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PMID |
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TITLE |
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Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. |
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ABSTRACT |
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Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). In a subset of 112,811 participants, a further one million SNVs were also genotyped and tested for association with the four smoking behaviour traits. SNV-trait associations with P < 5 × 10 in either analysis were taken forward for replication in up to 275,596 independent participants from UK Biobank. Lastly, a meta-analysis of the discovery and replication studies was performed. Sixteen SNVs were associated with at least one of the smoking behaviour traits (P < 5 × 10 ) in the discovery samples. Ten novel SNVs, including rs12616219 near TMEM182, were followed-up and five of them (rs462779 in REV3L, rs12780116 in CNNM2, rs1190736 in GPR101, rs11539157 in PJA1, and rs12616219 near TMEM182) replicated at a Bonferroni significance threshold (P < 4.5 × 10 ) with consistent direction of effect. A further 35 SNVs were associated with smoking behaviour traits in the discovery plus replication meta-analysis (up to 622,409 participants) including a rare SNV, rs150493199, in CCDC141 and two low-frequency SNVs in CEP350 and HDGFRP2. Functional follow-up implied that decreased expression of REV3L may lower the probability of smoking initiation. The novel loci will facilitate understanding the genetic aetiology of smoking behaviour and may lead to the identification of potential drug targets for smoking prevention and/or cessation. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2018/05/02 |
accepted |
2018/11/14 |
revised |
2018/09/30 |
entrez |
2019/01/09 06:00 |
pubmed |
2019/01/09 06:00 |
medline |
2019/01/09 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Erzurumluoglu AM |
|
Erzurumluoglu |
A Mesut |
AM |
|
Department of Health Sciences, University of Leicester, Leicester, UK. |
Liu M |
|
Liu |
Mengzhen |
M |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
Jackson VE |
|
Jackson |
Victoria E |
VE |
|
Department of Medical Biology, University of Melbourne, Melbourne, 3010, Parkville, Australia. |
Barnes DR |
|
Barnes |
Daniel R |
DR |
|
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. |
Datta G |
|
Datta |
Gargi |
G |
|
Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA. |
Melbourne CA |
|
Melbourne |
Carl A |
CA |
|
Department of Health Sciences, University of Leicester, Leicester, UK. |
Young R |
|
Young |
Robin |
R |
|
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. |
Batini C |
|
Batini |
Chiara |
C |
|
Department of Health Sciences, University of Leicester, Leicester, UK. |
Surendran P |
|
Surendran |
Praveen |
P |
|
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. |
Jiang T |
|
Jiang |
Tao |
T |
|
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. |
Adnan SD |
|
Adnan |
Sheikh Daud |
SD |
|
National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh. |
Afaq S |
|
Afaq |
Saima |
S |
|
Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK. |
Agrawal A |
|
Agrawal |
Arpana |
A |
|
Department of Psychiatry, Washington University, St. Louis, MO, USA. |
Altmaier E |
|
Altmaier |
Elisabeth |
E |
|
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. |
Antoniou AC |
|
Antoniou |
Antonis C |
AC |
|
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. |
Asselbergs FW |
|
Asselbergs |
Folkert W |
FW |
|
Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, UK. |
Baumbach C |
|
Baumbach |
Clemens |
C |
|
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. |
Bierut L |
|
Bierut |
Laura |
L |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
Bertelsen S |
|
Bertelsen |
Sarah |
S |
|
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
Boehnke M |
|
Boehnke |
Michael |
M |
|
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. |
Bots ML |
|
Bots |
Michiel L |
ML |
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Center for Circulatory Health, University Medical Center Utrecht, 3508GA, Utrecht, The Netherlands. |
Brazel DM |
|
Brazel |
David M |
DM |
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Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA. |
Chambers JC |
|
Chambers |
John C |
JC |
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Imperial College Healthcare NHS Trust, London, W12 0HS, UK. |
Chang-Claude J |
|
Chang-Claude |
Jenny |
J |
|
Cancer Epidemiology Group, University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany. |
Chen C |
|
Chen |
Chu |
C |
|
Department of Epidemiology, University of Washington, Seattle, WA, USA. |
Corley J |
|
Corley |
Janie |
J |
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Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. |
Chou YL |
|
Chou |
Yi-Ling |
YL |
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Department of Psychiatry, Washington University, St. Louis, MO, USA. |
David SP |
|
David |
Sean P |
SP |
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Department of Medicine, Stanford University, Stanford, CA, USA. |
de Boer RA |
|
de Boer |
Rudolf A |
RA |
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Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. |
de Leeuw CA |
|
de Leeuw |
Christiaan A |
CA |
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Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands. |
Dennis JG |
|
Dennis |
Joe G |
JG |
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Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. |
Dominiczak AF |
|
Dominiczak |
Anna F |
AF |
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Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. |
Dunning AM |
|
Dunning |
Alison M |
AM |
|
Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge Centre, University of Cambridge, Cambridge, CB1 8RN, UK. |
Easton DF |
|
Easton |
Douglas F |
DF |
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Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge Centre, University of Cambridge, Cambridge, CB1 8RN, UK. |
Eaton C |
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Eaton |
Charles |
C |
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Department of Epidemiology, University of Washington, Seattle, WA, USA. |
Elliott P |
|
Elliott |
Paul |
P |
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UK Dementia Research Institute (UK DRI) at Imperial College London, London, UK. |
Evangelou E |
|
Evangelou |
Evangelos |
E |
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Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. |
Faul JD |
|
Faul |
Jessica D |
JD |
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Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. |
Foroud T |
|
Foroud |
Tatiana |
T |
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Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. |
Goate A |
|
Goate |
Alison |
A |
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Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
Gong J |
|
Gong |
Jian |
J |
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Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. |
Grabe HJ |
|
Grabe |
Hans J |
HJ |
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Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475, Greifswald, Germany. |
Haessler J |
|
Haessler |
Jeff |
J |
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Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. |
Haiman C |
|
Haiman |
Christopher |
C |
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Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. |
Hallmans G |
|
Hallmans |
Göran |
G |
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Department of Public Health and Clinical Medicine, Nutritional research, Umeå University, Umeå, Sweden. |
Hammerschlag AR |
|
Hammerschlag |
Anke R |
AR |
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Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands. |
Harris SE |
|
Harris |
Sarah E |
SE |
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Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK. |
Hattersley A |
|
Hattersley |
Andrew |
A |
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Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK. |
Heath A |
|
Heath |
Andrew |
A |
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Department of Psychiatry, Washington University, St. Louis, MO, USA. |
Hsu C |
|
Hsu |
Chris |
C |
|
University of Southern California, California, CA, USA. |
Iacono WG |
|
Iacono |
William G |
WG |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
Kanoni S |
|
Kanoni |
Stavroula |
S |
|
Centre for Genomic Health, Queen Mary University of London, London, EC1M 6BQ, UK. |
Kapoor M |
|
Kapoor |
Manav |
M |
|
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
Kaprio J |
|
Kaprio |
Jaakko |
J |
|
Department of Public Health, University of Helsinki, Helsinki, Finland. |
Kardia SL |
|
Kardia |
Sharon L |
SL |
|
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. |
Karpe F |
|
Karpe |
Fredrik |
F |
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Oxford National Institute for Health Research, Biomedical Research Centre, Churchill Hospital, Oxford, UK. |
Kontto J |
|
Kontto |
Jukka |
J |
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Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland. |
Kooner JS |
|
Kooner |
Jaspal S |
JS |
|
National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK. |
Kooperberg C |
|
Kooperberg |
Charles |
C |
|
Department of Biostatistics, University of Washington School of Medicine, Seattle, WA, USA. |
Kuulasmaa K |
|
Kuulasmaa |
Kari |
K |
|
Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland. |
Laakso M |
|
Laakso |
Markku |
M |
|
University of Eastern Finland, Finland, Finland. |
Lai D |
|
Lai |
Dongbing |
D |
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Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. |
Langenberg C |
|
Langenberg |
Claudia |
C |
|
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK. |
Le N |
|
Le |
Nhung |
N |
|
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA. |
Lettre G |
|
Lettre |
Guillaume |
G |
|
Department of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada. |
Loukola A |
|
Loukola |
Anu |
A |
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Department of Public Health, University of Helsinki, Helsinki, Finland. |
Luan J |
|
Luan |
Jian'an |
J |
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MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK. |
Madden PAF |
|
Madden |
Pamela A F |
PAF |
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Department of Psychiatry, Washington University, St. Louis, MO, USA. |
Mangino M |
|
Mangino |
Massimo |
M |
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Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK. |
Marioni RE |
|
Marioni |
Riccardo E |
RE |
|
Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK. |
Marouli E |
|
Marouli |
Eirini |
E |
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Centre for Genomic Health, Queen Mary University of London, London, EC1M 6BQ, UK. |
Marten J |
|
Marten |
Jonathan |
J |
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MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Martin NG |
|
Martin |
Nicholas G |
NG |
|
Queensland Institute for Medical Research, Brisbane, Australia. |
McGue M |
|
McGue |
Matt |
M |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
Michailidou K |
|
Michailidou |
Kyriaki |
K |
|
Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, 1683, Nicosia, Cyprus. |
Mihailov E |
|
Mihailov |
Evelin |
E |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Moayyeri A |
|
Moayyeri |
Alireza |
A |
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Institute of Health Informatics, University College London, London, UK. |
Moitry M |
|
Moitry |
Marie |
M |
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Department of Epidemiology and Public health, University Hospital of Strasbourg, Strasbourg, France. |
Müller-Nurasyid M |
|
Müller-Nurasyid |
Martina |
M |
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DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. |
Naheed A |
|
Naheed |
Aliya |
A |
|
Initiative for Noncommunicable Diseases, Health Systems and Population Studies Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. |
Nauck M |
|
Nauck |
Matthias |
M |
|
DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany. |
Neville MJ |
|
Neville |
Matthew J |
MJ |
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Oxford National Institute for Health Research, Biomedical Research Centre, Churchill Hospital, Oxford, UK. |
Nielsen SF |
|
Nielsen |
Sune Fallgaard |
SF |
|
Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 74, DK-2730, Herlev, Denmark. |
North K |
|
North |
Kari |
K |
|
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. |
Perola M |
|
Perola |
Markus |
M |
|
Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland. |
Pharoah PDP |
|
Pharoah |
Paul D P |
PDP |
|
Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge Centre, University of Cambridge, Cambridge, CB1 8RN, UK. |
Pistis G |
|
Pistis |
Giorgio |
G |
|
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy. |
Polderman TJ |
|
Polderman |
Tinca J |
TJ |
|
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands. |
Posthuma D |
|
Posthuma |
Danielle |
D |
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Department of Clinical Genetics, VU University Medical Centre Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands. |
Poulter N |
|
Poulter |
Neil |
N |
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International Centre for Circulatory Health, Imperial College London, London, UK. |
Qaiser B |
|
Qaiser |
Beenish |
B |
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Department of Public Health, University of Helsinki, Helsinki, Finland. |
Rasheed A |
|
Rasheed |
Asif |
A |
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Centre for Non-Communicable Diseases, Karachi, Pakistan. |
Reiner A |
|
Reiner |
Alex |
A |
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Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. |
Renström F |
|
Renström |
Frida |
F |
|
Department of Biobank Research, Umeå University, SE-901 87, Umeå, Sweden. |
Rice J |
|
Rice |
John |
J |
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Departments of Psychiatry and Mathematics, Washington University St. Louis, St. Louis, MO, USA. |
Rohde R |
|
Rohde |
Rebecca |
R |
|
University of North Carolina, Chapel Hill, NC, USA. |
Rolandsson O |
|
Rolandsson |
Olov |
O |
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Department of Public Health & Clinical Medicine, Section for Family Medicine, Umeå universitet, SE, 90185, Umeå, Sweden. |
Samani NJ |
|
Samani |
Nilesh J |
NJ |
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Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK. |
Samuel M |
|
Samuel |
Maria |
M |
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Centre for Non-Communicable Diseases, Karachi, Pakistan. |
Schlessinger D |
|
Schlessinger |
David |
D |
|
National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. |
Scholte SH |
|
Scholte |
Steven H |
SH |
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Department of Psychology, University of Amsterdam & Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands. |
Scott RA |
|
Scott |
Robert A |
RA |
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MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK. |
Sever P |
|
Sever |
Peter |
P |
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International Centre for Circulatory Health, Imperial College London, London, UK. |
Shao Y |
|
Shao |
Yaming |
Y |
|
University of North Carolina, Chapel Hill, NC, USA. |
Shrine N |
|
Shrine |
Nick |
N |
|
Department of Health Sciences, University of Leicester, Leicester, UK. |
Smith JA |
|
Smith |
Jennifer A |
JA |
|
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. |
Starr JM |
|
Starr |
John M |
JM |
|
Alzheimer Scotland Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK. |
Stirrups K |
|
Stirrups |
Kathleen |
K |
|
Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK. |
Stram D |
|
Stram |
Danielle |
D |
|
Department of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. |
Stringham HM |
|
Stringham |
Heather M |
HM |
|
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. |
Tachmazidou I |
|
Tachmazidou |
Ioanna |
I |
|
Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. |
Tardif JC |
|
Tardif |
Jean-Claude |
JC |
|
Department of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada. |
Thompson DJ |
|
Thompson |
Deborah J |
DJ |
|
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. |
Tindle HA |
|
Tindle |
Hilary A |
HA |
|
Department of Medicine, Vanderbilt University, Nashville, TN, USA. |
Tragante V |
|
Tragante |
Vinicius |
V |
|
Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, 3508GA, Utrecht, The Netherlands. |
Trompet S |
|
Trompet |
Stella |
S |
|
Department of cardiology, Leiden University Medical Center, Leiden, The Netherlands. |
Turcot V |
|
Turcot |
Valerie |
V |
|
Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada. |
Tyrrell J |
|
Tyrrell |
Jessica |
J |
|
Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK. |
Vaartjes I |
|
Vaartjes |
Ilonca |
I |
|
Center for Circulatory Health, University Medical Center Utrecht, 3508GA, Utrecht, The Netherlands. |
van der Leij AR |
|
van der Leij |
Andries R |
AR |
|
Department of Psychology, University of Amsterdam & Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands. |
van der Meer P |
|
van der Meer |
Peter |
P |
|
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. |
Varga TV |
|
Varga |
Tibor V |
TV |
|
Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Skåne University Hospital, Lund University, SE-214 28, Malmö, Sweden. |
Verweij N |
|
Verweij |
Niek |
N |
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Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, 301 Binney Street, Cambridge, MA, 02142, USA. |
Völzke H |
|
Völzke |
Henry |
H |
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Institute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany. |
Wareham NJ |
|
Wareham |
Nicholas J |
NJ |
|
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK. |
Warren HR |
|
Warren |
Helen R |
HR |
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NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK. |
Weir DR |
|
Weir |
David R |
DR |
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Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. |
Weiss S |
|
Weiss |
Stefan |
S |
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Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, 17475, Greifswald, Germany. |
Wetherill L |
|
Wetherill |
Leah |
L |
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Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. |
Yaghootkar H |
|
Yaghootkar |
Hanieh |
H |
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Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK. |
Yavas E |
|
Yavas |
Ersin |
E |
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Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania, PA, 16802, USA. |
Jiang Y |
|
Jiang |
Yu |
Y |
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Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA. |
Chen F |
|
Chen |
Fang |
F |
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Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA. |
Zhan X |
|
Zhan |
Xiaowei |
X |
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Department of Clinical Science, Center for Genetics of Host Defense, University of Texas Southwestern, Dallas, TX, USA. |
Zhang W |
|
Zhang |
Weihua |
W |
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Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UB1 3HW, UK. |
Zhao W |
|
Zhao |
Wei |
W |
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Department of Biostatistics and Epidemiology, University of Pennsylvania, Pennsylvania, PA, USA. |
Zhao W |
|
Zhao |
Wei |
W |
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Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. |
Zhou K |
|
Zhou |
Kaixin |
K |
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School of Medicine, University of Dundee, Dundee, UK. |
Amouyel P |
|
Amouyel |
Philippe |
P |
|
Department of Epidemiology and Public Health, Institut Pasteur de Lille, Lille, France. |
Blankenberg S |
|
Blankenberg |
Stefan |
S |
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University Medical Center Hamburg Eppendorf, Hamburg, Germany. |
Caulfield MJ |
|
Caulfield |
Mark J |
MJ |
|
NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK. |
Chowdhury R |
|
Chowdhury |
Rajiv |
R |
|
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. |
Cucca F |
|
Cucca |
Francesco |
F |
|
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy. |
Deary IJ |
|
Deary |
Ian J |
IJ |
|
Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. |
Deloukas P |
|
Deloukas |
Panos |
P |
|
Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia. |
Di Angelantonio E |
|
Di Angelantonio |
Emanuele |
E |
|
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. |
Ferrario M |
|
Ferrario |
Marco |
M |
|
EPIMED Research Centre, Department of Medicine and Surgery, University of Insubria at Varese, Varese, Italy. |
Ferrières J |
|
Ferrières |
Jean |
J |
|
Department of Epidemiology, UMR 1027- INSERM, Toulouse University-CHU Toulouse, Toulouse, France. |
Franks PW |
|
Franks |
Paul W |
PW |
|
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA. |
Frayling TM |
|
Frayling |
Tim M |
TM |
|
Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK. |
Frossard P |
|
Frossard |
Philippe |
P |
|
Centre for Non-Communicable Diseases, Karachi, Pakistan. |
Hall IP |
|
Hall |
Ian P |
IP |
|
Division of Respiratory Medicine and NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK. |
Hayward C |
|
Hayward |
Caroline |
C |
|
MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Jansson JH |
|
Jansson |
Jan-Håkan |
JH |
|
Department of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, Umeå, Sweden. |
Jukema JW |
|
Jukema |
J Wouter |
JW |
|
The Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands. |
Kee F |
|
Kee |
Frank |
F |
|
UKCRC Centre of Excellence for Public Health, Queens, University, Belfast, Belfast, UK. |
Männistö S |
|
Männistö |
Satu |
S |
|
Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland. |
Metspalu A |
|
Metspalu |
Andres |
A |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Munroe PB |
|
Munroe |
Patricia B |
PB |
|
NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK. |
Nordestgaard BG |
|
Nordestgaard |
Børge Grønne |
BG |
|
Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 74, DK-2730, Herlev, Denmark. |
Palmer CNA |
|
Palmer |
Colin N A |
CNA |
|
Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK. |
Salomaa V |
|
Salomaa |
Veikko |
V |
|
Department of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland. |
Sattar N |
|
Sattar |
Naveed |
N |
|
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. |
Spector T |
|
Spector |
Timothy |
T |
|
Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK. |
Strachan DP |
|
Strachan |
David Peter |
DP |
|
Population Health Research Institute, St George!s, University of London, London, SW17 0RE, UK. |
|
Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium |
|
|
|
|
|
van der Harst P |
|
van der Harst |
Pim |
P |
|
Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. |
Zeggini E |
|
Zeggini |
Eleftheria |
E |
|
Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. |
Saleheen D |
|
Saleheen |
Danish |
D |
|
Center for Non-Communicable Diseases, Karachi, Pakistan. |
Butterworth AS |
|
Butterworth |
Adam S |
AS |
|
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. |
Wain LV |
|
Wain |
Louise V |
LV |
|
National Institute for Health Research Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK. |
Abecasis GR |
|
Abecasis |
Goncalo R |
GR |
|
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. |
Danesh J |
|
Danesh |
John |
J |
|
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. |
Tobin MD |
|
Tobin |
Martin D |
MD |
|
National Institute for Health Research Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK. |
Vrieze S |
|
Vrieze |
Scott |
S |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
Liu DJ |
|
Liu |
Dajiang J |
DJ |
|
Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA. dxl46@psu.edu. |
Howson JMM |
|
Howson |
Joanna M M |
JMM |
|
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. jmmh2@medschl.cam.ac.uk. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: |
ISSUE: |
TITLE: Molecular psychiatry |
ISOABBREVIATION: Mol. Psychiatry |
YEAR: 2019 |
MONTH: Jan |
DAY: 07 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1476-5578 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Mol Psychiatry |
COUNTRY: England |
ISSNLINKING: 1359-4184 |
NLMUNIQUEID: 9607835 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
SP/09/002 |
British Heart Foundation (BHF) |
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RG/13/13/30194 |
British Heart Foundation (BHF) |
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268834 |
EC | European Research Council (ERC) |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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