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| PMID |
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| TITLE |
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| Social Competence in Parents Increases Children's Educational Attainment: Replicable Genetically-Mediated Effects of Parenting Revealed by Non-Transmitted DNA. |
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| ABSTRACT |
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| We recently reported an association of offspring educational attainment with polygenic risk scores (PRS) computed on parent's non-transmitted alleles for educational attainment using the second GWAS meta-analysis article on educational attainment published by the Social Science Genetic Association Consortium. Here we test the replication of these findings using a more powerful PRS from the third GWAS meta-analysis article by the Consortium. Each of the key findings of our previous paper is replicated using this improved PRS (N = 2335 adolescent twins and their genotyped parents). The association of children's attainment with their own PRS increased substantially with the standardized effect size, moving from β = 0.134, 95% CI = 0.079, 0.188 for EA2, to β = 0.223, 95% CI = 0.169, 0.278, p < .001, for EA3. Parent's PRS again predicted the socioeconomic status (SES) they provided to their offspring and increased from β = 0.201, 95% CI = 0.147, 0.256 to β = 0.286, 95% CI = 0.239, 0.333. Importantly, the PRS for alleles not transmitted to their offspring - therefore acting via the parenting environment - was increased in effect size from β = 0.058, 95% CI = 0.003, 0.114 to β = 0.067, 95% CI = 0.012, 0.122, p = .016. As previously found, this non-transmitted genetic effect was fully accounted for by parental SES. The findings reinforce the conclusion that genetic effects of parenting are substantial, explain approximately one-third the magnitude of an individual's own genetic inheritance and are mediated by parental socioeconomic competence. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2019/01/22 06:00 |
| medline |
2019/04/19 06:00 |
| entrez |
2019/01/22 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Bates TC |
|
Bates |
Timothy C |
TC |
|
Department of Psychology,University of Edinburgh,Edinburgh,UK. |
| Maher BS |
|
Maher |
Brion S |
BS |
|
Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA. |
| Colodro-Conde L |
|
Colodro-Conde |
Lucía |
L |
|
QIMR Berghofer Medical Research Institute,Brisbane, Queensland,Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
QIMR Berghofer Medical Research Institute,Brisbane, Queensland,Australia. |
| McAloney K |
|
McAloney |
Kerrie |
K |
|
QIMR Berghofer Medical Research Institute,Brisbane, Queensland,Australia. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
Queensland Brain Institute,University of Queensland,Brisbane, Queensland,Australia. |
| Hansell NK |
|
Hansell |
Narelle K |
NK |
|
Queensland Brain Institute,University of Queensland,Brisbane, Queensland,Australia. |
| Okbay A |
|
Okbay |
Aysu |
A |
|
Department of Economics, School of Business and Economics,Vrije Universiteit Amsterdam,Amsterdam,The Netherlands. |
| Kendler KS |
|
Kendler |
Kenneth S |
KS |
|
Virginia Institute of Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute,Brisbane, Queensland,Australia. |
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
Virginia Institute of Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA. |
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| INVESTIGATORS |
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| JOURNAL |
|
| VOLUME: 22 |
| ISSUE: 1 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2019 |
| MONTH: 02 |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Multicenter Study |
| Research Support, Non-U.S. Gov't |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| PRS |
| SES |
| educational attainment |
| non-transmitted genotype |
| parental environment |
| parenting |
| polygenic risk scores |
| socioeconomic status |
| virtual-parent design |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
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| Educational Status |
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| Female |
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| Genome-Wide Association Study |
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| Humans |
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| Male |
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| Socioeconomic Factors |
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| Twins |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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