Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium.
DePaulo JR DePaulo J Raymond JR Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Djurovic S Djurovic Srdjan S NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Dobbyn AL Dobbyn Amanda L AL Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dumont A Dumont Ashley A Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Elvsåshagen T Elvsåshagen Torbjørn T NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.
Escott-Price V Escott-Price Valentina V Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Fan CC Fan Chun Chieh CC Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA.
Fischer SB Fischer Sascha B SB Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Flickinger M Flickinger Matthew M Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Foroud TM Foroud Tatiana M TM Department of Medical & Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Forty L Forty Liz L Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Frank J Frank Josef J Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Fraser C Fraser Christine C Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Freimer NB Freimer Nelson B NB Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Frisén L Frisén Louise L Child and Adolescent Psychiatry Research Center, Stockholm, Sweden.
Gade K Gade Katrin K Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Gage D Gage Diane D Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Garnham J Garnham Julie J Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Giambartolomei C Giambartolomei Claudia C Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Pedersen MG Pedersen Marianne Giørtz MG National Centre for Register-based Research and Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.
Goldstein J Goldstein Jaqueline J Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Gordon SD Gordon Scott D SD Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Gordon-Smith K Gordon-Smith Katherine K Department of Psychological Medicine, University of Worcester, Worcester, UK.
Green EK Green Elaine K EK School of Biomedical Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry, University of Plymouth, Plymouth, UK.
Green MJ Green Melissa J MJ Neuroscience Research Australia, Sydney, New South Wales, Australia.
Greenwood TA Greenwood Tiffany A TA Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Grove J Grove Jakob J Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
Guan W Guan Weihua W Biostatistics, University of Minnesota System, Minneapolis, MN, USA.
Guzman-Parra J Guzman-Parra José J Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
Hamshere ML Hamshere Marian L ML Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Hautzinger M Hautzinger Martin M Department of Psychology, Eberhard Karls Universität Tübingen, Tubingen, Germany.
Heilbronner U Heilbronner Urs U Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany.
Herms S Herms Stefan S Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Hipolito M Hipolito Maria M Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.
Hoffmann P Hoffmann Per P Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Holland D Holland Dominic D Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.
Huckins L Huckins Laura L Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jamain S Jamain Stéphane S Faculté de Médecine, Université Paris Est, Créteil, France.
Johnson JS Johnson Jessica S JS Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Juréus A Juréus Anders A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kandaswamy R Kandaswamy Radhika R MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Karlsson R Karlsson Robert R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kennedy JL Kennedy James L JL Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
Kittel-Schneider S Kittel-Schneider Sarah S Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Knowles JA Knowles James A JA Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Kogevinas M Kogevinas Manolis M ISGlobal, Barcelona, Spain.
Koller AC Koller Anna C AC Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Kupka R Kupka Ralph R Psychiatry, VU Medisch Centrum, Amsterdam, the Netherlands.
Lavebratt C Lavebratt Catharina C Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Lawrence J Lawrence Jacob J Department of, rth East London NHS Foundation Trust, Ilford, UK.
Lawson WB Lawson William B WB Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.
Leber M Leber Markus M Department of Neurodegenerative Diseases and Geropsychiatry, University Hospital Bonn, Bonn, Germany.
Lee PH Lee Phil H PH Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Levy SE Levy Shawn E SE HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Li JZ Li Jun Z JZ Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Liu C Liu Chunyu C Department of Psychiatry, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Lucae S Lucae Susanne S Max Planck Institute of Psychiatry, Munich, Germany.
Maaser A Maaser Anna A Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
MacIntyre DJ MacIntyre Donald J DJ Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Mahon PB Mahon Pamela B PB Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Maier W Maier Wolfgang W Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Martinsson L Martinsson Lina L Department of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
McCarroll S McCarroll Steve S Department of Genetics, Harvard Medical School, Boston, MA, USA.
McGuffin P McGuffin Peter P MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
McInnis MG McInnis Melvin G MG Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
McKay JD McKay James D JD Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France.
Medeiros H Medeiros Helena H Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Medland SE Medland Sarah E SE Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Meng F Meng Fan F Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Milani L Milani Lili L Estonian Genome Center, University of Tartu, Tartu, Estonia.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Morris DW Morris Derek W DW Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Mühleisen TW Mühleisen Thomas W TW Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Mullins N Mullins Niamh N MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Nguyen H Nguyen Hoang H Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nievergelt CM Nievergelt Caroline M CM Research/Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Adolfsson AN Adolfsson Annelie Nordin AN Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden.
Nwulia EA Nwulia Evaristus A EA Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.
O'Donovan C O'Donovan Claire C Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Loohuis LMO Loohuis Loes M Olde LMO Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Ori APS Ori Anil P S APS Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Oruc L Oruc Lilijana L Department of Clinical Psychiatry, Psychiatry Clinic, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Ösby U Ösby Urban U Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Perlis RH Perlis Roy H RH Division of Clinical Research, Massachusetts General Hospital, Boston, MA, USA.
Perry A Perry Amy A Department of Psychological Medicine, University of Worcester, Worcester, UK.
Pfennig A Pfennig Andrea A Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Potash JB Potash James B JB Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Purcell SM Purcell Shaun M SM Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Regeer EJ Regeer Eline J EJ Outpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, the Netherlands.
Reif A Reif Andreas A Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Reinbold CS Reinbold Céline S CS Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Rice JP Rice John P JP Department of Psychiatry, Washington University in Saint Louis, Saint Louis, MO, USA.
Rivas F Rivas Fabio F Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
Rivera M Rivera Margarita M Department of Biochemistry and Molecular Biology II, Institute of Neurosciences, Center for Biomedical Research, University of Granada, Granada, Spain.
Roussos P Roussos Panos P Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ruderfer DM Ruderfer Douglas M DM Medicine, Psychiatry, Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Ryu E Ryu Euijung E Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Sánchez-Mora C Sánchez-Mora Cristina C Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut, Universitat Autònoma de Barcelona, Barcelona, Spain.
Schatzberg AF Schatzberg Alan F AF Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Scheftner WA Scheftner William A WA Rush University Medical Center, Chicago, IL, USA.
Schork NJ Schork Nicholas J NJ Scripps Translational Science Institute, La Jolla, CA, USA.
Shannon Weickert C Shannon Weickert Cynthia C Neuroscience Research Australia, Sydney, New South Wales, Australia.
Shehktman T Shehktman Tatyana T Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Shilling PD Shilling Paul D PD Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Sigurdsson E Sigurdsson Engilbert E Faculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Slaney C Slaney Claire C Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Smeland OB Smeland Olav B OB NORMENT, University of Oslo, Oslo, Norway.
Sobell JL Sobell Janet L JL Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Søholm Hansen C Søholm Hansen Christine C Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Spijker AT Spijker Anne T AT Mood Disorders, PsyQ, Rotterdam, the Netherlands.
St Clair D St Clair David D Institute for Medical Sciences, University of Aberdeen, Aberdeen, UK.
Steffens M Steffens Michael M Research Division, Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany.
Strauss JS Strauss John S JS Centre for Addiction and Mental Health, Toronto, Onatario, Canada.
Streit F Streit Fabian F Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Strohmaier J Strohmaier Jana J Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Szelinger S Szelinger Szabolcs S Neurogenomics, TGen, Phoenix, AZ, USA.
Thompson RC Thompson Robert C RC Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Thorgeirsson TE Thorgeirsson Thorgeir E TE deCODE Genetics/Amgen, Reykjavik, Iceland.
Treutlein J Treutlein Jens J Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Vedder H Vedder Helmut H Department of Psychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany.
Wang W Wang Weiqing W Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Watson SJ Watson Stanley J SJ Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Weickert TW Weickert Thomas W TW Neuroscience Research Australia, Sydney, New South Wales, Australia.
Witt SH Witt Stephanie H SH Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Xi S Xi Simon S Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, USA.
Xu W Xu Wei W Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Young AH Young Allan H AH Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Zandi P Zandi Peter P Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Zhang P Zhang Peng P Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zöllner S Zöllner Sebastian S Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
eQTLGen Consortium
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Adolfsson R Adolfsson Rolf R Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden.
Agartz I Agartz Ingrid I NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine and Diakonhjemmet Hospital, University of Oslo, Oslo, Norway.
Alda M Alda Martin M National Institute of Mental Health, Klecany, Czech Republic.
Backlund L Backlund Lena L Department of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Baune BT Baune Bernhard T BT Department of Psychiatry, University of Munster, Munster, Germany.
Bellivier F Bellivier Frank F Department of Psychiatry, Université Paris Diderot, Paris, France.
Berrettini WH Berrettini Wade H WH Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Biernacka JM Biernacka Joanna M JM Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Blackwood DHR Blackwood Douglas H R DHR Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland.
Boehnke M Boehnke Michael M Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Børglum AD Børglum Anders D AD iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Corvin A Corvin Aiden A Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Craddock N Craddock Nicholas N Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Daly MJ Daly Mark J MJ Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Dannlowski U Dannlowski Udo U Department of Psychiatry, University of Munster, Munster, Germany.
Esko T Esko Tõnu T Division of Endocrinology, Children's Hospital Boston, Boston, MA, USA.
Etain B Etain Bruno B Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Frye M Frye Mark M Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
Fullerton JM Fullerton Janice M JM School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
Gershon ES Gershon Elliot S ES Department of Human Genetics, University of Chicago, Chicago, IL, USA.
Gill M Gill Michael M Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Goes F Goes Fernando F Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Grigoroiu-Serbanescu M Grigoroiu-Serbanescu Maria M Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Hauser J Hauser Joanna J Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Hougaard DM Hougaard David M DM Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Hultman CM Hultman Christina M CM Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Jones I Jones Ian I Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Jones LA Jones Lisa A LA Department of Psychological Medicine, University of Worcester, Worcester, UK.
Kahn RS Kahn René S RS Psychiatry, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, the Netherlands.
Kirov G Kirov George G Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Landén M Landén Mikael M Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Leboyer M Leboyer Marion M INSERM, Paris, France.
Lewis CM Lewis Cathryn M CM Department of Medical & Molecular Genetics, King's College London, London, UK.
Li QS Li Qingqin S QS Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA.
Lissowska J Lissowska Jolanta J Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
Martin NG Martin Nicholas G NG School of Psychology, The University of Queensland, Brisbane, Queensland, Australia.
Mayoral F Mayoral Fermin F Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
McElroy SL McElroy Susan L SL Research Institute, Lindner Center of HOPE, Mason, OH, USA.
McIntosh AM McIntosh Andrew M AM Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
McMahon FJ McMahon Francis J FJ Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
Melle I Melle Ingrid I Division of Mental Health and Addiction and Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway.
Metspalu A Metspalu Andres A Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Mitchell PB Mitchell Philip B PB School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Morken G Morken Gunnar G Department of Psychiatry, St Olavs University Hospital, Trondheim, Norway.
Mors O Mors Ole O Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.
Mortensen PB Mortensen Preben Bo PB National Centre for Register-based Research and Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.
Müller-Myhsok B Müller-Myhsok Bertram B University of Liverpool, Liverpool, UK.
Myers RM Myers Richard M RM HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Neale BM Neale Benjamin M BM Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Nimgaonkar V Nimgaonkar Vishwajit V Psychiatry and Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Nordentoft M Nordentoft Merete M Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
Nöthen MM Nöthen Markus M MM Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
O'Donovan MC O'Donovan Michael C MC Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Oedegaard KJ Oedegaard Ketil J KJ Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Owen MJ Owen Michael J MJ Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Paciga SA Paciga Sara A SA Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA.
Pato C Pato Carlos C College of Medicine Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Pato MT Pato Michele T MT Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Posthuma D Posthuma Danielle D Department of Clinical Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, the Netherlands.
Ramos-Quiroga JA Ramos-Quiroga Josep Antoni JA Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut, Universitat Autònoma de Barcelona, Barcelona, Spain.
Ribasés M Ribasés Marta M Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut, Universitat Autònoma de Barcelona, Barcelona, Spain.
Rietschel M Rietschel Marcella M Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Rouleau GA Rouleau Guy A GA Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada.
Schalling M Schalling Martin M Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Schofield PR Schofield Peter R PR School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
Schulze TG Schulze Thomas G TG Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
Serretti A Serretti Alessandro A Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
Smoller JW Smoller Jordan W JW Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Stefansson H Stefansson Hreinn H deCODE Genetics/Amgen, Reykjavik, Iceland.
Stefansson K Stefansson Kari K Faculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Stordal E Stordal Eystein E Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Sullivan PF Sullivan Patrick F PF Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Turecki G Turecki Gustavo G Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Vaaler AE Vaaler Arne E AE Department of Psychiatry, Sankt Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Norway.
Vieta E Vieta Eduard E Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Vincent JB Vincent John B JB Centre for Addiction and Mental Health, Toronto, Onatario, Canada.
Werge T Werge Thomas T Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Nurnberger JI Nurnberger John I JI Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Wray NR Wray Naomi R NR Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Di Florio A Di Florio Arianna A Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Edenberg HJ Edenberg Howard J HJ Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Cichon S Cichon Sven S Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Ophoff RA Ophoff Roel A RA Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Scott LJ Scott Laura J LJ Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Andreassen OA Andreassen Ole A OA NORMENT, University of Oslo, Oslo, Norway.
Kelsoe J Kelsoe John J Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. jkelsoe@ucsd.edu.
Sklar P Sklar Pamela P Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bipolar Disorder Working Group of the Psychiatric Genomics Consortium
INVESTIGATORS
JOURNAL
VOLUME: 51
ISSUE: 5
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2019
MONTH: 05
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
U01 MH109536 NIMH NIH HHS United States
U01 MH109514 NIMH NIH HHS United States
R00 MH101367 NIMH NIH HHS United States
Wellcome Trust United Kingdom
R01 MH119243 NIMH NIH HHS United States
MR/L023784/2 Medical Research Council United Kingdom
MR/L010305/1 Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Bipolar Disorder genetics
Case-Control Studies genetics
Depressive Disorder, Major genetics
Female genetics
Genetic Loci genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study genetics
Humans genetics
Male genetics
Polymorphism, Single Nucleotide genetics
Psychotic Disorders genetics
Schizophrenia genetics
Systems Biology genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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