|
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| PMID |
|
|
| TITLE |
|
| Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. |
|
| ABSTRACT |
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| Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2018/01/26 |
| accepted |
2018/11/07 |
| pubmed |
2019/01/16 06:00 |
| medline |
2019/04/25 06:00 |
| entrez |
2019/01/16 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Karlsson Linnér R |
|
Karlsson Linnér |
Richard |
R |
|
Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands. r.karlssonlinner@vu.nl. |
| Biroli P |
|
Biroli |
Pietro |
P |
|
Department of Economics, University of Zurich, Zurich, Switzerland. |
| Kong E |
|
Kong |
Edward |
E |
|
Department of Economics, Harvard University, Cambridge, MA, USA. |
| Meddens SFW |
|
Meddens |
S Fleur W |
SFW |
|
Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands. |
| Wedow R |
|
Wedow |
Robbee |
R |
|
Department of Sociology, Harvard University, Cambridge, MA, USA. |
| Fontana MA |
|
Fontana |
Mark Alan |
MA |
|
Department of Healthcare Policy and Research, Weill Cornell Medical College, Cornell University, New York, NY, USA. |
| Lebreton M |
|
Lebreton |
Maël |
M |
|
Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, the Netherlands. |
| Tino SP |
|
Tino |
Stephen P |
SP |
|
Department of Economics, University of Toronto, Toronto, Ontario, Canada. |
| Abdellaoui A |
|
Abdellaoui |
Abdel |
A |
|
Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. |
| Hammerschlag AR |
|
Hammerschlag |
Anke R |
AR |
|
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands. |
| Nivard MG |
|
Nivard |
Michel G |
MG |
|
Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. |
| Okbay A |
|
Okbay |
Aysu |
A |
|
Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands. |
| Rietveld CA |
|
Rietveld |
Cornelius A |
CA |
|
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. |
| Timshel PN |
|
Timshel |
Pascal N |
PN |
|
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. |
| Trzaskowski M |
|
Trzaskowski |
Maciej |
M |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. |
| Vlaming R |
|
Vlaming |
Ronald de |
R |
|
Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands. |
| Zünd CL |
|
Zünd |
Christian L |
CL |
|
Department of Economics, University of Zurich, Zurich, Switzerland. |
| Bao Y |
|
Bao |
Yanchun |
Y |
|
Institute for Social and Economic Research, University of Essex, Colchester, UK. |
| Buzdugan L |
|
Buzdugan |
Laura |
L |
|
Department of Economics, University of Zurich, Zurich, Switzerland. |
| Caplin AH |
|
Caplin |
Ann H |
AH |
|
Stuyvesant High School, New York, NY, USA. |
| Chen CY |
|
Chen |
Chia-Yen |
CY |
|
Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. |
| Eibich P |
|
Eibich |
Peter |
P |
|
Max Planck Institute for Demographic Research, Rostock, Germany. |
| Fontanillas P |
|
Fontanillas |
Pierre |
P |
|
Research, 23andMe, Inc., Mountain View, CA, USA. |
| Gonzalez JR |
|
Gonzalez |
Juan R |
JR |
|
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. |
| Joshi PK |
|
Joshi |
Peter K |
PK |
|
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland. |
| Karhunen V |
|
Karhunen |
Ville |
V |
|
Center for Life Course Health Research, University of Oulu, Oulu, Finland. |
| Kleinman A |
|
Kleinman |
Aaron |
A |
|
Research, 23andMe, Inc., Mountain View, CA, USA. |
| Levin RZ |
|
Levin |
Remy Z |
RZ |
|
Department of Economics, University of California San Diego, La Jolla, CA, USA. |
| Lill CM |
|
Lill |
Christina M |
CM |
|
Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany. |
| Meddens GA |
|
Meddens |
Gerardus A |
GA |
|
Team Loyalty BV, Hoofddorp, the Netherlands. |
| Muntané G |
|
Muntané |
Gerard |
G |
|
Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Reus, Spain. |
| Sanchez-Roige S |
|
Sanchez-Roige |
Sandra |
S |
|
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. |
| Rooij FJV |
|
Rooij |
Frank J van |
FJV |
|
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. |
| Taskesen E |
|
Taskesen |
Erdogan |
E |
|
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands. |
| Wu Y |
|
Wu |
Yang |
Y |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. |
| Zhang F |
|
Zhang |
Futao |
F |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. |
|
23and Me Research Team |
|
|
|
|
|
|
eQTLgen Consortium |
|
|
|
|
|
|
International Cannabis Consortium |
|
|
|
|
|
|
Social Science Genetic Association Consortium |
|
|
|
|
|
| Auton A |
|
Auton |
Adam |
A |
|
Research, 23andMe, Inc., Mountain View, CA, USA. |
| Boardman JD |
|
Boardman |
Jason D |
JD |
|
Department of Sociology, University of Colorado Boulder, Boulder, CO, USA. |
| Clark DW |
|
Clark |
David W |
DW |
|
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland. |
| Conlin A |
|
Conlin |
Andrew |
A |
|
Department of Economics and Finance, Oulu Business School, University of Oulu, Oulu, Finland. |
| Dolan CC |
|
Dolan |
Conor C |
CC |
|
Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. |
| Fischbacher U |
|
Fischbacher |
Urs |
U |
|
Thurgau Institute of Economics, Kreuzlingen, Switzerland. |
| Groenen PJF |
|
Groenen |
Patrick J F |
PJF |
|
Department of Econometrics, Erasmus University Rotterdam, Rotterdam, Rotterdam, the Netherlands. |
| Harris KM |
|
Harris |
Kathleen Mullan |
KM |
|
Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
| Hasler G |
|
Hasler |
Gregor |
G |
|
Unit of Psychiatry Research, University of Fribourg, Fribourg, Switzerland. |
| Hofman A |
|
Hofman |
Albert |
A |
|
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. |
| Ikram MA |
|
Ikram |
Mohammad A |
MA |
|
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. |
| Jain S |
|
Jain |
Sonia |
S |
|
Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA. |
| Karlsson R |
|
Karlsson |
Robert |
R |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Kessler RC |
|
Kessler |
Ronald C |
RC |
|
Department of Health Care Policy, Harvard Medical School, Boston, MA, USA. |
| Kooyman M |
|
Kooyman |
Maarten |
M |
|
SURFsara, Amsterdam, the Netherlands. |
| MacKillop J |
|
MacKillop |
James |
J |
|
Homewood Research Institute, Guelph, Ontario, Canada. |
| Männikkö M |
|
Männikkö |
Minna |
M |
|
Center for Life Course Health Research, University of Oulu, Oulu, Finland. |
| Morcillo-Suarez C |
|
Morcillo-Suarez |
Carlos |
C |
|
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain. |
| McQueen MB |
|
McQueen |
Matthew B |
MB |
|
Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA. |
| Schmidt KM |
|
Schmidt |
Klaus M |
KM |
|
Department of Economics, University of Munich, Munich, Germany. |
| Smart MC |
|
Smart |
Melissa C |
MC |
|
Institute for Social and Economic Research, University of Essex, Colchester, UK. |
| Sutter M |
|
Sutter |
Matthias |
M |
|
Department of Public Finance, University of Innsbruck, Innsbruck, Austria. |
| Thurik AR |
|
Thurik |
A Roy |
AR |
|
Montpellier Business School, Montpellier, France. |
| Uitterlinden AG |
|
Uitterlinden |
André G |
AG |
|
Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands. |
| White J |
|
White |
Jon |
J |
|
UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, London, UK. |
| Wit H |
|
Wit |
Harriet de |
H |
|
Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA. |
| Yang J |
|
Yang |
Jian |
J |
|
Queensland Brain Institute, The University of Queensland, Brisbane, Australia. |
| Bertram L |
|
Bertram |
Lars |
L |
|
School of Public Health, Imperial College London, London, UK. |
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. |
| Esko T |
|
Esko |
Tõnu |
T |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
| Fehr E |
|
Fehr |
Ernst |
E |
|
Department of Economics, University of Zurich, Zurich, Switzerland. |
| Hinds DA |
|
Hinds |
David A |
DA |
|
Research, 23andMe, Inc., Mountain View, CA, USA. |
| Johannesson M |
|
Johannesson |
Magnus |
M |
|
Department of Economics, Stockholm School of Economics, Stockholm, Sweden. |
| Kumari M |
|
Kumari |
Meena |
M |
|
Institute for Social and Economic Research, University of Essex, Colchester, UK. |
| Laibson D |
|
Laibson |
David |
D |
|
Department of Economics, Harvard University, Cambridge, MA, USA. |
| Magnusson PKE |
|
Magnusson |
Patrik K E |
PKE |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Meyer MN |
|
Meyer |
Michelle N |
MN |
|
Center for Translational Bioethics and Health Care Policy, Geisinger Health System, Danville, PA, USA. |
| Navarro A |
|
Navarro |
Arcadi |
A |
|
Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. |
| Palmer AA |
|
Palmer |
Abraham A |
AA |
|
Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA. |
| Pers TH |
|
Pers |
Tune H |
TH |
|
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. |
| Posthuma D |
|
Posthuma |
Danielle |
D |
|
Department of Clinical Genetics, VU Medical Centre, Amsterdam, the Netherlands. |
| Schunk D |
|
Schunk |
Daniel |
D |
|
Department of Economics, Johannes Gutenberg University, Mainz, Germany. |
| Stein MB |
|
Stein |
Murray B |
MB |
|
Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA. |
| Svento R |
|
Svento |
Rauli |
R |
|
Department of Economics and Finance, Oulu Business School, University of Oulu, Oulu, Finland. |
| Tiemeier H |
|
Tiemeier |
Henning |
H |
|
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. |
| Timmers PRHJ |
|
Timmers |
Paul R H J |
PRHJ |
|
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland. |
| Turley P |
|
Turley |
Patrick |
P |
|
Behavioral and Health Genomics Center, Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. |
| Ursano RJ |
|
Ursano |
Robert J |
RJ |
|
Department of Psychiatry, Center for the Study of Traumatic Stress, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. |
| Wagner GG |
|
Wagner |
Gert G |
GG |
|
Max Planck Institute for Human Development, Berlin, Germany. |
| Wilson JF |
|
Wilson |
James F |
JF |
|
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland. |
| Gratten J |
|
Gratten |
Jacob |
J |
|
Mater Medical Research Institute, Translational Research Institute, Brisbane, Australia. |
| Lee JJ |
|
Lee |
James J |
JJ |
|
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA. |
| Cesarini D |
|
Cesarini |
David |
D |
|
Department of Economics, New York University, New York, NY, USA. |
| Benjamin DJ |
|
Benjamin |
Daniel J |
DJ |
|
National Bureau of Economic Research, Cambridge, MA, USA. |
| Koellinger PD |
|
Koellinger |
Philipp D |
PD |
|
German Institute for Economic Research, DIW Berlin, Berlin, Germany. |
| Beauchamp JP |
|
Beauchamp |
Jonathan P |
JP |
|
Department of Economics, University of Toronto, Toronto, Ontario, Canada. jonathan.pierre.beauchamp@gmail.com. |
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Agee |
Michelle |
M |
|
| Alipanahi |
Babak |
B |
|
| Bell |
Robert K |
RK |
|
| Bryc |
Katarzyna |
K |
|
| Elson |
Sarah L |
SL |
|
| Furlotte |
Nicholas A |
NA |
|
| Huber |
Karen E |
KE |
|
| Litterman |
Nadia K |
NK |
|
| McCreight |
Jennifer C |
JC |
|
| McIntyre |
Matthew H |
MH |
|
| Mountain |
Joanna L |
JL |
|
| Northover |
Carrie A M |
CAM |
|
| Pitts |
Steven J |
SJ |
|
| Sathirapongsasuti |
J Fah |
JF |
|
| Sazonova |
Olga V |
OV |
|
| Shelton |
Janie F |
JF |
|
| Shringarpure |
Suyash |
S |
|
| Tian |
Chao |
C |
|
| Tung |
Joyce Y |
JY |
|
| Vacic |
Vladimir |
V |
|
| Wilson |
Catherine H |
CH |
|
| Agbessi |
Mawussé |
M |
|
| Ahsan |
Habibul |
H |
|
| Alves |
Isabel |
I |
|
| Andiappan |
Anand |
A |
|
| Awadalla |
Philip |
P |
|
| Battle |
Alexis |
A |
|
| Beutner |
Frank |
F |
|
| Jan Bonder |
Marc |
M |
|
| Boomsma |
Dorret I |
DI |
|
| Christiansen |
Mark |
M |
|
| Claringbould |
Annique |
A |
|
| Deelen |
Patrick |
P |
|
| Esko |
Tõnu |
T |
|
| Favé |
Marie-Julie |
MJ |
|
| Franke |
Lude |
L |
|
| Frayling |
Timothy |
T |
|
| Gharib |
Sina A |
SA |
|
| Gibson |
Gregory |
G |
|
| Heijmans |
Bastiaan |
B |
|
| Hemani |
Gibran |
G |
|
| Jansen |
Rick |
R |
|
| Kähönen |
Mika |
M |
|
| Kalnapenkis |
Anette |
A |
|
| Kasela |
Silva |
S |
|
| Kettunen |
Johannes |
J |
|
| Kim |
Yungil |
Y |
|
| Kirsten |
Holger |
H |
|
| Kovacs |
Peter |
P |
|
| Krohn |
Knut |
K |
|
| Kronberg-Guzman |
Jaanika |
J |
|
| Kukushkina |
Viktorija |
V |
|
| Kutalik |
Zoltan |
Z |
|
| Lee |
Bernett |
B |
|
| Lehtimäki |
Terho |
T |
|
| Loeffler |
Markus |
M |
|
| Marigorta |
Urko M |
UM |
|
| Metspalu |
Andres |
A |
|
| Milani |
Lili |
L |
|
| Montgomery |
Grant W |
GW |
|
| Müller-Nurasyid |
Martina |
M |
|
| Nauck |
Matthias |
M |
|
| Nivard |
Michel G |
MG |
|
| Penninx |
Brenda |
B |
|
| Perola |
Markus |
M |
|
| Pervjakova |
Natalia |
N |
|
| Pierce |
Brandon |
B |
|
| Powell |
Joseph |
J |
|
| Prokisch |
Holger |
H |
|
| Psaty |
Bruce M |
BM |
|
| Raitakari |
Olli |
O |
|
| Ring |
Susan |
S |
|
| Ripatti |
Samuli |
S |
|
| Rotzchke |
Olaf |
O |
|
| Rüeger |
Sina |
S |
|
| Saha |
Ashis |
A |
|
| Scholz |
Markus |
M |
|
| Schramm |
Katharina |
K |
|
| Seppälä |
Ilkka |
I |
|
| Stumvoll |
Michael |
M |
|
| Sullivan |
Patrick |
P |
|
| Hoen |
Peter-Bram T |
PT |
|
| Teumer |
Alexander |
A |
|
| Thiery |
Joachim |
J |
|
| Tong |
Lin |
L |
|
| Tönjes |
Anke |
A |
|
| Dongen |
Jenny van |
JV |
|
| Meurs |
Joyce van |
JV |
|
| Verlouw |
Joost |
J |
|
| Visscher |
Peter M |
PM |
|
| Völker |
Uwe |
U |
|
| Võsa |
Urmo |
U |
|
| Westra |
Harm-Jan |
HJ |
|
| Yaghootkar |
Hanieh |
H |
|
| Yang |
Jian |
J |
|
| Zeng |
Biao |
B |
|
| Zhang |
Futao |
F |
|
| Okbay |
Aysu |
A |
|
| Beauchamp |
Jonathan P |
JP |
|
| Fontana |
Mark Alan |
MA |
|
| Lee |
James J |
JJ |
|
| Pers |
Tune H |
TH |
|
| Rietveld |
Cornelius A |
CA |
|
| Turley |
Patrick |
P |
|
| Chen |
Guo-Bo |
GB |
|
| Emilsson |
Valur |
V |
|
| Meddens |
S Fleur W |
SFW |
|
| Oskarsson |
Sven |
S |
|
| Pickrell |
Joseph K |
JK |
|
| Thom |
Kevin |
K |
|
| Timshel |
Pascal |
P |
|
| de Vlaming |
Ronald |
R |
|
| Abdellaoui |
Abdel |
A |
|
| Ahluwalia |
Tarunveer S |
TS |
|
| Bacelis |
Jonas |
J |
|
| Baumbach |
Clemens |
C |
|
| Bjornsdottir |
Gyda |
G |
|
| Brandsma |
Johannes H |
JH |
|
| Concas |
Maria Pina |
MP |
|
| Derringer |
Jaime |
J |
|
| Furlotte |
Nicholas A |
NA |
|
| Galesloot |
Tessel E |
TE |
|
| Girotto |
Giorgia |
G |
|
| Gupta |
Richa |
R |
|
| Hall |
Leanne M |
LM |
|
| Harris |
Sarah E |
SE |
|
| Hofer |
Edith |
E |
|
| Horikoshi |
Momoko |
M |
|
| Huffman |
Jennifer E |
JE |
|
| Kaasik |
Kadri |
K |
|
| Kalafati |
Ioanna P |
IP |
|
| Karlsson |
Robert |
R |
|
| Kong |
Augustine |
A |
|
| Lahti |
Jari |
J |
|
| Lee |
Sven J van der |
SJV |
|
| de Leeuw |
Christiaan |
C |
|
| Lind |
Penelope A |
PA |
|
| Lindgren |
Karl-Oskar |
KO |
|
| Liu |
Tian |
T |
|
| Mangino |
Massimo |
M |
|
| Marten |
Jonathan |
J |
|
| Mihailov |
Evelin |
E |
|
| Miller |
Michael B |
MB |
|
| Most |
Peter J van der |
PJV |
|
| Oldmeadow |
Christopher |
C |
|
| Payton |
Antony |
A |
|
| Pervjakova |
Natalia |
N |
|
| Peyrot |
Wouter J |
WJ |
|
| Qian |
Yong |
Y |
|
| Raitakari |
Olli |
O |
|
| Rueedi |
Rico |
R |
|
| Salvi |
Erika |
E |
|
| Schmidt |
Börge |
B |
|
| Schraut |
Katharina E |
KE |
|
| Shi |
Jianxin |
J |
|
| Smith |
Albert V |
AV |
|
| Poot |
Raymond A |
RA |
|
| Pourcain |
Beate St |
BS |
|
| Teumer |
Alexander |
A |
|
| Thorleifsson |
Gudmar |
G |
|
| Verweij |
Niek |
N |
|
| Vuckovic |
Dragana |
D |
|
| Wellmann |
Juergen |
J |
|
| Westra |
Harm-Jan |
HJ |
|
| Yang |
Jingyun |
J |
|
| Zhao |
Wei |
W |
|
| Zhu |
Zhihong |
Z |
|
| Alizadeh |
Behrooz Z |
BZ |
|
| Amin |
Najaf |
N |
|
| Bakshi |
Andrew |
A |
|
| Baumeister |
Sebastian E |
SE |
|
| Biino |
Ginevra |
G |
|
| Bønnelykke |
Klaus |
K |
|
| Boyle |
Patricia A |
PA |
|
| Campbell |
Harry |
H |
|
| Cappuccio |
Francesco P |
FP |
|
| Davies |
Gail |
G |
|
| De Neve |
Jan-Emmanuel |
JE |
|
| Deloukas |
Panos |
P |
|
| Demuth |
Ilja |
I |
|
| Ding |
Jun |
J |
|
| Eibich |
Peter |
P |
|
| Eisele |
Lewin |
L |
|
| Eklund |
Niina |
N |
|
| Evans |
David M |
DM |
|
| Faul |
Jessica D |
JD |
|
| Feitosa |
Mary F |
MF |
|
| Forstner |
Andreas J |
AJ |
|
| Gandin |
Ilaria |
I |
|
| Gunnarsson |
Bjarni |
B |
|
| Halldórsson |
Bjarni V |
BV |
|
| Harris |
Tamara B |
TB |
|
| Heath |
Andrew C |
AC |
|
| Hocking |
Lynne J |
LJ |
|
| Holliday |
Elizabeth G |
EG |
|
| Homuth |
Georg |
G |
|
| Horan |
Michael A |
MA |
|
| Hottenga |
Jouke-Jan |
JJ |
|
| de Jager |
Philip L |
PL |
|
| Joshi |
Peter K |
PK |
|
| Jugessur |
Astanand |
A |
|
| Kaakinen |
Marika A |
MA |
|
| Kähönen |
Mika |
M |
|
| Kanoni |
Stavroula |
S |
|
| Keltigangas-Järvinen |
Liisa |
L |
|
| Kiemeney |
Lambertus A L M |
LALM |
|
| Kolcic |
Ivana |
I |
|
| Koskinen |
Seppo |
S |
|
| Kraja |
Aldi T |
AT |
|
| Kroh |
Martin |
M |
|
| Kutalik |
Zoltan |
Z |
|
| Latvala |
Antti |
A |
|
| Launer |
Lenore J |
LJ |
|
| Lebreton |
Maël P |
MP |
|
| Levinson |
Douglas F |
DF |
|
| Lichtenstein |
Paul |
P |
|
| Lichtner |
Peter |
P |
|
| Liewald |
David C M |
DCM |
|
| Loukola |
Anu |
A |
|
| Madden |
Pamela A |
PA |
|
| Mägi |
Reedik |
R |
|
| Mäki-Opas |
Tomi |
T |
|
| Marioni |
Riccardo E |
RE |
|
| Marques-Vidal |
Pedro |
P |
|
| Meddens |
Gerardus A |
GA |
|
| McMahon |
George |
G |
|
| Meisinger |
Christa |
C |
|
| Meitinger |
Thomas |
T |
|
| Milaneschi |
Yusplitri |
Y |
|
| Milani |
Lili |
L |
|
| Montgomery |
Grant W |
GW |
|
| Myhre |
Ronny |
R |
|
| Nelson |
Christopher P |
CP |
|
| Nyholt |
Dale R |
DR |
|
| Ollier |
William E R |
WER |
|
| Palotie |
Aarno |
A |
|
| Paternoster |
Lavinia |
L |
|
| Pedersen |
Nancy L |
NL |
|
| Petrovic |
Katja E |
KE |
|
| Porteous |
David J |
DJ |
|
| Räikkönen |
Katri |
K |
|
| Ring |
Susan M |
SM |
|
| Robino |
Antonietta |
A |
|
| Rostapshova |
Olga |
O |
|
| Rudan |
Igor |
I |
|
| Rustichini |
Aldo |
A |
|
| Salomaa |
Veikko |
V |
|
| Sanders |
Alan R |
AR |
|
| Sarin |
Antti-Pekka |
AP |
|
| Schmidt |
Helena |
H |
|
| Scott |
Rodney J |
RJ |
|
| Smith |
Blair H |
BH |
|
| Smith |
Jennifer A |
JA |
|
| Staessen |
Jan A |
JA |
|
| Steinhagen-Thiessen |
Elisabeth |
E |
|
| Strauch |
Konstantin |
K |
|
| Terracciano |
Antonio |
A |
|
| Tobin |
Martin D |
MD |
|
| Ulivi |
Sheila |
S |
|
| Vaccargiu |
Simona |
S |
|
| Quaye |
Lydia |
L |
|
| Rooij |
Frank J van |
FJV |
|
| Venturini |
Cristina |
C |
|
| Vinkhuyzen |
Anna A E |
AAE |
|
| Völker |
Uwe |
U |
|
| Völzke |
Henry |
H |
|
| Vonk |
Judith M |
JM |
|
| Vozzi |
Diego |
D |
|
| Waage |
Johannes |
J |
|
| Ware |
Erin B |
EB |
|
| Willemsen |
Gonneke |
G |
|
| Attia |
John R |
JR |
|
| Bennett |
David A |
DA |
|
| Berger |
Klaus |
K |
|
| Bertram |
Lars |
L |
|
| Bisgaard |
Hans |
H |
|
| Boomsma |
Dorret I |
DI |
|
| Borecki |
Ingrid B |
IB |
|
| Bültmann |
Ute |
U |
|
| Chabris |
Christopher F |
CF |
|
| Cucca |
Francesco |
F |
|
| Cusi |
Daniele |
D |
|
| Deary |
Ian J |
IJ |
|
| Dedoussis |
George V |
GV |
|
| Duijn |
Cornelia M van |
CMV |
|
| Eriksson |
Johan G |
JG |
|
| Franke |
Barbara |
B |
|
| Franke |
Lude |
L |
|
| Gasparini |
Paolo |
P |
|
| Gejman |
Pablo V |
PV |
|
| Gieger |
Christian |
C |
|
| Grabe |
Hans-Jörgen |
HJ |
|
| Gratten |
Jacob |
J |
|
| Groenen |
Patrick J F |
PJF |
|
| Gudnason |
Vilmundur |
V |
|
| Harst |
Pim van der |
PV |
|
| Hayward |
Caroline |
C |
|
| Hinds |
David A |
DA |
|
| Hoffmann |
Wolfgang |
W |
|
| Hyppönen |
Elina |
E |
|
| Iacono |
William G |
WG |
|
| Jacobsson |
Bo |
B |
|
| Järvelin |
Marjo-Riitta |
MR |
|
| Jöckel |
Karl-Heinz |
KH |
|
| Kaprio |
Jaakko |
J |
|
| Kardia |
Sharon L R |
SLR |
|
| Lehtimäki |
Terho |
T |
|
| Lehrer |
Steven F |
SF |
|
| Magnusson |
Patrik K E |
PKE |
|
| Martin |
Nicholas G |
NG |
|
| McGue |
Matt |
M |
|
| Metspalu |
Andres |
A |
|
| Pendleton |
Neil |
N |
|
| Penninx |
Brenda |
B |
|
| Perola |
Markus |
M |
|
| Pirastu |
Nicola |
N |
|
| Pirastu |
Mario |
M |
|
| Polasek |
Ozren |
O |
|
| Posthuma |
Danielle |
D |
|
| Power |
Christine |
C |
|
| Province |
Michael A |
MA |
|
| Samani |
Nilesh J |
NJ |
|
| Schlessinger |
David |
D |
|
| Schmidt |
Reinhold |
R |
|
| Sørensen |
Thorkild I A |
TIA |
|
| Spector |
Tim D |
TD |
|
| Stefansson |
Kari |
K |
|
| Thorsteinsdottir |
Unnur |
U |
|
| Thurik |
A Roy |
AR |
|
| Timpson |
Nicholas J |
NJ |
|
| Tiemeier |
Henning |
H |
|
| Tung |
Joyce Y |
JY |
|
| Uitterlinden |
André G |
AG |
|
| Vitart |
Veronique |
V |
|
| Vollenweider |
Peter |
P |
|
| Weir |
David R |
DR |
|
| Wilson |
James F |
JF |
|
| Wright |
Alan F |
AF |
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| Conley |
Dalton C |
DC |
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| Krueger |
Robert F |
RF |
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| Smith |
George Davey |
GD |
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| Hofman |
Albert |
A |
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| Laibson |
David I |
DI |
|
| Medland |
Sarah E |
SE |
|
| Meyer |
Michelle N |
MN |
|
| Yang |
Jian |
J |
|
| Johannesson |
Magnus |
M |
|
| Visscher |
Peter M |
PM |
|
| Esko |
Tõnu |
T |
|
| Koellinger |
Philipp D |
PD |
|
| Cesarini |
David |
D |
|
| Benjamin |
Daniel J |
DJ |
|
|
| JOURNAL |
|
| VOLUME: 51 |
| ISSUE: 2 |
| TITLE: Nature genetics |
| ISOABBREVIATION: Nat Genet |
| YEAR: 2019 |
| MONTH: 02 |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1546-1718 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Nat Genet |
| COUNTRY: United States |
| ISSNLINKING: 1061-4036 |
| NLMUNIQUEID: 9216904 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Meta-Analysis |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| G1001799 |
Medical Research Council |
United Kingdom |
| MR/N01104X/2 |
Medical Research Council |
United Kingdom |
| R01 AG017917 |
NIA NIH HHS |
United States |
| R56 AG042568 |
NIA NIH HHS |
United States |
| R03 HD097630 |
NICHD NIH HHS |
United States |
| P30 AG010161 |
NIA NIH HHS |
United States |
| G0600237 |
Medical Research Council |
United Kingdom |
| R01 AG015819 |
NIA NIH HHS |
United States |
| MR/K026992/1 |
Medical Research Council |
United Kingdom |
| R01 AG033678 |
NIA NIH HHS |
United States |
| P2C HD066613 |
NICHD NIH HHS |
United States |
| BB/F019394/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| P01 AG005842 |
NIA NIH HHS |
United States |
| G0100594 |
Medical Research Council |
United Kingdom |
| P30 AG012810 |
NIA NIH HHS |
United States |
| R01 AG042568 |
NIA NIH HHS |
United States |
| T32 AG000186 |
NIA NIH HHS |
United States |
| BB/F022441/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| G0901461 |
Medical Research Council |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Behavior |
physiology |
| Case-Control Studies |
physiology |
| Female |
physiology |
| Genetic Loci |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Genetics, Behavioral |
methods |
| Genome-Wide Association Study |
methods |
| Genotype |
methods |
| Humans |
methods |
| Male |
methods |
| Polymorphism, Single Nucleotide |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
