|
|
| PMID |
|
|
| TITLE |
|
| The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods. |
|
| ABSTRACT |
|
| BACKGROUND |
|
| Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. |
| METHODS |
|
| Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. |
| RESULTS |
|
| Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. |
| CONCLUSIONS |
|
| Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3. |
| Copyright © 2018. Published by Elsevier Inc. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2018/05/15 |
| revised |
2018/09/17 |
| accepted |
2018/09/28 |
| pubmed |
2018/10/06 06:00 |
| medline |
2019/11/26 06:00 |
| entrez |
2018/10/06 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Thornton LM |
|
Thornton |
Laura M |
LM |
|
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| Munn-Chernoff MA |
|
Munn-Chernoff |
Melissa A |
MA |
|
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| Baker JH |
|
Baker |
Jessica H |
JH |
|
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| Juréus A |
|
Juréus |
Anders |
A |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden. |
| Parker R |
|
Parker |
Richard |
R |
|
QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia. |
| Henders AK |
|
Henders |
Anjali K |
AK |
|
The University of Queensland, Brisbane, QLD 4072, Australia. |
| Larsen JT |
|
Larsen |
Janne T |
JT |
|
Aarhus University, Norde Ringgade 1, 8000 Aarhus, Denmark. |
| Petersen L |
|
Petersen |
Liselotte |
L |
|
Aarhus University, Norde Ringgade 1, 8000 Aarhus, Denmark. |
| Watson HJ |
|
Watson |
Hunna J |
HJ |
|
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia; Curtin University, GPO Box U1987, Perth, WA 6845, Australia. |
| Yilmaz Z |
|
Yilmaz |
Zeynep |
Z |
|
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| Kirk KM |
|
Kirk |
Katherine M |
KM |
|
QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia. |
| Gordon S |
|
Gordon |
Scott |
S |
|
QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia. |
| Leppä VM |
|
Leppä |
Virpi M |
VM |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden. |
| Martin FC |
|
Martin |
Felicity C |
FC |
|
QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia. |
| Whiteman DC |
|
Whiteman |
David C |
DC |
|
QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia. |
| Olsen CM |
|
Olsen |
Catherine M |
CM |
|
QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia. |
| Werge TM |
|
Werge |
Thomas M |
TM |
|
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Bartholin Alle 6, 8000 Aarhus, Denmark; Mental Health Services, Institute for Biological Psychiatry, MHC Sct. Hans, Kristineberg 3, 2100 Copenhagen, Denmark; University of Copenhagen, Nørregade 10, DK-1165 Copenhagen, Denmark. |
| Pedersen NL |
|
Pedersen |
Nancy L |
NL |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden. |
| Kaye W |
|
Kaye |
Walter |
W |
|
University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA. |
| Bergen AW |
|
Bergen |
Andrew W |
AW |
|
Biorealm Research, 6101 W Centinela Ave # 270, Culver City, CA 90230, USA; Oregon Research Institute, Eugene, OR 97403, USA. |
| Halmi KA |
|
Halmi |
Katherine A |
KA |
|
Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA. |
| Strober M |
|
Strober |
Michael |
M |
|
University of California at Los Angeles, Los Angeles, CA 90095, USA. |
| Kaplan AS |
|
Kaplan |
Allan S |
AS |
|
University of Toronto, 27 King's College Circle, Toronto, ON M5S 1A1, Canada. |
| Woodside DB |
|
Woodside |
D Blake |
DB |
|
University of Toronto, 27 King's College Circle, Toronto, ON M5S 1A1, Canada; Toronto General Hospital, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada. |
| Mitchell J |
|
Mitchell |
James |
J |
|
Neuropsychiatric Research Institute, 120 8th Street South, Fargo, ND 58103, USA. |
| Johnson CL |
|
Johnson |
Craig L |
CL |
|
Eating Recovery Center, 7351 E. Lowry Blvd., Suite 200, Denver, CO 80230, USA. |
| Brandt H |
|
Brandt |
Harry |
H |
|
The Center for Eating Disorders at Sheppard Pratt, 6501 N. Charles Street, Baltimore, MD 21204, USA. |
| Crawford S |
|
Crawford |
Steven |
S |
|
The Center for Eating Disorders at Sheppard Pratt, 6501 N. Charles Street, Baltimore, MD 21204, USA. |
| Horwood LJ |
|
Horwood |
L John |
LJ |
|
Christchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand. |
| Boden JM |
|
Boden |
Joseph M |
JM |
|
Christchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand. |
| Pearson JF |
|
Pearson |
John F |
JF |
|
Christchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand. |
| Duncan LE |
|
Duncan |
Laramie E |
LE |
|
Stanford University, 450 Serra Mall, Stanford, CA 94305-2004, USA. |
| Grove J |
|
Grove |
Jakob |
J |
|
Aarhus University, Norde Ringgade 1, 8000 Aarhus, Denmark. |
| Mattheisen M |
|
Mattheisen |
Manuel |
M |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden; Aarhus University, Norde Ringgade 1, 8000 Aarhus, Denmark; Stockholm Health Care Services, Stockholm County Council, Box 45436, 104 31 Stockholm, Sweden; University of Würzburg, Sanderring 2, 97070 Würzburg, Germany. |
| Jordan J |
|
Jordan |
Jennifer |
J |
|
Christchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand. |
| Kennedy MA |
|
Kennedy |
Martin A |
MA |
|
Christchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand. |
| Birgegård A |
|
Birgegård |
Andreas |
A |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Box 45436, 104 31 Stockholm, Sweden. |
| Lichtenstein P |
|
Lichtenstein |
Paul |
P |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden. |
| Norring C |
|
Norring |
Claes |
C |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Box 45436, 104 31 Stockholm, Sweden. |
| Wade TD |
|
Wade |
Tracey D |
TD |
|
Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia. |
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
The University of Queensland, Brisbane, QLD 4072, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia. |
| Landén M |
|
Landén |
Mikael |
M |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden; Gothenburg University, Box 100, SE-405 30 Gothenburg, Sweden. |
| Mortensen PB |
|
Mortensen |
Preben Bo |
PB |
|
Aarhus University, Norde Ringgade 1, 8000 Aarhus, Denmark; Mental Health Services, Institute for Biological Psychiatry, MHC Sct. Hans, Kristineberg 3, 2100 Copenhagen, Denmark; University of Copenhagen, Nørregade 10, DK-1165 Copenhagen, Denmark. |
| Sullivan PF |
|
Sullivan |
Patrick F |
PF |
|
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden. |
| Bulik CM |
|
Bulik |
Cynthia M |
CM |
|
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden. Electronic address: cbulik@med.unc.edu. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 74 |
| ISSUE: |
| TITLE: Contemporary clinical trials |
| ISOABBREVIATION: Contemp Clin Trials |
| YEAR: 2018 |
| MONTH: 11 |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1559-2030 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Contemp Clin Trials |
| COUNTRY: United States |
| ISSNLINKING: 1551-7144 |
| NLMUNIQUEID: 101242342 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| K01 MH109782 |
NIMH NIH HHS |
United States |
| K01 MH106675 |
NIMH NIH HHS |
United States |
| K01 AA025113 |
NIAAA NIH HHS |
United States |
| U24 MH068457 |
NIMH NIH HHS |
United States |
| U01 MH109528 |
NIMH NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Anorexia nervosa |
| Eating disorders |
| Genome-wide association |
| Psychiatric genetics |
| Psychiatric genomics consortium |
| Social media |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Aged |
|
| Anorexia Nervosa |
genetics |
| Australia |
genetics |
| Case-Control Studies |
genetics |
| Denmark |
genetics |
| Feeding and Eating Disorders |
diagnosis |
| Female |
diagnosis |
| Humans |
diagnosis |
| Internet |
diagnosis |
| Middle Aged |
diagnosis |
| New Zealand |
diagnosis |
| Patient Selection |
diagnosis |
| Reproducibility of Results |
diagnosis |
| Surveys and Questionnaires |
diagnosis |
| Sweden |
diagnosis |
| United States |
diagnosis |
| Young Adult |
diagnosis |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
