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| PMID |
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| TITLE |
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| Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization. |
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| ABSTRACT |
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| Consumption of coffee, tea and alcohol might be shaped by individual differences in bitter taste perception but inconsistent observational findings provide little insight regarding causality. We conducted Mendelian randomization analyses using genetic variants associated with the perception of bitter substances (rs1726866 for propylthiouracil [PROP], rs10772420 for quinine and rs2597979 for caffeine) to evaluate the intake of coffee, tea and alcohol among up to 438,870 UK Biobank participants. A standard deviation (SD) higher in genetically predicted bitterness of caffeine was associated with increased coffee intake (0.146 [95%CI: 0.103, 0.189] cups/day), whereas a SD higher in those of PROP and quinine was associated with decreased coffee intake (-0.021 [-0.031, -0.011] and -0.081 [-0.108, -0.054] cups/day respectively). Higher caffeine perception was also associated with increased risk of being a heavy (>4 cups/day) coffee drinker (OR 1.207 [1.126, 1.294]). Opposite pattern of associations was observed for tea possibly due to the inverse relationship between both beverages. Alcohol intake was only negatively associated with PROP perception (-0.141 [-1.88, -0.94] times/month per SD increase in PROP bitterness). Our results reveal that bitter perception is causally associated with intake of coffee, tea and alcohol, suggesting a role of bitter taste in the development of bitter beverage consumption. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2018/05/14 |
| accepted |
2018/10/19 |
| entrez |
2018/11/17 06:00 |
| pubmed |
2018/11/18 06:00 |
| medline |
2018/11/18 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Ong JS |
|
Ong |
Jue-Sheng |
JS |
|
School of Medicine, University of Queensland, Brisbane, Australia. juesheng.ong@qimrberghofer.edu.au. |
| Hwang DL |
|
Hwang |
Daniel Liang-Dar |
DL |
|
University of Queensland Diamantina Institute, University of Queensland, Brisbane, Australia. d.hwang@uq.edu.au. |
| Zhong VW |
|
Zhong |
Victor W |
VW |
|
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
| An J |
|
An |
Jiyuan |
J |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Gharahkhani P |
|
Gharahkhani |
Puya |
P |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Breslin PAS |
|
Breslin |
Paul A S |
PAS |
|
Department of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, 08901, USA. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, 4072, Australia. |
| Lawlor DA |
|
Lawlor |
Deborah A |
DA |
|
Population Health Science, Bristol Medical School, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PS, UK. |
| Whitfield J |
|
Whitfield |
John |
J |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| MacGregor S |
|
MacGregor |
Stuart |
S |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Cornelis MC |
|
Cornelis |
Marilyn C |
MC |
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Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 8 |
| ISSUE: 1 |
| TITLE: Scientific reports |
| ISOABBREVIATION: Sci Rep |
| YEAR: 2018 |
| MONTH: Nov |
| DAY: 15 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2045-2322 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Sci Rep |
| COUNTRY: England |
| ISSNLINKING: 2045-2322 |
| NLMUNIQUEID: 101563288 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| GNT1125200 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| APP1123248 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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| 241944 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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| 1031119 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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| 14SFRN20480260 |
American Heart Association (American Heart Association, Inc.) |
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| DC02995 |
U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) |
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| R03DC01337301A1 |
U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) |
|
| DP0664638 |
Australian Research Council (ARC) |
|
| DP1093900 |
Australian Research Council (ARC) |
|
| MC_UU_12013/5 |
Medical Research Council (MRC) |
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| GENERAL NOTE |
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