Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30388399
TITLE
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
ABSTRACT
C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5 × 10 ). After adjustment for body mass index in the regression analysis, the associations at all except three loci remained. The lead variants at the distinct loci explained up to 7.0% of the variance in circulating amounts of CRP. We identified 66 gene sets that were organized in two substantially correlated clusters, one mainly composed of immune pathways and the other characterized by metabolic pathways in the liver. Mendelian randomization analyses revealed a causal protective effect of CRP on schizophrenia and a risk-increasing effect on bipolar disorder. Our findings provide further insights into the biology of inflammation and could lead to interventions for treating inflammation and its clinical consequences.
Copyright 2018 American Society of Human Genetics. All rights reserved.
DATE PUBLISHED
2018 Nov 01
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/05/16
accepted 2018/09/20
entrez 2018/11/03 06:00
pubmed 2018/11/06 06:00
medline 2018/11/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ligthart S Ligthart Symen S Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands.
Vaez A Vaez Ahmad A Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Võsa U Võsa Urmo U Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
Stathopoulou MG Stathopoulou Maria G MG Université de Lorraine, INSERM, IGE-PCV, 54000 Nancy, France.
de Vries PS de Vries Paul S PS Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Prins BP Prins Bram P BP Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
Van der Most PJ Van der Most Peter J PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Tanaka T Tanaka Toshiko T Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
Naderi E Naderi Elnaz E Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands.
Rose LM Rose Lynda M LM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
Wu Y Wu Ying Y Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Karlsson R Karlsson Robert R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Barbalic M Barbalic Maja M University of Split School of Medicine, Split 21000, Croatia.
Lin H Lin Honghuang H Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Pool R Pool René R Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands; Amsterdam Public Health research institute, VU University Medical Center, Amsterdam 1081 BT, the Netherlands.
Zhu G Zhu Gu G QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Macé A Macé Aurélien A Department of Computational Biology, University of Lausanne, Lausanne 1010, Switzerland; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland; Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne 1010, Switzerland.
Sidore C Sidore Carlo C Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy.
Trompet S Trompet Stella S Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands.
Mangino M Mangino Massimo M Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK; NIHR Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London SE1 9RT, UK.
Sabater-Lleal M Sabater-Lleal Maria M Unit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau, Barcelona 08025, Spain; Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Kemp JP Kemp John P JP University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD 4102, Australia; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
Abbasi A Abbasi Ali A Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands; MRC Epidemiology Unit, University of Cambridge School of Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
Kacprowski T Kacprowski Tim T Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald 17475, Germany; German Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald 17475, Germany.
Verweij N Verweij Niek N University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen 9713 AV, the Netherlands.
Smith AV Smith Albert V AV Icelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
Huang T Huang Tao T Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Marzi C Marzi Carola C Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research, Partner Site Munich, Munich 85764, Germany.
Feitosa MF Feitosa Mary F MF Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108-2212, USA.
Lohman KK Lohman Kurt K KK Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Kleber ME Kleber Marcus E ME Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany.
Milaneschi Y Milaneschi Yuri Y Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center/GGZ inGeest Research & Innovation, Amsterdam 1081 HJ, the Netherlands.
Mueller C Mueller Christian C Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg 20246, Germany; Institute of Medical Biometry and Statistics, University Medical Center Schleswig-Holstein, Campus Luebeck, Lübeck 23562, Germany; German Center for Cardiovascular Research, Partner Site RhineMain, 55131 Mainz, Germany.
Huq M Huq Mahmudul M Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Vlachopoulou E Vlachopoulou Efthymia E Transplantation Laboratory, Medicum, University of Helsinki, Helsinki 00014, Finland.
Lyytikäinen LP Lyytikäinen Leo-Pekka LP Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33014, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland.
Oldmeadow C Oldmeadow Christopher C Hunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
Deelen J Deelen Joris J Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands; Max Planck Institute for Biology of Ageing, Cologne 50931, Germany.
Perola M Perola Markus M National Institute for Health and Welfare, Helsinki 00271, Finland.
Zhao JH Zhao Jing Hua JH MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Feenstra B Feenstra Bjarke B Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark.
LifeLines Cohort Study Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Amini M Amini Marzyeh M Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
CHARGE Inflammation Working Group
Lahti J Lahti Jari J Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki 00014, Finland; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland; Folkhälsan Research Centre, Helsinki 00250, Finland.
Schraut KE Schraut Katharina E KE Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK.
Fornage M Fornage Myriam M Human Genetics Center, School of Public Health and Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Suktitipat B Suktitipat Bhoom B Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Chen WM Chen Wei-Min WM Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Li X Li Xiaohui X Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Nutile T Nutile Teresa T Institute of Genetics and Biophysics "A. Buzzati-Traverso," Consiglio Nazionale delle Ricerche, Napoli 80131, Italy.
Malerba G Malerba Giovanni G Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona 37134, Italy.
Luan J Luan Jian'an J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Bak T Bak Tom T Interdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, the Netherlands.
Schork N Schork Nicholas N Human Biology, J. Craig Venter Institute, La Jolla, CA 92037, USA; Quantitative Medicine, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Del Greco M F Del Greco M Fabiola F Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy.
Thiering E Thiering Elisabeth E Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg 85764, Germany; Ludwig Maximilian University of Munich, Dr. von Hauner Children's Hospital, Munich 80337, Germany.
Mahajan A Mahajan Anubha A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Marioni RE Marioni Riccardo E RE Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Mihailov E Mihailov Evelin E Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
Eriksson J Eriksson Joel J Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden.
Ozel AB Ozel Ayse Bilge AB Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-5618, USA.
Zhang W Zhang Weihua W Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK.
Nethander M Nethander Maria M Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 90, Sweden.
Cheng YC Cheng Yu-Ching YC Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Aslibekyan S Aslibekyan Stella S Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA.
Ang W Ang Wei W Medical School, University of Western Australia, Perth, WA 6009, Australia.
Gandin I Gandin Ilaria I AREA Science Park, Trieste 34149, Italy.
Yengo L Yengo Loïc L Centre National de la Recherche Scientifique UMR 8199, University of Lille, Institut Pasteur de Lille, European Genomic Institute for Diabetes, FR 3508, 59000 Lille, France; Program in Complex Trait Genomics, Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia.
Portas L Portas Laura L Support OU, Institute of Genetic and Biomedic Research, Consiglio Nazionale delle Ricerche, Sassari 7100, Italy.
Kooperberg C Kooperberg Charles C Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Mail Stop M3-A410, 1100 Fairview Ave. N., Seattle, WA, USA.
Hofer E Hofer Edith E Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz 8036, Austria; Institute of Medical Informatics, Statistics and Documentation, Medical University Graz, Graz 8036, Austria.
Rajan KB Rajan Kumar B KB Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Schurmann C Schurmann Claudia C Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
den Hollander W den Hollander Wouter W Department of Medical Statistics and Bio-informatics, Section Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Ahluwalia TS Ahluwalia Tarunveer S TS Steno Diabetes Center Copenhagen, Gentofte 2820, Denmark; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.
Zhao J Zhao Jing J Center for Integrative Genomics, School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Draisma HHM Draisma Harmen H M HHM Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands; Amsterdam Public Health research institute, VU University Medical Center, Amsterdam 1081 BT, the Netherlands; Neuroscience Campus Amsterdam, Amsterdam 1081 HV, the Netherlands.
Ford I Ford Ian I Robertson Centre for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK.
Timpson N Timpson Nicholas N MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
Teumer A Teumer Alexander A Department SHIP-KEF, Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Huang H Huang Hongyan H Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Wahl S Wahl Simone S Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research, Partner Site Munich, Munich 85764, Germany.
Liu Y Liu YongMei Y Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Huang J Huang Jie J Boston VA Research Institute, Inc., Boston, MA 02130, USA.
Uh HW Uh Hae-Won HW Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Geller F Geller Frank F Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark.
Joshi PK Joshi Peter K PK Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK.
Yanek LR Yanek Lisa R LR GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Trabetti E Trabetti Elisabetta E Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona 37134, Italy.
Lehne B Lehne Benjamin B Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Vozzi D Vozzi Diego D Institute for Maternal and Child Health, IRCCS "Burlo Garofolo," Trieste 34140, Italy.
Verbanck M Verbanck Marie M Centre National de la Recherche Scientifique UMR 8199, University of Lille, Institut Pasteur de Lille, European Genomic Institute for Diabetes, FR 3508, 59000 Lille, France.
Biino G Biino Ginevra G Institute of Molecular Genetics, Consiglio Nazionale delle Ricerche, Pavia 27100, Italy.
Saba Y Saba Yasaman Y Gottfried Schatz Research Center, Institute for Molecular Biology and Biochemistry, 8010 Graz, Austria.
Meulenbelt I Meulenbelt Ingrid I Department of Medical Statistics and Bio-informatics, Section Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
O'Connell JR O'Connell Jeff R JR Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Laakso M Laakso Markku M Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.
Giulianini F Giulianini Franco F Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Ballantyne CM Ballantyne Christie M CM Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Methodist DeBakey Heart and Vascular Center, Houston, TX 77030, USA.
Hottenga JJ Hottenga Jouke Jan JJ Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Rivadineira F Rivadineira Fernando F Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Rueedi R Rueedi Rico R Department of Computational Biology, University of Lausanne, Lausanne 1010, Switzerland; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.
Steri M Steri Maristella M Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy.
Herzig KH Herzig Karl-Heinz KH Department of Physiology, Institute of Biomedicine, University of Oulu, Medical Research Center Oulu and Oulu University Hospital, Oulu 90014, Finland; Biocenter Oulu, University of Oulu, Oulu 90220, Finland; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan 60-512, Poland.
Stott DJ Stott David J DJ Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
Menni C Menni Cristina C Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Frånberg M Frånberg Mattias M Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden; Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm 100 44, Sweden.
St Pourcain B St Pourcain Beate B MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK; Donders Institute, Radboud University, Nijmegen 6525 XD, the Netherlands.
Felix SB Felix Stephan B SB German Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald 17475, Germany; Department for Internal Medicine B, University Medicine Greifswald, Greifswald 17475, Germany.
Pers TH Pers Tune H TH Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.
Bakker SJL Bakker Stephan J L SJL Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands.
Kraft P Kraft Peter P Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Peters A Peters Annette A Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherber 85764, Germany.
Vaidya D Vaidya Dhananjay D GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Delgado G Delgado Graciela G Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany.
Smit JH Smit Johannes H JH Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center/GGZ inGeest Research & Innovation, Amsterdam 1081 HJ, the Netherlands.
Großmann V Großmann Vera V Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz 55131, Germany.
Sinisalo J Sinisalo Juha J Heart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki 00029, Finland.
Seppälä I Seppälä Ilkka I Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33014, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland.
Williams SR Williams Stephen R SR Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA.
Holliday EG Holliday Elizabeth G EG Hunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
Moed M Moed Matthijs M Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Langenberg C Langenberg Claudia C MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Räikkönen K Räikkönen Katri K Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.
Ding J Ding Jingzhong J Department of Internal Medicine/Geriatrics, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Campbell H Campbell Harry H Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK.
Sale MM Sale Michele M MM Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Chen YI Chen Yii-Der I YI Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
James AL James Alan L AL Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia.
Ruggiero D Ruggiero Daniela D Institute of Genetics and Biophysics "A. Buzzati-Traverso," Consiglio Nazionale delle Ricerche, Napoli 80131, Italy; IRCCS Neuromed, Pozzilli (IS) 86077, Italy.
Soranzo N Soranzo Nicole N Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
Hartman CA Hartman Catharina A CA Interdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, the Netherlands.
Smith EN Smith Erin N EN Department of Pediatrics and Rady Children's Hospital, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
Berenson GS Berenson Gerald S GS Center for Cardiovascular Health, Tulane University, New Orleans, LA 70112, USA.
Fuchsberger C Fuchsberger Christian C Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy.
Hernandez D Hernandez Dena D Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
Tiesler CMT Tiesler Carla M T CMT Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg 85764, Germany; Ludwig Maximilian University of Munich, Dr. von Hauner Children's Hospital, Munich 80337, Germany.
Giedraitis V Giedraitis Vilmantas V Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala 752 37, Sweden.
Liewald D Liewald David D Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Fischer K Fischer Krista K Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
Mellström D Mellström Dan D Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden.
Larsson A Larsson Anders A Department of Medical Sciences, Uppsala University, Uppsala 751 41, Sweden.
Wang Y Wang Yunmei Y Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, Harrington Heart & Vascular Institute, University Hospitals, Cleveland, OH 44106, USA.
Scott WR Scott William R WR Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Lorentzon M Lorentzon Matthias M Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden; Geriatric Medicine, Sahlgrenska University Hospital, Mölndal 431 80, Sweden.
Beilby J Beilby John J PathWest Laboratory Medicine WA, Nedlands, WA 6009, Australia; School of Biomedical Sciences, University of Western Australia, Crawley, Perth, WA 6009, Australia.
Ryan KA Ryan Kathleen A KA Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Pennell CE Pennell Craig E CE Medical School, University of Western Australia, Perth, WA 6009, Australia.
Vuckovic D Vuckovic Dragana D Medical Sciences, Surgical and Health Department, University of Trieste, Trieste 34137, Italy.
Balkau B Balkau Beverly B INSERM U1018, Centre de Recherche en Epidémiologie et Santé des Populations, Team 5 (EpReC, Renal, and Cardiovascular Epidemiology), Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Villejuif 94807, France.
Concas MP Concas Maria Pina MP Institute for Maternal and Child Health, IRCCS "Burlo Garofolo," Trieste 34140, Italy.
Schmidt R Schmidt Reinhold R Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz 8036, Austria.
Mendes de Leon CF Mendes de Leon Carlos F CF Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Bottinger EP Bottinger Erwin P EP Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kloppenburg M Kloppenburg Margreet M Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Paternoster L Paternoster Lavinia L MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
Boehnke M Boehnke Michael M Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Musk AW Musk A W AW Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands.
Evans DM Evans David M DM University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD 4102, Australia; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
Madden PAF Madden Pamela A F PAF Department of Psychiatry, Washington University School of Medicine, 4560 Clayton Ave., Suite 1000, St. Louis, MO 63110, USA.
Kähönen M Kähönen Mika M Department of Clinical Physiology, Tampere University Hospital, Tampere 33520, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland.
Kutalik Z Kutalik Zoltán Z Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland; Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne 1010, Switzerland.
Zoledziewska M Zoledziewska Magdalena M Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy.
Karhunen V Karhunen Ville V Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulun yliopisto, Finland.
Kritchevsky SB Kritchevsky Stephen B SB Gerontology and Geriatric Medicine, Sticht Center on Aging and Rehabilitation, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Sattar N Sattar Naveed N BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow G12 8TA, UK.
Lachance G Lachance Genevieve G Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Clarke R Clarke Robert R Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Harris TB Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA.
Raitakari OT Raitakari Olli T OT Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20520, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland.
Attia JR Attia John R JR Hunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; John Hunter Hospital, New Lambton Heights, NWS 2305, Australia.
van Heemst D van Heemst Diana D Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands.
Kajantie E Kajantie Eero E Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki 00014, Finland; Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki 00290, Finland; Department of Obstetrics and Gynaecology, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu 90014, Finland.
Sorice R Sorice Rossella R Institute of Genetics and Biophysics "A. Buzzati-Traverso," Consiglio Nazionale delle Ricerche, Napoli 80131, Italy.
Gambaro G Gambaro Giovanni G Division of Nephrology and Dialysis, Columbus-Gemelli University Hospital, Università Cattolica del Sacro Cuore, Roma 168, Italy.
Scott RA Scott Robert A RA MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Hicks AA Hicks Andrew A AA Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy.
Ferrucci L Ferrucci Luigi L Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
Standl M Standl Marie M Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg 85764, Germany.
Lindgren CM Lindgren Cecilia M CM Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.
Starr JM Starr John M JM Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Alzheimer's Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Karlsson M Karlsson Magnus M Department of Clinical Sciences and Orthopaedic Surgery, Lund University, Malmo 20502, Sweden.
Lind L Lind Lars L Department of Medical Sciences, Uppsala University, Uppsala 751 41, Sweden.
Li JZ Li Jun Z JZ Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-5618, USA.
Chambers JC Chambers John C JC Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK; Imperial College Healthcare NHS Trust, London W12 0HS, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore; MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK.
Mori TA Mori Trevor A TA Medical School, University of Western Australia, Perth, WA 6009, Australia.
de Geus EJCN de Geus Eco J C N EJCN Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands; Amsterdam Public Health research institute, VU University Medical Center, Amsterdam 1081 BT, the Netherlands.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University School of Medicine, 4560 Clayton Ave., Suite 1000, St. Louis, MO 63110, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Auvinen J Auvinen Juha J Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulun yliopisto, Finland; Unit of Primary Health Care, Oulu University Hospital, Oulu 90220, Finland.
Buckley BM Buckley Brendan M BM Department of Epidemiology and Public Health, University College Cork, Cork T12 K8AF, Ireland.
de Craen AJM de Craen Anton J M AJM Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands.
Waldenberger M Waldenberger Melanie M Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, 80636 Munich, Germany.
Strauch K Strauch Konstantin K Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Genetic Epidemiology, Institute of Medical Informatics, Biometry, and Epidemiology, Faculty of Medicine, Ludwig Maximilian University of Munich, Neuherberg 85764, Germany.
Meitinger T Meitinger Thomas T Institute of Human Genetics, Technische Universität München, Munich 85764, Germany; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg 85764, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich 81377, Germany.
Scott RJ Scott Rodney J RJ Hunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Information-Based Medicine Stream, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
McEvoy M McEvoy Mark M Hunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
Beekman M Beekman Marian M Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Bombieri C Bombieri Cristina C Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona 37134, Italy.
Ridker PM Ridker Paul M PM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
Mohlke KL Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Morrison AC Morrison Alanna C AC Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands.
Whitfield JB Whitfield John B JB QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Strachan DP Strachan David P DP Population Health Research Institute, St. George's, University of London, London SW17 0RE, UK.
Hofman A Hofman Albert A Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands.
Vollenweider P Vollenweider Peter P Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne 1011, Switzerland.
Cucca F Cucca Francesco F Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy.
Jarvelin MR Jarvelin Marjo-Riitta MR Biocenter Oulu, University of Oulu, Oulu 90220, Finland; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulun yliopisto, Finland; Unit of Primary Health Care, Oulu University Hospital, Oulu 90220, Finland; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London W2 1PG, UK; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK.
Jukema JW Jukema J Wouter JW Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; Durrer Center for Cardiogenetic Research, Amsterdam 3501 DG, the Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht 3511 EP, the Netherlands.
Spector TD Spector Tim D TD Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Hamsten A Hamsten Anders A Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Zeller T Zeller Tanja T Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg 20246, Germany; German Center for Cardiovascular Research, Partner Site RhineMain, 55131 Mainz, Germany.
Uitterlinden AG Uitterlinden André G AG Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Nauck M Nauck Matthias M German Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald 17475, Germany; Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Gudnason V Gudnason Vilmundur V Icelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
Qi L Qi Lu L Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
Grallert H Grallert Harald H Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research, Partner Site Munich, Munich 85764, Germany.
Borecki IB Borecki Ingrid B IB Analytical Genetics Group, Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
Rotter JI Rotter Jerome I JI Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
März W März Winfried W Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim 68161, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.
Wild PS Wild Philipp S PS German Center for Cardiovascular Research, Partner Site RhineMain, 55131 Mainz, Germany; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz 55131, Germany; Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz 55131, Germany.
Lokki ML Lokki Marja-Liisa ML Transplantation Laboratory, Medicum, University of Helsinki, Helsinki 00014, Finland.
Boyle M Boyle Michael M John Hunter Hospital, New Lambton Heights, NWS 2305, Australia.
Salomaa V Salomaa Veikko V National Institute for Health and Welfare, Helsinki 00271, Finland.
Melbye M Melbye Mads M Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen 2300, Denmark; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Eriksson JG Eriksson Johan G JG National Institute for Health and Welfare, Helsinki 00271, Finland; Folkhälsan Research Centre, Helsinki 00250, Finland; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland.
Wilson JF Wilson James F JF Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK; MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center/GGZ inGeest Research & Innovation, Amsterdam 1081 HJ, the Netherlands.
Becker DM Becker Diane M DM GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Worrall BB Worrall Bradford B BB Departments of Neurology and Public Health Sciences, University of Virginia Charlottesville, Charlottesville, VA 22908-0394, USA.
Gibson G Gibson Greg G Center for Integrative Genomics, School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Krauss RM Krauss Ronald M RM Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Ciullo M Ciullo Marina M Institute of Genetics and Biophysics "A. Buzzati-Traverso," Consiglio Nazionale delle Ricerche, Napoli 80131, Italy; IRCCS Neuromed, Pozzilli (IS) 86077, Italy.
Zaza G Zaza Gianluigi G Renal Unit, Department of Medicine, Verona University Hospital, Verona 37126, Italy.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Oldehinkel AJ Oldehinkel Albertine J AJ Interdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, the Netherlands.
Palmer LJ Palmer Lyle J LJ School of Public Health, University of Adelaide, Adelaide, SA 5000, Australia.
Murray SS Murray Sarah S SS Department of Pathology, University of California, San Diego, San Diego, CA 92121, USA.
Pramstaller PP Pramstaller Peter P PP Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy; General Central Hospital, Department of Neurology, Bolzano 39100, Italy; Department of Neurology, University of Lübeck, Lübeck 23538, Germany.
Bandinelli S Bandinelli Stefania S Geriatric Unit, Azienda Sanitaria Firenze, Florence 50122, Italy.
Heinrich J Heinrich Joachim J Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg 85764, Germany; Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich, Member DZL, German Center for Lung Research, 81377 Munich, Germany.
Ingelsson E Ingelsson Erik E Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala 751 41, Sweden; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA.
Deary IJ Deary Ian J IJ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Mägi R Mägi Reedik R Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
Vandenput L Vandenput Liesbeth L Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden.
van der Harst P van der Harst Pim P University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen 9713 AV, the Netherlands.
Desch KC Desch Karl C KC Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109, USA.
Kooner JS Kooner Jaspal S JS Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK; Imperial College Healthcare NHS Trust, London W12 0HS, UK; MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
Ohlsson C Ohlsson Claes C Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden.
Hayward C Hayward Caroline C MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33014, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland.
Shuldiner AR Shuldiner Alan R AR Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Arnett DK Arnett Donna K DK University of Kentucky, College of Public Health, Lexington, KY 40508, USA.
Beilin LJ Beilin Lawrence J LJ Medical School, University of Western Australia, Perth, WA 6009, Australia.
Robino A Robino Antonietta A Institute for Maternal and Child Health, IRCCS "Burlo Garofolo," Trieste 34140, Italy.
Froguel P Froguel Philippe P Centre National de la Recherche Scientifique UMR 8199, University of Lille, Institut Pasteur de Lille, European Genomic Institute for Diabetes, FR 3508, 59000 Lille, France; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London SW7 2AZ, UK.
Pirastu M Pirastu Mario M Support OU, Institute of Genetic and Biomedic Research, Consiglio Nazionale delle Ricerche, Sassari 7100, Italy.
Jess T Jess Tine T Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg 2200, Denmark.
Koenig W Koenig Wolfgang W German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, 80636 Munich, Germany; Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, 80801 Ulm, Germany; Deutsches Herzzentrum München, Technische Universität München, 80636 Munich, Germany.
Loos RJF Loos Ruth J F RJF Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6542, USA.
Evans DA Evans Denis A DA Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Schmidt H Schmidt Helena H Department of Neurology, Medical University Graz, Graz 8010, Austria; Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz 8010, Austria.
Smith GD Smith George Davey GD MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
Slagboom PE Slagboom P Eline PE Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Eiriksdottir G Eiriksdottir Gudny G Icelandic Heart Association, Kopavogur 201, Iceland.
Morris AP Morris Andrew P AP Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
Psaty BM Psaty Bruce M BM Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98101, USA; Department of Health Services, University of Washington, Seattle, WA 98195-7660, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Tracy RP Tracy Russell P RP Department of Pathology, University of Vermont, Colchester, VT 05405, USA.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Boerwinkle E Boerwinkle Eric E Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Visvikis-Siest S Visvikis-Siest Sophie S Université de Lorraine, INSERM, IGE-PCV, 54000 Nancy, France.
Reiner AP Reiner Alex P AP Department of Epidemiology, University of Washington, Seattle, WA 98101, USA.
Gross M Gross Myron M Department of Lab Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Bis JC Bis Joshua C JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
Franke L Franke Lude L Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Franco OH Franco Oscar H OH Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland.
Benjamin EJ Benjamin Emelia J EJ Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Chasman DI Chasman Daniel I DI Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
Dupuis J Dupuis Josée J National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Snieder H Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Dehghan A Dehghan Abbas A Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London W2 1PG, UK. Electronic address: a.dehghan@imperial.ac.uk.
Alizadeh BZ Alizadeh Behrooz Z BZ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Electronic address: b.z.alizadeh@umcg.nl.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Alizadeh Behrooz Z BZ
Boezen H Marike HM
Franke Lude L
van der Harst Pim P
Navis Gerjan G
Rots Marianne M
Snieder Harold H
Swertz Morris M
Wolffenbuttel Bruce H R BHR
Wijmenga Cisca C
Benjamin Emelia E
Chasman Daniel I DI
Dehghan Abbas A
Ahluwalia Tarunveer Singh TS
Meigs James J
Tracy Russell R
Alizadeh Behrooz Z BZ
Ligthart Symen S
Bis Josh J
Eiriksdottir Gudny G
Pankratz Nathan N
Gross Myron M
Rainer Alex A
Snieder Harold H
Wilson James G JG
Psaty Bruce M BM
Dupuis Josee J
Prins Bram B
Vaso Urmo U
Stathopoulou Maria M
Franke Lude L
Lehtimaki Terho T
Koenig Wolfgang W
Jamshidi Yalda Y
Siest Sophie S
Abbasi Ali A
Uitterlinden Andre G AG
Abdollahi Mohammadreza M
Schnabel Renate R
Schick Ursula M UM
Nolte Ilja M IM
Kraja Aldi A
Hsu Yi-Hsiang YH
Tylee Daniel S DS
Zwicker Alyson A
Uher Rudolf R
Davey-Smith George G
Morrison Alanna C AC
Hicks Andrew A
van Duijn Cornelia M CM
Ward-Caviness Cavin C
Boerwinkle Eric E
Rotter J J
Rice Ken K
Lange Leslie L
Perola Markus M
de Geus Eco E
Morris Andrew P AP
Makela Kari Matti KM
Stacey David D
Eriksson Johan J
Frayling Tim M TM
Slagboom Eline P EP
JOURNAL
VOLUME: 103
ISSUE: 5
TITLE: American journal of human genetics
ISOABBREVIATION: Am. J. Hum. Genet.
YEAR: 2018
MONTH: Nov
DAY: 01
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1537-6605
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Hum Genet
COUNTRY: United States
ISSNLINKING: 0002-9297
NLMUNIQUEID: 0370475
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
C-reactive protein
DEPICT
Mendelian randomization
coronary artery disease
genome-wide association study
inflammation
inflammatory disorders
schizophrenia
system biology
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's