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PMID |
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TITLE |
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Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. |
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ABSTRACT |
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Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 × 10 ) and African ancestries (rs2066702; P = 2.2 × 10 ). Significant genetic correlations were observed with 17 phenotypes, including schizophrenia, attention deficit-hyperactivity disorder, depression, and use of cigarettes and cannabis. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and nonpathological drinking behaviors. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2018/01/22 |
accepted |
2018/10/12 |
entrez |
2018/11/29 06:00 |
pubmed |
2018/11/30 06:00 |
medline |
2019/05/17 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Walters RK |
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Walters |
Raymond K |
RK |
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Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. |
Polimanti R |
|
Polimanti |
Renato |
R |
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Department of Psychiatry, Yale School of Medicine and Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA. |
Johnson EC |
|
Johnson |
Emma C |
EC |
|
Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. |
McClintick JN |
|
McClintick |
Jeanette N |
JN |
|
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. |
Adams MJ |
|
Adams |
Mark J |
MJ |
|
University of Edinburgh, Division of Psychiatry, Edinburgh, UK. |
Adkins AE |
|
Adkins |
Amy E |
AE |
|
Department of Psychology & College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, VA, USA. |
Aliev F |
|
Aliev |
Fazil |
F |
|
Virginia Commonwealth University, Department of Psychology, Richmond, VA, USA. |
Bacanu SA |
|
Bacanu |
Silviu-Alin |
SA |
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Virginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. |
Batzler A |
|
Batzler |
Anthony |
A |
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Mayo Clinic, Psychiatric Genomics and Pharmacogenomics Program, Rochester, MN, USA. |
Bertelsen S |
|
Bertelsen |
Sarah |
S |
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Icahn School of Medicine at Mount Sinai, Department of Neuroscience, New York, NY, USA. |
Biernacka JM |
|
Biernacka |
Joanna M |
JM |
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Mayo Clinic, Department of Health Sciences Research, and Department of Psychiatry and Psychology, Rochester, MN, USA. |
Bigdeli TB |
|
Bigdeli |
Tim B |
TB |
|
Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, NY, USA. |
Chen LS |
|
Chen |
Li-Shiun |
LS |
|
Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. |
Clarke TK |
|
Clarke |
Toni-Kim |
TK |
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University of Edinburgh, Division of Psychiatry, Edinburgh, UK. |
Chou YL |
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Chou |
Yi-Ling |
YL |
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Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. |
Degenhardt F |
|
Degenhardt |
Franziska |
F |
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Institute of Human Genetics, University of Bonn; and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany. |
Docherty AR |
|
Docherty |
Anna R |
AR |
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University of Utah, Department of Psychiatry, Salt Lake City, UT, USA. |
Edwards AC |
|
Edwards |
Alexis C |
AC |
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Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA. |
Fontanillas P |
|
Fontanillas |
Pierre |
P |
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23andMe, Inc, Mountain View, CA, USA. |
Foo JC |
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Foo |
Jerome C |
JC |
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Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Fox L |
|
Fox |
Louis |
L |
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Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. |
Frank J |
|
Frank |
Josef |
J |
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Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Giegling I |
|
Giegling |
Ina |
I |
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Martin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics, Halle, Germany. |
Gordon S |
|
Gordon |
Scott |
S |
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QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Hack LM |
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Hack |
Laura M |
LM |
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Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. |
Hartmann AM |
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Hartmann |
Annette M |
AM |
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Martin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics, Halle, Germany. |
Hartz SM |
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Hartz |
Sarah M |
SM |
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Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. |
Heilmann-Heimbach S |
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Heilmann-Heimbach |
Stefanie |
S |
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Institute of Human Genetics, University of Bonn; and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany. |
Herms S |
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Herms |
Stefan |
S |
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Human Genomics Research Group, Department of Biomedicine, University of Basel Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland. |
Hodgkinson C |
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Hodgkinson |
Colin |
C |
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NIH/NIAAA, Laboratory of Neurogenetics, Bethesda, MD, USA. |
Hoffmann P |
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Hoffmann |
Per |
P |
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Human Genomics Research Group, Department of Biomedicine, University of Basel Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland. |
Jan Hottenga J |
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Jan Hottenga |
Jouke |
J |
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Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
Kennedy MA |
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Kennedy |
Martin A |
MA |
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University of Otago, Christchurch, New Zealand. |
Alanne-Kinnunen M |
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Alanne-Kinnunen |
Mervi |
M |
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Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. |
Konte B |
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Konte |
Bettina |
B |
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Martin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics, Halle, Germany. |
Lahti J |
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Lahti |
Jari |
J |
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Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland. |
Lahti-Pulkkinen M |
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Lahti-Pulkkinen |
Marius |
M |
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Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland. |
Lai D |
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Lai |
Dongbing |
D |
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Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. |
Ligthart L |
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Ligthart |
Lannie |
L |
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Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
Loukola A |
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Loukola |
Anu |
A |
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Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. |
Maher BS |
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Maher |
Brion S |
BS |
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Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. |
Mbarek H |
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Mbarek |
Hamdi |
H |
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Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
McIntosh AM |
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McIntosh |
Andrew M |
AM |
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University of Edinburgh, Division of Psychiatry, Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK. |
McQueen MB |
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McQueen |
Matthew B |
MB |
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Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA. |
Meyers JL |
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Meyers |
Jacquelyn L |
JL |
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Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA. |
Milaneschi Y |
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Milaneschi |
Yuri |
Y |
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Department of Psychiatry, Amsterdam Public Health Research Institute, VU University Medical Center/GGz inGeest, Amsterdam, The Netherlands. |
Palviainen T |
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Palviainen |
Teemu |
T |
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Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. |
Pearson JF |
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Pearson |
John F |
JF |
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Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand. |
Peterson RE |
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Peterson |
Roseann E |
RE |
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Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA. |
Ripatti S |
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Ripatti |
Samuli |
S |
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Department of Public Health, University of Helsinki, Helsinki, Finland. |
Ryu E |
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Ryu |
Euijung |
E |
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Mayo Clinic, Department of Health Sciences Research, Rochester, MN, USA. |
Saccone NL |
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Saccone |
Nancy L |
NL |
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Washington University School of Medicine, Department of Genetics, St. Louis, MO, USA. |
Salvatore JE |
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Salvatore |
Jessica E |
JE |
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Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA. |
Sanchez-Roige S |
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Sanchez-Roige |
Sandra |
S |
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University of California San Diego, Department of Psychiatry, San Diego, CA, USA. |
Schwandt M |
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Schwandt |
Melanie |
M |
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NIH/NIAAA, Office of the Clinical Director, Bethesda, MD, USA. |
Sherva R |
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Sherva |
Richard |
R |
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Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. |
Streit F |
|
Streit |
Fabian |
F |
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Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Strohmaier J |
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Strohmaier |
Jana |
J |
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Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Thomas N |
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Thomas |
Nathaniel |
N |
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Department of Psychology & College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, VA, USA. |
Wang JC |
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Wang |
Jen-Chyong |
JC |
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Icahn School of Medicine at Mount Sinai, Department of Neuroscience, New York, NY, USA. |
Webb BT |
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Webb |
Bradley T |
BT |
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Virginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. |
Wedow R |
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Wedow |
Robbee |
R |
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Department of Sociology, Harvard University, Cambridge, MA, USA. |
Wetherill L |
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Wetherill |
Leah |
L |
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Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. |
Wills AG |
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Wills |
Amanda G |
AG |
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University of Colorado School of Medicine, Department of Pharmacology, Aurora, CO, USA. |
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23andMe Research Team |
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Boardman JD |
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Boardman |
Jason D |
JD |
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Institute of Behavioral Science and Department of Sociology, University of Colorado, Boulder, CO, USA. |
Chen D |
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Chen |
Danfeng |
D |
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Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. |
Choi DS |
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Choi |
Doo-Sup |
DS |
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Mayo Clinic, Department of Molecular Pharmacology and Experimental Therapeutics, Rochester, MN, USA. |
Copeland WE |
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Copeland |
William E |
WE |
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Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA. |
Culverhouse RC |
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Culverhouse |
Robert C |
RC |
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Washington University School of Medicine, Department of Medicine and Division of Biostatistics, St. Louis, MO, USA. |
Dahmen N |
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Dahmen |
Norbert |
N |
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Department of Psychiatry, University of Mainz, Mainz, Germany. |
Degenhardt L |
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Degenhardt |
Louisa |
L |
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National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia. |
Domingue BW |
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Domingue |
Benjamin W |
BW |
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Stanford University Graduate School of Education, Stanford, CA, USA. |
Elson SL |
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Elson |
Sarah L |
SL |
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23andMe, Inc, Mountain View, CA, USA. |
Frye MA |
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Frye |
Mark A |
MA |
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Mayo Clinic, Department of Psychiatry and Psychology, Rochester, MN, USA. |
Gäbel W |
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Gäbel |
Wolfgang |
W |
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Department of Psychiatry and Psychotherapy, University of Düsseldorf, Düsseldorf, Germany. |
Hayward C |
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Hayward |
Caroline |
C |
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MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Ising M |
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Ising |
Marcus |
M |
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Max-Planck-Institute of Psychiatry, Munich, Germany. |
Keyes M |
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Keyes |
Margaret |
M |
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University of Minnesota, Department of Psychology, Minneapolis, MN, USA. |
Kiefer F |
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Kiefer |
Falk |
F |
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Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany. |
Kramer J |
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Kramer |
John |
J |
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University of Iowa Roy J and Lucille A Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA. |
Kuperman S |
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Kuperman |
Samuel |
S |
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University of Iowa Roy J and Lucille A Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA. |
Lucae S |
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Lucae |
Susanne |
S |
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Max-Planck-Institute of Psychiatry, Munich, Germany. |
Lynskey MT |
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Lynskey |
Michael T |
MT |
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Addictions Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
Maier W |
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Maier |
Wolfgang |
W |
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Department of Psychiatry, University of Bonn, Bonn, Germany. |
Mann K |
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Mann |
Karl |
K |
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Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany. |
Männistö S |
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Männistö |
Satu |
S |
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Institute for Health and Welfare, Helsinki, Finland. |
Müller-Myhsok B |
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Müller-Myhsok |
Bertram |
B |
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Department of Statistical Genetics, Max-Planck-Institute of Psychiatry, Munich, Germany. |
Murray AD |
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Murray |
Alison D |
AD |
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The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK. |
Nurnberger JI |
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Nurnberger |
John I |
JI |
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Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA. |
Palotie A |
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Palotie |
Aarno |
A |
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Department of Medicine, Department of Neurology and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. |
Preuss U |
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Preuss |
Ulrich |
U |
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Vitos Hospital Herborn, Department of Psychiatry and Psychotherapy, Herborn, Germany. |
Räikkönen K |
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Räikkönen |
Katri |
K |
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Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland. |
Reynolds MD |
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Reynolds |
Maureen D |
MD |
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University of Pittsburgh, School of Pharmacy, Pittsburgh, PA, USA. |
Ridinger M |
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Ridinger |
Monika |
M |
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Department of Psychiatry and Psychotherapy, University of Regensburg Psychiatric Health Care Aargau, Regensburg, Germany. |
Scherbaum N |
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Scherbaum |
Norbert |
N |
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LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Department of Addictive Behaviour and Addiction Medicine, Medical Faculty, University of Duisburg-Essen, Duisburg, Germany. |
Schuckit MA |
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Schuckit |
Marc A |
MA |
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University of California San Diego, Department of Psychiatry, San Diego, CA, USA. |
Soyka M |
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Soyka |
Michael |
M |
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Psychiatric Hospital, Ludwig-Maximilians-University, Munich, Germany. |
Treutlein J |
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Treutlein |
Jens |
J |
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Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Witt S |
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Witt |
Stephanie |
S |
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Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Wodarz N |
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Wodarz |
Norbert |
N |
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Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany. |
Zill P |
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Zill |
Peter |
P |
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Psychiatric Hospital, Ludwig-Maximilians-University, Munich, Germany. |
Adkins DE |
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Adkins |
Daniel E |
DE |
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University of Utah, Department of Sociology, Salt Lake City, UT, USA. |
Boden JM |
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Boden |
Joseph M |
JM |
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University of Otago, Christchurch, New Zealand. |
Boomsma DI |
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Boomsma |
Dorret I |
DI |
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Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
Bierut LJ |
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Bierut |
Laura J |
LJ |
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Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. |
Brown SA |
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Brown |
Sandra A |
SA |
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University of California, San Diego School of Medicine, Department of Psychology, San Diego, CA, USA. |
Bucholz KK |
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Bucholz |
Kathleen K |
KK |
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Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. |
Cichon S |
|
Cichon |
Sven |
S |
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Human Genomics Research Group, Department of Biomedicine, University of Basel Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland. |
Costello EJ |
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Costello |
E Jane |
EJ |
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Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA. |
de Wit H |
|
de Wit |
Harriet |
H |
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NIAAA Intramural Research Program, Bethesda, MD, USA. |
Diazgranados N |
|
Diazgranados |
Nancy |
N |
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NIAAA Intramural Research Program, Bethesda, MD, USA. |
Dick DM |
|
Dick |
Danielle M |
DM |
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Department of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA. |
Eriksson JG |
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Eriksson |
Johan G |
JG |
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Department of General Practice and Primary Health Care, University of Helsinki, and National Institute for Health and Welfare, Helsinki, Finland. |
Farrer LA |
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Farrer |
Lindsay A |
LA |
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Departments of Neurology, Ophthalmology, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA. |
Foroud TM |
|
Foroud |
Tatiana M |
TM |
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Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. |
Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA. |
Goate AM |
|
Goate |
Alison M |
AM |
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Icahn School of Medicine at Mount Sinai, Department of Neuroscience, New York, NY, USA. |
Goldman D |
|
Goldman |
David |
D |
|
NIH/NIAAA, Office of the Clinical Director, Bethesda, MD, USA. |
Grucza RA |
|
Grucza |
Richard A |
RA |
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Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. |
Hancock DB |
|
Hancock |
Dana B |
DB |
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Center for Omics Discovery and Epidemiology, Behavioral Health Research Division, RTI International, Research Triangle Park, NC, USA. |
Harris KM |
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Harris |
Kathleen Mullan |
KM |
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Department of Sociology and Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
Heath AC |
|
Heath |
Andrew C |
AC |
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Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. |
Hesselbrock V |
|
Hesselbrock |
Victor |
V |
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University of Connecticut School of Medicine, Department of Psychiatry, Farmington, CT, USA. |
Hewitt JK |
|
Hewitt |
John K |
JK |
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University of Colorado Boulder, Institute for Behavioral Genetics, Boulder, CO, USA. |
Hopfer CJ |
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Hopfer |
Christian J |
CJ |
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University of Colorado Denver, School of Medicine, Denver, CO, USA. |
Horwood J |
|
Horwood |
John |
J |
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University of Otago, Christchurch, New Zealand. |
Iacono W |
|
Iacono |
William |
W |
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University of Minnesota, Department of Psychology, Minneapolis, MN, USA. |
Johnson EO |
|
Johnson |
Eric O |
EO |
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RTI International, Fellows Program, Research Triangle Park, NC, USA. |
Kaprio JA |
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Kaprio |
Jaakko A |
JA |
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Department of Public Health, University of Helsinki, Helsinki, Finland. |
Karpyak VM |
|
Karpyak |
Victor M |
VM |
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Mayo Clinic, Department of Psychiatry and Psychology, Rochester, MN, USA. |
Kendler KS |
|
Kendler |
Kenneth S |
KS |
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Virginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. |
Kranzler HR |
|
Kranzler |
Henry R |
HR |
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University of Pennsylvania Perelman School of Medicine, Center for Studies of Addiction, Department of Psychiatry and VISN 4 MIRECC, Crescenz VAMC, Philadelphia, PA, USA. |
Krauter K |
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Krauter |
Kenneth |
K |
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University of Colorado Boulder, Department of Molecular, Cellular, and Developmental Biology, Boulder, CO, USA. |
Lichtenstein P |
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Lichtenstein |
Paul |
P |
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Department of Medical Epidemiology and Biostatistics, Karolinska Instituet, Stockholm, Sweden. |
Lind PA |
|
Lind |
Penelope A |
PA |
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QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
McGue M |
|
McGue |
Matt |
M |
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University of Minnesota, Department of Psychology, Minneapolis, MN, USA. |
MacKillop J |
|
MacKillop |
James |
J |
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Peter Boris Centre for Addictions Research, McMaster University/St. Joseph's Healthcare Hamilton; Michael G. DeGroote Centre for Medicinal Cannabis Research, Hamilton, Ontario, Canada. |
Madden PAF |
|
Madden |
Pamela A F |
PAF |
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Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. |
Maes HH |
|
Maes |
Hermine H |
HH |
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Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA. |
Magnusson P |
|
Magnusson |
Patrik |
P |
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Department of Medical Epidemiology and Biostatistics, Karolinska Instituet, Stockholm, Sweden. |
Martin NG |
|
Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Medland SE |
|
Medland |
Sarah E |
SE |
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QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Montgomery GW |
|
Montgomery |
Grant W |
GW |
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The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
Nelson EC |
|
Nelson |
Elliot C |
EC |
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Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. |
Nöthen MM |
|
Nöthen |
Markus M |
MM |
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Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany. |
Palmer AA |
|
Palmer |
Abraham A |
AA |
|
University of California San Diego, Institute for Genomic Medicine, San Diego, CA, USA. |
Pedersen NL |
|
Pedersen |
Nancy L |
NL |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Instituet, Stockholm, Sweden. |
Penninx BWJH |
|
Penninx |
Brenda W J H |
BWJH |
|
Department of Psychiatry, Amsterdam Public Health Research Institute, VU University Medical Center/GGz inGeest, Amsterdam, The Netherlands. |
Porjesz B |
|
Porjesz |
Bernice |
B |
|
Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA. |
Rice JP |
|
Rice |
John P |
JP |
|
Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. |
Rietschel M |
|
Rietschel |
Marcella |
M |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Riley BP |
|
Riley |
Brien P |
BP |
|
Virginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. |
Rose R |
|
Rose |
Richard |
R |
|
Department of Psychological & Brain Sciences, Indiana University Bloomington, Bloomington, IN, USA. |
Rujescu D |
|
Rujescu |
Dan |
D |
|
Martin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics, Halle, Germany. |
Shen PH |
|
Shen |
Pei-Hong |
PH |
|
NIH/NIAAA, Laboratory of Neurogenetics, Bethesda, MD, USA. |
Silberg J |
|
Silberg |
Judy |
J |
|
Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA. |
Stallings MC |
|
Stallings |
Michael C |
MC |
|
University of Colorado Boulder, Institute for Behavioral Genetics, Boulder, CO, USA. |
Tarter RE |
|
Tarter |
Ralph E |
RE |
|
University of Pittsburgh, School of Pharmacy, Pittsburgh, PA, USA. |
Vanyukov MM |
|
Vanyukov |
Michael M |
MM |
|
University of Pittsburgh, School of Pharmacy, Pittsburgh, PA, USA. |
Vrieze S |
|
Vrieze |
Scott |
S |
|
University of Minnesota, Department of Psychology, Minneapolis, MN, USA. |
Wall TL |
|
Wall |
Tamara L |
TL |
|
University of California San Diego, Department of Psychiatry, San Diego, CA, USA. |
Whitfield JB |
|
Whitfield |
John B |
JB |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Zhao H |
|
Zhao |
Hongyu |
H |
|
Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA. |
Neale BM |
|
Neale |
Benjamin M |
BM |
|
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. |
Gelernter J |
|
Gelernter |
Joel |
J |
|
Departments of Psychiatry, Genetics, and Neuroscience, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, USA. joel.gelernter@yale.edu. |
Edenberg HJ |
|
Edenberg |
Howard J |
HJ |
|
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. edenberg@iu.edu. |
Agrawal A |
|
Agrawal |
Arpana |
A |
|
Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. Arpana@wustl.edu. |
|
INVESTIGATORS |
|
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
Agee |
Michelle |
M |
|
Alipanahi |
Babak |
B |
|
Auton |
Adam |
A |
|
Bell |
Robert K |
RK |
|
Bryc |
Katarzyna |
K |
|
Elson |
Sarah L |
SL |
|
Fontanillas |
Pierre |
P |
|
Furlotte |
Nicholas A |
NA |
|
Hinds |
David A |
DA |
|
Huber |
Karen E |
KE |
|
Kleinman |
Aaron |
A |
|
Litterman |
Nadia K |
NK |
|
McCreight |
Jennifer C |
JC |
|
McIntyre |
Matthew H |
MH |
|
Mountain |
Joanna L |
JL |
|
Noblin |
Elizabeth S |
ES |
|
Northover |
Carrie A M |
CAM |
|
Pitts |
Steven J |
SJ |
|
Sathirapongsasuti |
J Fah |
JF |
|
Sazonova |
Olga V |
OV |
|
Shelton |
Janie F |
JF |
|
Shringarpure |
Suyash |
S |
|
Tian |
Chao |
C |
|
Tung |
Joyce Y |
JY |
|
Vacic |
Vladimir |
V |
|
Wilson |
Catherine H |
CH |
|
|
JOURNAL |
|
VOLUME: 21 |
ISSUE: 12 |
TITLE: Nature neuroscience |
ISOABBREVIATION: Nat Neurosci |
YEAR: 2018 |
MONTH: 12 |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1546-1726 |
ISSNTYPE: Electronic |
|
MEDLINE JOURNAL |
|
MEDLINETA: Nat Neurosci |
COUNTRY: United States |
ISSNLINKING: 1097-6256 |
NLMUNIQUEID: 9809671 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
|
COMMENTS AND CORRECTIONS |
|
REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
CommentIn |
Am J Psychiatry. 2019 Feb 1;176(2):92-95 |
30704278 |
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GENERAL NOTE |
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KEYWORDS |
|
|
MESH HEADINGS |
|
DESCRIPTORNAME |
QUALIFIERNAME |
Alcoholism |
genetics |
Alleles |
genetics |
Genetic Predisposition to Disease |
genetics |
Genome-Wide Association Study |
genetics |
Genotype |
genetics |
Humans |
genetics |
Mental Disorders |
genetics |
Phenotype |
genetics |
Polymorphism, Single Nucleotide |
genetics |
|
SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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