Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30949193
TITLE
Genetic Structure of IQ, Phonemic Decoding Skill, and Academic Achievement.
ABSTRACT
The aim of this study was to examine whether phonemic decoding skill (deficits of which characterize dyslexia) shares genetic and/or environmental covariance with scholastic abilities independent of general intelligence. Non-word reading ability, verbal and non-verbal IQ, and standardized academic achievement (Queensland Core Skills Test; QCST) were measured in Australian twins (up to 876 twin pairs and 80 singleton twins). Multivariate genetic analysis showed the presence of a general genetic factor, likely reflecting crystallized ability, which accounted for 45-76% of phenotypic variance in QCST scores, 62% of variance in Verbal IQ, 23% of variance in Performance IQ, and 19% of variance in phonological reading ability. The phonemic decoding genetic factor (explaining 48% of variance in phonemic decoding) was negatively associated with mathematical achievement scores (0.4%). Shared effects of common environment did not explain the relationship between reading ability and academic achievement beyond those also influencing IQ. The unique environmental reading factor (accounting for 26% of variance) influenced academic abilities related to written expression. Future research will need to address whether these reading-specific genetic and unique environment relationships arise from causal effects of reading on scholastic abilities, or whether both share a common influence, such as pleiotropic genes/environmental factors.
DATE PUBLISHED
2019
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/10/01
accepted 2019/02/25
entrez 2019/04/06 06:00
pubmed 2019/04/06 06:00
medline 2019/04/06 06:01
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Lazaroo NK Lazaroo Nikita K NK Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Bates TC Bates Timothy C TC Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Hansell NK Hansell Narelle K NK Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Wright MJ Wright Margaret J MJ Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Luciano M Luciano Michelle M Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
INVESTIGATORS
JOURNAL
VOLUME: 10
ISSUE:
TITLE: Frontiers in genetics
ISOABBREVIATION: Front Genet
YEAR: 2019
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1664-8021
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Front Genet
COUNTRY: Switzerland
ISSNLINKING: 1664-8021
NLMUNIQUEID: 101560621
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
intelligence
multivariate modeling
reading ability
scholastic achievement
twin design
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's