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PMID |
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TITLE |
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Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization. |
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ABSTRACT |
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Consumption of coffee, tea and alcohol might be shaped by individual differences in bitter taste perception but inconsistent observational findings provide little insight regarding causality. We conducted Mendelian randomization analyses using genetic variants associated with the perception of bitter substances (rs1726866 for propylthiouracil [PROP], rs10772420 for quinine and rs2597979 for caffeine) to evaluate the intake of coffee, tea and alcohol among up to 438,870 UK Biobank participants. A standard deviation (SD) higher in genetically predicted bitterness of caffeine was associated with increased coffee intake (0.146 [95%CI: 0.103, 0.189] cups/day), whereas a SD higher in those of PROP and quinine was associated with decreased coffee intake (-0.021 [-0.031, -0.011] and -0.081 [-0.108, -0.054] cups/day respectively). Higher caffeine perception was also associated with increased risk of being a heavy (>4 cups/day) coffee drinker (OR 1.207 [1.126, 1.294]). Opposite pattern of associations was observed for tea possibly due to the inverse relationship between both beverages. Alcohol intake was only negatively associated with PROP perception (-0.141 [-1.88, -0.94] times/month per SD increase in PROP bitterness). Our results reveal that bitter perception is causally associated with intake of coffee, tea and alcohol, suggesting a role of bitter taste in the development of bitter beverage consumption. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2018/05/14 |
accepted |
2018/10/19 |
entrez |
2018/11/17 06:00 |
pubmed |
2018/11/18 06:00 |
medline |
2018/11/18 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Ong JS |
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Ong |
Jue-Sheng |
JS |
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School of Medicine, University of Queensland, Brisbane, Australia. juesheng.ong@qimrberghofer.edu.au. |
Hwang DL |
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Hwang |
Daniel Liang-Dar |
DL |
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University of Queensland Diamantina Institute, University of Queensland, Brisbane, Australia. d.hwang@uq.edu.au. |
Zhong VW |
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Zhong |
Victor W |
VW |
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Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
An J |
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An |
Jiyuan |
J |
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QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
Gharahkhani P |
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Gharahkhani |
Puya |
P |
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QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
Breslin PAS |
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Breslin |
Paul A S |
PAS |
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Department of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, 08901, USA. |
Wright MJ |
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Wright |
Margaret J |
MJ |
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Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, 4072, Australia. |
Lawlor DA |
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Lawlor |
Deborah A |
DA |
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Population Health Science, Bristol Medical School, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PS, UK. |
Whitfield J |
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Whitfield |
John |
J |
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QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
MacGregor S |
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MacGregor |
Stuart |
S |
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QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
Martin NG |
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Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
Cornelis MC |
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Cornelis |
Marilyn C |
MC |
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Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 8 |
ISSUE: 1 |
TITLE: Scientific reports |
ISOABBREVIATION: Sci Rep |
YEAR: 2018 |
MONTH: Nov |
DAY: 15 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 2045-2322 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Sci Rep |
COUNTRY: England |
ISSNLINKING: 2045-2322 |
NLMUNIQUEID: 101563288 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
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COMMENTS AND CORRECTIONS |
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REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
Cites |
Scand J Clin Lab Invest. 2011 Jul;71(4):274-9 |
21338274 |
|
Cites |
Perception. 2017 Mar-Apr;46(3-4):245-256 |
28118781 |
|
Cites |
Asia Pac J Clin Nutr. 2010;19(4):491-8 |
21147709 |
|
Cites |
Alcohol Clin Exp Res. 1996 May;20(3):493-7 |
8727242 |
|
Cites |
PLoS Med. 2015 Mar 31;12(3):e1001779 |
25826379 |
|
Cites |
Appetite. 2017 Sep 1;116:57-64 |
28455260 |
|
Cites |
Chem Senses. 2011 Mar;36(3):311-9 |
21163912 |
|
Cites |
Hum Mol Genet. 2014 Jan 1;23(1):259-67 |
23966204 |
|
Cites |
Int J Epidemiol. 2004 Feb;33(1):10-1 |
15075137 |
|
Cites |
Hum Mol Genet. 2010 Nov 1;19(21):4278-85 |
20675712 |
|
Cites |
Annu Rev Genomics Hum Genet. 2015;16:327-50 |
25939054 |
|
Cites |
Chem Senses. 2016 Aug 9;: |
27506221 |
|
Cites |
Mol Psychiatry. 2012 Apr;17(4):445-50 |
21968928 |
|
Cites |
Bioinformatics. 2016 Oct 15;32(20):3207-3209 |
27318201 |
|
Cites |
Chem Senses. 2012 Nov;37(9):869-81 |
22977065 |
|
Cites |
PLoS One. 2013 Dec 02;8(12):e80512 |
24312479 |
|
Cites |
Mol Psychiatry. 2015 May;20(5):647-656 |
25288136 |
|
Cites |
Annu Rev Nutr. 2017 Aug 21;37:131-156 |
28826374 |
|
Cites |
Chem Senses. 2006 Jun;31(5):403-13 |
16527870 |
|
Cites |
Prog Mol Biol Transl Sci. 2010;94:213-40 |
21036327 |
|
Cites |
Am J Clin Nutr. 2013 Oct;98(4):1136-43 |
24025627 |
|
Cites |
BMC Genomics. 2018 Sep 17;19(1):678 |
30223776 |
|
Cites |
Gigascience. 2015 Feb 25;4:7 |
25722852 |
|
Cites |
Alcohol Clin Exp Res. 2004 Nov;28(11):1629-37 |
15547448 |
|
Cites |
Physiol Behav. 2005 Jan 17;83(5):821-31 |
15639168 |
|
Cites |
Alcohol Clin Exp Res. 2007 Feb;31(2):209-15 |
17250611 |
|
Cites |
Alcohol Res Health. 2006;29(4):245-54 |
17718403 |
|
Cites |
Nat Genet. 2018 Aug;50(8):1067-1071 |
30054594 |
|
Cites |
Nat Genet. 2015 Mar;47(3):284-90 |
25642633 |
|
Cites |
Hepatology. 1986 May-Jun;6(3):502-10 |
3519419 |
|
Cites |
Am J Epidemiol. 2017 Nov 1;186(9):1026-1034 |
28641372 |
|
Cites |
Physiol Behav. 1994 Dec;56(6):1251-5 |
7878098 |
|
Cites |
Physiol Behav. 2015 Jan;138:219-26 |
25446205 |
|
Cites |
Int J Epidemiol. 2018 Feb 1;47(1):226-235 |
29040562 |
|
Cites |
Science. 2003 Feb 21;299(5610):1221-5 |
12595690 |
|
Cites |
Nutr Cancer. 1997;29(2):146-51 |
9427978 |
|
Cites |
Appetite. 2017 Feb 1;109:182-189 |
27915079 |
|
Cites |
Genet Epidemiol. 2013 Nov;37(7):658-65 |
24114802 |
|
Cites |
Eur Heart J. 2013 Aug;34(32):2519-28 |
23492672 |
|
Cites |
Alcohol Alcohol. 2001 Jan-Feb;36(1):79-84 |
11139421 |
|
Cites |
Addiction. 2005 Oct;100(10):1510-7 |
16185212 |
|
Cites |
Int J Epidemiol. 2016 Jun;45(3):908-15 |
27427429 |
|
Cites |
Genet Epidemiol. 2016 May;40(4):304-14 |
27061298 |
|
Cites |
Chem Senses. 2001 Jan;26(1):41-7 |
11124214 |
|
Cites |
PLoS Med. 2007 Dec;4(12):e352 |
18076282 |
|
Cites |
Int J Epidemiol. 2015 Apr;44(2):512-25 |
26050253 |
|
Cites |
Eur J Nutr. 2018 Jul 6;:null |
29980925 |
|
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
GNT1125200 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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APP1123248 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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241944 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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1031119 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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14SFRN20480260 |
American Heart Association (American Heart Association, Inc.) |
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DC02995 |
U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) |
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R03DC01337301A1 |
U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) |
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DP0664638 |
Australian Research Council (ARC) |
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DP1093900 |
Australian Research Council (ARC) |
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MC_UU_12013/5 |
Medical Research Council (MRC) |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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