Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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30617275
TITLE
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
ABSTRACT
Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). In a subset of 112,811 participants, a further one million SNVs were also genotyped and tested for association with the four smoking behaviour traits. SNV-trait associations with P < 5 × 10 in either analysis were taken forward for replication in up to 275,596 independent participants from UK Biobank. Lastly, a meta-analysis of the discovery and replication studies was performed. Sixteen SNVs were associated with at least one of the smoking behaviour traits (P < 5 × 10 ) in the discovery samples. Ten novel SNVs, including rs12616219 near TMEM182, were followed-up and five of them (rs462779 in REV3L, rs12780116 in CNNM2, rs1190736 in GPR101, rs11539157 in PJA1, and rs12616219 near TMEM182) replicated at a Bonferroni significance threshold (P < 4.5 × 10 ) with consistent direction of effect. A further 35 SNVs were associated with smoking behaviour traits in the discovery plus replication meta-analysis (up to 622,409 participants) including a rare SNV, rs150493199, in CCDC141 and two low-frequency SNVs in CEP350 and HDGFRP2. Functional follow-up implied that decreased expression of REV3L may lower the probability of smoking initiation. The novel loci will facilitate understanding the genetic aetiology of smoking behaviour and may lead to the identification of potential drug targets for smoking prevention and/or cessation.
DATE PUBLISHED
2019 Jan 07
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/05/02
accepted 2018/11/14
revised 2018/09/30
entrez 2019/01/09 06:00
pubmed 2019/01/09 06:00
medline 2019/01/09 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Erzurumluoglu AM Erzurumluoglu A Mesut AM Department of Health Sciences, University of Leicester, Leicester, UK.
Liu M Liu Mengzhen M Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Jackson VE Jackson Victoria E VE Department of Medical Biology, University of Melbourne, Melbourne, 3010, Parkville, Australia.
Barnes DR Barnes Daniel R DR MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Datta G Datta Gargi G Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Melbourne CA Melbourne Carl A CA Department of Health Sciences, University of Leicester, Leicester, UK.
Young R Young Robin R MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Batini C Batini Chiara C Department of Health Sciences, University of Leicester, Leicester, UK.
Surendran P Surendran Praveen P MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Jiang T Jiang Tao T MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Adnan SD Adnan Sheikh Daud SD National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh.
Afaq S Afaq Saima S Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Agrawal A Agrawal Arpana A Department of Psychiatry, Washington University, St. Louis, MO, USA.
Altmaier E Altmaier Elisabeth E Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Antoniou AC Antoniou Antonis C AC Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Asselbergs FW Asselbergs Folkert W FW Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, UK.
Baumbach C Baumbach Clemens C Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Bierut L Bierut Laura L Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Bertelsen S Bertelsen Sarah S Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Boehnke M Boehnke Michael M Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Bots ML Bots Michiel L ML Center for Circulatory Health, University Medical Center Utrecht, 3508GA, Utrecht, The Netherlands.
Brazel DM Brazel David M DM Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.
Chambers JC Chambers John C JC Imperial College Healthcare NHS Trust, London, W12 0HS, UK.
Chang-Claude J Chang-Claude Jenny J Cancer Epidemiology Group, University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany.
Chen C Chen Chu C Department of Epidemiology, University of Washington, Seattle, WA, USA.
Corley J Corley Janie J Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Chou YL Chou Yi-Ling YL Department of Psychiatry, Washington University, St. Louis, MO, USA.
David SP David Sean P SP Department of Medicine, Stanford University, Stanford, CA, USA.
de Boer RA de Boer Rudolf A RA Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
de Leeuw CA de Leeuw Christiaan A CA Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands.
Dennis JG Dennis Joe G JG Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Dominiczak AF Dominiczak Anna F AF Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Dunning AM Dunning Alison M AM Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge Centre, University of Cambridge, Cambridge, CB1 8RN, UK.
Easton DF Easton Douglas F DF Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge Centre, University of Cambridge, Cambridge, CB1 8RN, UK.
Eaton C Eaton Charles C Department of Epidemiology, University of Washington, Seattle, WA, USA.
Elliott P Elliott Paul P UK Dementia Research Institute (UK DRI) at Imperial College London, London, UK.
Evangelou E Evangelou Evangelos E Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Foroud T Foroud Tatiana T Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Goate A Goate Alison A Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gong J Gong Jian J Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Grabe HJ Grabe Hans J HJ Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475, Greifswald, Germany.
Haessler J Haessler Jeff J Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Haiman C Haiman Christopher C Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Hallmans G Hallmans Göran G Department of Public Health and Clinical Medicine, Nutritional research, Umeå University, Umeå, Sweden.
Hammerschlag AR Hammerschlag Anke R AR Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands.
Harris SE Harris Sarah E SE Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Hattersley A Hattersley Andrew A Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Heath A Heath Andrew A Department of Psychiatry, Washington University, St. Louis, MO, USA.
Hsu C Hsu Chris C University of Southern California, California, CA, USA.
Iacono WG Iacono William G WG Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Kanoni S Kanoni Stavroula S Centre for Genomic Health, Queen Mary University of London, London, EC1M 6BQ, UK.
Kapoor M Kapoor Manav M Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kaprio J Kaprio Jaakko J Department of Public Health, University of Helsinki, Helsinki, Finland.
Kardia SL Kardia Sharon L SL Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Karpe F Karpe Fredrik F Oxford National Institute for Health Research, Biomedical Research Centre, Churchill Hospital, Oxford, UK.
Kontto J Kontto Jukka J Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland.
Kooner JS Kooner Jaspal S JS National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.
Kooperberg C Kooperberg Charles C Department of Biostatistics, University of Washington School of Medicine, Seattle, WA, USA.
Kuulasmaa K Kuulasmaa Kari K Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland.
Laakso M Laakso Markku M University of Eastern Finland, Finland, Finland.
Lai D Lai Dongbing D Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Langenberg C Langenberg Claudia C MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Le N Le Nhung N Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA.
Lettre G Lettre Guillaume G Department of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada.
Loukola A Loukola Anu A Department of Public Health, University of Helsinki, Helsinki, Finland.
Luan J Luan Jian'an J MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Madden PAF Madden Pamela A F PAF Department of Psychiatry, Washington University, St. Louis, MO, USA.
Mangino M Mangino Massimo M Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK.
Marioni RE Marioni Riccardo E RE Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Marouli E Marouli Eirini E Centre for Genomic Health, Queen Mary University of London, London, EC1M 6BQ, UK.
Marten J Marten Jonathan J MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Martin NG Martin Nicholas G NG Queensland Institute for Medical Research, Brisbane, Australia.
McGue M McGue Matt M Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Michailidou K Michailidou Kyriaki K Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, 1683, Nicosia, Cyprus.
Mihailov E Mihailov Evelin E Estonian Genome Center, University of Tartu, Tartu, Estonia.
Moayyeri A Moayyeri Alireza A Institute of Health Informatics, University College London, London, UK.
Moitry M Moitry Marie M Department of Epidemiology and Public health, University Hospital of Strasbourg, Strasbourg, France.
Müller-Nurasyid M Müller-Nurasyid Martina M DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Naheed A Naheed Aliya A Initiative for Noncommunicable Diseases, Health Systems and Population Studies Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Nauck M Nauck Matthias M DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany.
Neville MJ Neville Matthew J MJ Oxford National Institute for Health Research, Biomedical Research Centre, Churchill Hospital, Oxford, UK.
Nielsen SF Nielsen Sune Fallgaard SF Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 74, DK-2730, Herlev, Denmark.
North K North Kari K Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Perola M Perola Markus M Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland.
Pharoah PDP Pharoah Paul D P PDP Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge Centre, University of Cambridge, Cambridge, CB1 8RN, UK.
Pistis G Pistis Giorgio G Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
Polderman TJ Polderman Tinca J TJ Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands.
Posthuma D Posthuma Danielle D Department of Clinical Genetics, VU University Medical Centre Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands.
Poulter N Poulter Neil N International Centre for Circulatory Health, Imperial College London, London, UK.
Qaiser B Qaiser Beenish B Department of Public Health, University of Helsinki, Helsinki, Finland.
Rasheed A Rasheed Asif A Centre for Non-Communicable Diseases, Karachi, Pakistan.
Reiner A Reiner Alex A Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Renström F Renström Frida F Department of Biobank Research, Umeå University, SE-901 87, Umeå, Sweden.
Rice J Rice John J Departments of Psychiatry and Mathematics, Washington University St. Louis, St. Louis, MO, USA.
Rohde R Rohde Rebecca R University of North Carolina, Chapel Hill, NC, USA.
Rolandsson O Rolandsson Olov O Department of Public Health & Clinical Medicine, Section for Family Medicine, Umeå universitet, SE, 90185, Umeå, Sweden.
Samani NJ Samani Nilesh J NJ Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK.
Samuel M Samuel Maria M Centre for Non-Communicable Diseases, Karachi, Pakistan.
Schlessinger D Schlessinger David D National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Scholte SH Scholte Steven H SH Department of Psychology, University of Amsterdam & Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands.
Scott RA Scott Robert A RA MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Sever P Sever Peter P International Centre for Circulatory Health, Imperial College London, London, UK.
Shao Y Shao Yaming Y University of North Carolina, Chapel Hill, NC, USA.
Shrine N Shrine Nick N Department of Health Sciences, University of Leicester, Leicester, UK.
Smith JA Smith Jennifer A JA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Starr JM Starr John M JM Alzheimer Scotland Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Stirrups K Stirrups Kathleen K Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK.
Stram D Stram Danielle D Department of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Stringham HM Stringham Heather M HM Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Tachmazidou I Tachmazidou Ioanna I Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
Tardif JC Tardif Jean-Claude JC Department of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada.
Thompson DJ Thompson Deborah J DJ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Tindle HA Tindle Hilary A HA Department of Medicine, Vanderbilt University, Nashville, TN, USA.
Tragante V Tragante Vinicius V Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, 3508GA, Utrecht, The Netherlands.
Trompet S Trompet Stella S Department of cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Turcot V Turcot Valerie V Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada.
Tyrrell J Tyrrell Jessica J Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Vaartjes I Vaartjes Ilonca I Center for Circulatory Health, University Medical Center Utrecht, 3508GA, Utrecht, The Netherlands.
van der Leij AR van der Leij Andries R AR Department of Psychology, University of Amsterdam & Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands.
van der Meer P van der Meer Peter P Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Varga TV Varga Tibor V TV Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Skåne University Hospital, Lund University, SE-214 28, Malmö, Sweden.
Verweij N Verweij Niek N Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, 301 Binney Street, Cambridge, MA, 02142, USA.
Völzke H Völzke Henry H Institute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Warren HR Warren Helen R HR NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Weir DR Weir David R DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Weiss S Weiss Stefan S Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, 17475, Greifswald, Germany.
Wetherill L Wetherill Leah L Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Yaghootkar H Yaghootkar Hanieh H Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Yavas E Yavas Ersin E Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania, PA, 16802, USA.
Jiang Y Jiang Yu Y Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA.
Chen F Chen Fang F Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA.
Zhan X Zhan Xiaowei X Department of Clinical Science, Center for Genetics of Host Defense, University of Texas Southwestern, Dallas, TX, USA.
Zhang W Zhang Weihua W Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UB1 3HW, UK.
Zhao W Zhao Wei W Department of Biostatistics and Epidemiology, University of Pennsylvania, Pennsylvania, PA, USA.
Zhao W Zhao Wei W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Zhou K Zhou Kaixin K School of Medicine, University of Dundee, Dundee, UK.
Amouyel P Amouyel Philippe P Department of Epidemiology and Public Health, Institut Pasteur de Lille, Lille, France.
Blankenberg S Blankenberg Stefan S University Medical Center Hamburg Eppendorf, Hamburg, Germany.
Caulfield MJ Caulfield Mark J MJ NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Chowdhury R Chowdhury Rajiv R MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Cucca F Cucca Francesco F Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
Deary IJ Deary Ian J IJ Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Deloukas P Deloukas Panos P Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Di Angelantonio E Di Angelantonio Emanuele E National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Ferrario M Ferrario Marco M EPIMED Research Centre, Department of Medicine and Surgery, University of Insubria at Varese, Varese, Italy.
Ferrières J Ferrières Jean J Department of Epidemiology, UMR 1027- INSERM, Toulouse University-CHU Toulouse, Toulouse, France.
Franks PW Franks Paul W PW Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA.
Frayling TM Frayling Tim M TM Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Frossard P Frossard Philippe P Centre for Non-Communicable Diseases, Karachi, Pakistan.
Hall IP Hall Ian P IP Division of Respiratory Medicine and NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
Hayward C Hayward Caroline C MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Jansson JH Jansson Jan-Håkan JH Department of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, Umeå, Sweden.
Jukema JW Jukema J Wouter JW The Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands.
Kee F Kee Frank F UKCRC Centre of Excellence for Public Health, Queens, University, Belfast, Belfast, UK.
Männistö S Männistö Satu S Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland.
Metspalu A Metspalu Andres A Estonian Genome Center, University of Tartu, Tartu, Estonia.
Munroe PB Munroe Patricia B PB NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Nordestgaard BG Nordestgaard Børge Grønne BG Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 74, DK-2730, Herlev, Denmark.
Palmer CNA Palmer Colin N A CNA Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Salomaa V Salomaa Veikko V Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland.
Sattar N Sattar Naveed N Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Spector T Spector Timothy T Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK.
Strachan DP Strachan David Peter DP Population Health Research Institute, St George!s, University of London, London, SW17 0RE, UK.
Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium
van der Harst P van der Harst Pim P Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Zeggini E Zeggini Eleftheria E Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
Saleheen D Saleheen Danish D Center for Non-Communicable Diseases, Karachi, Pakistan.
Butterworth AS Butterworth Adam S AS National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Wain LV Wain Louise V LV National Institute for Health Research Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Abecasis GR Abecasis Goncalo R GR Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Danesh J Danesh John J National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Tobin MD Tobin Martin D MD National Institute for Health Research Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Vrieze S Vrieze Scott S Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Liu DJ Liu Dajiang J DJ Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA. dxl46@psu.edu.
Howson JMM Howson Joanna M M JMM MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. jmmh2@medschl.cam.ac.uk.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol. Psychiatry
YEAR: 2019
MONTH: Jan
DAY: 07
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
SP/09/002 British Heart Foundation (BHF)
RG/13/13/30194 British Heart Foundation (BHF)
268834 EC | European Research Council (ERC)
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
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