Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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30283035
TITLE
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia.
ABSTRACT
Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = -0.71 to -1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = -0.95, P = 0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P = 0.0032, 8.9 × 10 , 1.7 × 10 , 3.5 × 10 and 1.0 × 10 , respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non-carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.
DATE PUBLISHED
2018 Oct 03
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/02/12
accepted 2018/05/25
revised 2018/05/02
pubmed 2018/10/05 06:00
medline 2018/10/05 06:00
entrez 2018/10/05 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Sønderby IE Sønderby Ida E IE NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Gústafsson Ó Gústafsson Ómar Ó deCODE Genetics/Amgen, Reykjavik, Iceland.
Doan NT Doan Nhat Trung NT NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Hibar DP Hibar Derrek P DP Janssen Research and Development, La Jolla, CA, USA.
Martin-Brevet S Martin-Brevet Sandra S Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Abdellaoui A Abdellaoui Abdel A Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.
Ames D Ames David D Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia.
Amunts K Amunts Katrin K JARA-BRAIN, Juelich-Aachen Research Alliance, Wilhelm-Johnen-Str., 52425, Juelich, Germany.
Andersson M Andersson Michael M Umeå Center for Functional Brain Imaging (UFBI), Umeå University, 90187, Umeå, Sweden.
Armstrong NJ Armstrong Nicola J NJ Mathematics and Statistics, Murdoch University, Perth, Australia.
Bernard M Bernard Manon M The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, Canada.
Blackburn N Blackburn Nicholas N South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, One West University Blvd., 78520, Brownsville, TX, USA.
Blangero J Blangero John J South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, One West University Blvd., 78520, Brownsville, TX, USA.
Boomsma DI Boomsma Dorret I DI Netherlands Twin Register, Vrije Universiteit, van der Boechorststraat 1, 1081BT, Amsterdam, Netherlands.
Bralten J Bralten Janita J Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Brattbak HR Brattbak Hans-Richard HR Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Brodaty H Brodaty Henry H Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, UNSW, Sydney, Australia.
Brouwer RM Brouwer Rachel M RM Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Bülow R Bülow Robin R Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Calhoun V Calhoun Vince V The Mind Research Network, The University of New Mexico, Albuquerque, NM, Mexico.
Caspers S Caspers Svenja S JARA-BRAIN, Juelich-Aachen Research Alliance, Wilhelm-Johnen-Str., 52425, Juelich, Germany.
Cavalleri G Cavalleri Gianpiero G The Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.
Chen CH Chen Chi-Hua CH Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, USA.
Cichon S Cichon Sven S Institute of Medical Genetics and Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031, Basel, Switzerland.
Ciufolini S Ciufolini Simone S Psychosis Studies, Insitute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespingy Park, SE5 8AF, London, United Kingdom.
Corvin A Corvin Aiden A Neuropsychiatric Genetics Research Group, Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
Crespo-Facorro B Crespo-Facorro Benedicto B CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, 39011, Spain.
Curran JE Curran Joanne E JE South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, One West University Blvd., 78520, Brownsville, TX, USA.
Dale AM Dale Anders M AM Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, USA.
Dalvie S Dalvie Shareefa S Department of Psychiatry and Mental Health, Anzio Road, 7925, Cape Town, South Africa.
Dazzan P Dazzan Paola P National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, United Kingdom.
de Geus EJC de Geus Eco J C EJC Amsterdam Neuroscience, VU University medical center, van der Boechorststraat 1, 1081 BT, Amsterdam, NH, Netherlands.
de Zubicaray GI de Zubicaray Greig I GI Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
de Zwarte SMC de Zwarte Sonja M C SMC Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Delanty N Delanty Norman N Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, 4860 Y Street, Suite 3700, Sacramento, California, 95817, USA.
den Braber A den Braber Anouk A Alzheimer Center and Department of Neurology, VU University Medical Center, De Boelelaan 1105, 1081HV, Amsterdam, Netherlands.
Desrivières S Desrivières Sylvane S Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Donohoe G Donohoe Gary G Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 8, Ireland.
Draganski B Draganski Bogdan B Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Ehrlich S Ehrlich Stefan S Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, 02129, USA.
Espeseth T Espeseth Thomas T Department of Psychology, University of Oslo, Oslo, Norway.
Fisher SE Fisher Simon E SE Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
Franke B Franke Barbara B Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Frouin V Frouin Vincent V NeuroSpin, CEA, Université Paris-Saclay, F-91191, Gif-sur-Yvette, France.
Fukunaga M Fukunaga Masaki M Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, Japan.
Gareau T Gareau Thomas T NeuroSpin, CEA, Université Paris-Saclay, F-91191, Gif-sur-Yvette, France.
Glahn DC Glahn David C DC Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, 300 George Street, 6106, Hartford, CT, USA.
Grabe H Grabe Hans H Department of Psychiatry und Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Groenewold NA Groenewold Nynke A NA Department of Psychiatry and Mental Health, Anzio Road, 7925, Cape Town, South Africa.
Haavik J Haavik Jan J K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
Håberg A Håberg Asta A Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Hashimoto R Hashimoto Ryota R Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan.
Hehir-Kwa JY Hehir-Kwa Jayne Y JY Princess Máxima Center for Pediatric Oncology, Lundlaan 6, 3584 EA, Utrecht, The Netherlands.
Heinz A Heinz Andreas A Dept. of Psychiatry and Psychotherapie, Charite, Humboldt University, Chariteplatz 1, 10017, Berlin, Germany.
Hillegers MHJ Hillegers Manon H J MHJ Child and adolescent Psychiatry / Psychology, Erasmus medical center-Sophia's Childerens hospitaal, Rotterdam, Wytemaweg 8, 3000 CB, Rotterdam, The Netherlands.
Hoffmann P Hoffmann Per P Institute of Human Genetics, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
Holleran L Holleran Laurena L The Centre for Neuroimaging & Cognitive Genomics (NICOG) and NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland.
Hottenga JJ Hottenga Jouke-Jan JJ Biological Psychology, Vrije Universiteit Amsterdam, van Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Hulshoff HE Hulshoff Hilleke E HE Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Ikeda M Ikeda Masashi M Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, USA.
Jernigan T Jernigan Terry T Center for Human Development, University of California San Diego, San Diego, CA, USA.
Jockwitz C Jockwitz Christiane C Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Medical Faculty, Pauwelsstraße 30, 52074, Aachen, Germany.
Johansson S Johansson Stefan S K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
Jonsdottir GA Jonsdottir Gudrun A GA deCODE Genetics/Amgen, Reykjavik, Iceland.
Jönsson EG Jönsson Erik G EG Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital Solna, R5:00, SE-17176, Stockholm, Sweden.
Kahn R Kahn Rene R Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Kaufmann T Kaufmann Tobias T NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Kelly S Kelly Sinead S The Centre for Neuroimaging & Cognitive Genomics (NICOG) and NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland.
Kikuchi M Kikuchi Masataka M Department of Genome Informatics, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Knowles EEM Knowles Emma E M EEM Department of Psychiatry, Yale University, 40 Temple Street, 6515, New Haven, CT, USA.
Kolskår KK Kolskår Knut K KK Sunnaas Rehabilitation Hospital HT, Nesodden, Norway.
Kwok JB Kwok John B JB Brain and Mind Centre, University of Sydney, Sydney, Australia.
Hellard SL Hellard Stephanie Le SL Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Jonas Lies veg 87, 5021, Bergen, Norway.
Leu C Leu Costin C Institute of Neurology, University College London, London, United Kingdom.
Liu J Liu Jingyu J Dept. of Electrical and Computer Engineering, University of New Mexico, 87131, Albuquerque, New Mexico, USA.
Lundervold AJ Lundervold Astri J AJ Department of Biological and Medical Psychology, Jonas Lies vei 91, N-5009, Bergen, Norway.
Lundervold A Lundervold Arvid A Department of Biomedicine, University of Bergen, 5009, Bergen, Norway.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Mather K Mather Karen K Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, 2052, Australia.
Mathias SR Mathias Samuel R SR Department of Psychiatry, Yale University, 40 Temple Street, 6515, New Haven, CT, USA.
McCormack M McCormack Mark M Centre for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, Netherlands.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
McRae A McRae Allan A Program in Complex Trait Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia.
Milaneschi Y Milaneschi Yuri Y Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands, Oldenaller 1, 1081 HJ, Amsterdam, The Netherlands.
Moreau C Moreau Clara C CHU Sainte-Justine Research Center, Université de Montréal, Montréal, QC, Canada.
Morris D Morris Derek D Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 8, Ireland.
Mothersill D Mothersill David D The Centre for Neuroimaging & Cognitive Genomics (NICOG) and NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland.
Mühleisen TW Mühleisen Thomas W TW Human Genomics Research Group, Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland.
Murray R Murray Robin R Departments of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Nordvik JE Nordvik Jan E JE Sunnaas Rehabilitation Hospital HT, Nesodden, Norway.
Nyberg L Nyberg Lars L Umeå Center for Functional Brain Imaging (UFBI), Umeå University, 90187, Umeå, Sweden.
Olde Loohuis LM Olde Loohuis Loes M LM Center for Neurobehavioral Genetics, University of California, Los Angeles, California, 90095, USA.
Ophoff R Ophoff Roel R Center for Neurobehavioral Genetics, University of California, Los Angeles, California, 90095, USA.
Paus T Paus Tomas T Department of Psychology, University of Toronto, Toronto, M5S 1A1, Canada.
Pausova Z Pausova Zdenka Z The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, Canada.
Penninx B Penninx Brenda B Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical, Amsterdam, Netherlands.
Peralta JM Peralta Juan M JM South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, One West University Blvd., 78520, Brownsville, TX, USA.
Pike B Pike Bruce B Departments of Radiology & Clinical Neuroscience, University of Calgary, Calgary, T2N 1N4, Canada.
Prieto C Prieto Carlos C Bioinformatics Service, Nucleus, University of Salamanca (USAL), 37007, Salamanca, Spain.
Pudas S Pudas Sara S Department of Integrative Medical Biology, Linnéus väg 9, 901 87, Umeå, Sweden.
Quinlan E Quinlan Erin E Centre for Population Neuroscience and Stratified Medicine, Social, Genetic and Development Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, London, UK.
Quintana DS Quintana Daniel S DS Department of Psychology, University of Oslo, Oslo, Norway.
Reinbold CS Reinbold Céline S CS Institute of Medical Genetics and Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031, Basel, Switzerland.
Marques TR Marques Tiago Reis TR Psychiatry Imaging Group, MRC London Institute of Medical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, W12 0NN, London, UK.
Reymond A Reymond Alexandre A Center for Integrative Genomics, University of Lausanne, Genopode building, CH-1015, Lausanne, Switzerland.
Richard G Richard Genevieve G Sunnaas Rehabilitation Hospital HT, Nesodden, Norway.
Rodriguez-Herreros B Rodriguez-Herreros Borja B CHU Sainte-Justine Research Center, Université de Montréal, Montréal, QC, Canada.
Roiz-Santiañez R Roiz-Santiañez Roberto R CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, 39011, Spain.
Rokicki J Rokicki Jarek J NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Rucker J Rucker James J Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Sachdev P Sachdev Perminder P Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, 2052, Australia.
Sanders AM Sanders Anne-Marthe AM Brain and Mind Centre, University of Sydney, Sydney, Australia.
Sando SB Sando Sigrid B SB Department of Neurology, University Hospital of Trondheim, Edvard Griegs gate 8, N-7006, Trondheim, Norway.
Schmaal L Schmaal Lianne L Department of Psychiatry, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands.
Schofield PR Schofield Peter R PR School of Medical Sciences, University of New South Wales, Sydney, Australia.
Schork AJ Schork Andrew J AJ Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, USA.
Schumann G Schumann Gunter G Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Shin J Shin Jean J Center for Neurobehavioral Genetics, University of California, Los Angeles, California, 90095, USA.
Shumskaya E Shumskaya Elena E Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
Sisodiya S Sisodiya Sanjay S Chalfont Centre for Epilepsy, London, UK.
Steen VM Steen Vidar M VM Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Jonas Lies veg 87, 5021, Bergen, Norway.
Stein DJ Stein Dan J DJ MRC Unit on Risk & Resilience in Mental Disorders, Stellenbosch, South Africa.
Steinberg S Steinberg Stacy S deCODE Genetics/Amgen, Reykjavik, Iceland.
Strike L Strike Lachlan L Queensland Brain Institute, University of Queensland, St Lucia, Queensland, Australia.
Teumer A Teumer Alexander A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Thalamuthu A Thalamuthu Anbu A Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, 2052, Australia.
Tordesillas-Gutierrez D Tordesillas-Gutierrez Diana D Neuroimaging Unit, Technological Facilities. Valdecilla Biomedical Research Institute IDIVAL, Santander, Cantabria, 39011, Spain.
Turner J Turner Jessica J Department of Psychology, Georgia State University, Atlanta, GA, USA.
Ueland T Ueland Torill T NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Uhlmann A Uhlmann Anne A Department of Psychiatry, 1 South Prospect Street, 5401, Burlington, Vermont, USA.
Ulfarsson MO Ulfarsson Magnus O MO Faculty of Electrical and Computer Engineering, University of Iceland, Reykjavik, Iceland.
van 't Ent D van 't Ent Dennis D Biological Psychology, Vrije Universiteit Amsterdam, van Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
van der Meer D van der Meer Dennis D NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
van Haren NEM van Haren Neeltje E M NEM Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Vaskinn A Vaskinn Anja A NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Vassos E Vassos Evangelos E MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, London, UK.
Walters GB Walters G Bragi GB Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Wang Y Wang Yunpeng Y NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Wen W Wen Wei W Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, 2052, Australia.
Whelan CD Whelan Christopher D CD Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St. Stephens Green, D02 YN77, Dublin, Ireland.
Wittfeld K Wittfeld Katharina K German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, Greifswald, Germany.
Wright M Wright Margie M Centre for Advanced Imaging, University of Queensland, St Lucia, Queensland, Australia.
Yamamori H Yamamori Hidenaga H Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Zayats T Zayats Tetyana T Department of Biomedicine, University of Bergen, 5009, Bergen, Norway.
Agartz I Agartz Ingrid I NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Westlye LT Westlye Lars T LT Department of Psychology, University of Oslo, Oslo, Norway.
Jacquemont S Jacquemont Sébastien S Department of Pediatrics, University of Montreal, Montreal, H3C 3J7, Canada.
Djurovic S Djurovic Srdjan S Department of Medical Genetics, Oslo University Hospital, Kirkeveien 166, 424, Oslo, Norway.
Stefánsson H Stefánsson Hreinn H deCODE Genetics/Amgen, Reykjavik, Iceland.
Stefánsson K Stefánsson Kári K Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Thompson P Thompson Paul P Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, USA.
Andreassen OA Andreassen Ole A OA NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. andreassen@medisin.uio.no.
16p11.2 European Consortium, for the ENIGMA-CNV working group
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol. Psychiatry
YEAR: 2018
MONTH: Oct
DAY: 03
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
ErratumIn Mol Psychiatry. 2019 Jan 31;: 30705424
GRANTS
GRANTID AGENCY COUNTRY
223273 Norges Forskningsråd (Research Council of Norway)
32003B_159780 Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
31003A_160203 Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
SFARI274424 Simons Foundation
GENERAL NOTE
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