Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30498212
TITLE
PPD ACT: an app-based genetic study of postpartum depression.
ABSTRACT
Postpartum depression (PPD) is one of the most frequent complications of childbirth and particularly is suited to genetic investigation as it is more homogenous than major depression outside of the perinatal period. We developed an iOS app (PPD ACT) to recruit, consent, screen, and enable DNA collection from women with a lifetime history of PPD to sufficiently power genome-wide association studies. In 1 year, we recruited 7344 women with a history of PPD and have biobanked 2946 DNA samples from the US. This sample of PPD cases was notably severely affected and within 2 years of their worst episode of PPD. Clinical validation was performed within a hospital setting on a subset of participants and recall validity assessed 6-9 months after initial assessment to ensure reliability of screening tools. Here we detail the creation of the PPD ACT mobile app including design, ethical, security, and deployment considerations. We emphasize the importance of multidisciplinary collaboration to correctly implement such a research project. Additionally, we describe our ability to customize the PPD ACT platform to deploy internationally in order to collect a global sample of women with PPD.
DATE PUBLISHED
2018 Nov 29
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/03/15
accepted 2018/09/26
entrez 2018/12/01 06:00
pubmed 2018/12/01 06:00
medline 2018/12/01 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Guintivano J Guintivano Jerry J Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. guinti@email.unc.edu.
Krohn H Krohn Holly H Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lewis C Lewis Carol C Center for Health Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Byrne EM Byrne Enda M EM Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Henders AK Henders Anjali K AK Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Ploner A Ploner Alexander A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kirk K Kirk Katherine K QIMR Berghofer Institute for Medical Research, Brisbane, QLD, Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Institute for Medical Research, Brisbane, QLD, Australia.
Milgrom J Milgrom Jeannette J Parent-Infant Research Institute and University of Melbourne, Melbourne, VIC, Australia.
Wray NR Wray Naomi R NR Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Sullivan PF Sullivan Patrick F PF Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Meltzer-Brody S Meltzer-Brody Samantha S Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
INVESTIGATORS
JOURNAL
VOLUME: 8
ISSUE: 1
TITLE: Translational psychiatry
ISOABBREVIATION: Transl Psychiatry
YEAR: 2018
MONTH: Nov
DAY: 29
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2158-3188
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Transl Psychiatry
COUNTRY: United States
ISSNLINKING: 2158-3188
NLMUNIQUEID: 101562664
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
T32MH093315 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
GENERAL NOTE
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