|
|
| PMID |
|
|
| TITLE |
|
| Half the Genetic Variance in Vitamin D Concentration is Shared with Skin Colour and Sun Exposure Genes. |
|
| ABSTRACT |
|
|
|
| This study assessed the heritability of 25 hydroxyvitamin D3 (25(OH)D3) in a large twin cohort and the shared effect of sun exposure and skin colour on 25(OH)D3 variance. Study participants included 1604 twin pairs and their siblings (n = 4020). Twin correlations for 25(OH)D3 concentration were rMZ=0.79 (584 pairs) and rDZ = 0.52 (1020 pairs) consistent with an average h = 0.50 throughout the year. Significant phenotypic and genetic seasonal fluctuation was observed in 25(OH)D3 concentrations with heritability decreasing during the winter (h = 0.37) compared to summer (h = 0.62). Skin colour (measured both ordinally and quantitatively) and self-reported sun exposure were found to significantly affect 25(OH)D3 concentration. Twins with olive/dark skin had significantly lower 25(OH)D3 concentrations than those with fair/pale skin and multivariate genetic analysis showed that approximately half of the total additive genetic variation in 25(OH)D3 results from genes whose primary influence is on skin colour and sun exposure. Additionally, 37% of the total variance was attributed to shared environmental effects on vitamin D, skin colour and sun exposure measures. These results support a moderate estimate of vitamin D heritability and suggest significant influence of season, skin colour and sun exposure on the genetic variance. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2018/11/12 |
| accepted |
2019/03/01 |
| pubmed |
2019/03/17 06:00 |
| medline |
2020/02/14 06:00 |
| entrez |
2019/03/17 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
|
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia. Brittany.mitchell@qimrberghofer.edu.au. |
| Zhu G |
|
Zhu |
Gu |
G |
|
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia. |
| Renteria ME |
|
Renteria |
Miguel E |
ME |
|
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia. |
| Eyles DW |
|
Eyles |
Darryl W |
DW |
|
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia. |
| Grasby KL |
|
Grasby |
Katrina L |
KL |
|
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia. |
| McGrath JJ |
|
McGrath |
John J |
JJ |
|
National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 49 |
| ISSUE: 4 |
| TITLE: Behavior genetics |
| ISOABBREVIATION: Behav Genet |
| YEAR: 2019 |
| MONTH: 07 |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1573-3297 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Behav Genet |
| COUNTRY: United States |
| ISSNLINKING: 0001-8244 |
| NLMUNIQUEID: 0251711 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| 241944, 552485, 552498, 1031119, 1049894 |
National Health and Medical Research Council |
|
| APP 1007677, APP 1099709 |
National Health and Medical Research Council |
|
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Genetics |
| Heritability |
| Skin colour |
| Sun exposure |
| Twin |
| Vitamin D |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| 25-Hydroxyvitamin D 2 |
metabolism |
| Adolescent |
metabolism |
| Calcifediol |
genetics |
| Child |
genetics |
| Female |
genetics |
| Genetic Variation |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Skin Pigmentation |
physiology |
| Sunlight |
adverse effects |
| Vitamin D |
metabolism |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 1406-16-2 |
Vitamin D |
| 21343-40-8 |
25-Hydroxyvitamin D 2 |
| P6YZ13C99Q |
Calcifediol |
|
| OTHER ID's |
|
|
|
