Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30507021
TITLE
Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy.
ABSTRACT
Electroconvulsive therapy (ECT) is the treatment of choice for severe and treatment-resistant depression; disorder severity and unfavorable treatment outcomes are shown to be influenced by an increased genetic burden for major depression (MD). Here, we tested whether ECT assignment and response/nonresponse are associated with an increased genetic burden for major depression (MD) using polygenic risk score (PRS), which summarize the contribution of disease-related common risk variants. Fifty-one psychiatric inpatients suffering from a major depressive episode underwent ECT. MD-PRS were calculated for these inpatients and a separate population-based sample (n = 3,547 healthy; n = 426 self-reported depression) based on summary statistics from the Psychiatric Genomics Consortium MDD-working group (Cases: n = 59,851; Controls: n = 113,154). MD-PRS explained a significant proportion of disease status between ECT patients and healthy controls (p = .022, R = 1.173%); patients showed higher MD-PRS. MD-PRS in population-based depression self-reporters were intermediate between ECT patients and controls (n.s.). Significant associations between MD-PRS and ECT response (50% reduction in Hamilton depression rating scale scores) were not observed. Our findings indicate that ECT cohorts show an increased genetic burden for MD and are consistent with the hypothesis that treatment-resistant MD patients represent a subgroup with an increased genetic risk for MD. Larger samples are needed to better substantiate these findings.
© 2018 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals, Inc.
DATE PUBLISHED
2019 01
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/05/14
revised 2018/09/21
accepted 2018/10/19
pubmed 2018/12/07 06:00
medline 2020/03/10 06:00
entrez 2018/12/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Foo JC Foo Jerome C JC Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Streit F Streit Fabian F Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Frank J Frank Josef J Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Witt SH Witt Stephanie H SH Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Treutlein J Treutlein Jens J Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Baune BT Baune Bernhard T BT Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.
Moebus S Moebus Susanne S Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Jöckel KH Jöckel Karl-Heinz KH Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Forstner AJ Forstner Andreas J AJ Department of Genomics, Life & Brain Research Center, University of Bonn, Bonn, Germany.
Nöthen MM Nöthen Markus M MM Department of Genomics, Life & Brain Research Center, University of Bonn, Bonn, Germany.
Rietschel M Rietschel Marcella M Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Sartorius A Sartorius Alexander A Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Kranaster L Kranaster Laura L Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
INVESTIGATORS
JOURNAL
VOLUME: 180
ISSUE: 1
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2019
MONTH: 01
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1552-485X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
NO246/10-1 Deutsche Forschungsgemeinschaft International
U01 MH1095320 NIDA NIH HHS United States
MR/K026992/1 Medical Research Council United Kingdom
G0200243 Medical Research Council United Kingdom
U01 MH109536 NIMH NIH HHS United States
01ZX1311A Bundesministerium für Bildung und Forschung International
U01 MH109528 NIMH NIH HHS United States
01ZX1314G Bundesministerium für Bildung und Forschung International
RI 908/11-1 Deutsche Forschungsgemeinschaft International
U01 MH109532 NIMH NIH HHS United States
01ZX1314A Bundesministerium für Bildung und Forschung International
GENERAL NOTE
KEYWORDS
KEYWORD
depression
electroconvulsive therapy
major depression
polygenic risk scores
treatment-resistance
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Depressive Disorder, Major therapy
Electroconvulsive Therapy methods
Female methods
Genetic Predisposition to Disease genetics
Genetic Testing methods
Humans methods
Male methods
Middle Aged methods
Multifactorial Inheritance genetics
Psychiatric Status Rating Scales genetics
Risk Factors genetics
Self Report genetics
Treatment Outcome genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's