Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30887376
TITLE
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects.
ABSTRACT
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
DATE PUBLISHED
2019 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/11/20
accepted 2019/01/25
pubmed 2019/03/20 06:00
medline 2019/09/12 06:00
entrez 2019/03/20 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Middeldorp CM Middeldorp Christel M CM Department of Biological Psychology, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, The Netherlands. c.middeldorp@uq.edu.au.
Felix JF Felix Janine F JF Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, 3015 CE, Rotterdam, The Netherlands.
Mahajan A Mahajan Anubha A Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.
EArly Genetics Lifecourse Epidemiology (EAGLE) consortium
Early Growth Genetics (EGG) consortium
McCarthy MI McCarthy Mark I MI Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LE, UK.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Ahluwalia Tarunveer S TS
Auvinen Juha J
Bartels Meike M
Bilbao Jose Ramon JR
Bisgaard Hans H
Bønnelykke Klaus K
Boomsma Dorret I DI
Bradfield Jonathan P JP
Bustamante Mariona M
Chen Zhanghua Z
Curtin John A JA
Custovic Adnan A
Smith George Davey GD
Davies Gareth E GE
Duijts Liesbeth L
Eastwood Peter R PR
Eliasen Anders U AU
Estivill Xavier X
Evans David M DM
Fedko Iryna O IO
Felix Janine F JF
Gauderman W James WJ
Gilliland Frank F
Granell Raquel R
Grant Struan F A SFA
Guxens Monica M
Hakonarson Hakon H
Hartman Catharina A CA
Heinrich Joachim J
Henders Anjali K AK
Henderson John J
Holt Patrick P
Hottenga Jouke-Jan JJ
Hyppönen Elina E
Iñíguez Carmen C
Jacobsson Bo B
Jaddoe Vincent W V VWV
Järvelin Marjo-Riitta MR
Jugessur Astanand A
Kähönen Mika M
Kaprio Jaakko J
Karhunen Ville V
Kemp John P JP
Koppelman Gerard H GH
Kumar Ashish A
Lahti Jari J
Larsson Henrik H
Lawlor Debbie A DA
Lehtimäki Terho T
Li Jin J
Lichtenstein Paul P
Lundström Sebastian S
Lyytikäinen Leo-Pekka LP
Magnus Per P
Mamun Abdullah A AA
Mannikko Minna M
Martin Nicholas G NG
Mbarek Hamdi H
Medland Sarah E SE
Melén Erik E
Middeldorp Christel M CM
Najman Jackob M JM
Nivard Michel G MG
Nolte Ilja M IM
Oldehinkel Albertine J AJ
Pahkala Katja K
Palviainen Teemu T
Paternoster Lavinia L
Pennell Craig E CE
Pershagen Göran G
Pitkänen Niina N
Plomin Robert R
Pourcain Beate St BS
Power Christine C
Pulkkinen Lea L
Räikkönen Katri K
Raitakari Olli T OT
Richmond Rebecca C RC
Rivadeneira Fernando F
Rose Richard J RJ
Santa-Marina Loreto L
Scott James G JG
Sebert Sylvain S
Selzam Saskia S
Simpson Angela A
Sleiman Patrick M A PMA
Snieder Harold H
Standl Marie M
Stoltenberg Camilla C
Strachan David P DP
Straker Leon L
Strandberg Timo T
Sunyer Jordi J
Thiering Elisabeth E
Tiemeier Henning H
Timpson Nicholas J NJ
Torrent Maties M
Uitterlinden André G AG
van Beijsterveldt Toos T
van der Most Peter J PJ
van Duijn Cornelia M CM
Viikari Jorma J
Vilor-Tejedor Natalia N
Vonk Judith M JM
Vrijkotte Tanja G M TGM
Vuoksimaa Eero E
Wang Carol A CA
Whitehouse Andrew J O AJO
Willemsen Gonneke G
Williams Gail M GM
Wray Naomi R NR
Xu Shujing S
Xu Cheng-Jian CJ
Yi Lu L
Zafarmand Mohammad Hadi MH
JOURNAL
VOLUME: 34
ISSUE: 3
TITLE: European journal of epidemiology
ISOABBREVIATION: Eur. J. Epidemiol.
YEAR: 2019
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-7284
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Eur J Epidemiol
COUNTRY: Netherlands
ISSNLINKING: 0393-2990
NLMUNIQUEID: 8508062
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
P50 HD028138 NICHD NIH HHS United States
P30 ES007048 NIEHS NIH HHS United States
MC_U147585827 Medical Research Council United Kingdom
MR/L01341X/1 Medical Research Council United Kingdom
MC_UP_A620_1014 Medical Research Council United Kingdom
MC_PC_15018 Medical Research Council United Kingdom
MC_UU_12013/4 Medical Research Council United Kingdom
MC_UU_12011/1 Medical Research Council United Kingdom
G0400491 Medical Research Council United Kingdom
G9815508 Medical Research Council United Kingdom
MC_U147585819 Medical Research Council United Kingdom
MR/K002449/1 Medical Research Council United Kingdom
MC_UU_00011/1 Medical Research Council United Kingdom
G0601361 Medical Research Council United Kingdom
104150 Wellcome Trust United Kingdom
MC_UU_12013/5 Medical Research Council United Kingdom
MC_U147585824 Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
KEYWORD
Childhood traits and disorders
Consortium
Genetics
Longitudinal
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Child
Child, Preschool
Cohort Studies
Disease genetics
Female genetics
Forecasting genetics
Genetic Predisposition to Disease genetics
Humans genetics
Infant genetics
Infant, Newborn genetics
Male genetics
Phenotype genetics
Pregnancy genetics
Research Design genetics
United Kingdom epidemiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's