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| PMID |
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| TITLE |
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| Identification of 55,000 Replicated DNA Methylation QTL. |
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| ABSTRACT |
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| DNA methylation plays an important role in the regulation of transcription. Genetic control of DNA methylation is a potential candidate for explaining the many identified SNP associations with disease that are not found in coding regions. We replicated 52,916 cis and 2,025 trans DNA methylation quantitative trait loci (mQTL) using methylation from whole blood measured on Illumina HumanMethylation450 arrays in the Brisbane Systems Genetics Study (n = 614 from 177 families) and the Lothian Birth Cohorts of 1921 and 1936 (combined n = 1366). The trans mQTL SNPs were found to be over-represented in 1 Mbp subtelomeric regions, and on chromosomes 16 and 19. There was a significant increase in trans mQTL DNA methylation sites in upstream and 5' UTR regions. The genetic heritability of a number of complex traits and diseases was partitioned into components due to mQTL and the remainder of the genome. Significant enrichment was observed for height (p = 2.1 × 10 ), ulcerative colitis (p = 2 × 10 ), Crohn's disease (p = 6 × 10 ) and coronary artery disease (p = 5.5 × 10 ) when compared to a random sample of SNPs with matched minor allele frequency, although this enrichment is explained by the genomic location of the mQTL SNPs. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2016/04/14 |
| accepted |
2018/11/12 |
| entrez |
2018/12/06 06:00 |
| pubmed |
2018/12/06 06:00 |
| medline |
2018/12/06 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| McRae AF |
|
McRae |
Allan F |
AF |
|
Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia. a.mcrae@uq.edu.au. |
| Marioni RE |
|
Marioni |
Riccardo E |
RE |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK. |
| Shah S |
|
Shah |
Sonia |
S |
|
The Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia. |
| Yang J |
|
Yang |
Jian |
J |
|
Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia. |
| Powell JE |
|
Powell |
Joseph E |
JE |
|
The Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia. |
| Harris SE |
|
Harris |
Sarah E |
SE |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK. |
| Gibson J |
|
Gibson |
Jude |
J |
|
Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. |
| Henders AK |
|
Henders |
Anjali K |
AK |
|
The Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia. |
| Bowdler L |
|
Bowdler |
Lisa |
L |
|
QIMR Berghofer Medical Research Institute, Brisbane, 4029, QLD, Australia. |
| Painter JN |
|
Painter |
Jodie N |
JN |
|
QIMR Berghofer Medical Research Institute, Brisbane, 4029, QLD, Australia. |
| Murphy L |
|
Murphy |
Lee |
L |
|
Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, 4029, QLD, Australia. |
| Starr JM |
|
Starr |
John M |
JM |
|
Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK. |
| Wray NR |
|
Wray |
Naomi R |
NR |
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Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia. |
| Deary IJ |
|
Deary |
Ian J |
IJ |
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Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. |
| Visscher PM |
|
Visscher |
Peter M |
PM |
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Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK. |
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
The Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 8 |
| ISSUE: 1 |
| TITLE: Scientific reports |
| ISOABBREVIATION: Sci Rep |
| YEAR: 2018 |
| MONTH: Dec |
| DAY: 04 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2045-2322 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Sci Rep |
| COUNTRY: England |
| ISSNLINKING: 2045-2322 |
| NLMUNIQUEID: 101563288 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| APP1010374 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP1083656 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP1050218 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP1107599 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP1010374 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP389891 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP1078901 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP1050218 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP1078037 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP1050218 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP1046880 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP496667 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP3893891 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP1078399 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP1046880 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP496667 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP389891 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
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| GENERAL NOTE |
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