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| PMID |
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| TITLE |
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| The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. |
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| ABSTRACT |
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| The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2018/11/20 |
| accepted |
2019/01/25 |
| pubmed |
2019/03/20 06:00 |
| medline |
2019/09/12 06:00 |
| entrez |
2019/03/20 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Middeldorp CM |
|
Middeldorp |
Christel M |
CM |
|
Department of Biological Psychology, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, The Netherlands. c.middeldorp@uq.edu.au. |
| Felix JF |
|
Felix |
Janine F |
JF |
|
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, 3015 CE, Rotterdam, The Netherlands. |
| Mahajan A |
|
Mahajan |
Anubha |
A |
|
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK. |
|
EArly Genetics Lifecourse Epidemiology (EAGLE) consortium |
|
|
|
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|
Early Growth Genetics (EGG) consortium |
|
|
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| McCarthy MI |
|
McCarthy |
Mark I |
MI |
|
Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LE, UK. |
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Ahluwalia |
Tarunveer S |
TS |
|
| Auvinen |
Juha |
J |
|
| Bartels |
Meike |
M |
|
| Bilbao |
Jose Ramon |
JR |
|
| Bisgaard |
Hans |
H |
|
| Bønnelykke |
Klaus |
K |
|
| Boomsma |
Dorret I |
DI |
|
| Bradfield |
Jonathan P |
JP |
|
| Bustamante |
Mariona |
M |
|
| Chen |
Zhanghua |
Z |
|
| Curtin |
John A |
JA |
|
| Custovic |
Adnan |
A |
|
| Smith |
George Davey |
GD |
|
| Davies |
Gareth E |
GE |
|
| Duijts |
Liesbeth |
L |
|
| Eastwood |
Peter R |
PR |
|
| Eliasen |
Anders U |
AU |
|
| Estivill |
Xavier |
X |
|
| Evans |
David M |
DM |
|
| Fedko |
Iryna O |
IO |
|
| Felix |
Janine F |
JF |
|
| Gauderman |
W James |
WJ |
|
| Gilliland |
Frank |
F |
|
| Granell |
Raquel |
R |
|
| Grant |
Struan F A |
SFA |
|
| Guxens |
Monica |
M |
|
| Hakonarson |
Hakon |
H |
|
| Hartman |
Catharina A |
CA |
|
| Heinrich |
Joachim |
J |
|
| Henders |
Anjali K |
AK |
|
| Henderson |
John |
J |
|
| Holt |
Patrick |
P |
|
| Hottenga |
Jouke-Jan |
JJ |
|
| Hyppönen |
Elina |
E |
|
| Iñíguez |
Carmen |
C |
|
| Jacobsson |
Bo |
B |
|
| Jaddoe |
Vincent W V |
VWV |
|
| Järvelin |
Marjo-Riitta |
MR |
|
| Jugessur |
Astanand |
A |
|
| Kähönen |
Mika |
M |
|
| Kaprio |
Jaakko |
J |
|
| Karhunen |
Ville |
V |
|
| Kemp |
John P |
JP |
|
| Koppelman |
Gerard H |
GH |
|
| Kumar |
Ashish |
A |
|
| Lahti |
Jari |
J |
|
| Larsson |
Henrik |
H |
|
| Lawlor |
Debbie A |
DA |
|
| Lehtimäki |
Terho |
T |
|
| Li |
Jin |
J |
|
| Lichtenstein |
Paul |
P |
|
| Lundström |
Sebastian |
S |
|
| Lyytikäinen |
Leo-Pekka |
LP |
|
| Magnus |
Per |
P |
|
| Mamun |
Abdullah A |
AA |
|
| Mannikko |
Minna |
M |
|
| Martin |
Nicholas G |
NG |
|
| Mbarek |
Hamdi |
H |
|
| Medland |
Sarah E |
SE |
|
| Melén |
Erik |
E |
|
| Middeldorp |
Christel M |
CM |
|
| Najman |
Jackob M |
JM |
|
| Nivard |
Michel G |
MG |
|
| Nolte |
Ilja M |
IM |
|
| Oldehinkel |
Albertine J |
AJ |
|
| Pahkala |
Katja |
K |
|
| Palviainen |
Teemu |
T |
|
| Paternoster |
Lavinia |
L |
|
| Pennell |
Craig E |
CE |
|
| Pershagen |
Göran |
G |
|
| Pitkänen |
Niina |
N |
|
| Plomin |
Robert |
R |
|
| Pourcain |
Beate St |
BS |
|
| Power |
Christine |
C |
|
| Pulkkinen |
Lea |
L |
|
| Räikkönen |
Katri |
K |
|
| Raitakari |
Olli T |
OT |
|
| Richmond |
Rebecca C |
RC |
|
| Rivadeneira |
Fernando |
F |
|
| Rose |
Richard J |
RJ |
|
| Santa-Marina |
Loreto |
L |
|
| Scott |
James G |
JG |
|
| Sebert |
Sylvain |
S |
|
| Selzam |
Saskia |
S |
|
| Simpson |
Angela |
A |
|
| Sleiman |
Patrick M A |
PMA |
|
| Snieder |
Harold |
H |
|
| Standl |
Marie |
M |
|
| Stoltenberg |
Camilla |
C |
|
| Strachan |
David P |
DP |
|
| Straker |
Leon |
L |
|
| Strandberg |
Timo |
T |
|
| Sunyer |
Jordi |
J |
|
| Thiering |
Elisabeth |
E |
|
| Tiemeier |
Henning |
H |
|
| Timpson |
Nicholas J |
NJ |
|
| Torrent |
Maties |
M |
|
| Uitterlinden |
André G |
AG |
|
| van Beijsterveldt |
Toos |
T |
|
| van der Most |
Peter J |
PJ |
|
| van Duijn |
Cornelia M |
CM |
|
| Viikari |
Jorma |
J |
|
| Vilor-Tejedor |
Natalia |
N |
|
| Vonk |
Judith M |
JM |
|
| Vrijkotte |
Tanja G M |
TGM |
|
| Vuoksimaa |
Eero |
E |
|
| Wang |
Carol A |
CA |
|
| Whitehouse |
Andrew J O |
AJO |
|
| Willemsen |
Gonneke |
G |
|
| Williams |
Gail M |
GM |
|
| Wray |
Naomi R |
NR |
|
| Xu |
Shujing |
S |
|
| Xu |
Cheng-Jian |
CJ |
|
| Yi |
Lu |
L |
|
| Zafarmand |
Mohammad Hadi |
MH |
|
|
| JOURNAL |
|
| VOLUME: 34 |
| ISSUE: 3 |
| TITLE: European journal of epidemiology |
| ISOABBREVIATION: Eur J Epidemiol |
| YEAR: 2019 |
| MONTH: Mar |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1573-7284 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Eur J Epidemiol |
| COUNTRY: Netherlands |
| ISSNLINKING: 0393-2990 |
| NLMUNIQUEID: 8508062 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
|
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| P50 HD028138 |
NICHD NIH HHS |
United States |
| P30 ES007048 |
NIEHS NIH HHS |
United States |
| MC_U147585827 |
Medical Research Council |
United Kingdom |
| MR/L01341X/1 |
Medical Research Council |
United Kingdom |
| MC_UP_A620_1014 |
Medical Research Council |
United Kingdom |
| MC_PC_15018 |
Medical Research Council |
United Kingdom |
| MC_UU_12013/4 |
Medical Research Council |
United Kingdom |
| MC_UU_12011/1 |
Medical Research Council |
United Kingdom |
| G0400491 |
Medical Research Council |
United Kingdom |
| G9815508 |
Medical Research Council |
United Kingdom |
| MC_U147585819 |
Medical Research Council |
United Kingdom |
| MR/K002449/1 |
Medical Research Council |
United Kingdom |
| MC_UU_00011/1 |
Medical Research Council |
United Kingdom |
| U01 LM012675 |
NLM NIH HHS |
United States |
| G0601361 |
Medical Research Council |
United Kingdom |
| 104150 |
Wellcome Trust |
United Kingdom |
| MC_UU_12013/5 |
Medical Research Council |
United Kingdom |
| MC_U147585824 |
Medical Research Council |
United Kingdom |
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| GENERAL NOTE |
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| KEYWORDS |
|
| KEYWORD |
| Childhood traits and disorders |
| Consortium |
| Genetics |
| Longitudinal |
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
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| Adult |
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| Child |
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| Child, Preschool |
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| Cohort Studies |
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| Disease |
genetics |
| Female |
genetics |
| Forecasting |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Humans |
genetics |
| Infant |
genetics |
| Infant, Newborn |
genetics |
| Male |
genetics |
| Phenotype |
genetics |
| Pregnancy |
genetics |
| Research Design |
genetics |
| United Kingdom |
epidemiology |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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